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  3. VONAZ INJECTION

VONAZ INJECTION, Pack of 1 INJECTION
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
VONAZ INJECTION is used to treat a broad range of fungal infections. It contains 'Voriconazole' that kills or prevents fungus by inhibiting an enzyme in fungi responsible for its normal fat metabolism, thereby interfering with the fungal cell membrane formation. As a result, fungal cells get killed, or their growth is minimized. Common side effects of VONAZ INJECTION are injection site reactions, peripheral oedema, headache, diarrhoea, vomiting, abdominal pain, chest pain, nausea, fever, anxiety, insomnia, confusion, weakness, tingling sensation, sleepiness, dizziness, irregular heartbeats, low blood pressure, stomach upset, constipation, rashes, itchiness, red skin, back pain and chills.
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Composition :

VORICONAZOLE-200MG

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About VONAZ INJECTION

VONAZ INJECTION belongs to the class of medicines known as 'antifungals' used to treat a broad range of fungal infections. A fungal infection is caused when a fungus invades and affects any body part, including the mouth, throat, oesophagus, lungs, bladder, genital area and blood.

VONAZ INJECTION contains 'Voriconazole' that kills or prevents fungus by inhibiting an enzyme in fungi responsible for its normal fat metabolism, thereby interfering with the fungal cell membrane formation. As a result, fungal cells get killed, or their growth is minimized.

VONAZ INJECTION will be administered by a qualified healthcare professional. In some cases, you may experience certain common side effects, such as injection site reactions, peripheral oedema, headache, diarrhoea, vomiting, abdominal pain, chest pain, nausea, fever, anxiety, insomnia, confusion, weakness, tingling sensation, sleepiness, dizziness, irregular heartbeats, low blood pressure, stomach upset, constipation, rashes, itchiness, red skin, back pain and chills. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Before taking VONAZ INJECTION, let your doctor know about your medical condition, sensitivities, and medications. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. VONAZ INJECTION may affect your ability to drive or operate machinery; thus, avoid driving or using machinery.

Uses of VONAZ INJECTION

Treatment of Fungal infections

Directions for Use

VONAZ INJECTION will be administered by a qualified healthcare professional. Kindly do not self-administer.

Medicinal Benefits

VONAZ INJECTION belongs to the class of medicines known as 'antifungal agents', used to treat a broad range of fungal infections, including aspergillosis (a disease caused by Aspergillus), candidiasis (fungal infection caused by yeast), coccidioidomycosis (an infection caused by the fungus Coccidioides), histoplasmosis (an infection caused by a fungus called Histoplasma), and penicilliosis (a disease caused by the fungus Talaromyces marneffei). It also effectively treats CNS fungal infections transmitted by epidural injection of contaminated steroids. On the other hand, it can prevent fungal infections in people undergoing bone marrow transplants. VONAZ INJECTION works by killing or preventing fungi or yeast by inhibiting an enzyme in fungi responsible for its normal fat metabolism, thereby interfering with the fungal cell membrane formation. As a result, fungal cells get killed, or their growth is minimized.

How VONAZ INJECTION Works

VONAZ INJECTION contains 'Voriconazole' that kills or prevents fungus by inhibiting an enzyme in fungi responsible for its normal fat metabolism, thereby interfering with the fungal cell membrane formation. As a result, fungal cells get killed, or their growth is minimized.

Storage

Store in a cool and dry place away from sunlight
Side effects of Vonaz Injection
  • Your doctor may recommend regular liver function tests (LFT) to monitor liver enzyme levels.
  • To support your liver, eat a healthy diet with lots of fruits, vegetables, lean proteins, and healthy fats.
  • Avoid eating processed meats, sugary foods, and unhealthy fats.
  • Limit your alcohol consumption, since too much can worsen liver function and contribute to high levels of Alkaline Phosphatase (ALP).
  • Stay active with regular exercise, drink plenty of water, and try to avoid harmful chemicals that can damage your liver.
  • Quit smoking to lower the risk of elevated ALP levels.
  • Increased creatinine levels must be corrected immediately with the help of a doctor.
  • Reduce strenuous activities that can lead to muscle breakdown and production of creatinine.
  • Sleep for 7-8 hours per night to assist your body in repairing and rebuilding tissue.
  • Manage your blood pressure by implementing changes in lifestyle like losing weight, reducing stress and exercising regularly.
  • Avoid smoking and drinking alcohol.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Eat more potassium-rich foods, like bananas, leafy greens, sweet potatoes, avocados, and nuts/seeds.
  • Choose potassium-fortified foods such as orange juice and sports beverages.
  • Limit potassium-depleting foods like caffeine, processed foods, and sugary drinks.
  • Exercise regularly, like walking or yoga, to help maintain potassium balance.
  • Inform your doctor if hypokalemia doesn't improve or worsen despite treatment.

