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  3. Tretoact 25 Capsule

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Tretoact 25 Capsule, Pack of 1 Capsule
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Tretoact 25 Capsule is used to treat psoriasis. It contains Acitretin, which slows down the progression of the disease. It slows the growth of skin cells and gradually clears the affected skin. It helps reduce the redness, scaling, and thickness of psoriasis rashes. It may cause side effects such as dry lips, skin peeling, skin scaling and thinning, skin reddening, and a burning or itching sensation on the skin.

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Composition :

ACITRETIN-25MG

Manufacturer/Marketer :

Rockmed Pharma Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Tretoact 25 Capsule

Tretoact 25 Capsule is used to treat psoriasis. Psoriasis is an autoimmune (immune system attacks healthy cells) skin disorder in which the skin becomes scaly, swollen, and itchy. It mostly affects the knee, elbows, scalp, and trunk. It is a lifelong condition, and treatment aims to remove affected skin cells and prevent flare-ups.

Tretoact 25 Capsule contains ‘Acitretin’, which belongs to the class of retinoids derived from vitamin A. It has anti-inflammatory and antiproliferative (anti-proliferative) properties (i.e., it decreases skin cell multiplication). It works by slowing down the progression of the disease. It slows the growth of skin cells and gradually clears the affected skin. It helps reduce the redness, scaling, and thickness of psoriasis rashes.

Tretoact 25 Capsule may cause side effects such as dry lips, peeling of the skin, especially the palms of the hands and soles of the feet, nose bleed, scaling and thinning of healthy skin, reddening of the skin, itching, burning sensation on the skin, sticky skin, hair loss, swelling and pain in the area around your nails, fragile nails, inflammation of the eye (conjunctivitis), increased thirst, and feeling cold. These side effects usually go away after discontinuing the treatment. However, if any of these side effects persist or worsen, inform your doctor immediately.

Do not take Tretoact 25 Capsule if you are allergic to Acitretin or any other ingredients present in it. Tretoact 25 Capsule should not be used in pregnant and breastfeeding women, in patients with liver or kidney failure or high cholesterol and who are taking other medicines containing retinoids or supplements containing vitamin A.

Tretoact 25 Capsule should be used with caution in children as it may affect growth and bone development. Tretoact 25 Capsule may require dose adjustments when used in older people. Do not consume alcohol, as it may increase the risk of side effects. Tretoact 25 Capsule may cause vision problems, especially in the dark, so do not drive or operate heavy machinery if you notice any vision problems.

Uses of Tretoact 25 Capsule

Tretoact 25 Capsule is used in the treatment of psoriasis and other skin conditions. The detailed uses of Tretoact 25 Capsule are as follows:

  • Treats Psoriasis: Tretoact 25 Capsule is used to treat psoriasis when other conventional treatments (corticosteroids or phototherapy) are ineffective. It helps reduce skin thickening and scaling by slowing down excessive skin cell growth.
  • Manages Keratinisation Disorders: Tretoact 25 Capsule is also used to treat skin conditions involving abnormal skin thickening due to excess keratin production, such as ichthyosis, pityriasis, lichen planus, and keratosis follicularis.

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Directions for Use

  • Tretoact 25 Capsule can be taken preferably with meals or a glass of milk as advised by a doctor.
  • It is advised to take Tretoact 25 Capsule once daily, or as directed by your doctor, at the same time each day for best results.
  • Swallow it as a whole with a glass of water.
  • Do not crush, chew, or break it.

Medicinal Benefits

  • Tretoact 25 Capsule effectively treats severe psoriasis by reducing excessive skin cell growth.
  • Helps clear scaly, thickened, and inflamed skin lesions.
  • Improves overall skin texture and appearance in chronic skin conditions.
  • Reduces inflammation and scaling associated with psoriasis and keratinisation disorders.
  • Used in treating other skin conditions like ichthyosis and keratosis pilaris.
  • Helps normalise skin cell differentiation and turnover.
  • Provides long-term improvement and remission in severe, resistant psoriasis.
  • It can be used as part of a comprehensive therapy to enhance skin healing and reduce flare-ups.

