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Tri Glucodol Tablet is used in the treatment of Type 2 diabetes mellitus. It increases the production of insulin by acting on the pancreas, decreases liver glucose production and intestinal glucose uptake. It may cause side effects such as nausea, vomiting, diarrhoea, stomach ache, respiratory infection, weight gain, numbness, and vision problems. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

GLIBENCLAMIDE-5MG+METFORMIN-500MG+PIOGLITAZONE-15MG

Manufacturer/Marketer :

Diacardus Pharmacy Pvt Ltd

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Tri Glucodol Tablet

Tri Glucodol Tablet is a prescription medicine in tablet form used to manage high blood sugar levels in adults with type 2 diabetes. It is designed to help control glucose levels when a single or dual-action treatment is no longer sufficient. Keeping your blood sugar in check is crucial for reducing the risk of serious health complications over time.

To achieve the best results, you must take Tri Glucodol Tablet consistently every day exactly as prescribed. It is highly recommended to take this medication with meals to lower the chances of experiencing an upset stomach. Combining your treatment with a balanced diet and routine physical activity is essential to help the medicine work effectively.

While taking Tri Glucodol Tablet, you may experience common side effects such as low blood sugar, mild weight gain, or a temporary upset stomach. If you experience any severe or persistent side effects, such as sudden shortness of breath or yellowing of your skin or eyes, contact your doctor immediately.

Before starting this medicine, talk to your doctor if you have a history of heart, kidney, or liver conditions. Do not take this if you suffer from severe kidney failure, active liver disease, severe heart failure, or diabetic ketoacidosis.

This medication can interact with other substances like alcohol, which can significantly raise your risk of severe low blood sugar or serious chemical imbalances in your blood. If you are pregnant, breastfeeding, or an older adult, consult your doctor or pharmacist to ensure this medicine is appropriate for your specific needs.

Uses of Tri Glucodol Tablet

Tri Glucodol Tablet is used to treat Type 2 diabetes mellitus. The detailed uses of Tri Glucodol Tablet are as follows:

  • Type 2 Diabetes Mellitus: Tri Glucodol Tablet helps lower high blood sugar levels in adults whose diabetes is not adequately controlled by other single or dual medications.
     

Key Benefits

Maintaining optimal blood sugar control with Tri Glucodol Tablet provides several key health benefits:

  • Helps Maintain Healthy Blood Sugar Levels: By improving blood sugar control throughout the day, including fasting and post-meal glucose levels, Tri Glucodol Tablet supports stable energy levels and effective diabetes management.
  • Supports Long-Term Protection Against Diabetes Complications: Maintaining healthy blood sugar levels with Tri Glucodol Tablet helps reduce the risk of diabetes-related complications, such as kidney disease, nerve damage, vision problems, and cardiovascular disease.
  • Offers Convenient Triple Combination Therapy: By combining three antidiabetic medicines into a single daily tablet, Tri Glucodol Tablet simplifies your treatment routine, supports better medication adherence, and helps maintain consistent blood sugar control.
Side effects of Tri Glucodol Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the steps to manage Gastrointestinal Air and Swelling (GAS) caused by medication:
  • Tell your doctor about your GAS symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
  • To manage GAS symptoms, eat a balanced diet of fibre, vegetables, and fruits.
  • Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
  • Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
  • Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
  • Take medication for GAS symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
  • If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.
  • If you experience low blood sugar levels, inform your doctor. They will assess the severity and make recommendations for the next actions.
  • Your doctor will assess your symptoms, blood sugar levels, and overall health before recommending the best course of action, which may include treatment, lifestyle modifications, or prescription adjustments.
  • Follow your doctor's instructions carefully to manage the episode and adjust your treatment plan.
  • Make medication adjustments as recommended by your doctor to prevent future episodes.
  • Implement diet and lifestyle modifications as your doctor advises to manage low blood sugar levels.
  • Monitor your blood sugar levels closely for patterns and changes.
  • Track your progress by recording your blood sugar levels, food intake, and physical activity.
  • Seek further guidance from your doctor if symptoms persist or worsen so that your treatment plan can be revised.
  • Eat fiber-rich foods, fruits, and vegetables, and track your food intake to monitor calorie consumption.
  • Limit takeout and restaurant meals, and weigh yourself weekly to stay motivated.
  • Build balanced meals, allow yourself to enjoy treats in moderation, and prioritize sleep and stress management through exercise and relaxation techniques.

