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compositionComposition:HYDROXYUREA-500MG
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Prescription Medicine
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Unidrea 500 mg Capsule is used to treat head and neck cancer and sickle cell anaemia (blocking the flow of blood that causes pain and organ damage). It works by blocking an enzyme that is required for growing cells. This prevents the cancer cells from multiplying and growing. In sickle cell disease, it works by increasing fetal haemoglobin (HbF) (haemoglobin of the unborn baby) levels in red blood cells (RBCs). This helps the RBCs accept a normal shape, restores the flow of blood, and protects against problems like painful sickle cell attacks. It may cause side effects such as loss of appetite (feeling unwell and stomach upset), increased bleeding tendency, nausea, upset stomach, and vomiting.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

HYDROXYUREA-500MG

Manufacturer/Marketer :

United Biotech Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Unidrea 500 mg Capsule

Unidrea 500 mg Capsule is an oral prescription medication used to reduce the frequency of painful crises and the need for blood transfusions in people with sickle cell anaemia. It is also prescribed to treat certain types of blood cancers, such as chronic myeloid leukaemia, and other blood disorders like polycythaemia vera. This medication works by helping the body produce healthier red blood cells or by slowing down the growth of abnormal cells.

To get the best results, you must take Unidrea 500 mg Capsule consistently at the same time every day as directed by your doctor. You can take this medicine with or without food, but taking it with a full glass of water is generally recommended. Along with taking this medication, staying well-hydrated by drinking plenty of fluids is a crucial lifestyle step that supports your body during treatment.

While taking Unidrea 500 mg Capsule , you may experience mild side effects like nausea, mild stomach upset, or temporary hair thinning. However, you must contact your doctor immediately if you notice signs of serious issues, such as unusual bruising, fever, sore throat, or sores on your legs.

Do not take this if you are pregnant, planning to become pregnant, or breastfeeding, as this medication can cause severe harm to an unborn baby. Before starting, talk to your doctor if you have a history of kidney disease, liver damage, or a weakened immune system.

This medicine can interact with certain vaccines, gout medications, and antiviral drugs, which may increase the risk of severe side effects or reduce how well your treatments work. Elderly individuals and those with reduced kidney function should consult their doctor closely, as they may require special monitoring while taking Unidrea 500 mg Capsule .

Uses of Unidrea 500 mg Capsule

Unidrea 500 mg Capsule is used to manage and treat sickle cell anaemia, chronic myeloid leukaemia and polycythaemia vera. The detailed uses of Unidrea 500 mg Capsule are as follows:

  • Sickle cell anaemia: Unidrea 500 mg Capsule helps by increasing the amount of foetal haemoglobin in the blood, which prevents red blood cells from changing into a crescent shape, thereby reducing painful crises and the need for blood transfusions.
  • Chronic myeloid leukaemia: Unidrea 500 mg Capsule works by slowing down the overproduction of abnormal white blood cells in the bone marrow, helping to manage blood cell counts.
  • Polycythaemia vera: Unidrea 500 mg Capsule helps control the excess production of red blood cells, which lowers the risk of blood clots and improves blood flow throughout the body.
     

Key Benefits

Unidrea 500 mg Capsule helps manage certain blood disorders by improving blood cell function and reducing disease-related complications. By supporting healthier blood cell levels and circulation, it helps improve quality of life and long-term health outcomes.

  • Helps Reduce Painful Sickle Cell Crises: For individuals with sickle cell disease, Unidrea 500 mg Capsule helps reduce the frequency and severity of painful vaso-occlusive episodes, supporting greater comfort and reducing the need for hospitalisation.
  • Supports Healthy Blood Cell Function: By improving blood cell production and reducing complications associated with blood disorders, Unidrea 500 mg Capsule helps lessen symptoms such as fatigue and weakness related to anaemia, supporting better daily functioning.
  • Helps Protect Against Long-Term Complications: Regular use of Unidrea 500 mg Capsule helps reduce the risk of complications caused by abnormal blood cells or impaired blood flow, supporting the health of vital organs and improving long-term disease management.
     