How Tretoact 25 Capsule Works

Tretoact 25 Capsule contains Acitretin, which belongs to the class of retinoids derived from vitamin A. It has anti-inflammatory and antiproliferative (anti-proliferative) properties (i.e., it decreases skin cell multiplication). It works by slowing down the progression of the disease. It slows the growth of skin cells and gradually clears the affected skin.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Tretoact 25 Capsule
  • Know your allergens that cause dermatitis and avoid them.
  • Use fragrance-free detergents and soaps.
  • Apply moisturizer after taking bath to retain moisture in the skin.
  • Apply cool, moist compresses to the rash.
  • Talk to your doctor about creams and ointments to manage your dermatitis.
Managing Medication-Related Skin Allergies: A Step-by-Step Guide
  • If you experience signs of skin allergies such as redness, itching, or irritation after taking medication, contact your doctor right away.
  • To alleviate skin allergy symptoms, your doctor may change your medication regimen or offer tailored medication management advice.
  • Your doctor may recommend or prescribe drugs to relieve discomfort.
  • Cool compresses or calamine lotion can help relieve redness and itching on the afflicted skin area.
  • Staying hydrated by consuming plenty of water can help relieve discomfort.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
Here are the steps to manage angioedema (Swelling Under The Skin) as a side effect of medication:
  • If you experience angioedema, inform your doctor immediately. Treatment can help keep the swelling under control.
  • Seek medical attention if symptoms are severe, such as difficulty breathing or swallowing.
  • Follow your doctor's instructions to manage symptoms, which may include stopping or adjusting the medication that triggered angioedema.
  • Your doctor may also recommend antihistamines, steroids, or other treatments to reduce swelling and inflammation.
  • Make dietary and lifestyle changes as recommended, such as avoiding trigger foods or reducing stress.
  • Monitor your condition closely and track your symptoms to report them to your doctor.
  • Consult your doctor again if symptoms worsen or do not improve or if you experience any new or concerning symptoms.
  • Avoid trigger foods that can cause allergic reactions, such as nuts, shellfish, or dairy products.
  • Keep a food diary to track potential food allergens.
  • Include omega-3 rich foods like salmon and walnuts to reduce inflammation.
  • Wear loose, comfortable clothing made from soft fabrics like cotton.
  • Apply cool compresses or take cool baths to reduce itching.
  • Use gentle soaps and avoid harsh skin products.
  • Reduce stress through relaxation techniques like meditation or deep breathing.
  • Try to practice deep breathing exercises or repeat calming words or phrases.
  • Seek for medical help if aggression occurs frequently, as it can worsen gradually if not attended.
  • You can also try listening to music or relaxing or writing a journal to express the feeling that aggravates to find a solution.
  • Suicidal thoughts need immediate medical attention else they can be uncontrollable.
  • Try to be in a comfortable space where there is someone to share your thoughts and discuss your problem.
  • Regularly do strengthening exercises to divert your thought process.
  • Prevent smoking and drinking alcohol, as they can affect your mind and increase suicidal thoughts.
  • Keep yourself engaged in any activity that prevents suicidal thoughts.
  • Practice yoga and meditation to improve your mental and overall health.
  • Eat fiber-rich foods like broccoli, cauliflower, leafy greens, and Brussels sprouts.
  • Limit sugar and refined carbs like avoid sugary drinks, white bread, and processed foods.
  • Choose lean protein sources like chicken, fish, and tofu.
  • Choose low-sugar fruits like berries, citrus fruits, and apples in moderation.
  • Maintain good hygiene and keep affected areas clean and dry.
  • Wear breathable clothing to reduce moisture.
  • Consider natural antifungal agents like coconut oil, tea tree oil, and garlic (consult a healthcare professional before use).

