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compositionComposition:SODIUM VALPROATE-333MG+VALPROIC ACID-145MG
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Prescription Medicine
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Valprocin CR 500mg Capsule is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat mood disorders and migraine. It contains Sodium valproate and Valproic acid, which works by decreasing the excessive and abnormal nerve activity in the brain. Thereby, it helps in controlling seizures. It blocks the nerve transmission across the brain and provides a calming effect. In some cases, it may cause common side effects such as headache, sleepiness, drowsiness, impaired coordination, apathy (lack of interest), irregular periods and weight gain. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

SODIUM VALPROATE-333MG+VALPROIC ACID-145MG

Manufacturer/Marketer :

Navnidhi Life Science

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Valprocin CR 500mg Capsule

Valprocin CR 500mg Capsule is a prescription medicine primarily used to treat and control different types of seizures in people with epilepsy. It is also prescribed to manage manic episodes associated with bipolar disorder and to prevent migraine headaches from starting. It helps stabilise overactive electrical activity in the brain to keep these conditions under control.

For this medicine to work effectively, you must take it consistently at the same times every day. You can take Valprocin CR 500mg Capsule with or without food, but taking it with a meal can help prevent an upset stomach. Making positive lifestyle changes, such as maintaining a consistent sleep schedule and managing stress, can further support the success of your treatment.

While taking Valprocin CR 500mg Capsule , some people may experience mild side effects like drowsiness or temporary hair thinning. However, you must monitor your body closely and contact your doctor immediately if you notice signs of serious complications, such as severe upper stomach pain, persistent vomiting, or yellowing of your eyes or skin.

Do not take this if you have active liver disease, a personal or family history of severe liver problems, or genetic mitochondrial disorders. Before starting treatment, tell your doctor if you have kidney problems, a history of depression or suicidal thoughts, or a urea cycle disorder. It is highly important to discuss these conditions to ensure the medicine is safe for you.

This medicine can interact with other substances; for instance, drinking alcohol while taking Valprocin CR 500mg Capsule can lead to extreme drowsiness and increase the strain on your liver. If you are pregnant, planning to become pregnant, breastfeeding, or are an elderly individual, you must consult your healthcare provider before taking this medication. Valprocin CR 500mg Capsule can cause serious birth defects and developmental disorders in an unborn baby and should generally be avoided during pregnancy unless no suitable alternative treatment is available. Women who can become pregnant should use effective contraception and discuss pregnancy planning with their doctor before starting or continuing treatment.

Uses of Valprocin CR 500mg Capsule

Valprocin CR 500mg Capsule is used to manage neurological and psychiatric conditions by helping stabilise electrical activity in the brain. It is commonly prescribed for the following conditions:

  • Epilepsy and Seizures: Valprocin CR 500mg Capsule helps control and prevent various types of seizures by calming hyperactive nerve signals in the brain.
  • Bipolar Disorder (Manic Episodes): Valprocin CR 500mg Capsule helps stabilise mood swings, reducing periods of extreme high energy, excitement, or irritability.
  • Migraine Prevention: Valprocin CR 500mg Capsule reduces the frequency and severity of migraine attacks, though it is not used to treat a migraine headache that has already started.
     

Key Benefits

By helping stabilise brain activity, Valprocin CR 500mg Capsule provides several important benefits that improve long-term symptom control and quality of life, including:

  • Reduces Seizure Frequency: Helps prevent seizures, allowing better day-to-day functioning and reducing the risk of seizure-related injuries.
  • Supports Mood Stability: Helps control manic episodes and promotes more stable moods in people with bipolar disorder.
  • Prevents Migraine Attacks: Reduces the number and severity of migraine episodes, helping minimise disruption to daily activities.
  • Promotes Better Quality of Life: Improved control of seizures, mood swings, or migraines helps support a more consistent and independent lifestyle.
  • Provides Long-Term Symptom Control: When taken regularly as prescribed, it helps maintain stable brain function and reduces the likelihood of symptom recurrence.
  • Convenient Dual-Component Therapy: Combines sodium valproate and valproic acid to provide effective and sustained therapeutic levels for ongoing management of eligible conditions.
     

