Buy Virolfi 450 mg Tablet online | Uses, Side Effects, Price and substitutes

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Composition:VALGANCICLOVIR-450MG

Prescription Medicine

Virolfi 450 mg Tablet is used to treat cytomegalovirus retinitis (viral infection of the retina). It contains Valganciclovir, which works by inhibiting viral replication. In some cases, this medicine may cause side effects such as diarrhoea, loss of appetite, cough, headache, stomach pain, nausea, fever, and tiredness. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

Written By Veda Maddala , M Pharmacy

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

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More about the Product

Composition :

VALGANCICLOVIR-450MG

Manufacturer/Marketer :

Zydus Cadila

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Virolfi 450 mg Tablet

Virolfi 450 mg Tablet is used to treat cytomegalovirus (CMV) infection of the retina of the eye in adult AIDS patients. Also, Virolfi 450 mg Tablet is used to prevent CMV infection in patients who received an organ transplant from a donor infected with CMV.

Virolfi 450 mg Tablet contains Valganciclovir, which is converted to ganciclovir in the body and inhibits viral multiplication.

In some cases, you may experience diarrhoea, loss of appetite, cough, headache, stomach pain, nausea, fever, tiredness, or sinusitis (sinus infection). Most of these side effects do not require medical attention. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Virolfi 450 mg Tablet or any other medicines, please tell your doctor. Avoid taking Virolfi 450 mg Tablet if you are pregnant, as it may cause birth defects. If you are breastfeeding, do not take Virolfi 450 mg Tablet as it may be excreted in human milk and cause adverse effects in the baby. Women are recommended to use effective contraceptive measures while taking Virolfi 450 mg Tablet and for 30 days after treatment with Virolfi 450 mg Tablet .

Uses of Virolfi 450 mg Tablet

Virolfi 450 mg Tablet is used in the treatment of Cytomegalovirus (CMV) infection of the retina. The detailed uses of Virolfi 450 mg Tablet are as follows:

CMV Retinitis: Virolfi 450 mg Tablet treats viral eye infections in patients with AIDS.
CMV Prophylaxis: Virolfi 450 mg Tablet prevents CMV disease in organ transplant recipients (kidney, heart, pancreas).

Key Benefits

Virolfi 450 mg Tablet contains Valganciclovir, an antiviral drug used to treat cytomegalovirus (CMV) infection of the retina of the eye in adult AIDS patients.
Virolfi 450 mg Tablet is converted to ganciclovir in the body and inhibits viral replication.
Virolfi 450 mg Tablet is used to prevent CMV infection in patients who received an organ transplant from a donor infected with CMV.

Side effects of Virolfi 450 mg Tablet

Loose And Watery Stools

Here are the precise steps to cope with diarrhoea caused by medication usage:

Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Anemia

Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
Consume vitamin C-rich foods as they aid iron absorption.
Limit tea, cocoa, and coffee as these can slow iron absorption.
Exercise regularly; however, do not overdo it.

Involuntary Shaking

Here are the steps to manage medication-triggered tremors or involuntary shaking:

Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.

Trouble Falling/ Staying Asleep

Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:

Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
Try relaxing techniques like deep breathing, mindfulness meditation and any others.
Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.

Nausea

Overcome Medication-Induced Nausea: A 9-Step Plan

Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
Divide your daily food intake into smaller, more frequent meals to reduce nausea.
Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
Use ginger (tea, ale, or candies) to help relieve nausea.
Get adequate rest and also avoid strenuous activities that can worsen nausea.
Talk to your doctor about taking anti-nausea medication if your nausea is severe.
Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Vomiting

To prevent, manage, and treat Constipation caused by medication usage, follow these steps:

Preventing Vomiting (Before it Happens)
Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
Having a small meal before taking your medication can help reduce nausea and vomiting.
Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
Managing Vomiting (If it Happens)
Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
What to Do if Vomiting Persists
Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Fungal Mouth Infection

Limit sugary drinks and foods to reduce yeast growth.
Avoid yeast-rich foods like beer, wine, and sourdough bread.
Include probiotic-rich foods like yogurt, kefir, kimchi, and sauerkraut.
Eat antifungal foods like garlic, onions, cinnamon, and coconut oil.
Focus on nutrient-rich foods high in vitamins C and E.
Use a warm saltwater rinse in your mouth several times daily.
Practice excellent oral hygiene through regular brushing, flossing, and denture cleaning.
Stay hydrated by drinking plenty of water.
To manage stress, try relaxation methods like deep breathing exercises, meditation, or yoga to help calm your mind and body.
Avoid smoking and tobacco to prevent immune function impairment.
Consult a doctor for proper diagnosis and treatment.