What if I have taken an overdose of Tretoact 25 Capsule

Do not take more than the prescribed dose of Tretoact 25 Capsule as it may cause overdose. The symptoms of overdose include headache, nausea, vomiting, drowsiness, itching and irritability. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

  • Tretoact 25 Capsule should not be used in pregnant and breastfeeding women. So, the doctor may advise you to take a pregnancy test before using Tretoact 25 Capsule. You should also take effective and reliable contraception (such as an intrauterine device, contraceptive implant, contraceptive pill and condom) during the treatment and for three years after discontinuing the treatment.
  • You should take reliable contraception even if your periods are not regular or you are not sexually active, unless your doctor decides that this is unnecessary.
  • You should not donate blood during treatment or for 3 years after discontinuing treatment.
  • Tretoact 25 Capsule should be used with caution in patients with diabetes as it can alter blood glucose levels.
  • Tretoact 25 Capsule may cause vision problems, especially in the night-time. So, inform your doctor if you notice vision problems.
  • Do not wear contact lenses during treatment, as Tretoact 25 Capsule may cause dry eyes.
  • Tretoact 25 Capsule may increase skin sensitivity, so avoid going in strong sunlight and using a sunbed.
  • Tretoact 25 Capsule may affect your mood, so inform your doctor if you have mental health problems like depression. Also, inform your doctor if you notice drastic mood changes while using Tretoact 25 Capsule.

Drug-Drug Interactions

verifiedApollotooltip
AcitretinOxytetracycline
Critical
AcitretinMedroxyprogesterone
Critical

Drug-Drug Interactions

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AcitretinOxytetracycline
Critical
How does the drug interact with Tretoact 25 Capsule:
Co-administration of Tretoact 25 Capsule with Oxytetracycline can increase the risk of a rare and serious condition called pseudotumor cerebri (caused by increased pressure in the brain).

How to manage the interaction:
Taking Tretoact 25 Capsule with Oxytetracycline together is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience headaches, nausea, vomiting, and visual disturbances, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AcitretinMedroxyprogesterone
Critical
How does the drug interact with Tretoact 25 Capsule:
Coadministration of Tretoact 25 Capsule with Medroxyprogesterone can increase the risk and severity of birth defects when taken by a pregnant woman.

How to manage the interaction:
Taking Tretoact 25 Capsule with Medroxyprogesterone together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. Consult a doctor if you get pregnant while taking these medications. Do not discontinue any medications without consulting a doctor.
AcitretinEtonogestrel
Critical
How does the drug interact with Tretoact 25 Capsule:
Coadministration of Tretoact 25 Capsule with Etonogestrel can increase the risk and severity of birth defects when taken in pregnant women.

How to manage the interaction:
Taking Tretoact 25 Capsule with Etonogestrel together is generally avoided as it can result in an interaction which can be serious, it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
AcitretinLevonorgestrel
Critical
How does the drug interact with Tretoact 25 Capsule:
Coadministration of Tretoact 25 Capsule with Levonorgestrel can increase the risk and severity of birth defects in unborn when taken by a pregnant woman.

How to manage the interaction:
Taking Tretoact 25 Capsule with Levonorgestrel together is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. Consult a doctor if you get pregnant while taking these medications. Never use Tretoact 25 Capsule if you are pregnant. Do not stop using any medications without talking to a doctor.
AcitretinEthanol
Critical
How does the drug interact with Tretoact 25 Capsule:
Coadministration of Tretoact 25 Capsule with Ethanol can increase the risk and severity of birth defects.

How to manage the interaction:
Taking Tretoact 25 Capsule with Ethanol together is avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience headaches, nausea, vomiting, and visual disturbances, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AcitretinTetracycline
Critical
How does the drug interact with Tretoact 25 Capsule:
Coadministration of Tretoact 25 Capsule with Tetracycline can increase the risk and severity of pseudotumor cerebri (caused by increased pressure in the brain).

