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compositionComposition:ACECLOFENAC-100MG+PARACETAMOL-500MG
prescriptionPrescription Medicine
Trifenac-AP 100mg/500mg Tablet

Trifenac-AP 100mg/500mg Tablet is used to reduce pain and inflammation. It helps in relieving pain from conditions like headaches, mild migraine, muscle pain, dental pain, rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. It contains Aceclofenac and Paracetamol, which work by blocking the chemical messengers responsible for causing pain, inflammation, and fever. In some cases, it may cause side effects like dizziness, nausea, digestion problems (constipation, flatulence, diarrhoea) and skin reactions (like rashes and hives). Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ACECLOFENAC-100MG+PARACETAMOL-500MG

Manufacturer/Marketer :

Trigenesis Life Sciences Pvt Ltd

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Trifenac-AP 100mg/500mg Tablet

Trifenac-AP 100mg/500mg Tablet is an prescription medication used to manage pain, swelling, and inflammation in various conditions affecting the joints and muscles. It is commonly prescribed to treat pain associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. This medication helps ease everyday discomfort, allowing for better physical function and mobility.

For the best results, Trifenac-AP 100mg/500mg Tablet should be taken consistently at the exact times prescribed by your doctor. It is highly recommended to take this tablet with or immediately after a meal to protect your stomach from irritation. Alongside taking your medication regularly, incorporating gentle, low-impact exercise and maintaining a healthy weight can significantly improve your joint health and pain management.

While taking Trifenac-AP 100mg/500mg Tablet, some people may experience mild side effects such as nausea, indigestion, or mild stomach pain. However, you should consult your doctor immediately if you notice serious signs of trouble, such as dark or tarry stools, severe stomach pain, vomiting blood, or yellowing of your eyes and skin.

Before starting Trifenac-AP 100mg/500mg Tablet, talk to your doctor if you have a history of high blood pressure, heart problems, asthma, or kidney or liver disease. Do not take this medication if you currently have an active stomach ulcer, severe heart failure, or if you have previously had an allergic reaction to aspirin or other pain-relieving medicines.

Avoid drinking alcohol while taking Trifenac-AP 100mg/500mg Tablet, as this combination greatly increases the risk of stomach bleeding and liver damage. It is also important to talk to your doctor or pharmacist if you are pregnant, breastfeeding, or elderly, as your dosage and monitoring may need to be carefully adjusted by a healthcare professional.

Uses of Trifenac-AP 100mg/500mg Tablet

Trifenac-AP 100mg/500mg Tablet is used to treat pain. The detailed uses of Trifenac-AP 100mg/500mg Tablet are as follows:

  • Osteoarthritis: Helps reduce joint pain, stiffness, and swelling in the knees, hips, and hands.
  • Rheumatoid arthritis: Eases long-term joint inflammation, pain, and swelling caused by an overactive immune system.
  • Ankylosing spondylitis: Relieves spine stiffness and back pain, helping you stay active and flexible.
  • Acute pain: Eases short-term pain from muscle aches, dental procedures, ear or throat pain, or minor physical injuries.

Key Benefits

Trifenac-AP 100mg/500mg Tablet provides reliable, daily support to help you manage your health. This medicine brings several key health benefits:

  • Faster Recovery: By targeting both pain and inflammation at the source, Trifenac-AP 100mg/500mg Tablet helps you recover more quickly from painful flare-ups and muscle strains.
  • Improved Joint Mobility: The reduction in swelling allows for smoother joint movement, making it easier to perform daily activities like walking, climbing stairs, and bending without discomfort.
  • Dual-Action Pain Relief: Because it contains two distinct active ingredients that work in different ways, it provides more comprehensive relief than single-ingredient pain relievers.
Side effects of Trifenac-AP 100mg/500mg Tablet
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.

Directions for Use

Follow these steps to take Trifenac-AP 100mg/500mg Tablet safely and effectively:

  1. Swallow the tablet whole with a full glass of water. Do not crush, chew, or break it, as this can affect how the medicine is absorbed.
  2. Always take this medication with or after a meal. This helps protect your stomach lining and prevents mild indigestion.
  3. Take the medicine at the same time each day to maintain a consistent level in your body.

Remember to always follow your doctor's exact instructions regarding your specific schedule and length of treatment.