Directions for Use

  • Tri Glucodol Tablet is taken with food to prevent hypoglycemia or as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Tri Glucodol Tablet as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Tri Glucodol Tablet Works

Tri Glucodol Tablet contains three active ingredients that work in harmony through different mechanisms to manage your blood sugar. The first active component, glibenclamide, works by stimulating your pancreas to release more insulin, which is the natural hormone responsible for clearing sugar from your bloodstream. The second component, metformin, works by decreasing the amount of sugar your liver releases into your body, slowing down sugar absorption from food in your intestines, and helping your muscles use insulin better. The third component, pioglitazone, directly targets insulin resistance by making your body’s fat and muscle cells highly responsive to insulin, allowing them to absorb and clear sugar from your bloodstream more effectively.
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Alcohol

Caution

Alcohol may increase the risk of side effects and worsen the condition. Therefore, avoid alcohol consumption.

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Pregnancy

Unsafe

Tri Glucodol Tablet is a category C drug and may cause harmful effects to the unborn baby. So, it is used only when the benefits of this medicine outweigh the risks.

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Breast Feeding

Unsafe

Tri Glucodol Tablet should not be used in breastfeeding mothers as it may be secreted in the breast milk and cause unwanted effects in the nursing babies.

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Driving

Caution

Tri Glucodol Tablet may cause vision problems. So, do not drive or operate heavy machinery if you have any problems with your vision while using Tri Glucodol Tablet.

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Liver

Caution

Tri Glucodol Tablet should be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Tri Glucodol Tablet should be taken with caution in patients with kidney diseases. The dose may have to be adjusted by your doctor.

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Children

Unsafe

Tri Glucodol Tablet is not recommended for use in children below 18 years of age.

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Heart

Consult your doctor

Please inform your doctor if you have any pre-existing heart problems before taking Tri Glucodol Tablet.

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Geriatrics

Consult your doctor

This medicine is not safe for use in elderly patients due to its serious side effects.

What if I have taken an overdose of Tri Glucodol Tablet

If you suspect an overdose, seek immediate medical attention or contact emergency services. An overdose of this medicine can cause severe low blood sugar, extreme confusion, rapid heart rate, or loss of consciousness.

Diet & Lifestyle Advise

  • Check your blood sugar levels regularly to monitor how your body is responding to the medication.
  • Eat a balanced diet high in dietary fibre, whole grains, and fresh vegetables while keeping your intake of sugary foods and drinks to a minimum.
  • Stay physically active with regular, moderate exercise like brisk walking to help your body use insulin more efficiently.
  • Always carry a fast-acting sugar source, such as glucose tablets, fruit juice, or hard candies, to quickly treat sudden drops in blood sugar.
  • Stay hydrated by drinking plenty of water, especially during hot weather or when exercising, to support kidney function.
health query

Have a query?

How Soon It Starts Working

The time required for Tri Glucodol Tablet to start to work: The time required for Tri Glucodol Tablet to start to work is 15 to 60 minutes after administration.

The time for which the effects of Tri Glucodol Tablet last: The duration of action for Tri Glucodol Tablet is not clinically established.

What if you forget to take Tri Glucodol Tablet

Take your missed dose with your next meal if it is close to your scheduled time. If it is almost time for your next scheduled dose, skip the missed one entirely and return to your regular schedule. Do not take a double dose to make up for a missed one, as this can cause your blood sugar to drop too low.

Storage

•Store Tri Glucodol Tablet tablets at room temperature, strictly between 20°C and 25°C (68°F to 77°F). •Keep the tablets in their original packaging to protect them from light and moisture.

Drug Warnings

  • Inspect your feet daily for any slow-healing cuts, blisters, or redness, as managing diabetes requires careful attention to foot care.
  • Get your liver and kidney function checked regularly using routine blood tests as advised by your doctor.
  • Do not skip meals while taking this medication, as a lack of food can trigger a severe drop in your blood sugar levels.
  • Avoid alcohol completely, as it significantly increases your risk of severe low blood sugar and a serious acid buildup in your blood.
  • Tell any dentist, surgeon, or medical specialist that you are taking Tri Glucodol Tablet before you have any procedure or scan involving contrast dyes.
  • Tell your doctor immediately if you notice blood in your urine, pain while passing urine, or a new or persistent urge to urinate.
  • Pioglitazone has been associated with an increased risk of bladder cancer in some studies, and these symptoms should be evaluated promptly.
  • Pioglitazone may increase the risk of bone fractures, particularly in older women. Talk to your doctor about maintaining bone health through adequate calcium, vitamin D, exercise, and other preventive measures where appropriate. 