Directions for Use

  • Take Unidrea 500 mg Capsule with or without food as advised by your doctor.
  • Unidrea 500 mg Capsule is generally taken once a day or as directed by the doctor.
  • Swallow Unidrea 500 mg Capsule as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Unidrea 500 mg Capsule Works

Unidrea 500 mg Capsule contains hydroxyurea. It works by targeting the way certain cells in your body grow and divide. It acts as an inhibitor of an enzyme called ribonucleotide reductase, which is essential for making DNA. By temporarily blocking this enzyme, the medicine slows down or stops the rapid division of abnormal or overactive cells, such as those found in leukaemia or polycythaemia vera. In patients with sickle cell anaemia, Unidrea 500 mg Capsule helps by prompting the bone marrow to produce foetal haemoglobin. This specific type of haemoglobin prevents red blood cells from stiffening and bending into the sickle shape. As a result, the cells remain round and flexible, allowing them to flow smoothly through small blood vessels without causing blockages or pain.
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Alcohol

Consult your doctor

The drinking of alcohol (in small amounts) does not appear to affect the safety or usefulness of Unidrea 500 mg Capsule . Taking alcohol in larger amounts causes dizziness.

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Pregnancy

Unsafe

Unidrea 500 mg Capsule is not safe during pregnancy because it may cause harmful effects to the baby.

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Breast Feeding

Consult your doctor

It is unknown whether Unidrea 500 mg Capsule is excreted in human milk. Please consult a doctor before using Unidrea 500 mg Capsule while breastfeeding.

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Driving

Caution

Unidrea 500 mg Capsule may cause dizziness or a severe headache. Therefore, drive only if you are alert after taking Unidrea 500 mg Capsule .

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Liver

Consult your doctor

If you have any concerns regarding the use of Unidrea 500 mg Capsule in patients with liver problems, please consult a doctor.

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Kidney

Consult your doctor

If you have any concerns regarding the use of Unidrea 500 mg Capsule in patients with kidney problems, please consult a doctor.

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Children

Unsafe

The safety and efficacy of Unidrea 500 mg Capsule have not been established in children. Therefore, it is not recommended for children.

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Heart

Consult your doctor

Please inform your doctor if you have any pre-existing heart problems

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Geriatrics

Consult your doctor

Limited information available for use of Unidrea 500 mg Capsule in elderly patients. Please consult your doctor.

What if I have taken an overdose of Unidrea 500 mg Capsule

If you suspect an overdose or have taken more than your prescribed amount, seek immediate medical attention right away. Symptoms of an overdose may include severe skin changes, swelling, or extreme fatigue.

Diet & Lifestyle Advise

  • Stay well-hydrated: Drink plenty of water throughout the day. Staying hydrated is particularly crucial for sickle cell patients to help prevent blood flow blockages.
  • Protect your skin: This medication can make your skin more sensitive to the sun and increase the risk of skin damage. Wear protective clothing and apply a broad-spectrum sunscreen daily when outdoors.
  • Practice strict hand hygiene: Because this medicine can lower your white blood cell count and weaken your immune system, wash your hands frequently and avoid close contact with individuals who are sick.
  • Avoid live vaccines: Talk to your healthcare provider before receiving any immunisations, as live vaccines should be avoided during treatment.
     
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How Soon It Starts Working

  • The time required for Unidrea 500 mg Capsule to start working: The time required for Unidrea 500 mg Capsule to start working is 1 to 4 hours after administration.
  • The time for which the effects of Unidrea 500 mg Capsule last: The effect of Unidrea 500 mg Capsule lasts for 24 hours.

What if you forget to take Unidrea 500 mg Capsule

If you miss a dose of Unidrea 500 mg Capsule , take it as soon as you remember on the same day. If you do not remember until the next day, skip the missed dose and return to your regular schedule. Do not take a double dose to make up for a missed one.

Storage

•Store Unidrea 500 mg Capsule at room temperature, between 20°C and 25°C (68°F to 77°F). •Keep the container tightly closed and protect it from excessive heat, moisture, and direct sunlight.

