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compositionComposition:VORICONAZOLE-200MG
prescriptionPrescription Medicine
VONAZ INJECTION

VONAZ INJECTION is used to treat a broad range of fungal infections. It contains 'Voriconazole' that kills or prevents fungus by inhibiting an enzyme in fungi responsible for its normal fat metabolism, thereby interfering with the fungal cell membrane formation. As a result, fungal cells get killed, or their growth is minimised. Common side effects of VONAZ INJECTION are injection site reactions, peripheral oedema, headache, diarrhoea, vomiting, abdominal pain, chest pain, nausea, fever, anxiety, insomnia, confusion, weakness, tingling sensation, sleepiness, dizziness, irregular heartbeats, low blood pressure, stomach upset, constipation, rashes, itchiness, red skin, back pain and chills.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

VORICONAZOLE-200MG

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About VONAZ INJECTION

VONAZ INJECTION is used to treat a broad range of fungal infections. A fungal infection is caused when a fungus invades and affects any body part, including the mouth, throat, oesophagus, lungs, bladder, genital area and blood.

VONAZ INJECTION contains ‘Voriconazole’ that kills or prevents fungi or yeast by inhibiting an enzyme in fungi, which interferes with the fungal cell membrane's formation.

In some cases, you may experience certain common side effects, such as injection site reactions, headache, diarrhoea, vomiting, abdominal pain, chest pain, nausea, fever, insomnia, confusion, weakness, tingling sensation, sleepiness, dizziness, stomach upset, constipation, rashes, itchiness, red skin, back pain and chills. Talk to your doctor if you experience these side effects persistently.

Before taking VONAZ INJECTION, let your doctor know about your medical condition, sensitivities, and medications. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. VONAZ INJECTION may affect your ability to drive or operate machinery; thus, avoid driving or using machinery.

Uses of VONAZ INJECTION

VONAZ INJECTION is used in the treatment of Fungal infections. The detailed uses of VONAZ INJECTION are as follows:

  • Treat invasive aspergillosis: VONAZ INJECTION is a first-line antifungal therapy for serious infections caused by Aspergillus species, especially in immunocompromised patients such as those undergoing chemotherapy or organ transplantation.
  • Manage candidemia and deep tissue Candida infections: VONAZ INJECTION is used to treat bloodstream infections and other severe Candida infections in patients who are not neutropenic, offering broad-spectrum antifungal coverage.
  • Treat esophageal candidiasis: VONAZ INJECTION helps eliminate Candida infections in the esophagus, especially in patients who cannot tolerate oral antifungals.
  • Combat rare and resistant fungal infections: VONAZ INJECTION is effective against Scedosporium apiospermum and Fusarium species, including Fusarium solani, in patients who are intolerant of or refractory to other antifungal therapies.

Key Benefits

  • VONAZ INJECTION is an antifungal medicine containing Voriconazole, used to treat a broad range of infections caused due to fungi and yeast.
  • It treats various fungal infections like invasive aspergillosis (fungal infection in the lungs), esophageal candidiasis (white patching in the mouth and throat) and candidemia (a fungal infection in the blood).
  • It is also used to treat certain fungal infections when other medications do not work for certain patients.
  • It works by killing or preventing fungi or yeast by inhibiting an enzyme in fungi responsible for their normal fat metabolism, thereby interfering with the formation of the fungal cell membrane.
  • It also effectively treats CNS fungal infections transmitted by epidural injection of contaminated steroids.
  • On the other hand, it can prevent fungal infections in people undergoing bone marrow transplants.
Side effects of Vonaz Injection
  • Your doctor may recommend regular liver function tests (LFT) to monitor liver enzyme levels.
  • To support your liver, eat a healthy diet with lots of fruits, vegetables, lean proteins, and healthy fats.
  • Avoid eating processed meats, sugary foods, and unhealthy fats.
  • Limit your alcohol consumption, since too much can worsen liver function and contribute to high levels of Alkaline Phosphatase (ALP).
  • Stay active with regular exercise, drink plenty of water, and try to avoid harmful chemicals that can damage your liver.
  • Quit smoking to lower the risk of elevated ALP levels.
  • Increased creatinine levels must be corrected immediately with the help of a doctor.
  • Reduce strenuous activities that can lead to muscle breakdown and production of creatinine.
  • Sleep for 7-8 hours per night to assist your body in repairing and rebuilding tissue.
  • Manage your blood pressure by implementing changes in lifestyle like losing weight, reducing stress and exercising regularly.
  • Avoid smoking and drinking alcohol.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Eat more potassium-rich foods, like bananas, leafy greens, sweet potatoes, avocados, and nuts/seeds.
  • Choose potassium-fortified foods such as orange juice and sports beverages.
  • Limit potassium-depleting foods like caffeine, processed foods, and sugary drinks.
  • Exercise regularly, like walking or yoga, to help maintain potassium balance.
  • Inform your doctor if hypokalemia doesn't improve or worsen despite treatment.

Directions for Use

  • Your doctor will determine the dosage and frequency depending on your condition.
  • VONAZ INJECTION will be administered by a healthcare professional.
  • Do not self-administer.

How VONAZ INJECTION Works

VONAZ INJECTION contains 'Voriconazole' that kills or prevents fungus by inhibiting an enzyme in fungi responsible for its normal fat metabolism, thereby interfering with the fungal cell membrane formation. As a result, fungal cells get killed, or their growth is minimized.
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Alcohol

Consult your doctor

It is not known if alcohol affects VONAZ INJECTION. Please consult your doctor.

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Pregnancy

Consult your doctor

VONAZ INJECTION is generally not recommended in pregnancy. Your doctor may prescribe this medicine if the benefit to the mother outweighs the potential risk to the fetus.