Drug-Drug Interactions

verifiedApollotooltip
  • Beta-blockers: May mask the physical warning signs of low blood sugar, such as a fast heartbeat or shakiness.
  • Water pills (diuretics) and steroids: Can raise your blood sugar levels, making Tri Glucodol Tablet less effective.
  • Pain relievers (NSAIDs): Can increase the risk of low blood sugar and strain your kidneys when used together with this medicine.
  • Contrast dyes used in medical scans: May increase the risk of a rare, serious acid buildup in the blood; your doctor may advise you to stop taking Tri Glucodol Tablet temporarily.
Metformin + Pioglitazone + GlibenclamideIopamidol
Critical
Metformin + Pioglitazone + GlibenclamideGatifloxacin
Critical

Drug-Drug Interactions

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Metformin + Pioglitazone + GlibenclamideIopamidol
Critical
How does the drug interact with Tri Glucodol Tablet:
Co-administration of Iopamidol with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Metformin with Iopamidol is not recommended, consult a doctor before taking it. Do not discontinue any medications without consulting a doctor.
Metformin + Pioglitazone + GlibenclamideGatifloxacin
Critical
How does the drug interact with Tri Glucodol Tablet:
Co-administration of Metformin with Gatifloxacin can cause both hypoglycemia (low blood glucose) and, less frequently, hyperglycemia (high blood glucose).

How to manage the interaction:
There is a possibility of interaction between Metformin and Gatifloxacin but they can be taken together if a doctor has prescribed them. Do not discontinue without consulting a doctor.
Metformin + Pioglitazone + GlibenclamideIodixanol
Critical
How does the drug interact with Tri Glucodol Tablet:
Co-administration of Iodixanol with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Metformin with Iodixanol is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Metformin + Pioglitazone + GlibenclamideMetrizamide
Critical
How does the drug interact with Tri Glucodol Tablet:
Co-administration of Metformin and Metrizamide together can cause the risk of lactic acidosis (when the body produces too much lactic acid ).

How to manage the interaction:
Taking Metformin with Metrizamide is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
Metformin + Pioglitazone + GlibenclamideIopromide
Critical
How does the drug interact with Tri Glucodol Tablet:
Co-administration of Iopromide with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Iopromide with Metformin is not recommended, consult a doctor before taking it. Do not discontinue any medications without consulting a doctor.
Metformin + Pioglitazone + GlibenclamideIodamide
Critical
How does the drug interact with Tri Glucodol Tablet:
Co-administration of Metformin and Iodamide can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Metformin with Iodamide is generally avoided as it can result in an interaction, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Metformin + Pioglitazone + GlibenclamideIomeprol
Critical
How does the drug interact with Tri Glucodol Tablet:
Co-administration of Iomeprol with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Metformin with Iomeprol is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Metformin + Pioglitazone + GlibenclamideTopiramate
Severe
How does the drug interact with Tri Glucodol Tablet:
The combined use of Metformin and Topiramate may increase the risk of Lactic acidosis (excessive lactic acid production in the blood).

How to manage the interaction:
Coadministration Metformin and Topiramate can lead to an interaction, it can be taken if prescribed by a doctor. However, if you experience symptoms such as weakness, muscle pain, respiratory distress, fatigue, loss of appetite, slow or irregular heartbeat, breathing difficulty, or chills consult the doctor immediately. Do not stop using any medication without a doctor's advice.
Metformin + Pioglitazone + GlibenclamideNorfloxacin
Severe
How does the drug interact with Tri Glucodol Tablet:
Co-administration of Norfloxacin with Glibenclamide may sometimes cause both high blood glucose and low blood glucose.

How to manage the interaction:
Although there is a possible interaction, Glibenclamide can be taken with Norfloxacin if prescribed by the doctor. Consult the prescriber if you experience headache, dizziness, drowsiness, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat, increased urination, increased thirst, and increased hunger. Do not discontinue any medications without consulting a doctor.
Metformin + Pioglitazone + GlibenclamideLevofloxacin
Severe
How does the drug interact with Tri Glucodol Tablet:
Co-administration of Levofloxacin with Glibenclamide may cause both hyperglycemia (high blood glucose) and hypoglycemia (low blood glucose).

