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compositionComposition:HYDROXYPROGESTERONE-500MG
prescription
Prescription Medicine
info
Uniprogestin 500 mg Injection 2 ml
Uniprogestin 500 mg Injection 2 ml
Uniprogestin 500 mg Injection 2 ml
Uniprogestin 500 mg Injection 2 ml
Uniprogestin 500 mg Injection 2 ml

Uniprogestin 500 mg Injection 2 ml is used to prevent premature labour. It contains Hydroxyprogesterone, which modulates the immune response of pregnant women to prevent rejection of the embryo and allow its attachment to the uterus. It prevents miscarriage and helps lower the risk of premature birth in pregnant women who have had past premature labour. In some cases, you may experience certain common side effects such as nausea, vomiting, itching, hives (skin rashes), swelling in the face, lips, tongue, or throat, and diarrhea.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

HYDROXYPROGESTERONE-500MG

Manufacturer/Marketer :

Torrent Pharmaceuticals Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Uniprogestin 500 mg Injection 2 ml

Uniprogestin 500 mg Injection 2 ml is a prescription hormonal treatment used to help reduce the risk of preterm birth in pregnant women who have previously delivered a baby too early. This injection provides essential hormonal support to help carry a pregnancy closer to its full term. It is medically indicated only for individuals with a history of a single, spontaneous premature delivery.

This therapy is typically injected once a week by a healthcare professional, and maintaining a highly consistent schedule is vital for its effectiveness. Because it is given as an injection, its absorption is not affected by food, meaning it can be taken regardless of meal times. Adopting supportive lifestyle habits, such as staying well-hydrated and avoiding prolonged standing, can further help optimise your pregnancy outcomes while on this treatment.

Common side effects of this medication include redness, swelling, or pain at the injection site, as well as mild nausea or diarrhoea. While these are usually manageable, you must consult your doctor immediately if you experience serious side effects like sudden leg pain, warmth, or swelling, which could indicate a blood clot. Seeking prompt medical advice ensures any severe issues are addressed quickly and safely.

Before starting this medication, it is essential to talk to your doctor if you have a history of diabetes, high blood pressure, kidney disease, or depression. Do not take this if you have a history of blood clots, severe liver damage, breast cancer, or unusual vaginal bleeding that has not been evaluated by a physician. Your healthcare provider will determine if this therapy is safe for your specific health profile.

This injection can interact with certain liver-enzyme medications, which may reduce how well the hormone works. It is specifically designed for pregnant individuals, but you should consult your doctor if you are breastfeeding or have specific age-related concerns. Avoid smoking and alcohol, as smoking significantly increases your risk of dangerous blood clots during hormone therapy.

Uses of Uniprogestin 500 mg Injection 2 ml

Uniprogestin 500 mg Injection 2 ml is used to help reduce the risk of preterm birth. The detailed uses of Uniprogestin 500 mg Injection 2 ml are as follows:

  • Preterm birth prevention: Uniprogestin 500 mg Injection 2 ml helps lower the risk of early delivery in pregnant individuals who have already had a single baby born prematurely in the past.
  • Other hormonal uses: Hydroxyprogesterone formulations have been used in various hormone-related conditions; however, management of menstrual irregularities is not a standard indication for hydroxyprogesterone caproate. Use outside its approved pregnancy-related indication should only occur when specifically recommended by a healthcare professional.

Key Benefits

Uniprogestin 500 mg Injection 2 ml helps support reproductive health by providing pregnancy-focused hormonal support when prescribed by a healthcare professional. By supporting normal hormonal function during pregnancy, it may contribute to better maternal health and pregnancy management in appropriately selected patients. 

  • Supports Pregnancy-Focused Hormonal Management: When prescribed by a qualified obstetrician, Uniprogestin 500 mg Injection 2 ml may be used as part of an individualised strategy for patients considered at risk of recurrent preterm birth. It provides progesterone-like hormonal support intended to help maintain a pregnancy-favourable uterine environment. The potential benefits, limitations, and appropriateness of treatment should be assessed on an individual basis in the context of current clinical evidence and guidance.
Side effects of Uniprogestin 500 mg Injection 2 ml
  • Avoid trigger foods that can cause allergic reactions, such as nuts, shellfish, or dairy products.
  • Keep a food diary to track potential food allergens.
  • Include omega-3 rich foods like salmon and walnuts to reduce inflammation.
  • Wear loose, comfortable clothing made from soft fabrics like cotton.
  • Apply cool compresses or take cool baths to reduce itching.
  • Use gentle soaps and avoid harsh skin products.
  • Reduce stress through relaxation techniques like meditation or deep breathing.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Directions for Use

This medication is administered as an injection, typically given by a healthcare provider. Always follow your doctor's exact instructions regarding your injection schedule.

