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compositionComposition:DARUNAVIR-600MG
prescription
Prescription Medicine
info
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Virem 600mg Tablet belongs to the class of antiretroviral drugs used in the treatment of HIV infection. This medicine works by inhibiting a protein called protease, which is required by virus-infected cells to generate new viruses. Common side effects include dizziness, headache, diarrhoea, nausea, vomiting, rashes, and feeling weak.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

DARUNAVIR-600MG

Manufacturer/Marketer :

Emcure Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Virem 600mg Tablet

Virem 600mg Tablet is an oral medication prescribed to treat human immunodeficiency virus (HIV-1) infection in both adults and children. It belongs to a class of medicines known as protease inhibitors, which play a crucial role in managing the virus. When used correctly in combination with other antiretroviral drugs, it helps keep the amount of HIV in the body at very low levels.

To get the best results, you must take Virem 600mg Tablet every single day exactly as your doctor directs, without skipping any doses. Skipping doses can make the virus resistant to the treatment, making it much harder to manage. Always take this medication with food, as food helps your body absorb the medicine properly so it can work effectively. Incorporating a nutrient-rich diet and keeping up with regular medical checkups will further support your immune system during treatment.

While taking Virem 600mg Tablet , you may experience some common side effects like mild stomach upset, headache, or diarrhoea. However, you should contact your doctor immediately if you experience severe skin rashes, persistent nausea, or signs of liver damage. It is vital to monitor how you feel and report any unusual symptoms to your healthcare provider right away.

Before starting Virem 600mg Tablet , tell your doctor if you have a history of liver disease, diabetes, high cholesterol, or haemophilia. Do not take this medicine if you have severe liver damage or if you are taking certain medications that can cause dangerous drug interactions. It is also important to tell your doctor if you have an allergy to sulfa medicines, as this medication contains a similar chemical structure.

This medication can interact with many other drugs, including herbal supplements like St. John's wort, which can significantly lower its effectiveness. You should also consult your doctor or pharmacist if you drink alcohol regularly, as it can place extra strain on your liver. If you are pregnant, planning to become pregnant, breastfeeding, or are an elderly individual, discuss the safety of this medication with your healthcare team.

Uses of Virem 600mg Tablet

Virem 600mg Tablet is used in the treatment of HIV (human immunodeficiency virus) infection. The detailed use of Virem 600mg Tablet is as follows:

  • HIV-1 Infection: Virem 600mg Tablet is used in combination with other antiretroviral medicines to control HIV infection, helping to reduce the viral load and strengthen the body's natural defence system to fight off other infections.

Key Benefits

Virem 600mg Tablet helps control HIV infection by reducing viral replication and supporting immune system function.

The following are the benefits of this medication:

  • Helps reduce the amount of HIV in the bloodstream.
  • Supports recovery and maintenance of immune system function.
  • Helps lower the risk of HIV-related infections.
  • Helps maintain an undetectable viral load when used as prescribed with other antiretroviral medicines.
  • Reduces the risk of transmitting HIV to others when viral suppression is achieved.
  • Supports longer and healthier living for people with HIV.
Side effects of Virem 600mg Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.

Directions for Use

  • Virem 600mg Tablet should be taken with food, or as a doctor advises.
  • It is usually taken once or twice a day. However, follow your doctor's instructions regarding dosage and timing for optimal results.
  • Swallow Virem 600mg Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Virem 600mg Tablet Works

Virem 600mg Tablet works by targeting a specific protein that the virus needs to grow and multiply. This protein, called an enzyme, is responsible for cutting large viral proteins into smaller, functional pieces that form new, mature virus particles. By blocking this enzyme, Virem 600mg Tablet prevents the virus from replicating and spreading to healthy cells in your body. Because the virus can adapt quickly, Virem 600mg Tablet is always taken with a small dose of another medicine, known as a booster. This booster slows down how quickly your liver breaks down Virem 600mg Tablet , ensuring there is always a sufficient amount of medicine in your bloodstream to keep the virus suppressed.
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Alcohol

Caution

It is unknown whether consuming alcohol with Virem 600mg Tablet is safe. However, it is best to avoid or limit alcohol consumption as a precaution.

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Pregnancy

Caution

If you are pregnant or planning for pregnancy, please seek medical advice. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Breastfeeding should be avoided by HIV-infected mothers due to the risk of HIV transmission.