How to manage the interaction:
Taking Tretoact 25 Capsule with Tetracycline together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience headaches, nausea, vomiting, and visual disturbances, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AcitretinDemeclocycline
Critical
How does the drug interact with Tretoact 25 Capsule:
Coadministration of Tretoact 25 Capsule with Demeclocycline can increase the risk and severity of pseudotumor cerebri (caused by increased pressure in the brain).

How to manage the interaction:
Taking Tretoact 25 Capsule with Demeclocycline together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience headaches, nausea, vomiting, and visual disturbances, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AcitretinMinocycline
Critical
How does the drug interact with Tretoact 25 Capsule:
Co-administration of Tretoact 25 Capsule with Minocycline may increase the risk of a serious condition called pseudomotor cerebral (false brain tumour).

How to manage the interaction:
There's a possible interaction between Tretoact 25 Capsule and Minocycline should be used together only if prescribed by a doctor. However, if you develop symptoms such as nausea, vomiting, headache, or visual disturbances during treatment with either medication, contact a doctor immediately. Do not discontinue any medication without consulting a doctor.
AcitretinDoxycycline
Critical
How does the drug interact with Tretoact 25 Capsule:
Coadministration of Tretoact 25 Capsule with Doxycycline can increase the risk and severity of vision problems.

How to manage the interaction:
Taking Tretoact 25 Capsule with Doxycycline together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience headaches, nausea, vomiting, and visual disturbances, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AcitretinAminolevulinic acid
Severe
How does the drug interact with Tretoact 25 Capsule:
Coadministration of Aminolevulinic acid with Tretoact 25 Capsule may increase the risk of severe sunburn.

How to manage the interaction:
Although there is a possible interaction between Aminolevulinic acid and Acetretin, you can take these medicines together if prescribed by your doctor. Following treatment, you should limit or avoid exposure of the eyes and skin to sunlight or bright indoor lights for 48 hours. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Use mild soap while taking baths and prefer warm baths.
  • Do not scratch or pick your skin to avoid infecting the affected area.
  • Avoid harsh products on your skin.
  • Manage stress, eat healthily, drink plenty of water, exercise regularly, and get plenty of sleep.
  • Limit intake of food that might trigger allergies, such as dairy products, soy, eggs, and nuts.
  • Avoid consuming foods high in sugar, as it may flare inflammation.
  • Include fruits, vegetables, whole grains, healthy fats, and fish in your diet.
  • Avoid getting in contact with harsh soaps, detergents, and rough fabrics.

Habit Forming

No

Therapeutic Class

RETINOIDS

All Substitutes & Brand Comparisons

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Alcohol

Unsafe

Tretoact 25 Capsule may interact with alcohol and increase the risk of side effects. So, it is not recommended to take alcohol, especially women of childbearing potential, during the treatment and at least 2 months after completing the treatment.

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Pregnancy

Unsafe

Tretoact 25 Capsule should not be used in pregnant women as it may cause harmful effects to the unborn baby or fetus. Consult your doctor for further advice.

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Breast Feeding

Unsafe

Tretoact 25 Capsule should not be given to breastfeeding mothers as it may pass into breast milk and harm the nursing baby. Consult your doctor for further advice.

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Driving

Unsafe

Tretoact 25 Capsule may suddenly cause vision problems, especially in the dark. So, do not drive or operate heavy machinery if you notice any vision problems, especially at night.

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Liver

Caution

Tretoact 25 Capsule should not be used in patients with severe liver failure, as Tretoact 25 Capsule may cause liver damage. In mild to moderate liver disease, your doctor may need to adjust the dose.

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Kidney

Caution

Tretoact 25 Capsule should not be used in patients with severe kidney failure. In mild to moderate kidney disease, your doctor may need to adjust the dose.

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Children

Caution

Tretoact 25 Capsule should be used in children only if clinically needed, as it may affect growth and bone development. The dose may have to be adjusted by your doctor.