  • The injection is usually given slowly into the muscle of the buttocks (intramuscularly).
  • Ensure the injection site is cleaned thoroughly with an alcohol swab before the shot is administered.
  • Rotate the injection site each week (alternating buttocks) to minimise pain, redness, or skin irritation.
  • Keep all scheduled appointments with your healthcare provider to ensure you receive the injection at the same time each week.
  • For patients receiving hydroxyprogesterone caproate for prevention of recurrent preterm birth, treatment is commonly initiated between 16 and 20 weeks of pregnancy and continued until approximately 37 weeks of gestation or delivery, according to the treating physician's recommendations.

How Uniprogestin 500 mg Injection 2 ml Works

Uniprogestin 500 mg Injection 2 ml contains 'Hydroxyprogesterone', a progestin (female hormones) that modulates the immune response of pregnant women to prevent rejection of the embryo and allow its attachment to the uterus. Uniprogestin 500 mg Injection 2 ml prevents miscarriage and helps lower the risk of premature birth in pregnant women who have had past premature labour.
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Alcohol

Consult your doctor

There is not enough scientific data available for Uniprogestin 500 mg Injection 2 ml interaction with alcohol, hence it is best to consult a doctor.

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Pregnancy

Safe if prescribed

Uniprogestin 500 mg Injection 2 ml can be used during pregnancy if prescribed by the doctor.

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Breast Feeding

Consult your doctor

Please consult your doctor before using Uniprogestin 500 mg Injection 2 ml during breastfeeding.

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Driving

Caution

It is advised to drive with caution after taking Uniprogestin 500 mg Injection 2 ml as it may interfere with driving capabilities. It can make you feel drowsy.

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Liver

Caution

Uniprogestin 500 mg Injection 2 ml should be taken with caution, especially if you have a history of liver diseases. Your doctor may have to adjust the dose.

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Kidney

Caution

Uniprogestin 500 mg Injection 2 ml should be taken with caution, especially if you have a history of kidney diseases. Your doctor may have to adjust the dose.

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Children

Unsafe

Uniprogestin 500 mg Injection 2 ml not indicated for use in children. Safety and effectiveness in pediatric patients less than 16 years of age have not been established.

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Heart

Unsafe

Uniprogestin 500 mg Injection 2 ml is not recommended for use in heart patients as it can lead to cardiovascular effects.

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Geriatrics

Unsafe

Uniprogestin 500 mg Injection 2 ml is not recommended for use in elderly patients as it can lead to side effects.

What if I have taken an overdose of Uniprogestin 500 mg Injection 2 ml

Since a trained professional typically injects this medication, an overdose is highly unlikely. However, if you suspect an accidental overdose or experience severe symptoms like extreme dizziness, breathing difficulties, or severe nausea, seek immediate medical attention or contact emergency services.

Diet & Lifestyle Advise

  • Eat a nutrient-dense diet rich in folic acid, iron, and calcium to support your baby's development and protect your own bone health during pregnancy.
  • Drink plenty of water throughout the day, as staying hydrated helps prevent uterine irritability and early contractions.
  • Avoid prolonged sitting or standing to help reduce the risk of blood clots, which is a known risk during pregnancy and hormonal therapies.
  • Perform safe, low-impact exercises like walking only if approved by your doctor to promote healthy blood circulation.
  • Ensure complete avoidance of smoking, alcohol, and exposure to secondhand smoke to minimise the risk of vascular complications and early labour.

Have a query?

How Soon It Starts Working

  • The time required for Uniprogestin 500 mg Injection 2 ml to start to work: The time required for Uniprogestin 500 mg Injection 2 ml to show its action is unknown.
  • The time for which the effects of Uniprogestin 500 mg Injection 2 ml last: The duration of action for Uniprogestin 500 mg Injection 2 ml is unknown.