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Driving

Caution

Virem 600mg Tablet may cause dizziness and drowsiness. Drive or operate heavy machinery only if you are alert.

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Liver

Caution

Please consult your doctor if you have liver problems. Avoid taking Virem 600mg Tablet if you have severe liver impairment.

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Kidney

Caution

Limited data is available regarding the usage of Virem 600mg Tablet in patients with kidney impairment, therefore, please consult your doctor if you have any concerns.

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Children

Caution

Virem 600mg Tablet is not recommended for children younger than 3 years of age or weighing below 15kg.

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Heart

Caution

Virem 600mg Tablet should be used with caution in patients with heart problems. Inform your doctor about any heart-related conditions before taking Virem 600mg Tablet .

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Geriatrics

Caution

Virem 600mg Tablet should be given with caution in elderly patients due to an increased risk of side effects. Please consult your doctor before using Virem 600mg Tablet .

What if I have taken an overdose of Virem 600mg Tablet

If you take more than your prescribed dose of Virem 600mg Tablet , seek immediate medical attention or call a poison control centre. Do not wait for symptoms of illness to appear before seeking help.

Diet & Lifestyle Advise

  • Always take with food: Never take Virem 600mg Tablet on an empty stomach. A full meal or a calorie-dense snack is essential to help your body absorb the drug completely.
  • Support your liver: Avoid or significantly limit alcohol consumption. Your liver processes this medicine, and adding alcohol increases the risk of liver damage.
  • Eat an immune-supporting diet: Focus on a balanced diet rich in whole grains, fruits, vegetables, and lean proteins to help support your immune system and maintain a healthy weight.
  • Manage your blood sugar and lipids: Since HIV medications can sometimes affect blood sugar and cholesterol, focus on high-fiber foods and limit saturated fats.
  • Stay hydrated: Drink plenty of water throughout the day to help your kidneys and liver process your medications smoothly.
health query

Have a query?

How Soon It Starts Working

The time required for Virem 600mg Tablet to start to work: The time required for Virem 600mg Tablet to show its action is unknown. The time for which the effects of Virem 600mg Tablet last: The effect of Virem 600mg Tablet lasts for 15 hours.

What if you forget to take Virem 600mg Tablet

If you miss a dose, take it with food as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and take your next one at the normal time. Do not take two doses at once to make up for a missed dose. If you are unsure what to do, talk to your doctor or pharmacist.

Storage

• Store Virem 600mg Tablet tablets at room temperature, between 68°F to 77°F (20°C to 25°C).

Drug Warnings

  • Watch for skin rashes: Check your skin every day, especially during the first few weeks of treatment. Contact your doctor immediately if you notice any rash.
  • Take it with your HIV medicines: Always take Virem 600mg Tablet together with your other prescribed HIV medicines. Taking it alone will not treat HIV effectively.
  • Tell your doctor about allergies: Inform your doctor if you are allergic to sulfa medicines. Virem 600mg Tablet may increase the risk of an allergic reaction in some people.
  • Do not miss doses: Make sure you do not run out of your medicine and refill your prescription before it finishes. Missing doses can make the virus harder to treat.
  • Attend regular check-ups: Keep all your follow-up appointments and blood tests. These help your doctor monitor your liver function, blood sugar, and how well your treatment is working.
  • Watch for signs of infection: As your immune system gets stronger, hidden infections may become noticeable. Contact your doctor if you develop a persistent fever, swollen glands, a worsening cough, or other unexplained symptoms.
  • Get emergency medical help when needed: Seek immediate medical care if you develop severe skin blisters, trouble breathing, swelling of the face or throat, yellowing of the skin or eyes, severe stomach pain, or signs of a serious allergic reaction.

Drug-Drug Interactions

verifiedApollotooltip
  • Statins/Cholesterol-lowering drugs (e.g., simvastatin, lovastatin): Taking Virem 600mg Tablet with certain statins can increase their levels in your body, raising the risk of severe muscle pain and damage.
  • Anti-tuberculosis drugs (e.g., rifampicin): Do not take rifampicin with Virem 600mg Tablet because it can greatly reduce the amount of Virem 600mg Tablet in your body, making HIV treatment ineffective.
  • Erectile dysfunction medications (e.g., sildenafil, tadalafil) : Virem 600mg Tablet can greatly increase the blood levels of these medicines, raising the risk of serious side effects like low blood pressure and vision changes.
  • Hormonal contraceptives (e.g., ethinylestradiol): This medication may reduce the effectiveness of birth control pills, patches, or rings. Use a reliable non-hormonal backup method of birth control.
  • Herbal supplements used for depression (e.g., St. John's wort): Avoid using this herbal supplement, as it can drastically lower the amount of Virem 600mg Tablet in your blood, making the treatment fail.
DarunavirColchicine
Critical
DarunavirLurasidone
Critical