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Heart

Caution

Tretoact 25 Capsule should be taken with caution in patients with heart problems. Please inform your doctor about any existing heart problems before using Tretoact 25 Capsule.

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Geriatrics

Caution

Tretoact 25 Capsule can be given in elderly patients with extreme caution due to the risk of increased side effects

FAQs

Tretoact 25 Capsule is used to treat psoriasis, an autoimmune (immune system attacks healthy cells) skin disorder characterised by scaly, swollen, and itchy skin.

Tretoact 25 Capsule contains Acitretin, which belongs to the class of retinoids and is used to treat severe psoriasis. It has anti-inflammatory action and reduces the rashes, redness, scaling, and thickness. It also has antiproliferative properties and slows disease progression by slowing skin cell growth.

Tretoact 25 Capsule may suddenly cause vision problems, especially in the dark. So, inform your doctor immediately if you experience vision problems. Also, refrain from activities such as driving or operating heavy machinery if you have vision problems.

You should not donate blood during the treatment with Tretoact 25 Capsule and for three years after discontinuing the treatment. An unborn baby may be harmed if a pregnant woman receives your donated blood.

Tretoact 25 Capsule may not affect your immune system. It is not an immunosuppressant. It controls psoriasis by slowing its progression.

Tretoact 25 Capsule may affect blood glucose levels and should be used with caution in patients with diabetes. You may have to regularly monitor blood glucose levels while using this medicine.

Tretoact 25 Capsule may cause side-effects such as dry lips, peeling of the skin, especially the palms of the hands and soles of the feet, nose bleed, scaling and thinning of healthy skin, reddening of the skin, itching, burning sensation on the skin, sticky skin, hair loss, swelling and pain in the area around your nails, fragile nails, inflammation of the eye (conjunctivitis), increased thirst, and feeling cold. If any of these side effects persist or worsen, inform your doctor immediately.

Tretoact 25 Capsule should not be used in pregnant women as it may cause harmful effects to the unborn baby or foetus. Consult your doctor for further advice.

No, Tretoact 25 Capsule is not an immunosuppressant. It belongs to the class of retinoids used to treat psoriasis.

Drinking alcohol with Tretoact 25 Capsule may increase the risk of side effects. So, it is not recommended to take alcohol, especially women of childbearing potential, during the treatment and for at least 2 months after completing the treatment.

You may notice an improvement in 4-6 weeks of using Tretoact 25 Capsule. However, it might take 3-4 months to notice the full benefits.

Tretoact 25 Capsule may cause foetal harm; so, do not take Tretoact 25 Capsule if you are pregnant or plan to become pregnant within the next 3 years. Tretoact 25 Capsule may cause liver damage. Inform the doctor if you have or have ever had liver disease. Consult your doctor immediately if you experience symptoms of liver damage, such as nausea, vomiting, upper right abdominal pain, loss of appetite, yellowing of the skin or eyes, or dark urine.

Tretoact 25 Capsule may not affect semen. However, a small amount of Tretoact 25 Capsule is present in the semen of male patients who take this medication. Though it is not known if this affects the foetus, talk to your doctor about the risks of taking Tretoact 25 Capsule if your partner is pregnant or plans to become pregnant.

Take Tretoact 25 Capsule with the main meal. It should be swallowed as a whole with water; do not crush or chew it.

Avoid becoming pregnant and alcohol consumption during treatment with Tretoact 25 Capsule as it might affect the foetus. Do not donate blood while taking Tretoact 25 Capsule and for 3 years after treatment. Tretoact 25 Capsule may cause blurred vision; so, do not drive or operate machinery unless you are alert. Tretoact 25 Capsule may make your skin sensitive to sunlight; therefore, avoid prolonged exposure.

Country of origin

India

Manufacturer/Marketer address

H.No K-101, Kh.No,271 Abul Fazal Enclave Part-1, Okhla New Delhi South Delhi Dl 110025 In
Other Info - TRET308

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Dec 24, 2025 | 7:51 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.5264.pdf
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