Drug Warnings

  • Wear gloves when handling: Caregivers handling the capsules should wear disposable gloves to prevent direct skin contact with the medication.
  • Keep up with blood tests: You will need regular blood tests while taking this medication so your doctor can monitor your blood cell counts and ensure your kidneys and liver are functioning safely.
  • Use reliable birth control: Both men and women must use highly effective, reliable birth control during treatment and for several months after stopping the medication to prevent pregnancy.
  • Monitor for skin ulcers: Inspect your skin, especially your legs and ankles, regularly for any red spots, sores, or painful ulcers, and report them to your doctor immediately.
  • Avoid touching broken capsules: If a capsule accidentally breaks or spills, clean the area with a damp paper towel immediately, place it in a sealed bag, and throw it away, making sure not to inhale the powder.
     

Drug-Drug Interactions

verifiedApollotooltip
  • Certain antiretroviral medicines (e.g., didanosine, stavudine): Taking Unidrea 500 mg Capsule with certain medicines used to treat HIV may increase the risk of serious side effects, including liver damage and pancreatitis. Your doctor may recommend alternative treatment or closer monitoring if these medicines are used together.
  • Medicines that suppress the immune system or bone marrow: Combining Unidrea 500 mg Capsule with other medicines that reduce bone marrow function may increase the risk of low white blood cell, red blood cell, or platelet counts. Regular blood tests may be needed during treatment.
     
HydroxycarbamideCertolizumab
Severe
HydroxycarbamideTeriflunomide
Severe

Drug-Drug Interactions

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HydroxycarbamideCertolizumab
Severe
How does the drug interact with Unidrea 500 mg Capsule:
Unidrea 500 mg Capsule when used with certolizumab may raise the risk of severe infections.

How to manage the interaction:
There may be a possibility of interaction between Unidrea 500 mg Capsule with certolizumab, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhoea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
HydroxycarbamideTeriflunomide
Severe
How does the drug interact with Unidrea 500 mg Capsule:
Unidrea 500 mg Capsule when used in conjunction with teriflunomide may raise the risk of severe infections.

How to manage the interaction:
There may be a possibility of interaction between Unidrea 500 mg Capsule with teriflunomide, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhoea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
HydroxycarbamideTofacitinib
Severe
How does the drug interact with Unidrea 500 mg Capsule:
Unidrea 500 mg Capsule when used with tofacitinib may raise the risk of severe infections, cancers.

How to manage the interaction:
There may be a possibility of interaction between Unidrea 500 mg Capsule with tofacitinib, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhoea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
HydroxycarbamideLevobupivacaine
Severe
How does the drug interact with Unidrea 500 mg Capsule:
Levobupivacaine has the potential to cause methemoglobinemia (a rare disorder in which the iron in the haemoglobin molecule (the red blood pigment) is defective, preventing it from carrying oxygen to the tissues adequately). This risk increases when used with Unidrea 500 mg Capsule, which may lead to methemoglobinemia. When taking these drugs, those who are extremely young (particularly newborns and babies), have heart or lung conditions, certain genetic predispositions, or have a glucose-6-phosphate dehydrogenase deficit may be more likely to develop methemoglobinemia.

How to manage the interaction:
Although taking Unidrea 500 mg Capsule and levobupivacaine together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as grey discolouration of the skin, abnormal blood colouration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
HydroxycarbamideVoclosporin
Severe
How does the drug interact with Unidrea 500 mg Capsule:
Unidrea 500 mg Capsule when used with voclosporin may raise the risk of severe infections, some kinds of cancer, including skin cancer and cancer of the lymph glands (lymphoma).

How to manage the interaction:
There may be a possibility of interaction between Unidrea 500 mg Capsule with voclosporin, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhoea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
HydroxycarbamideMepivacaine
Severe
How does the drug interact with Unidrea 500 mg Capsule:
Mepivacaine has the potential to cause methemoglobinemia (a rare disorder in which the iron in the haemoglobin molecule (the red blood pigment) is defective, preventing it from carrying oxygen to the tissues adequately). This risk increases when used with Unidrea 500 mg Capsule, which may lead to methemoglobinemia. When taking these drugs, those who are extremely young (particularly newborns and babies), have heart or lung conditions, certain genetic predispositions, or have a glucose-6-phosphate dehydrogenase deficiencies may be more likely to develop methemoglobinemia.