What if I have taken an overdose of VONAZ INJECTION

As VONAZ INJECTION is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away.

Drug Warnings

Inform your doctor about your medical conditions, sensitivities, and medications you are using. And also, let your doctor know if you are pregnant, planning to become pregnant, or breastfeeding. Women of childbearing potential should always use effective contraception during treatment. Please inform your doctor if you are suffering from a heart problem like an irregular heartbeat, slow heart rate or abnormality in ECG (electrocardiogram), QT prolongation, or if you have hereditary intolerance for galactose, Lapp lactase deficiency, or glucose-galactose malabsorption. VONAZ INJECTION may affect your ability to drive or operate machinery; thus, avoid driving or using machinery.

Drug-Drug Interactions

verifiedApollotooltip
VoriconazoleErgometrine
Critical
VoriconazoleMethylergometrine
Critical

Drug-Drug Interactions

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VoriconazoleErgometrine
Critical
How does the drug interact with Vonaz Injection:
The concentration of Ergometrine can be increased when it is combined with Vonaz Injection.

How to manage the interaction:
Taking Ergometrine with Vonaz Injection is not recommended, please consult a doctor before taking it. Do not discontinue any medication without consulting a doctor.
VoriconazoleMethylergometrine
Critical
How does the drug interact with Vonaz Injection:
Coadministration of Methylergometrine with Vonaz Injection may increase the blood level of Methylergometrine.

How to manage the interaction:
Although Methylergometrine with Vonaz Injection can cause an interaction, they can be taken if prescribed by a doctor. Do not discontinue any medication without consulting a doctor.
VoriconazoleTolvaptan
Critical
How does the drug interact with Vonaz Injection:
Co-administration of Tolvaptan together with Vonaz Injection may significantly increase the blood levels and effects of Tolvaptan.

How to manage the interaction:
There may be a possibility of interaction between Tolvaptan and Vonaz Injection, but it can be taken if prescribed by a doctor. If you experience difficulty swallowing, trouble speaking, muscle weakness call a doctor right away. Do not stop using any medications without a doctor's advice.
VoriconazoleRifabutin
Critical
How does the drug interact with Vonaz Injection:
When Vonaz Injection is taken with Rifabutin, the amount of Vonaz Injection in the blood may decrease.

How to manage the interaction:
Taking Rifabutin with Vonaz Injection is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, consult a doctor immediately If you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
VoriconazoleRitonavir
Critical
How does the drug interact with Vonaz Injection:
When Vonaz Injection is taken with Ritonavir, the amount of Vonaz Injection in the blood may decrease.

How to manage the interaction:
Taking Vonaz Injection with Ritonavir is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
VoriconazoleTicagrelor
Critical
How does the drug interact with Vonaz Injection:
Using Ticagrelor together with Vonaz Injection can significantly increase the blood levels of Ticagrelor.

How to manage the interaction:
Taking Ticagrelor with Vonaz Injection is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience vomiting, headache, dizziness, or weakness. Do not discontinue any medications without consulting a doctor.
VoriconazoleRifampicin
Critical
How does the drug interact with Vonaz Injection:
Taking Vonaz Injection with Rifampicin can increase blood level of Vonaz Injection.

How to manage the interaction:
Although there is an interaction between Vonaz Injection with Rifampicin, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
VoriconazolePhenobarbital
Critical
How does the drug interact with Vonaz Injection:
Using Vonaz Injection together with Phenobarbital may significantly reduce the blood levels of Vonaz Injection.