How Trifenac-AP 100mg/500mg Tablet Works

Trifenac-AP 100mg/500mg Tablet works by combining two active ingredients to target pain and swelling from different angles. The first ingredient, aceclofenac, belongs to a class of medications called non-steroidal anti-inflammatory drugs (NSAIDs). It works by inhibiting cyclooxygenase (COX) enzymes, particularly through a preferential effect on COX-2 pathways, thereby reducing the production of prostaglandins that contribute to pain and inflammation. The second ingredient, paracetamol, is an analgesic (pain reliever) and antipyretic (fever reducer). Its exact mechanism of action is not fully understood, but it is thought to work mainly within the central nervous system by reducing the production of prostaglandins involved in pain and temperature regulation. This helps relieve pain and lower fever.
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Alcohol

Unsafe

You are recommended not to consume alcohol along with Trifenac-AP 100mg/500mg Tablet as it contains paracetamol which can together damage your liver severely.

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Pregnancy

Consult your doctor

The safety of this medicine for use during pregnancy is not known. Hence, it is not recommended for use in pregnancy unless considered essential by your doctor.

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Breast Feeding

Consult your doctor

Trifenac-AP 100mg/500mg Tablet should not be used without consultation with your doctor if you are breast-feeding. It is not known if this medicine passes into breast milk. It is not recommended for use during breast-feeding unless considered essential by your doctor.

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Driving

Unsafe

Trifenac-AP 100mg/500mg Tablet usually causes dizziness, drowsiness and visual disturbances which may affect their ability to drive or operate machinery. Make sure you are not affected before driving or operating machinery.

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Liver

Caution

Trifenac-AP 100mg/500mg Tablet to be taken with caution, especially if you have a history of liver disease. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Trifenac-AP 100mg/500mg Tablet to be taken with caution, especially if you have a history of kidney disease. The dose may have to be adjusted by your doctor.

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Children

Unsafe

The safety and efficacy of Trifenac-AP 100mg/500mg Tablet in children have not been established. Trifenac-AP 100mg/500mg Tablet is not recommended in children.

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Heart

Unsafe

Trifenac-AP 100mg/500mg Tablet should be avoided in cardiac patients as it can lead to serious cardiavascular risks

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Geriatrics

Caution

Trifenac-AP 100mg/500mg Tablet should be used under caution in geriatric patients as it can lead to serious side effects/

What if I have taken an overdose of Trifenac-AP 100mg/500mg Tablet

Do not take more than the prescribed dose of Trifenac-AP 100mg/500mg Tablet as it may cause adverse effects. If you suspect you have taken an overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Maintain a healthy weight: Carrying excess weight puts additional strain on weight-bearing joints like the knees and hips, which can worsen joint pain.
  • Engage in low-impact exercise: Swimming, walking, and cycling keep the muscles surrounding your joints strong and flexible without causing high impact or stress.
  • Stay well-hydrated: Drinking plenty of water helps your kidneys flush out medications safely and supports overall joint lubrication.
  • Incorporate anti-inflammatory foods: A diet rich in leafy greens, berries, olive oil, and nuts can help support your body's natural defense against inflammation.
  • Avoid smoking: Smoking can worsen tissue inflammation and slow down your body's natural recovery process.

Have a query?

How Soon It Starts Working

  • The time required for Trifenac-AP 100mg/500mg Tablet to start to work: Trifenac-AP 100mg/500mg Tablet ideally shows its action within 30 minutes after administration.
  • The time for which the effects of Trifenac-AP 100mg/500mg Tablet last: The effect of Trifenac-AP 100mg/500mg Tablet lasts 8 to 12 hours.

What if you forget to take Trifenac-AP 100mg/500mg Tablet

If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and take the next dose at the scheduled time. Do not take a double dose.

Storage

• Store Trifenac-AP 100mg/500mg Tablet at room temperature, ideally below 30°C (86°F). • Keep the tablets in their original blister pack to protect them from direct sunlight, moisture, and extreme heat. Do not store them in the bathroom cabinet where humidity is high.

Drug Warnings

  • Do not take other medications containing paracetamol or NSAIDs (like ibuprofen or naproxen) while taking Trifenac-AP 100mg/500mg Tablet to prevent accidental overdose.
  • Avoid alcohol completely while taking this medicine, as it increases the risk of stomach bleeding and liver damage.
  • Monitor your stool color closely; if you notice dark, black, or tarry stools, stop taking the medicine and consult your doctor immediately.
  • Be cautious if you drive or operate machinery, as this medication can occasionally cause dizziness or drowsiness in some people.
  • If you are scheduled for any surgery, including dental procedures, inform your surgeon or dentist that you are taking Trifenac-AP 100mg/500mg Tablet.