How to manage the interaction:
Although taking Unidrea 500 mg Capsule and mepivacaine together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as grey discolouration of the skin, abnormal blood colouration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
HydroxycarbamideProcaine
Severe
How does the drug interact with Unidrea 500 mg Capsule:
Procaine has the potential to cause methemoglobinemia (a rare disorder in which the iron in the haemoglobin molecule (the red blood pigment) is defective, preventing it from carrying oxygen to the tissues adequately). This risk increases when used with Unidrea 500 mg Capsule, which may lead to methemoglobinemia. When taking these drugs, those who are extremely young (particularly newborns and babies), have heart or lung conditions, certain genetic predispositions, or have a glucose-6-phosphate dehydrogenase deficiencies may be more likely to develop methemoglobinemia.

How to manage the interaction:
Although taking Unidrea 500 mg Capsule and procaine together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as grey discolouration of the skin, abnormal blood colouration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
HydroxycarbamideBacitracin
Severe
How does the drug interact with Unidrea 500 mg Capsule:
Unidrea 500 mg Capsule when used in conjunction with bacitracin may raise the risk of severe infections.

How to manage the interaction:
There may be a possibility of interaction between Unidrea 500 mg Capsule with bacitracin, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhoea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult your doctor immediately. Do not stop using any medications without a doctor's advice.
HydroxycarbamideLeflunomide
Severe
How does the drug interact with Unidrea 500 mg Capsule:
Unidrea 500 mg Capsule when used with leflunomide may raise the risk of severe infections.

How to manage the interaction:
There may be a possibility of interaction between Unidrea 500 mg Capsule with leflunomide, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhoea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
HydroxycarbamidePrilocaine
Severe
How does the drug interact with Unidrea 500 mg Capsule:
Prilocaine has the potential to cause methemoglobinemia (a rare disorder in which the iron in the haemoglobin molecule (the red blood pigment) is defective, preventing it from carrying oxygen to the tissues adequately). This risk increases when used with Unidrea 500 mg Capsule, which may lead to methemoglobinemia. When taking these drugs, those who are extremely young (particularly newborns and babies), have heart or lung conditions, certain genetic predispositions, or have a glucose-6-phosphate dehydrogenase deficiencies may be more likely to develop methemoglobinemia.

How to manage the interaction:
Although taking Unidrea 500 mg Capsule and Prilocaine together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as grey discolouration of the skin, abnormal blood colouration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Unidrea 500 mg Capsule when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIMETABOLITES]