How to manage the interaction:
Taking Vonaz Injection with Phenobarbital is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
VoriconazoleCarbamazepine
Critical
How does the drug interact with Vonaz Injection:
Using Vonaz Injection together with Carbamazepine may significantly reduce the blood levels of Vonaz Injection.

How to manage the interaction:
Taking Carbamazepine with Vonaz Injection is not recommended, but it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
VoriconazoleNimodipine
Critical
How does the drug interact with Vonaz Injection:
Using Nimodipine together with Vonaz Injection may significantly increase the risk of serous side effects.

How to manage the interaction:
Taking Nimodipine with Vonaz Injection is not recommended, as it may lead to an interaction, but it can be taken if prescribed by the doctor. However, if you experience symptoms such as irregular heart rhythm, swelling, and low blood pressure, consult the doctor. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • In wet places such as changing rooms and gym showers, don’t walk barefoot to prevent fungal infections.
  • Do not scratch the affected skin, as it can spread the infection to other body parts.
  • Avoid sharing towels, combs, bedsheets, shoes or socks with others.
  • Wash your bedsheets and towels regularly.
  • It is advisable to follow a candida diet during fungal infections. This diet excludes sugar, gluten, certain dairy products, and alcohol. Switch to low-sugar fruits, non-starchy vegetables and gluten-free foods. A very-high sugar or high-carbohydrate diet may increase the count of Candida in some people.

Habit Forming

No

Therapeutic Class

ANTIFUNGALS

VONAZ INJECTION Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Consult your doctor

It is not known if alcohol affects VONAZ INJECTION. Please consult your doctor.

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Pregnancy

Caution

VONAZ INJECTION is generally not recommended in pregnancy. Your doctor may prescribe this medicine if the benefit to the mother outweighs the potential risk to the fetus.

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Breast Feeding

Caution

If you are breastfeeding, please inform your doctor. It is not known if VONAZ INJECTION passes into breastmilk. Your doctor may advise you to stop breastfeeding before starting the treatment with VONAZ INJECTION.

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Driving

Unsafe

VONAZ INJECTION may affect your ability to drive or operate machinery; thus, avoid driving or using machinery.

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Liver

Caution

Inform your doctor if you have liver problems before receiving VONAZ INJECTION.

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Kidney

Caution

Inform your doctor if you have kidney problems before receiving VONAZ INJECTION.

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Children

Caution

Your doctor may prescribe this medicine if the benefits outweigh the risks.

Have a query?

FAQs

VONAZ INJECTION is used to treat Fungal infections.

VONAZ INJECTION contains Voriconazole that kills or prevents fungus by inhibiting an enzyme in fungi responsible for its normal fat metabolism, thereby interfering with the fungal cell membrane formation. As a result, fungal cells get killed, or their growth is minimized.

VONAZ INJECTION can also prevent fungal infections in people undergoing bone marrow transplants.

VONAZ INJECTION may not be suitable in patients with known hypersensitivity to any of the components present in VONAZ INJECTION; or with a hereditary intolerance for galactose, Lapp lactase deficiency, or glucose-galactose malabsorption.

You can take VONAZ INJECTION with contraceptive pills. However, some studies show a chance of an increase in the body's hormonal levels when you take VONAZ INJECTION with a combined pill. Seek your doctor's advice if any side effects occur.

Yes, fungal infection is a contagious skin condition that spreads from one person to another through direct skin-to-skin contact or by contact with contaminated soil or surfaces and infected animals. Therefore, it is recommended to avoid close direct contact until the infection is clear and avoid sharing things with the infected person, as it can also spread the infection.

VONAZ INJECTION can use women of childbearing potential; however, they must always use effective contraception during treatment.

Country of origin

INDIA
Other Info - VON0004

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Santoshini Reddy GDoctor badge

Reviewed By

Santoshini Reddy G

M Pharmacy

Last Updated

Jan 1, 2025 | 2:45 PM IST

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Reference

  1. https://labeling.pfizer.com/ShowLabeling.aspx?id=12292
  2. https://www.ikrispharmanetwork.com/voriconazole-200mg/
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