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TRIGETROL TABLET is an anti-diabetic medicine used in the treatment of Type II diabetes. This combination medicine works by stimulating beta cells in the pancreas that produce insulin and also reduces sugar production by cells in the liver and delays sugar absorption. This medicine may cause common side effects like stomach pain, nausea, diarrhea, vomiting, headache, or low blood sugar.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

GLIBENCLAMIDE-5MG+METFORMIN-500MG+ROSIGLITAZONE-15MG

Manufacturer/Marketer :

Aretaeus Pharmaceuticals Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About TRIGETROL TABLET

TRIGETROL TABLET is an oral prescription medication used to manage and control high blood sugar in adults with type 2 diabetes. This combination therapy is prescribed when diet, physical exercise, and single-agent medications are not enough to maintain healthy blood glucose levels. By keeping blood sugar within a target range, it helps prevent serious health complications over time.

For this medicine to work effectively, you must take it consistently and exactly as prescribed by your doctor. It is typically taken with food, usually with your first main meal of the day, to reduce the likelihood of an upset stomach. Combining this medication with a balanced diet and regular physical activity is essential to achieve the best results for your metabolic health.

While taking TRIGETROL TABLET , you may experience some common side effects, such as mild stomach upset, weight gain, or low blood sugar. However, you must contact your doctor immediately if you experience serious side effects, such as sudden shortness of breath, severe swelling in your legs, yellowing of your eyes or skin, or dark urine.

Before starting this medicine, tell your doctor if you have heart disease, a previous heart attack, heart failure, kidney disease, liver disease, or diabetic ketoacidosis. The rosiglitazone component may increase the risk of heart failure and certain cardiovascular events in some patients and should not be used in people with symptomatic heart failure. Your doctor will carefully assess whether this medicine is appropriate for you before prescribing it.

Certain substances can interact with TRIGETROL TABLET and affect how it works. For example, drinking alcohol increases your risk of experiencing dangerously low blood sugar and a rare but serious chemical buildup in the blood. If you are pregnant, breastfeeding, or are an older adult, consult your doctor or pharmacist, as special precautions or alternative treatments may be necessary.

Uses of TRIGETROL TABLET

TRIGETROL TABLET is used in the treatment of Type 2 diabetes mellitus. The detailed uses of TRIGETROL TABLET are as follows:

  • Type 2 Diabetes Mellitus: TRIGETROL TABLET helps lower blood glucose levels in adults whose blood sugar cannot be controlled by diet, exercise, or other single-agent medications alone.

Key Benefits

  • Helps control blood sugar levels: The three medicines work together to lower blood sugar through different mechanisms, providing better overall glucose control.
  • Convenient combination therapy: Combines three antidiabetic medicines in a single tablet, making your treatment routine simpler and easier to follow.
  • Improves insulin action: Helps your body use insulin more effectively, allowing glucose to enter cells for energy and reducing high blood sugar levels.
  • Supports steady energy levels: Better blood sugar control may help reduce energy fluctuations and improve day-to-day wellbeing.
  • Lowers the risk of diabetes complications: Keeping blood sugar under control can help reduce the long-term risk of complications such as kidney disease, nerve damage, eye problems, and heart disease.

Directions for Use

  • Take TRIGETROL TABLET with food to avoid stomach upset.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow TRIGETROL TABLET as a whole with a glass of water.
  • Do not crush or break it.

How TRIGETROL TABLET Works

TRIGETROL TABLET contains Glibenclamide, Metformin and Rosiglitazone. Glibenclamide: Stimulates the pancreas to release more insulin. Metformin: Reduces the amount of sugar produced by the liver and helps the body use insulin more effectively. Rosiglitazone: Improves the body's response to insulin, allowing cells to absorb and use glucose more efficiently. Together, these medicines help control blood sugar levels and improve overall diabetes management.
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Alcohol

Unsafe

You are recommended to avoid consumption of alcohol with TRIGETROL TABLET as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

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Pregnancy

Unsafe

TRIGETROL TABLET is not recommended for pregnant women as it may harm an unborn baby. Please consult a doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking TRIGETROL TABLET as it may be excreted in breastmilk and cause adverse effects in the baby. Therefore, please consult a doctor before using TRIGETROL TABLET if you are breastfeeding.