Drug-Drug Interactions

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Drug-Drug Interactions

Inform your doctor if you are taking any of the following medicines, as they may interact.

  • Other NSAIDs or blood thinners (like warfarin or aspirin): May increase the risk of stomach ulcers and serious stomach bleeding.
  • Blood pressure medicines (like ACE inhibitors or beta-blockers): May reduce the effectiveness of these medications, making blood pressure harder to control.
  • Diuretics (water pills) or immunosuppressants (like cyclosporine): May increase the risk of kidney damage when combined with Trifenac-AP 100mg/500mg Tablet.
  • Methotrexate: Taking this medicine with methotrexate may increase methotrexate levels in the body and raise the risk of serious side effects, including bone marrow suppression, liver toxicity, and kidney problems. Close medical supervision may be required. 

Drug-Disease Interactions

Inform your doctor if you have a history of the following conditions before taking Trifenac-AP 100mg/500mg Tablet, as it may worsen your condition or cause complications.

  • Stomach Ulcers or Bleeding: May worsen active stomach ulcers or history of gastrointestinal bleeding. Do not take this if you have these conditions.
  • Kidney or Liver Disease: May reduce organ function further; require careful monitoring and potential dose adjustments.
  • Severe Heart Failure or High Blood Pressure: May cause fluid retention, worsening heart failure or elevating blood pressure.
Aceclofenac + ParacetamolEthanol
Severe
Aceclofenac + ParacetamolLomitapide
Severe

Drug-Drug Interactions

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Aceclofenac + ParacetamolEthanol
Severe
How does the drug interact with Trifenac-AP 100mg/500mg Tablet:
Co-administration of Trifenac-AP 100mg/500mg Tablet with Ethanol can increase the risk of liver damage.

How to manage the interaction:
Although taking Trifenac-AP 100mg/500mg Tablet with Ethanol can lead to an interaction, it can be taken if prescribed by the doctor. However, if you experience symptoms such as fever, chills, swollen or painful joints, unexpected bleeding or bruises, skin rash, itching, vomiting, abdominal pain, light-colored stool, dark-colored urine, yellowing of the skin or eyes, decreased hunger, consult the doctor. Do not stop using any medications without talking to the doctor.
Aceclofenac + ParacetamolLomitapide
Severe
How does the drug interact with Trifenac-AP 100mg/500mg Tablet:
Co-administration of Lomitapide and Trifenac-AP 100mg/500mg Tablet may increase the risk of severity of liver injury.

How to manage the interaction:
Although there is a possible interaction between Trifenac-AP 100mg/500mg Tablet and Lomitapide, you can take these medicines together if prescribed by a doctor. However, if you experience symptoms such as fever, chills, swollen or painful joints, unexpected bleeding or bruises, skin rash, itching, vomiting, abdominal pain, light-colored stool, dark-colored urine, yellowing of the skin or eyes, decreased hunger, consult the doctor. Do not stop using any medications without talking to the doctor.
Aceclofenac + ParacetamolTeriflunomide
Severe
How does the drug interact with Trifenac-AP 100mg/500mg Tablet:
Co-administration of Teriflunomide with Trifenac-AP 100mg/500mg Tablet may increase the risk or severity of Liver problems.

How to manage the interaction:
Taking Trifenac-AP 100mg/500mg Tablet with Teriflunomide together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience symptoms such as fever, chills, swollen or painful joints, unexpected bleeding or bruises, skin rash, itching, vomiting, abdominal pain, light-colored stool, dark-colored urine, yellowing of the skin or eyes, decreased hunger, consult the doctor. Do not stop using any medications without talking to the doctor.
Aceclofenac + ParacetamolKetoconazole
Severe
How does the drug interact with Trifenac-AP 100mg/500mg Tablet:
Co-administration of Trifenac-AP 100mg/500mg Tablet and Ketoconazole may increase the risk of liver injury.

How to manage the interaction:
Although there is a possible interaction between Trifenac-AP 100mg/500mg Tablet and Ketoconazole, you can take these medicines together if prescribed by a doctor. However, if you experience fever, chills, swollen or painful joints, unexpected bleeding or bruises, skin rash, itching, vomiting, abdominal pain, light-colored stool, dark-colored urine, yellowing of the skin or eyes, decreased hunger, consult the doctor. Do not stop using any medications without talking to the doctor.
Aceclofenac + ParacetamolAtenolol
Severe
How does the drug interact with Trifenac-AP 100mg/500mg Tablet:
Co-administration of Atenolol with Trifenac-AP 100mg/500mg Tablet could decrease the action of Atenolol.