Drug-Drug Interactions

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DarunavirColchicine
Critical
How does the drug interact with Virem 600mg Tablet:
Coadministration of colchicine with Virem 600mg Tablet may increase the blood levels of colchicine, increasing the risk of serious side effects.

How to manage the interaction:
Taking Colchicine with Virem 600mg Tablet is not recommended, they can be taken together if advised by your doctor. However, contact your doctor if you experience abdominal pain, nausea, vomiting, diarrhea, fever, muscle pain, weakness, fatigue, and/or numbness or tingling in your hands and feet. Do not stop taking any medications without consulting a doctor.
DarunavirLurasidone
Critical
How does the drug interact with Virem 600mg Tablet:
Using Lurasidone together with Virem 600mg Tablet may result in significantly higher Lurasidone blood levels. This may increase the possibility of negative effects like Parkinson's disease. (It is a brain disorder that produces uncontrollable movements.)

How to manage the interaction:
While Lurasidone and Virem 600mg Tablet may interact, they can be used if prescribed by a doctor. Consult a doctor if you have any abnormal muscle activity, fits, high blood sugar, high sugars, high cholesterol, heat intolerance or heat stroke, dizziness, lightheadedness, headache, flushing, fainting, or heart palpitations. Do not discontinue any medications without consulting a doctor.
DarunavirSimvastatin
Critical
How does the drug interact with Virem 600mg Tablet:
Combining Virem 600mg Tablet and Simvastatin can increase the blood levels and effects of Simvastatin. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Virem 600mg Tablet and Simvastatin together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
DarunavirRifampicin
Critical
How does the drug interact with Virem 600mg Tablet:
Taking Virem 600mg Tablet with rifampicin can decrease the blood levels of Virem 600mg Tablet, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between Virem 600mg Tablet and rifampicin, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
DarunavirSildenafil
Critical
How does the drug interact with Virem 600mg Tablet:
Combining Virem 600mg Tablet and Sildenafil can increase the blood levels and effects of Sildenafil.

How to manage the interaction:
Taking Virem 600mg Tablet and Sildenafil together is avoided as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, shortness of breath, dizziness, lightheadedness, fainting, visual disturbances, ringing in the ears, vision or hearing loss, chest pain or tightness, irregular heartbeat, and/or priapism (prolonged and painful erection unrelated to sexual activity), contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DarunavirEverolimus
Severe
How does the drug interact with Virem 600mg Tablet:
Taking Everolimus with Virem 600mg Tablet can considerably raise blood levels of everolimus, increasing the risk of serious side effects (pneumonitis - lung inflammation, infection, mouth ulcers, anemia, or bleeding).

How to manage the interaction:
Although there is a possible interaction between Virem 600mg Tablet and Everolimus, you can take these medicines together if prescribed by a doctor. Do not discontinue any medications without a doctor's advice.
DarunavirIbrutinib
Severe
How does the drug interact with Virem 600mg Tablet:
Taking Ibrutinib with Virem 600mg Tablet may increase the levels of Ibrutinib.

How to manage the interaction:
Although taking Ibrutinib and Virem 600mg Tablet together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in coughing fluid, red or inflamed skin, body sores, pain or burning during urination, nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, irregular heart rhythm, consult a doctor. Do not discontinue any medications without a doctor's advice.
DarunavirRanolazine
Severe
How does the drug interact with Virem 600mg Tablet:
When Virem 600mg Tablet is taken with Ranolazine, may significantly increase the blood levels and effects of ranolazine. High blood levels of ranolazine can occasionally cause an irregular heart rhythm that may be serious.