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Driving

Caution

TRIGETROL TABLET may decrease alertness in some people. Therefore, drive only if you are alert after taking TRIGETROL TABLET .

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Liver

Caution

Take TRIGETROL TABLET with caution, especially if you have a history of liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take TRIGETROL TABLET with caution, especially if you have a history of kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Unsafe

TRIGETROL TABLET is not recommended for children below 18 years of age as the safety and effectiveness were not established.

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Heart

Caution

TRIGETROL TABLET should be used with caution in patients with heart problems. Inform your doctor about any heart-related conditions before taking TRIGETROL TABLET .

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Geriatrics

Caution

TRIGETROL TABLET should be given with caution in elderly patients due to an increased risk of side effects. It is important to inform your doctor before using it.

What if I have taken an overdose of TRIGETROL TABLET

If you take more than your prescribed dose, seek immediate emergency medical care. An overdose can lead to dangerously low blood sugar or a serious medical emergency called lactic acidosis

Diet & Lifestyle Advise

  • Eat balanced, regular meals containing complex carbohydrates, lean protein, and plenty of fiber to keep your blood sugar levels stable throughout the day.
  • Engage in moderate-intensity physical activity, such as brisk walking, for at least 150 minutes per week, as exercise helps your body use insulin more effectively.
  • Always carry a fast-acting source of sugar with you, such as glucose tablets, fruit juice, or hard candies, to quickly treat any sudden episodes of low blood sugar.
  • Monitor your blood sugar levels regularly at home as recommended by your doctor to track your progress and detect any unusual trends early.
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Have a query?

How Soon It Starts Working

The time required for TRIGETROL TABLET to start to work: The time required for TRIGETROL TABLET to show its action is unknown. The time for which the effects of TRIGETROL TABLET last: The duration of action for TRIGETROL TABLET is clinically unknown.

What if you forget to take TRIGETROL TABLET

If you miss a dose, take it with food as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and return to your regular dosing schedule. Do not take two doses at the same time to make up for a missed one.

Storage

• Store TRIGETROL TABLET tablets at a controlled room temperature between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Always inspect your medication packaging before use to ensure the blister pack or bottle seal is fully intact and undamaged.
  • Limit or avoid alcohol consumption, as alcohol significantly increases your risk of experiencing severe low blood sugar and lactic acidosis.
  • Tell all healthcare providers, including your dentist or surgeons, that you are taking TRIGETROL TABLET before you undergo any medical procedures or diagnostic tests.
  • Consider wearing a medical alert bracelet or carrying an ID card that states you have type 2 diabetes and are taking this combination medication.
  • Avoid driving or operating machinery if you feel dizzy, confused, or shaky, as these are common signs that your blood sugar has dropped too low.

Drug-Drug Interactions

verifiedApollotooltip
  • Insulin or other diabetes medicines (such as sulfonylureas, DPP-4 inhibitors, GLP-1 receptor agonists, or SGLT2 inhibitors): Taking these medicines together may increase the risk of low blood sugar or other side effects. Your doctor may adjust your doses and recommend closer blood glucose monitoring.
  • Beta-blockers: May mask common warning signs of low blood sugar, such as a fast heartbeat or shakiness.
    Corticosteroids and diuretics (water pills): May increase blood sugar levels, making your diabetes harder to control.
  • Certain antifungals or antibiotics: May increase the amount of this medicine in your body, raising the risk of low blood sugar.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Can interact unpredictably with this medication, drastically lowering your blood sugar or increasing the risk of lactic acidosis.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIDIABETICS]