Directions for Use

  • Take Valprocin CR 500mg Capsule with food to avoid stomach upset or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Valprocin CR 500mg Capsule Works

Valprocin CR 500mg Capsule works by calming overactive electrical signals in your brain through several complementary mechanisms. It increases the activity of a natural chemical messenger called GABA (gamma-aminobutyric acid), which acts as a natural 'brake' in the nervous system. It also helps stabilise overactive nerve cells by affecting sodium and calcium channels involved in transmitting electrical signals. Together, these actions help prevent the uncontrolled nerve activity that can lead to seizures, manic episodes, and migraine attacks.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Valprocin CR 500mg Capsule as it may increase the risk of seizures.

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Pregnancy

Unsafe

Valprocin CR 500mg Capsule belongs to pregnancy category D. Avoid taking Valprocin CR 500mg Capsule if you are pregnant unless prescribed by a doctor, as it could lead to serious birth defects.

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Breast Feeding

Consult your doctor

Valprocin CR 500mg Capsule may pass into breastmilk. Consult your doctor before taking Valprocin CR 500mg Capsule if you are breastfeeding.

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Driving

Unsafe

Valprocin CR 500mg Capsule causes dizziness, sleepiness and drowsiness. Do not drive or operate machinery unless you are alert.

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Liver

Unsafe

Valprocin CR 500mg Capsule should not be used if you have liver problems or your family has a history of liver problems. Please consult your doctor if you have any concerns regarding this.

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Kidney

Consult your doctor

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Valprocin CR 500mg Capsule can be given to children if prescribed by the doctor. The dose will be adjusted by the doctor depending upon the child's body weight.

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Heart

Consult your doctor

Please inform your doctor if you have any pre-existing heart problems

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Geriatrics

Caution

Valprocin CR 500mg Capsule should be given with caution in elderly patients due to an increased risk of side effects. Seek medical advice before using Valprocin CR 500mg Capsule .

What if I have taken an overdose of Valprocin CR 500mg Capsule

If you take too much of this medicine, seek immediate emergency medical attention or contact a poison control center right away. Symptoms of an overdose can include extreme sleepiness, shallow breathing, or loss of consciousness.

Diet & Lifestyle Advise

  • Avoid alcohol: Drinking alcohol while taking this medicine can cause severe drowsiness and significantly increases the risk of liver damage.
  • Track your symptoms: Keep a daily diary of your seizures, mood changes, or migraine episodes to share with your doctor at your next visit.
  • Prioritize sleep: Lack of sleep can trigger seizures and migraines. Aim for 7 to 9 hours of quality sleep every night.
  • Eat consistent meals: Taking your medicine with food can protect your stomach lining and reduce nausea.
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Have a query?

How Soon It Starts Working

  • The time required for Valprocin CR 500mg Capsule to start to work: The time required for Valprocin CR 500mg Capsule to show its action is not clinically established.
  • The time for which the effects of Valprocin CR 500mg Capsule last: The duration of action for Valprocin CR 500mg Capsule is not clinically established.

What if you forget to take Valprocin CR 500mg Capsule

If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Storage

•Store Valprocin CR 500mg Capsule at room temperature, between 15°C and 30°C, in a dry place away from direct heat, moisture, and light. •Do not store this medicine in the bathroom.

Drug Warnings

  • Do not stop taking Valprocin CR 500mg Capsule suddenly, as doing so can trigger continuous, life-threatening seizures.
  • If you are of childbearing age, use highly effective birth control, as this medicine can cause severe birth defects in an unborn baby.
  • Avoid driving, riding a bike, or operating heavy machinery until you are certain that this medicine does not make you dizzy or sleepy.
  • Carry a medical ID card or wear a medical alert bracelet to let emergency responders know you are taking this medication.
  • Regular blood tests may be required to monitor your liver function, complete blood count (including platelet levels), and, when appropriate, the level of medicine in your body. Your doctor may also check your blood ammonia level if you develop unexplained drowsiness, vomiting, or confusion during treatment. 