How to manage the interaction:
Although there is a possible interaction between Atenolol and Trifenac-AP 100mg/500mg Tablet, you can take these medicines together if prescribed by a doctor. However, if you experience any unusual symptoms, consult the doctor. Do not discontinue any medications without a doctor's advice.
Aceclofenac + ParacetamolLeflunomide
Severe
How does the drug interact with Trifenac-AP 100mg/500mg Tablet:
Co-administration of Trifenac-AP 100mg/500mg Tablet and Leflunomide may increase the risk of liver problems.

How to manage the interaction:
Although there is a possible interaction between Trifenac-AP 100mg/500mg Tablet and Leflunomide, they can be taken together if prescribed by a doctor. However, if you experience symptoms such as fever, chills, swollen or painful joints, unexpected bleeding or bruises, skin rash, itching, vomiting, abdominal pain, light-colored stool, dark-colored urine, yellowing of the skin or eyes, decreased hunger, consult the doctor. Do not stop using any medications without talking to the doctor.
Aceclofenac + ParacetamolMipomersen
Severe
How does the drug interact with Trifenac-AP 100mg/500mg Tablet:
Co-administration of Trifenac-AP 100mg/500mg Tablet with Mipomersen may increase the risk or severity of liver injury.

How to manage the interaction:
There may be a possibility of interaction between Trifenac-AP 100mg/500mg Tablet and Mipomersen, but it can be taken if prescribed by a doctor. However, if you experience symptoms such as fever, chills, swollen or painful joints, unexpected bleeding or bruises, skin rash, itching, vomiting, abdominal pain, light-colored stool, dark-colored urine, yellowing of the skin or eyes, decreased hunger, consult the doctor. Do not stop using any medications without talking to the doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANALGESIC AND ANTIPYRETIC AGENT]

FAQs

Trifenac-AP 100mg/500mg Tablet is used to reduce pain and inflammation.

No, Trifenac-AP 100mg/500mg Tablet does not cure Rheumatoid arthritis but instead, it helps in reducing the pain and inflammation caused by it as it a pain killer.

Yes, Trifenac-AP 100mg/500mg Tablet is may cause nausea or vomiting in some people. In order to avoid the same, you should take Trifenac-AP 100mg/500mg Tablet with milk or food. In case you are still experiencing excessive nausea while consuming Trifenac-AP 100mg/500mg Tablet, speak with your doctor right away.

No, do not suddenly stop taking Trifenac-AP 100mg/500mg Tablet. If you want to stop taking this medicine, consult your doctor and he might gradually reduce the dose to avoid an unwanted increase in pain or inflammation.

No, Trifenac-AP 100mg/500mg Tablet should ideally not be taken for stomach pain without consulting a physician. This medication can increase the secretion of stomach acid, which may worsen gastritis or an unknown underlying stomach ulcer.

Patients with mild to moderate renal impairment should be kept under surveillance. The lowest effective dose should be used and renal function monitored regularly. Effects on renal function are usually reversible on withdrawal of Trifenac-AP 100mg/500mg Tablet.

Yes, let your doctor know if you are taking any other medicine for pain, arthritis or fever. If you experience dark stools, blood in vomit, or stomach pain, stop taking Trifenac-AP 100mg/500mg Tablet and consult your doctor immediately, as these could be signs of bleeding in your stomach or intestine. Take Trifenac-AP 100mg/500mg Tablet only for the duration as prescribed by your doctor. Do not take more than the prescribed dose, as it may cause an overdose.

Trifenac-AP 100mg/500mg Tablet already contains Paracetamol and Aceclofenac. So, avoid taking additional paracetamol. If your pain does not subside, consult your doctor so that they may increase the dose or add another medicine depending on your condition.

Yes, Trifenac-AP 100mg/500mg Tablet is a painkiller. It contains Aceclofenac and Paracetamol, which helps to relieve pain.

You are recommended to consult your doctor before taking Trifenac-AP 100mg/500mg Tablet with antibiotics to avoid drug interactions.

Trifenac-AP 100mg/500mg Tablet is safe if used as advised by the doctor. Follow your doctor’s instructions.

Yes, the use of Trifenac-AP 100mg/500mg Tablet can cause dizziness (feeling faint, lightheaded, unsteady, or weak) in some patients. If you feel dizzy or lightheaded, take rest for sometime and resume once you feel better.