What if you forget to take Uniprogestin 500 mg Injection 2 ml

Because this medication is usually injected by a healthcare professional, missing a dose means missing an appointment. If you miss a scheduled injection, contact your doctor or clinic immediately to reschedule. Do not double the next dose or receive injections closer together than prescribed.

Storage

•Store the vials or syringes at room temperature, ideally between 20°C to 25°C (68°F to 77°F). •Do not freeze this medication. If the injection solution freezes, it must be discarded.

Drug Warnings

  • Check the solution: Inspect the vial before injecting. The liquid should be clear and pale yellow. Do not use if it is cloudy, contains particles, or is dark yellow.
  • Rotate injection sites: Alternate sides of your buttocks with each weekly injection to prevent skin thickening, deep bruising, or scar tissue.
  • Track your schedule: Use a calendar or phone alarm to ensure you get your injection exactly every 7 days. Consistency is key for preventing early labour.
  • Monitor blood sugar: If you have gestational diabetes, check your blood glucose levels regularly, as this hormonal injection can alter sugar tolerance.
  • Pre-surgery warning: Inform your surgeon or dentist that you are receiving a progestin injection, as you may need to pause treatment temporarily before surgeries to avoid blood clots.
  • The role of Uniprogestin 500 mg Injection 2 ml in preventing preterm birth: It has been the subject of ongoing regulatory and scientific review in some countries. Decisions regarding its use should be made by the treating obstetrician based on an individual assessment of potential benefits, risks, and current clinical guidance. 

Drug-Drug Interactions

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Drug-Drug Interactions

  • Liver-enzyme inducers: Medicines like rifampin or certain anti-seizure medications (such as carbamazepine) can speed up how your body processes this hormone, which may reduce the effectiveness of Uniprogestin 500 mg Injection 2 ml in preventing preterm birth.

Drug-Disease Interactions

  • Liver disease: Do not use this medication if you have active or severe liver disease unless specifically advised by your healthcare provider. Impaired liver function can alter the metabolism and clearance of Uniprogestin 500 mg Injection 2 ml, potentially leading to unpredictable hormone levels and changes in treatment response.
  • Blood clotting disorders: Avoid use if you have a history of blood clots, strokes, or deep vein thrombosis, as hormone therapy can increase clotting risks.
  • Hormone-sensitive cancers: Do not use if you have or are suspected of having breast cancer or other hormone-dependent tumours.
  • Unexplained vaginal bleeding: Use is restricted if you have undiagnosed vaginal bleeding, as the underlying cause must be evaluated first.
HydroxyprogesteroneRifabutin
Severe
HydroxyprogesteroneItraconazole
Severe

Drug-Drug Interactions

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HydroxyprogesteroneRifabutin
Severe
How does the drug interact with Uniprogestin 500 mg Injection 2 ml:
Coadministration of Rifabutin and Uniprogestin 500 mg Injection 2 ml may reduce the blood levels and effects of Uniprogestin 500 mg Injection 2 ml.

How to manage the interaction:
Using Rifabutin and Uniprogestin 500 mg Injection 2 ml together can lead to an interaction; they can be taken if your doctor advises. However, if you experience any abnormal bleeding, or pain, swelling, itching, bruising, or a lump at the injection site, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
HydroxyprogesteroneItraconazole
Severe
How does the drug interact with Uniprogestin 500 mg Injection 2 ml:
Coadministration of Itraconazole and Uniprogestin 500 mg Injection 2 ml can cause an increase in the levels of Uniprogestin 500 mg Injection 2 ml.

How to manage the interaction:
Using Itraconazole and Uniprogestin 500 mg Injection 2 ml together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, or vaginal bleeding, consult the doctor . Do not stop using any medications without a doctor's advice.
HydroxyprogesteroneNicotine
Severe
How does the drug interact with Uniprogestin 500 mg Injection 2 ml:
Coadministration of Nicotine and Uniprogestin 500 mg Injection 2 ml may reduce the blood levels and effects of nicotine.