Directions for Use

Virolfi 450 mg Tablet can be taken with food to minimise stomach discomfort or as advised by your doctor.
Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
Swallow Virolfi 450 mg Tablet as a whole with a glass of water.
Do not chew, crush, or break it.

How Virolfi 450 mg Tablet Works

Virolfi 450 mg Tablet contains Valganciclovir, which works by getting converted to ganciclovir in the body and inhibits the multiplication of the virus. Thereby, it helps to control the infection.

Alcohol

Consult your doctor

The interaction of alcohol with Virolfi 450 mg Tablet is unknown. Please consult a doctor before consuming alcohol while using Virolfi 450 mg Tablet .

Pregnancy

Unsafe

Virolfi 450 mg Tablet is not recommended for pregnant women as it may cause birth defects. Please consult a doctor if you are pregnant.

Breast Feeding

Unsafe

Avoid breastfeeding while taking Virolfi 450 mg Tablet as it may pass into breast milk. Therefore, please consult a doctor if you are breastfeeding.

Driving

Unsafe

Virolfi 450 mg Tablet may cause dizziness, tiredness, drowsiness, shakiness or confusion in some people. Therefore, avoid driving or operating heavy machinery if you experience any of these symptoms after taking Virolfi 450 mg Tablet .

Liver

Caution

Take Virolfi 450 mg Tablet with caution, especially if you have a history of liver disease. The dose may be adjusted by your doctor as required.

Kidney

Caution

Take Virolfi 450 mg Tablet with caution, especially if you have a history of kidney disease. The dose may be adjusted by your doctor as required.

Children

Consult your doctor

Virolfi 450 mg Tablet should be used in children only if recommended by a doctor.

Heart

Caution

Virolfi 450 mg Tablet should be used with caution in patients with heart problems. Inform your doctor about any heart-related conditions before taking Virolfi 450 mg Tablet .

Geriatrics

Caution

Limited data is available regarding the use of Virolfi 450 mg Tablet in elderly patients. If you have any concerns about the usage of Virolfi 450 mg Tablet in geriatrics, please consult your doctor.

What if I have taken an overdose of Virolfi 450 mg Tablet

Take Virolfi 450 mg Tablet only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include upset stomach, vomiting, stomach pain, diarrhoea, uncontrolled shaking, seizures, decreased urination, bloody urine, signs of infection (sore throat, fever, chills, cough), excessive tiredness, pale skin, yellowing of skin or eyes, dizziness, fast heartbeat, weakness, and unusual bleeding or bruising. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Diet & Lifestyle Advise

Eat a healthy and balanced diet. Eat vitamin and nutrient-rich food such as dark-green, yellow, orange, and red vegetables and fruits as it helps to boost your immune system. Opt for lean protein and whole grains.
Avoid eating raw meat and eggs. Consume properly boiled and cooked meat, poultry or seafood.
Eat bland and low-fat foods and avoid spicy or oily foods if you experience nausea or vomiting.

Have a query?

How Soon It Starts Working

The time required for Virolfi 450 mg Tablet to start to work: Virolfi 450 mg Tablet ideally shows its action within 2 hours after administration.
The time for which the effects of Virolfi 450 mg Tablet last: The effect of Virolfi 450 mg Tablet lasts for 4 hours.

What if you forget to take Virolfi 450 mg Tablet

If you miss a dose of Virolfi 450 mg Tablet , take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not take a double dose to make up for the missed dose.