How to manage the interaction:
Although there is a possible interaction, glibenclamide can be taken with levofloxacin if prescribed by the doctor. Consult the prescriber if you experience nervousness, confusion, headache, dizziness, drowsiness, tremors, nausea, hunger, weakness, perspiration, pulse, rapid heartbeat, increased urination, increased thirst, and increased hunger. Do not discontinue the medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Can cause severe, unpredictable drops in blood sugar and increases the risk of lactic acidosis.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIDIABETICS AND ANTIHYPERGLYCEMICS]

FAQs

Tri Glucodol Tablet is used in the treatment of type 2 diabetes mellitus.
Tri Glucodol Tablet is a combination of three antidiabetic medicines, Glibenclamide, Metformin, and Pioglitazone. It works by increasing insulin production, helping restore your body's appropriate response to insulin, and thereby lowering your elevated blood sugar levels.
Tri Glucodol Tablet is used to treat type 2 diabetes. It is not recommended for the treatment of type 1 diabetes.
Tri Glucodol Tablet may cause hypoglycemia (low blood sugar levels). Hypoglycemia can occur if you miss or delay your food, drink alcohol, engage in intense exercise, or take other antidiabetic medicines along with this medicine. So, take your medicine as advised by your doctor to avoid any unwanted effects of this medicine.
You may experience symptoms such as increased thirst and hunger, frequent urination, weight loss, delayed wound healing, and frequent infections if you have diabetes. Consult a doctor to confirm the diagnosis.
Stopping Tri Glucodol Tablet may cause a rise in blood sugar levels. Therefore, continue taking Tri Glucodol Tablet as directed even if your symptoms improve.
Regularly monitor your blood sugar levels and keep your doctor informed about any kidney or heart issues. If you have allergies, are pregnant, or are breastfeeding, consult your doctor before using this medication. Maintain a healthy lifestyle, including a balanced diet and regular exercise, and stay hydrated by drinking plenty of water. Also, be sure to disclose all medications you're taking to your doctor to avoid potential interactions. By following these guidelines, you'll be able to use this medication safely and effectively.
Some individuals may feel tired and drowsy after taking Tri Glucodol Tablet. Drive or operate machinery only if you are alert. If you're experiencing any of these symptoms persistantly, it's crucial to consult your doctor.
No, Tri Glucodol Tablet does not contain steroids. Tri Glucodol Tablet is a medication specifically designed to manage type 2 diabetes. It's a combination therapy that helps regulate blood sugar levels.
Tri Glucodol Tablet may take around 2-3 months to reach its full effect, but you may start noticing improvements in your blood sugar control within the first few weeks.
It is generally safe to take Tri Glucodol Tablet and Fexofenadine together if it is prescribed by your doctor. Fexofenadine is an antihistamine used to treat allergies, and it doesn't typically interact with Tri Glucodol Tablet. However, it's always best to consult your doctor or pharmacist before combining any medications.
The common side effects of Tri Glucodol Tablet include nausea, vomiting, and stomach issues. Consult the doctor if the side effects persist or worsen.
It is highly recommended to avoid alcohol while taking Tri Glucodol Tablet. Alcohol can increase your risk of experiencing dangerously low blood sugar levels and can also increase the risk of a rare but life-threatening condition called lactic acidosis. Talk to your doctor or pharmacist if you have questions about alcohol use.
If you feel shaky, sweaty, dizzy, or hungry, your blood sugar may have dropped too low. Immediately consume a fast-acting sugar source, such as half a cup of fruit juice, three to four glucose tablets, or hard candies. If symptoms persist or worsen, contact your doctor right away.
Yes, some people may experience weight gain while taking Tri Glucodol Tablet. This can be due to improved blood sugar control or fluid retention. Eating a balanced diet and exercising regularly can help manage your weight. Talk to your doctor if you notice sudden or significant weight gain, especially in your face, ankles, or feet.
Do not take Tri Glucodol Tablet if you are pregnant, planning to become pregnant, or breastfeeding unless specifically directed by your doctor. Other treatments are typically preferred to manage blood sugar during pregnancy and breastfeeding. Talk to your doctor or pharmacist to discuss safer options.
Lactic acidosis is a rare but very serious medical emergency caused by a buildup of acid in your blood. Symptoms include unusual muscle pain, trouble breathing, severe stomach discomfort, or feeling unusually cold and weak. If you experience these symptoms, stop taking Tri Glucodol Tablet and seek immediate medical help.
Unless your doctor or the product information specifically states otherwise, swallow Tri Glucodol Tablet tablets whole with a glass of water. Follow the administration instructions provided with your specific product. If you have difficulty swallowing tablets, speak with your doctor or pharmacist before altering the tablet.

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Country of origin

India
Other Info - TR84928
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