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compositionComposition:SODIUM VALPROATE-400MG
prescription
Prescription Medicine
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Valcare CR-400 Tablet 10's is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat bipolar disorder and prevent symptoms of migraine (like a headache). It helps reduce mood swings and improve impulsive behaviour.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

SODIUM VALPROATE-400MG

Manufacturer/Marketer :

Cerin Pharma

Consume Type :

Oral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Valcare CR-400 Tablet 10's

Valcare CR-400 Tablet 10's is an oral prescription medicine used to treat different types of seizures in epilepsy. It is also prescribed to manage manic episodes associated with bipolar disorder and to prevent migraine headaches in adults. This medicine works by calming overactive nerves in the brain to help you stay balanced and seizure-free.

For Valcare CR-400 Tablet 10's to work effectively, you must take it consistently every day at the same times. It is usually taken once or twice a day, and taking it with or after food can help prevent stomach upset. Making simple lifestyle adjustments, such as getting enough sleep, managing daily stress, and eating regular meals, can also support your treatment and improve your overall results.

While taking Valcare CR-400 Tablet 10's, you might experience mild side effects like drowsiness, nausea, or temporary hair thinning. However, you must contact your doctor immediately if you notice serious symptoms such as severe upper stomach pain, unexplained bruising, or yellowing of your skin and eyes.

Do not take this if you have active liver disease or a family history of severe liver problems. Before starting Valcare CR-400 Tablet 10's, tell your doctor if you have kidney problems, urea cycle disorders, or mitochondrial disease. It is especially important to discuss your medical history because this medicine should not be taken during pregnancy unless there is no other treatment option.

This medicine can interact with alcohol, which can make you feel extremely sleepy and increase the risk of seizures, so it is best to avoid drinking while on this treatment. You should also consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding, or if you are an older adult, as your body may handle the medication differently.
 

Uses of Valcare CR-400 Tablet 10's

Valcare CR-400 Tablet 10's is used to treat different types of seizures in epilepsy. The detailed uses of Valcare CR-400 Tablet 10's are as follows:

  • Epilepsy (Seizures): Valcare CR-400 Tablet 10's helps control and prevent various kinds of seizures, including generalised and partial seizures, by stabilising the electrical activity in the brain.
  • Bipolar Disorder (Manic Episodes): Valcare CR-400 Tablet 10's manages periods of extreme excitement, high energy, or irritability by helping to restore the balance of certain natural chemicals in your brain.
  • Migraine Prevention: Valcare CR-400 Tablet 10's helps by reducing how often you get severe migraine headaches, though it is not used to treat a migraine attack that has already started.
     

Key Benefits

Valcare CR-400 Tablet 10's helps manage certain neurological conditions by stabilising electrical activity in the brain. Depending on the condition being treated, it helps control seizures, stabilise mood, or reduce the frequency of migraine attacks, supporting a better quality of life.

  • Helps Control Seizures: By reducing abnormal electrical activity in the brain, Valcare CR-400 Tablet 10's helps decrease the frequency of seizures, allowing you to carry out daily activities with greater safety and confidence.
  • Supports Mood Stability: For individuals with bipolar disorder, Valcare CR-400 Tablet 10's helps reduce extreme mood swings and prevent manic episodes, promoting greater emotional stability and improved daily functioning.
  • Helps Prevent Migraine Attacks: When used for migraine prevention, Valcare CR-400 Tablet 10's helps reduce the frequency of migraine episodes, allowing you to spend more time enjoying your daily activities with fewer interruptions from headaches.
     
Side effects of Valcare CR-400 Tablet
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Apply a hot/cold pack to the affected area.
  • Doing gentle exercises can help cope with pain by stretching muscles.
  • Get enough sleep. It helps enhance mood and lower pain sensitivity.
  • Avoid alcohol, smoking and tobacco as they can increase pain.
  • Follow a well-balanced meal.
  • Meditation and massages may also help with pain.

Directions for Use

  • Valcare CR-400 Tablet 10's can be taken with or without food.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Valcare CR-400 Tablet 10's as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Valcare CR-400 Tablet 10's Works

Valcare CR-400 Tablet 10's contains sodium valproate, which helps to look at the chemistry of the brain. Your brain relies on electrical signals and chemical messengers to function. Sometimes, overactive electrical signals can cause a seizure or trigger a migraine. Valcare CR-400 Tablet 10's works by increasing the levels of a natural calming chemical in your brain called gamma-aminobutyric acid (GABA). By boosting GABA, Valcare CR-400 Tablet 10's helps block the excessive and rapid electrical signals that cause brain cells to overreact. This balancing effect calms brain activity, which helps prevent the onset of seizures, reduces the frequency of migraines, and stabilises fluctuating moods.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Valcare CR-400 Tablet 10's as it may cause increased dizziness and sleepiness.