Important Warning: This medicine carries a risk of severe liver damage, particularly in children younger than 2 years of age and those taking multiple seizure medicines. Contact your doctor immediately if you develop persistent vomiting, unusual sleepiness, severe stomach pain, or yellowing of the skin or eyes. 

verifiedApollotooltip

Valprocin CR 500mg Capsule can interact with certain medicines, affecting how they work or increasing the risk of side effects. Inform your doctor about all prescription, over-the-counter, and herbal medicines you are taking, including:

  • Aspirin: May increase the level of Valprocin CR 500mg Capsule in your blood, raising the risk of side effects.
  • Other seizure medicines: Medications like carbamazepine, phenytoin, or phenobarbital can alter how Valprocin CR 500mg Capsule is processed, or vice versa.
  • Lamotrigine: Valprocin CR 500mg Capsule can significantly increase lamotrigine levels, raising the risk of serious skin reactions and other side effects. Your doctor may prescribe a lower lamotrigine dose and monitor you closely.
  • Carbapenem antibiotics (such as meropenem or imipenem): These antibiotics can rapidly reduce valproate levels in your blood, increasing the risk of breakthrough seizures. Alternative antibiotics may be recommended whenever possible.
  • Blood thinners: Taking this medicine with blood thinners can increase your risk of bleeding or bruising.

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verifiedApollotooltip

Certain foods and beverages may increase the side effects of Valprocin CR 500mg Capsule . Keep the following in mind during treatment:

  • Alcohol: Greatly increases the sedating effects of Valprocin CR 500mg Capsule , leading to dangerous drowsiness, and increases the risk of liver damage.

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Habit Forming

No

Therapeutic Class

[ANTICONVULSANT]