Trifenac-AP 100mg/500mg Tablet is contraindicated in patients with known allergy to any of its ingredients or in patients or other painkillers (NSAIDs). Patients with a history of stomach ulcers or active, recurrent stomach ulcer/bleeding should ideally avoid taking Trifenac-AP 100mg/500mg Tablet. Additionally, patients with a history of high blood pressure, heart failure, and kidney or liver disease, should also avoid taking Trifenac-AP 100mg/500mg Tablet.

Yes, Trifenac-AP 100mg/500mg Tablet be taken with vitamin B-complex as it helps to treat vitamin deficiency that may be the cause of underlying pain. However, please consult your doctor before using Trifenac-AP 100mg/500mg Tablet with other medicines or supplements.

No, taking higher dose of Trifenac-AP 100mg/500mg Tablet than recommended may cause serious liver damage or allergic reactions such as swelling of the mouth, face and throat; itching; rash or difficulty in breathing. If the pain is not relieved or if you are experience increased severity of pain by the recommended doses, please consult your doctor.

Store Trifenac-AP 100mg/500mg Tablet at room temperature in a dry place. Protect from sunlight. Keep it out of reach of children.

Trifenac-AP 100mg/500mg Tablet typically begins to work within 30 to 60 minutes after taking it. However, the exact time can vary depending on individual factors and whether you took it with a heavy meal. If your pain does not improve after a few days, talk to your doctor.

The dosage of Trifenac-AP 100mg/500mg Tablet will be decided by your doctor. Follow doctor’s instructions. Do not take more than the recommended dose.

You should avoid taking other medications containing paracetamol or NSAIDs (like ibuprofen or naproxen) while taking Trifenac-AP 100mg/500mg Tablet. Doing so increases your risk of accidental overdose and serious side effects like liver damage or stomach ulcers. Always check labels and talk to your doctor or pharmacist before combining medicines.

Trifenac-AP 100mg/500mg Tablet is not recommended for children as the safety and efficacy have not been established.

Trifenac-AP 100mg/500mg Tablet contains Aceclofenac (pain reducer) and Paracetamol (fever reducer) which work by blocking the chemical messengers responsible for causing pain, inflammation, and fever.

Take Trifenac-AP 100mg/500mg Tablet as advised by your doctor. Swallow it as whole with a glass of water. Do not crush, chew or break it.

Trifenac-AP 100mg/500mg Tablet may cause side effects such as nausea, dizziness, diarrhoea, flatulence, or constipation. If these side effects persist or worsen, please consult your doctor.

It is highly recommended to take Trifenac-AP 100mg/500mg Tablet with or after a meal. Taking it on an empty stomach can increase the risk of mild indigestion, stomach pain, or irritation. If you experience stomach upset, talk to your doctor or pharmacist.

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for the missed one. Talk to your doctor or pharmacist if you have questions.

You are recommended to consult your doctor before taking other medicines with Trifenac-AP 100mg/500mg Tablet to avoid drug interactions.

No, you should avoid drinking alcohol while taking Trifenac-AP 100mg/500mg Tablet. Alcohol increases the risk of stomach bleeding and can cause severe liver damage when combined with this medication. If you consume alcohol regularly, talk to your doctor.

You should consult your doctor before taking Trifenac-AP 100mg/500mg Tablet if you are pregnant, planning to become pregnant, or breastfeeding. This medicine is generally not recommended during pregnancy unless specifically prescribed by your doctor. NSAID-containing medicines such as aceclofenac may pose risks during pregnancy, particularly from around 20 weeks onward, where they may affect fetal kidney function and amniotic fluid levels. Use during the third trimester is generally contraindicated because it may cause premature closure of the fetal ductus arteriosus and other serious complications. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before taking this medicine.

Some people may experience dizziness, drowsiness, or visual disturbances while taking Trifenac-AP 100mg/500mg Tablet. If you feel dizzy or sleepy after taking this medicine, do not drive, ride a bicycle, or operate heavy machinery. If these symptoms persist, talk to your doctor.

Trifenac-AP 100mg/500mg Tablet is generally prescribed for short-term pain relief or during flare-ups of chronic conditions. Long-term use without medical supervision can increase the risk of serious side effects like stomach ulcers, kidney problems, and liver damage. Always take it for the shortest time possible, and talk to your doctor if you need long-term pain management.

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Country of origin

India

Manufacturer/Marketer address

72, Ist Floor, 5Th Main Road Chamarajpet, Bengaluru 560 018 India
Other Info - TR54851
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