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Pregnancy

Unsafe

Valcare CR-400 Tablet 10's belongs to pregnancy category D. Avoid taking Valcare CR-400 Tablet 10's if you are pregnant as it could lead to serious birth defects.

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Breast Feeding

Consult your doctor

Valcare CR-400 Tablet 10's may pass into breastmilk. Consult your doctor before taking Valcare CR-400 Tablet 10's if you are breastfeeding.

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Driving

Unsafe

Valcare CR-400 Tablet 10's causes dizziness, sleepiness and tiredness. Do not drive or operate machinery unless you are alert.

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Liver

Unsafe

Valcare CR-400 Tablet 10's should not be used if you have liver problems or your family has a history of liver problems. Please consult your doctor if you have any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Consult your doctor

Valcare CR-400 Tablet 10's can be given to children if prescribed by the doctor. The dose will be adjusted by the doctor depending upon the child's body weight.

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Heart

Consult your doctor

It is unknown whether Valcare CR-400 Tablet 10's is safe for use in cardiac patients or not. Please consult your physician.

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Geriatrics

Caution

Valcare CR-400 Tablet 10's should be given with caution in elderly patients due to age-related side effects. Seek medical advice before using Valcare CR-400 Tablet 10's.

What if I have taken an overdose of Valcare CR-400 Tablet 10's

In case of an accidental overdose, seek immediate emergency medical attention right away. Symptoms of an overdose can include extreme drowsiness, confusion, shallow breathing, or loss of consciousness.

Diet & Lifestyle Advise

  • Maintain a consistent sleep routine: Lack of sleep is a well-known trigger for both seizures and migraines. Aim for 7 to 8 hours of quality sleep every night.
  • Avoid alcohol completely: Alcohol can increase the sedative effects of Valcare CR-400 Tablet 10's, making you extremely dizzy or sleepy, and it can also lower your seizure threshold.
  • Eat regular meals: Skipping meals can trigger migraines or affect your metabolic balance. Eating consistent, balanced meals helps maintain steady energy levels.
  • Keep a health diary: Track your daily doses, any seizures or migraine attacks, and any mild side effects you notice. This record is highly valuable for your doctor during check-ups.
  • Stay adequately hydrated: Drinking enough water throughout the day supports overall brain health and can help reduce the frequency of headaches.
     
health query

Have a query?

How Soon It Starts Working

  • The time required for Valcare CR-400 Tablet 10's to start to work: Valcare CR-400 Tablet 10's ideally shows its action within 2 hours after administration.
  • The time for which the effects of Valcare CR-400 Tablet 10's last: The effect of Valcare CR-400 Tablet 10's lasts for 24 hours.

What if you forget to take Valcare CR-400 Tablet 10's

If you miss a dose of Valcare CR-400 Tablet 10's, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure, talk to your doctor or pharmacist.

Storage

• Store Valcare CR-400 Tablet 10's tablets, capsules, or oral solutions at room temperature, ideally between 15°C and 30°C (59°F to 86°F).

Drug Warnings

  • Use highly effective birth control: This medication carries a high risk of causing severe birth defects. If you are of childbearing age, discuss safe, reliable contraception options with your doctor.
  • Do not stop treatment abruptly: Stopping Valcare CR-400 Tablet 10's suddenly can cause severe, continuous seizures that can be dangerous. Always consult your doctor before making any changes.
  • Avoid driving or operating machinery: This medicine can make you feel sleepy or dizzy, especially when you first start taking it. Do not perform tasks requiring full alertness until you know how it affects you.
  • Monitor your mood: Pay close attention to any sudden changes in your mental health. Report any signs of depression, anxiety, or unusual thoughts to your doctor immediately.
  • Get regular blood tests: Your doctor will need to perform periodic blood tests to monitor your liver function, platelet counts, and the level of medicine in your body. Keep all your medical appointments.
     

Drug-Drug Interactions

verifiedApollotooltip
  • Aspirin: Taking aspirin with Valcare CR-400 Tablet 10's can increase the level of this medicine in your blood, raising the risk of side effects.
  • Other seizure medications: Medicines like carbamazepine, phenytoin, or phenobarbital can speed up how your body processes Valcare CR-400 Tablet 10's, while taking it with lamotrigine can increase lamotrigine levels to unsafe amounts.
  • Blood thinners: Combining this medicine with blood thinners like warfarin can increase your risk of bleeding or bruising.
     