FAQs

Valprocin CR 500mg Capsule is primarily used to treat epilepsy/seizures/fits. It is also used to treat mood disorders and migraine.
Valprocin CR 500mg Capsule decreases the excessive and abnormal nerve activity in the brain. Valprocin CR 500mg Capsule increases the amount of a chemical substance called GABA, this helps in blocking the nerve transmission across the brain and provides a calming effect. Thereby helps in controlling seizures.
Do not discontinue Valprocin CR 500mg Capsule without consulting your doctor. To treat your condition effectually, continue taking Valprocin CR 500mg Capsule for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Valprocin CR 500mg Capsule ; your doctor will reduce the dose gradually to avoid worsening of seizures.
Valprocin CR 500mg Capsule may cause thrombocytopenia (low levels of platelets). This might increase the risk of bleeding and bruising. Be cautious while using sharp objects. Consult your doctor if you notice unexplained bleeding or bruising.
Valprocin CR 500mg Capsule may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a proper diet and exercising regularly.
Valprocin CR 500mg Capsule may increase the effect of aspirin when taken together. Please consult your doctor before taking Valprocin CR 500mg Capsule with aspirin to avoid unpleasant side-effects. Valprocin CR 500mg Capsule and aspirin should not be given together to children below 3 years as it could lead to liver intoxication.
Valprocin CR 500mg Capsule contains sodium valproate and valproic acid as the active ingredients. It is used for the treatment of all types of epilepsy.
Take Valprocin CR 500mg Capsule with or after food as advised by your doctor.
No, Valprocin CR 500mg Capsule does not cause addiction. However, it should be taken as per dose and duration prescribed by your doctor. Avoid self-medication as it may have severe unwanted effects.
Valprocin CR 500mg Capsule does not cure epilepsy, it only prevents the seizures from occurring. Therefore, you may need to continue taking it for years. If you experience any problems while taking Valprocin CR 500mg Capsule , please consult your doctor.
Yes, Valprocin CR 500mg Capsule has no influence on the working of birth control pills. However, contraceptives (birth control pills) may interfere with the working of Valprocin CR 500mg Capsule and seizures may occur. Thus, it is essential to inform your doctor if you are using birth control pills. Your doctor will monitor your response to the treatment and Valprocin CR 500mg Capsule levels in your blood.
Long term use of Valprocin CR 500mg Capsule is safe for large number of patients. Rarely, using Valprocin CR 500mg Capsule for long term may weaken your bones, thereby increasing their chances of breaking easily (osteopenia and osteoporosis). Get regular check-ups done for bone health if you are taking Valprocin CR 500mg Capsule for a prolonged time.
Valprocin CR 500mg Capsule may cause change of hair colour, thinning of hair, and even hair loss. If you have any concerns, discuss with your doctor if it is possible to reduce the dose of Valprocin CR 500mg Capsule . Your hair may regrow after either switching to a different medicine or reducing your dose.
Valprocin CR 500mg Capsule may cause side effects such as nausea, diarrhoea, hair loss, weight gain, headache and irregular periods. If these side effects persist or worsen, please consult your doctor.
You are recommended to avoid taking Valprocin CR 500mg Capsule if you have known hypersensitivity to valproic acid, have liver disease, or are pregnant. It should be used with caution in kidney impairment patients.
Valprocin CR 500mg Capsule overdose can cause serious symptoms such as metabolic acidosis and deep coma. If you suspect you have taken overdose of Valprocin CR 500mg Capsule , seek medical help immediately.
This medicine carries a high risk of causing birth defects and developmental issues in unborn babies. If you are pregnant or planning to become pregnant, talk to your doctor immediately about alternative treatments.
Mild sleepiness is common when starting this medicine. Avoid driving or operating machinery until you know how it affects you, and talk to your doctor if the sleepiness does not go away.
No, you should avoid alcohol. Mixing alcohol with this medication can cause extreme drowsiness and put extra stress on your liver. Talk to your doctor for more advice.
Regular blood tests help your doctor monitor your liver function, blood cell counts (including platelets), and, when appropriate, the amount of medicine in your bloodstream. If you develop symptoms such as unexplained drowsiness, vomiting, or confusion, your doctor may also check your blood ammonia level. These tests help ensure the medicine remains both safe and effective.
Yes, increased appetite and weight gain are recognised side effects of this medicine. Maintaining a balanced diet and regular exercise can help manage this. Talk to your doctor if weight gain becomes a concern.
No, you should swallow the tablets or capsules whole. Crushing or chewing them can destroy their protective coating, leading to stomach irritation or a bitter taste. Talk to your pharmacist if you have difficulty swallowing pills.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. MedlinePlus. A682412 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Valproic Acid,Valproate Sodium Drug Interactions Reference. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. Masum Rahman, Hoang Nguyen. Valproic Acid. NIH National Library of Medicine. National Centre for Biotechnology Information. StatPearls [Internet]. [Revised in October 2021] [Assessed 29th April 2025]Check here
  4. E Perucca, R Grimaldi, G Gatti, S Pirracchio, F Crema, G M Frigo. NIH National Library of Medicine. National Centre for Biotechnology Information. PMC PubMed Central. June 1984. [Assessed 29th April 2025]Check here
  5. Sanofi-Aventis. Electronic Medicine Compendium (EMC). [Revised in January 2022] [Assessed 29th April 2025]Check here
  6. Sodium Valproate and Valproic Acid [Package Information]. 2022. [Accessed on 17 Jan. 2026]Check here
  7. Nlh 0678 001. [Accessed on 02 Jun. 2026]Check here

Country of origin

India

Manufacturer/Marketer address

213, 214 City Center, Science City Road, Sola Opposite Shukan Mall, Near Cims Hospital, Ahmedabad-380060, Gujarat, India
Other Info - VAL0153

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