How to manage the interaction:
Using Nicotine and Uniprogestin 500 mg Injection 2 ml together can lead to an interaction, they can be taken if advised by your doctor. Consult your doctor if your symptoms do not improve or worsen. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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HYDROXYPROGESTERONE-500MGCaffeine containing foods/drinks, Grapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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HYDROXYPROGESTERONE-500MGCaffeine containing foods/drinks, Grapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu, Grapefruit Juice, Grapefruit

How to manage the interaction:
Uniprogestin 500 mg Injection 2 ml may reduce the blood levels and effects of caffeine. Grapefruit juice may increase the blood levels of Uniprogestin 500 mg Injection 2 ml. Avoid or limit taking caffeine and grape juice while taking Uniprogestin 500 mg Injection 2 ml as it can lead to interaction.

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Therapeutic Class

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FAQs

Uniprogestin 500 mg Injection 2 ml is used to prevent premature labour. It prevents miscarriage and helps lower the risk of premature birth in pregnant women.
Uniprogestin 500 mg Injection 2 ml may cause weight gain. It can be due to water retention. If you feel that you are gaining a lot of weight while taking Uniprogestin 500 mg Injection 2 ml, please consult your doctor.
Uniprogestin 500 mg Injection 2 ml works by modulating the immune response of pregnant women to prevent the rejection of the embryo and allow its attachment to the uterus.
Uniprogestin 500 mg Injection 2 ml should be taken in the dose and duration as prescribed by the doctor.
Progesterone is an endogenous steroid and progestogen sex hormone secreted by the female reproductive part in the second half of the menstrual cycle to prepare for the release of the egg in the uterus. It is also necessary for the implantation of the fertilized egg in the uterus, for maintaining pregnancy and in hormonal replacement therapy in women deficient in progesterone.
Some of the common side effects of Uniprogestin 500 mg Injection 2 ml include nausea, vomiting, itching, hives (skin rashes), swelling of the face, lips, tongue, or throat, and diarrhea.
You should stop using Uniprogestin 500 mg Injection 2 ml and tell a doctor before using Uniprogestin 500 mg Injection 2 ml if you have uncontrolled high blood pressure (hypertension), unusual vaginal bleeding, liver disease, liver cancer, jaundice during pregnancy, circulation problems or bleeding problems, stroke, blood clot problems, breast cancer, uterus/cervix/vaginal cancer.
Since Uniprogestin 500 mg Injection 2 ml is administered by a doctor, it's unlikely you will stop taking Uniprogestin 500 mg Injection 2 ml on your own. Complete the duration of treatment as prescribed by the doctor.
Uniprogestin 500 mg Injection 2 ml will be administered by a doctor. The doctor will determine the dose based on your condition.
Since Uniprogestin 500 mg Injection 2 ml is administered by a doctor, it's unlikely for you to miss a dose. Consult the doctor if you think you have missed a dose.
You should not receive Uniprogestin 500 mg Injection 2 ml if you are allergic to any of its components, if you have blood clotting problems, uncontrolled high blood pressure, or breast cancer.
No, this medication is only established for use in women carrying a single baby who have a history of preterm birth. It is not shown to be effective or safe for multiple pregnancies. Talk to your doctor.
It is given as an intramuscular injection, usually in the buttocks, by a trained healthcare professional on a weekly schedule. Talk to your doctor.
Mild injection site reactions like pain, redness, or swelling are common. Applying a warm compress can help soothe the area, but if you notice pus, severe warmth, or worsening swelling, talk to your doctor.
It is highly recommended to avoid alcohol during your treatment, both to protect your pregnancy and to prevent additional stress on your liver. Talk to your doctor.
Yes, hormonal injections can increase the risk of blood clots. You should seek immediate medical help if you experience sudden leg swelling, chest pain, or breathing problems. Talk to your doctor.
This hormone injection can affect how your body processes glucose, potentially raising your blood sugar levels. You will need to monitor your blood sugar more closely. Talk to your doctor.
For prevention of recurrent preterm birth, treatment is commonly started between 16 and 20 weeks of pregnancy and continued until around 37 weeks of gestation or until delivery, depending on your doctor's assessment and treatment plan. Talk to your doctor.

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Country of origin

India

Manufacturer/Marketer address

Off. Ashram Road, Ahmedabad - 380 009., Gujarat, India
Other Info - UNI0435

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