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Drinking alcohol while taking this medicine can cause severe drowsiness, impair coordination, and increase the risk of seizures.

 

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTICONVULSANT]

FAQs

Valcare CR-400 Tablet 10's is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat bipolar disorder and prevent symptoms of migraine (like a headache).
Valcare CR-400 Tablet 10's decreases the excessive and abnormal nerve activity in the brain. It balances the brain's chemical messenger and prevents overactivity of the brain, thereby controlling seizure episodes.
Valcare CR-400 Tablet 10's helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA; this helps in blocking the nerve transmission across the brain and provides a calming effect.
Valcare CR-400 Tablet 10's limits the transmission of nerve pain, thereby preventing migraine headaches. Migraines are a neurological condition characterised by intense headaches.
Do not discontinue Valcare CR-400 Tablet 10's without consulting your doctor. To treat your condition effectively, continue taking Valcare CR-400 Tablet 10's for as long as prescribed. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Valcare CR-400 Tablet 10's; your doctor will reduce the dose gradually to avoid worsening of seizures.
Birth-control pills like oestrogen-containing products may affect the way Valcare CR-400 Tablet 10's works. It is better to consult the doctor if you are using birth control pills to avoid pregnancy.
Valcare CR-400 Tablet 10's might cause fertility issues in both men and women. However, it can be reversible upon discontinuation of Valcare CR-400 Tablet 10's. In rare cases, Valcare CR-400 Tablet 10's can be a contributing factor in male infertility.
Limit caffeine intake, avoid smoking and mouthwashes containing alcohol, drink water regularly, and chew sugar-free gum/candy might prevent dry mouth.
Valcare CR-400 Tablet 10's may change the results of liver enzymes, urine and blood tests. Inform the person doing the tests that you are taking Valcare CR-400 Tablet 10's.
Store Valcare CR-400 Tablet 10's at room temperature, in a dry place. Keep out of sight and reach of children.
Valcare CR-400 Tablet 10's may cause side effects like stomach pain, nausea, vomiting, dry mouth, tremors, tiredness, sleepiness, headache, weight gain, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
Yes, Valcare CR-400 Tablet 10's causes dizziness, sleepiness and tiredness. Do not drive or operate machinery unless you are alert.
No, taking higher than the recommended dose of Valcare CR-400 Tablet 10's will not be more effective and may cause unpleasant side effects. Do not take more than the prescribed dose of Valcare CR-400 Tablet 10's as it may cause an overdose.
No, you should avoid drinking alcohol while taking this medicine. Alcohol can increase the sleepiness and dizziness caused by Valcare CR-400 Tablet 10's and may also increase your risk of having a seizure. Talk to your doctor.
You must contact your doctor immediately before planning a pregnancy or as soon as you discover you are pregnant. This medicine carries a high risk of causing physical and developmental birth defects. Your doctor will help you evaluate alternative treatments. Talk to your doctor.
Yes, weight gain is a common side effect for some people taking this medicine. Managing your diet and staying physically active can help, but you should not make drastic changes without medical advice. Talk to your doctor.
No, you should never stop taking this medicine on your own. Stopping it suddenly can cause your seizures to return more frequently or become more severe. If you need to stop, your doctor will guide you on how to reduce your dose safely. Talk to your doctor.
Your doctor needs to check your blood regularly to monitor your liver health, check your blood platelet counts, and ensure the level of medicine in your body is within a safe and effective range. Talk to your doctor.
Some people experience temporary thinning or loss of hair while taking this medicine. In most cases, the hair grows back once the treatment is stopped or adjusted, though it may grow back with a slightly different texture. Talk to your doctor.
You can take this medicine with or without food. However, taking it with or immediately after a meal can help reduce common stomach upsets, such as nausea or indigestion. Talk to your doctor.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.1500 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. National Health Service (NHS). Sodium Valproate - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Valproate Sodium Intravenous Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Valproic acid [Package Leaflet]. 2023. [Accessed on 06 Apr. 2024]Check here
  5. Valproate sodium [Prescribing Information]. 2013. [Accessed on 18 Sep. 2024]Check here
  6. Rahman M, Awosika AO, Nguyen H Valproic Acid. [Updated 2024 Mar 19]. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024Check here
  7. Valproic Acid: MedlinePlus Drug InformationMedlinePlus. Sulfasalazine [Internet]. U.S. National Library of Medicine; 2025 [Accessed on 10 Mar 2025]Check here

Country of origin

India

Manufacturer/Marketer address

No.Ff-4A, Devnandan Complex, Arshi Technical Road, Ghatlodia, Ahmedabad - 380061, Gujarat , India
Other Info - VAL0604

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