Storage

• Store in a cool and dry place away from sunlight.• Keep Virolfi 450 mg Tablet out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

If you are allergic to Virolfi 450 mg Tablet or any other medicines, please tell your doctor.
If you have a low number of platelets, white blood cells or red blood cells and kidney problems, inform your doctor before taking Virolfi 450 mg Tablet .
Avoid taking Virolfi 450 mg Tablet if you are pregnant as it may cause birth defects.
If you are breastfeeding, do not take Virolfi 450 mg Tablet as it may be excreted in human milk and cause adverse effects in the baby.
Women are recommended to use effective contraceptive measures while taking Virolfi 450 mg Tablet and 30 days after treatment with Virolfi 450 mg Tablet .
Men are advised to continue using contraceptive measures for 90 days after treatment with Virolfi 450 mg Tablet .
Drive only if you are alert as Virolfi 450 mg Tablet may cause dizziness, tiredness, drowsiness, shakiness or confusion.
If you are having blood dialysis or radiotherapy, please inform your doctor before taking Virolfi 450 mg Tablet .

Drug-Drug Interactions

Drug-Drug Interaction: Virolfi 450 mg Tablet may interact with antibiotics (imipenem + cilastatin, trimethoprim, dapsone), gout medicine (probenecid), antifungals (amphotericin B, flucytosine), antiprotozoals (pentamidine), anti-cancer (vinblastine, hydroxyurea, vincristine, doxorubicin), immunosuppressants (tacrolimus, mycophenolate mofetil, ciclosporin), HIV/AIDS medicines (tenofovir, zidovudine, stavudine, didanosine), medicines used to treat hepatitis B infection (adefovir).

Drug-Food Interaction: No interactions found.

Drug-Disease Interaction: If you have a low platelet count, white blood cell or red blood cell count, or kidney problems, inform your doctor before taking Virolfi 450 mg Tablet .

ValganciclovirCidofovir

Critical

ValganciclovirEtanercept

Severe

Drug-Drug Interactions

ValganciclovirCidofovir

Critical

How does the drug interact with Virolfi 450 mg Tablet:
Taking cidofovir with Virolfi 450 mg Tablet can increase the risk of kidney problems.

How to manage the interaction:
Taking Virolfi 450 mg Tablet with Cidofovir is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or loss, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.

ValganciclovirEtanercept

Severe

How does the drug interact with Virolfi 450 mg Tablet:
The combined use of etanercept and Virolfi 450 mg Tablet can increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction between Virolfi 450 mg Tablet and Etanercept, you can take these medicines together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.

ValganciclovirMaribavir

Severe

How does the drug interact with Virolfi 450 mg Tablet:
When Virolfi 450 mg Tablet is used with Maribavir, it may make Virolfi 450 mg Tablet less effective in treating your condition

How to manage the interaction:
Although there is a possible interaction between Virolfi 450 mg Tablet and Maribavir, you can take these medicines together if prescribed by your doctor. If you're having any unusual symptoms, contact a doctor right away. Do not stop using any medications without talking to your doctor.

ValganciclovirCertolizumab

Severe

How does the drug interact with Virolfi 450 mg Tablet:
Taking Virolfi 450 mg Tablet and Certolizumab may increase the risk of serious infection.

How to manage the interaction:
Although there is a possible interaction between Virolfi 450 mg Tablet and Certolizumab, you can take these medicines together if prescribed by your doctor. If you notice any of the following symptoms - fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain, or burning while urinating - contact your doctor right away. Do not discontinue any medications without consulting your doctor.

ValganciclovirGolimumab

Severe

How does the drug interact with Virolfi 450 mg Tablet:
The combined use of golimumab and Virolfi 450 mg Tablet can increase the risk of infections.

How to manage the interaction:
Although taking Virolfi 450 mg Tablet and Golimumab together can cause an interaction, it can be taken if your doctor has suggested it. If you notice any of the following symptoms - fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain or burning while peeing - contact your doctor right away. Do not stop using any medications without talking to your doctor.

ValganciclovirAdalimumab

Severe

How does the drug interact with Virolfi 450 mg Tablet:
The combined use of adalimumab and Virolfi 450 mg Tablet can increase the risk of serious infections.

How to manage the interaction:
There may be a possibility of interaction between Virolfi 450 mg Tablet and Adalimumab, but it can be taken if prescribed by a doctor. If you notice any of the following symptoms - fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain or burning while peeing - reach out to your doctor right away. Do not stop using any medications without talking to your doctor.