How to manage the interaction:
Although there is a possible interaction between Virem 600mg Tablet and Ranolazine, you can take these medicines together if prescribed by a doctor. If you notice any of these signs, it's important to contact a doctor right away: your heart beating irregularly, feeling suddenly dizzy or lightheaded, fainting, or having a fast or strong heartbeat. Do not discontinue any medications without consulting a doctor.
DarunavirCarbamazepine
Severe
How does the drug interact with Virem 600mg Tablet:
Using carbamazepine and Virem 600mg Tablet together may cause Virem 600mg Tablet to be less effective.

How to manage the interaction:
Although taking carbamazepine and Virem 600mg Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
DarunavirDasatinib
Severe
How does the drug interact with Virem 600mg Tablet:
When Dasatinib is taken with Virem 600mg Tablet may significantly increase the blood levels of dasatinib.

How to manage the interaction:
There may be a possibility of interaction between Virem 600mg Tablet and Dasatinib, but it can be taken if prescribed by a doctor. If you notice any symptoms like dizziness or shortness of breath - make sure to call a doctor right away. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Taking with food: Virem 600mg Tablet must be taken with a meal or snack. If taken on an empty stomach, your body will not absorb enough medicine to control the virus.
  • Grapefruit or grapefruit juice: Avoid consuming grapefruit, as it can interfere with how your body processes this medicine, leading to higher drug levels and a greater risk of side effects.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIRETROVIRAL AGENTS]

FAQs

Virem 600mg Tablet belongs to a class of antiretroviral drugs called protease inhibitors primarily used to treat HIV (Human Immunodeficiency Virus) infection in adults and children aged 3 years and above weighing at least 15kg.
Virem 600mg Tablet works by inhibiting protease enzyme that is essential for the reproduction of the human immunodeficiency virus. Thereby, it prevents the production of the new human immunodeficiency virus. Thus, Virem 600mg Tablet lowers virus load in the body and helps treat the infection.
Some patients taking antiretroviral combination therapy may develop osteonecrosis (death of bone tissue due to loss of blood supply to the bone). If you experience joint ache, pain, stiffness, or difficulty movement, consult your doctor.
In some cases, Virem 600mg Tablet may cause a rash, especially when used in combination with raltegravir. A rash is generally mild to moderate. However, occasionally it may become severe. Please inform your doctor if you develop a rash.
Virem 600mg Tablet might increase sugar levels in the blood, therefore, consult your doctor before taking Virem 600mg Tablet if you are diabetic. You are advised to monitor your blood glucose levels regularly while taking Virem 600mg Tablet .
Do not stop taking Virem 600mg Tablet without consulting your doctor as it may reduce the effectiveness of anti-HIV therapy. Continue taking Virem 600mg Tablet for as long as your doctor has prescribed it to you to treat your condition effectually. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Virem 600mg Tablet .
No, you should never take Virem 600mg Tablet on an empty stomach. Taking it with food is necessary because food significantly increases the absorption of the medicine into your bloodstream. If taken without food, the medication will not be fully effective in fighting the virus. Talk to your doctor or pharmacist if you are having trouble keeping food down.
No, Virem 600mg Tablet does not cure HIV infection. Instead, it helps control the virus, lowers your viral load, and protects your immune system so you can lead a healthier life. You must continue taking it daily as prescribed by your doctor.
It is highly recommended to limit or avoid alcohol while taking Virem 600mg Tablet . Both alcohol and this medication are processed by your liver, and combining them can increase the risk of liver damage. Talk to your doctor about what is safe for you.
If you are pregnant, planning to become pregnant, or breastfeeding, you must discuss this with your doctor. They will carefully weigh the benefits and risks to determine the safest treatment plan for you and your baby.
If you miss a dose, take it with food as soon as you remember. However, if it is almost time for your next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for a missed one. Talk to your doctor or pharmacist if you need guidance.
If you have previously received HIV treatment, your doctor may recommend resistance testing to check whether the virus has become less sensitive to certain medicines. This helps select the most effective treatment regimen for you.
No. The dose depends on factors such as your age, body weight, whether you are starting HIV treatment for the first time or have received treatment before, your liver function, and the other HIV medicines you take. Children receive weight-based doses prescribed by their doctor.
Yes, Virem 600mg Tablet can lower the effectiveness of hormonal contraceptives, including birth control pills, patches, or implants. It is recommended to use a reliable non-hormonal method of birth control (such as condoms) while taking this medicine. Talk to your doctor to find the best option for you.

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Country of origin

India

Manufacturer/Marketer address

255/2, Hinjawadi, Pune - 411057, India
Other Info - VIR0061
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