FAQs

TRIGETROL TABLET belongs to a class of medicines called antidiabetic drugs used in the treatment of type 2 diabetes, especially in patients whose blood sugar levels are not controlled by diet and exercise alone.
TRIGETROL TABLET contains Glibenclamide, Metformin and Rosiglitazone. Glibenclamide works by stimulating beta cells in the pancreas that produce insulin. Thus, insulin helps to remove sugar from the blood. Metformin works by reducing the sugar production by cells in the liver and delays sugar absorption from the intestines. Also, it increases the sensitivity of muscle cells to insulin which enables these cells to remove sugar more effectively from the blood. Rosiglitazone works by increasing the sensitivity of liver, muscle and fat cells to insulin and enables cells to remove glucose from blood more effectively. Thereby, TRIGETROL TABLET helps to control blood sugar levels.
TRIGETROL TABLET may increase the risk of low blood sugar levels, especially with alcohol intake, when you exercise more than usual, delay or miss snacks or meal. However, if you experience any signs of low blood pressure such as dizziness, nausea, light-headedness, dehydration or fainting, please consult a doctor.
You are not recommended to take TRIGETROL TABLET with levothyroxine as it may reduce the hypoglycemic (lowering blood sugar levels) effect of metformin. However, please consult a doctor before using TRIGETROL TABLET with other medicines.
In type 1 diabetes, the body doesn’t produce insulin as the islet cells (insulin-producing cells) in the pancreas are destroyed completed. In type 2 diabetes, though islet cells are working, the body doesn’t respond to insulin as the body becomes resistant to insulin.
You are not recommended to stop taking TRIGETROL TABLET on your own as discontinuing TRIGETROL TABLET suddenly may cause recurring symptoms or worsen the condition. However, if you experience any difficulty while taking TRIGETROL TABLET , please consult your doctor so that alternative medicine may be prescribed.
It is highly recommended to avoid or strictly limit alcohol while taking this medicine. Alcohol can increase the risk of dangerously low blood sugar and raise the chances of a rare but life-threatening condition called lactic acidosis. Talk to your doctor or pharmacist about safe habits.
If you feel shaky, sweaty, or dizzy, immediately consume 15 grams of fast-acting sugar, such as half a cup of fruit juice, three to four glucose tablets, or a few hard candies. Recheck your blood sugar after 15 minutes. If symptoms persist, talk to your doctor or seek medical help.
Yes, weight gain is a known side effect of some components in this medication, partly due to improved glucose storage and potential fluid retention. Following a healthy diet and exercising regularly can help manage this. Talk to your doctor if you experience rapid, unexpected weight gain.
No, this medication is generally not recommended during pregnancy or breastfeeding. Managing blood sugar is critical during these times, and alternative treatments like insulin are typically preferred. Talk to your doctor to discuss the safest treatment options for you and your baby.
The individual components of this medicine begin working within a few hours of your first dose to help lower blood glucose levels. However, it may take several weeks of consistent use, alongside diet and exercise changes, to see the full clinical impact on your HbA1c levels. Talk to your doctor if you have concerns.
Metformin-associated lactic acidosis is a rare but serious complication linked to the metformin component of this medicine. The risk is higher in people with severe kidney disease, liver disease, dehydration, severe infection, or excessive alcohol intake. Staying well hydrated, avoiding excessive alcohol, and attending regular kidney function tests can help reduce the risk. Seek immediate medical attention if you develop unusual muscle pain, severe weakness, trouble breathing, or extreme drowsiness.
Unless your doctor or pharmacist tells you otherwise, swallow the tablet whole with water. Splitting or crushing the tablet may result in an inaccurate dose and could affect how well your treatment works. If you have difficulty swallowing tablets, speak with your doctor or pharmacist about suitable alternatives.
No, TRIGETROL TABLET does not cure type 2 diabetes; it helps you manage and control your blood sugar levels. You must continue taking this medication as prescribed, even if you feel well, and maintain your diet and exercise plan. Talk to your doctor about your long-term care strategy.
Yes. Your doctor may recommend regular HbA1c, blood glucose, kidney function, and liver function tests to monitor how well the medicine is working and detect any side effects early. Keep all scheduled follow-up appointments to help ensure your diabetes remains well controlled.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

INDIA

Manufacturer/Marketer address

NO 77/31, 53rd STREET ASHOK NAGAR CHENNAI TN 600083 IN , - , .
Other Info - TRI0187
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