FAQs

Unidrea 500 mg Capsule is used to treat head and neck cancer and sickle cell anaemia (blocking the flow of blood that causes pain and organ damage).
Take the Unidrea 500 mg Capsule as soon as you can, but avoid the missed dose if it is nearly time for your next dose. Do not take two doses at one time. Get your prescription refilled before you run out of Unidrea 500 mg Capsule entirely.
Immediately go to the emergency department of your nearest hospital. Be ready to tell or show what was taken, how much, and when it happened.
Unidrea 500 mg Capsule may cause a risk of skin cancer. Avoid contact with sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outside. Do not handle Unidrea 500 mg Capsule without the protection of skin.
Unidrea 500 mg Capsule can cause dizziness and drowsiness during the first limited hours after you take it. These side effects are more expected to happen when you start taking Unidrea 500 mg Capsule or when your doctor increases your dose.
Do not stop taking Unidrea 500 mg Capsule without discussing it with your doctor. Your doctor will most likely tell you to take another medicine, folic acid (a vitamin), to reduce some of the side effects of this Unidrea 500 mg Capsule . Take this Unidrea 500 mg Capsule exactly as instructed.
Unidrea 500 mg Capsule is a medication that requires careful monitoring and dosing based on your individual medical condition, weight, and other factors. Please consult your healthcare provider if you have any questions about your hydroxyurea dosage. They can provide personal guidance and ensure you're taking the correct amount.
Unidrea 500 mg Capsule can cause diarrhoea as a side effect. If you have watery or bloody diarrhoea, call your doctor. Do not use anti-diarrhea medicine unless your paediatrician tells you to.
Yes, it is recommended that you avoid certain foods and drinks while taking Unidrea 500 mg Capsule . Some substances can interact with the medication, potentially affecting its effectiveness or increasing the risk of side effects. Here are some things to avoid: alcohol, grapefruit, grapefruit juice, Foods high in tyramine (aged cheeses, cured meats, fermented foods, and certain types of beans), and excessive caffeine.
If you're feeling tired and weak while taking hydroxyurea, try these tips: rest when needed, eat healthy foods, drink plenty of water, and get enough sleep. Gentle exercise can also help. Discuss with your healthcare provider if you're experiencing severe fatigue or weakness that interferes with your daily activities. They may be able to adjust your treatment or recommend additional strategies.
Unidrea 500 mg Capsule is not safe during pregnancy because it may cause harmful effects to the baby.
Unidrea 500 mg Capsule can make your hair thin or fall out. This is a common side effect, but how much hair you lose can change from person to person. Sometimes, hair loss is temporary, but in rare cases, it can be permanent. If you're worried about hair loss, talk to your doctor. They can help you manage it.
If you notice any changes in your skin while taking Unidrea 500 mg Capsule , talk to your doctor. It's common to have darker skin or a rash. To protect your skin, use sunscreen, moisturize, and avoid things that might irritate it. If your skin problems are severe, see a dermatologist.
If you are having trouble with constipation while taking Unidrea 500 mg Capsule , try these tips: eat more fibre, drink plenty of water, exercise regularly, and consider using over-the-counter laxatives after talking to your doctor. Avoid food that can worsen constipation, and try to go to the bathroom at the same time each day. If your constipation is severe, talk to your doctor.
To reduce the risk of infection while taking Unidrea 500 mg Capsule , wash your hands often, avoid sick people, keep your home clean, get vaccinated, watch for signs of infection, and follow your doctor's instructions.
Common side effects of Unidrea 500 mg Capsule may include loss of appetite (feeling unwell and stomach upset), increased bleeding tendency, nausea, upset stomach, and vomiting. Most of these side effects of Unidrea 500 mg Capsule do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.
No, you should not open, break, or chew Unidrea 500 mg Capsule capsules. The powder inside can be harmful if it touches your skin or is inhaled. If you have trouble swallowing capsules, talk to your doctor or pharmacist for safe alternative options.
No, Unidrea 500 mg Capsule can cause severe birth defects. Both men and women should use effective contraception while taking this medicine and for a specific period after stopping. If you are planning a family, talk to your doctor to discuss safer alternatives.
You should avoid receiving live vaccines (such as the yellow fever or MMR vaccine) while taking Unidrea 500 mg Capsule , as your weakened immune system may not react safely. Always check with your doctor or pharmacist before getting any vaccine.
Mild skin darkening or nail changes are common side effects of Unidrea 500 mg Capsule . However, you should still mention any skin changes to your doctor to rule out other issues, especially if you notice painful sores or ulcers.
Yes, regular blood tests are absolutely essential. Your doctor needs to monitor your red blood cells, white blood cells, and platelets to make sure your dose is safe. Talk to your doctor to set up your blood test schedule.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Drugs.com Clinical Review Team. Hydroxyurea Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Product Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. WebMD Medical Reference Review Board. Details Drug and Treatment Monograph. Atlanta, GA: WebMD; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Hydroxyurea solution [Prescribing Information]. 2025. [Accessed on 23 May 2025]Check here
  5. Central Drugs Standard Control Organisation: New Drug Approval List from SND Division (From 01/01/2024 to 30/04/2024). 2024. [Accessed on 23 May 2025]Check here
  6. Hydroxyurea [Prescribing Information]. 2024. [Accessed on 23 May 2025]Check here
  7. EMC, Hydroxyurea. [Accessed on 14 Sep, 2019]Check here

Country of origin

INDIA

Manufacturer/Marketer address

FC/B-1 (Extn.), Mohan Co-operative Industrial Estate Mathura Road, New Delhi - 110 044.
Other Info - UNI0066
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