ValganciclovirTenofovir alafenamide

Severe

How does the drug interact with Virolfi 450 mg Tablet:
When Virolfi 450 mg Tablet is taken with Tenofovir alafenamide it may increase the risk of kidney problems.

How to manage the interaction:
Although taking Tenofovir alafenamide and Virolfi 450 mg Tablet together can cause an interaction, it can be taken if your doctor has suggested it. However, consult your doctor immediately if you experience symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without talking to your doctor.

ValganciclovirClozapine

Severe

How does the drug interact with Virolfi 450 mg Tablet:
Taking Clozapine and Virolfi 450 mg Tablet may increase the risk of severe infections.

How to manage the interaction:
Taking Clozapine with Virolfi 450 mg Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you're having any of these symptoms - like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination - contact your doctor right away. Do not stop using any medications without a doctor's advice.

ValganciclovirZidovudine

Severe

How does the drug interact with Virolfi 450 mg Tablet:
Combining Virolfi 450 mg Tablet with Zidovudine can increase the risk of side effects.

How to manage the interaction:
Although taking Virolfi 450 mg Tablet and Zidovudine together can cause an interaction, it can be taken if your doctor has suggested it. If you experience any complications or symptoms, make sure to contact your doctor right away. Do not stop using any medications without a doctor's advice.

ValganciclovirInfliximab

Severe

How does the drug interact with Virolfi 450 mg Tablet:
The combined use of infliximumab and Virolfi 450 mg Tablet can increase the risk of infections.

How to manage the interaction:
Co-administration of Virolfi 450 mg Tablet with Infliximab can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

Therapeutic Class

[ANTIVIRALS]

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Author Details

Written By

Veda Maddala
M Pharmacy

Reviewed By

Dr Aneela Siddabathuni
MPharma., PhD

Last Updated

Jun 26, 2026 | 8:28 AM IST

We provide you with authentic, trustworthy and relevant information.

See our editorial policy

Reference

Country of origin

India

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads,Ahmedabad 380015 Gujarat, India.

Other Info - VIR0093

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Virolfi 450 mg Tablet 10's

Delivery Information

More about the Product

Composition :

Manufacturer/Marketer :

Consume Type :

Expires on or after :

Return Policy :

NPPA :

About Virolfi 450 mg Tablet

Uses of Virolfi 450 mg Tablet

Key Benefits

Loose And Watery Stools

Anemia

Involuntary Shaking

Trouble Falling/ Staying Asleep

Nausea

Vomiting

Fungal Mouth Infection

Directions for Use

How Virolfi 450 mg Tablet Works

Alcohol

Pregnancy

Breast Feeding

Driving

Liver

Kidney

Children

Heart

Geriatrics

What if I have taken an overdose of Virolfi 450 mg Tablet

Diet & Lifestyle Advise

How Soon It Starts Working

What if you forget to take Virolfi 450 mg Tablet

Storage

Drug Warnings

Drug-Drug Interactions

Drug-Drug Interactions

Drug-Food Interactions

Drug-Food Interactions

All Substitutes & Brand Comparisons

Valnova Tablet 10's

Cmvcel 450 mg Tablet 10's

Valsure Tablet 10's

Habit Forming

Therapeutic Class

FAQs

What is the use of Virolfi 450 mg Tablet ?

How does Virolfi 450 mg Tablet work?

Is Virolfi 450 mg Tablet used to prevent cytomegalovirus infection?

Does Virolfi 450 mg Tablet cause diarrhoea?

Is Virolfi 450 mg Tablet safe for patients with kidney problems?

Can I take Virolfi 450 mg Tablet with tacrolimus?

Is Virolfi 450 mg Tablet cytotoxic?

What are the common side effects of Virolfi 450 mg Tablet ?

Does Virolfi 450 mg Tablet cover HSV?

What is the key component present in it?

What is Cytomegalovirus (CMV) retinitis?

Is Virolfi 450 mg Tablet safe to use in pregnant women?

Is it safe to give breastfeeding while on treatment with Virolfi 450 mg Tablet ?

Does Virolfi 450 mg Tablet impact on driving ability?

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