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Breast Feeding

Consult your doctor

If you are breastfeeding, please inform your doctor. It is not known if VONAZ INJECTION passes into breastmilk. Your doctor may advise you to stop breastfeeding before starting the treatment with VONAZ INJECTION.

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Driving

Unsafe

VONAZ INJECTION may affect your ability to drive or operate machinery; thus, avoid driving or using machinery.

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Liver

Consult your doctor

Inform your doctor if you have liver problems before receiving VONAZ INJECTION.

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Kidney

Consult your doctor

Inform your doctor if you have kidney problems before receiving VONAZ INJECTION.

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Children

Consult your doctor

Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Heart

Caution

VONAZ INJECTION may disrupt heart rhythm, so patients with heart conditions must consult their doctor before use. Careful monitoring is crucial to avoid serious cardiac side effects.

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Geriatrics

Caution

Geriatric patients may receive VONAZ INJECTION, but only with close medical supervision. Older adults are more prone to side effects like visual disturbances, liver issues, and heart rhythm changes, so dosage and monitoring must be carefully tailored.

What if I have taken an overdose of VONAZ INJECTION

As VONAZ INJECTION is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away.

Diet & Lifestyle Advise

  • In wet places such as changing rooms and gym showers, don’t walk barefoot to prevent fungal infections.
  • Do not scratch the affected skin, as it can spread the infection to other body parts.
  • Avoid sharing towels, combs, bedsheets, shoes or socks with others.
  • Wash your bedsheets and towels regularly.
  • It is advisable to follow a candida diet during fungal infections. This diet excludes sugar, gluten, certain dairy products, and alcohol. Switch to low-sugar fruits, non-starchy vegetables and gluten-free foods. A very-high sugar or high-carbohydrate diet may increase the count of Candida in some people.

Have a query?

How Soon It Starts Working

  • The time required for VONAZ INJECTION to start to work: VONAZ INJECTION effect is observed within 1 to 2 hours of administration. 
  • The time for which the effects of VONAZ INJECTION last: VONAZ INJECTION effect lasts approximately for 6 hours.

What if you forget to take VONAZ INJECTION

As this medicine will be administered by a healthcare professional, the chances of missing a dose are less. However, consult your doctor if you have any concerns.

Storage

• Store in a cool and dry place away from sunlight.• Keep VONAZ INJECTION out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Inform your doctor about your medical conditions, sensitivities, and medications you are using.
  • And also, let your doctor know if you are pregnant, planning to become pregnant, or breastfeeding.
  • Women of childbearing potential should always use effective contraception during treatment.
  • Please inform your doctor if you are suffering from a heart problem like an irregular heartbeat, slow heart rate or abnormality in ECG (electrocardiogram), QT prolongation, or if you have hereditary intolerance for galactose, Lapp lactase deficiency, or glucose-galactose malabsorption.
  • VONAZ INJECTION may affect your ability to drive or operate machinery; thus, avoid driving or using machinery.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interactions: VONAZ INJECTION is known to interact with immunosuppressants (e.g. Sirolimus), antibiotics (e.g. rifampicin, rifabutin) and anticonvulsant medications (e.g. carbamazepine).

Drug-Food Interactions: VONAZ INJECTION is known to interact with St. John's wort (a natural remedy to treat depression). 

Drug-Disease Interactions: VONAZ INJECTION may interact with disease conditions, including cardiac disorders (QT prolongation), hereditary intolerance for galactose (a person lacks the protein needed to break down fructose), Lapp lactase deficiency (hereditary condition; difficult to digest lactose), or glucose-galactose malabsorption (a genetic metabolic disease characterized by impaired glucose-galactose absorption).

VoriconazolePhenobarbital
Critical
VoriconazoleMesoridazine
Critical

Drug-Drug Interactions

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VoriconazolePhenobarbital
Critical
How does the drug interact with Vonaz Injection:
Using Vonaz Injection together with Phenobarbital may significantly reduce the blood levels of Vonaz Injection.

How to manage the interaction:
Taking Vonaz Injection with Phenobarbital is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
VoriconazoleMesoridazine
Critical
How does the drug interact with Vonaz Injection:
Using Mesoridazine together with Vonaz Injection can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Mesoridazine with Vonaz Injection is not recommended, please consult a doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.
VoriconazoleRifampicin
Critical
How does the drug interact with Vonaz Injection:
Taking Vonaz Injection with Rifampicin can increase blood level of Vonaz Injection.

How to manage the interaction:
Although there is an interaction between Vonaz Injection with Rifampicin, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
VoriconazolePrimidone
Critical
How does the drug interact with Vonaz Injection:
Taking Vonaz Injection together with primidone may reduce the blood levels of Vonaz Injection, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between Vonaz Injection and Primidone, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
VoriconazoleMethylergometrine
Critical
How does the drug interact with Vonaz Injection:
Coadministration of Methylergometrine with Vonaz Injection may increase the blood level of Methylergometrine.

How to manage the interaction:
Although Methylergometrine with Vonaz Injection can cause an interaction, they can be taken if prescribed by a doctor. Do not discontinue any medication without consulting a doctor.
VoriconazoleCarbamazepine
Critical
How does the drug interact with Vonaz Injection:
Using Vonaz Injection together with Carbamazepine may significantly reduce the blood levels of Vonaz Injection.

How to manage the interaction:
Taking Carbamazepine with Vonaz Injection is not recommended, but it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
VoriconazoleLovastatin
Critical
How does the drug interact with Vonaz Injection:
Using Lovastatin together with Vonaz Injection may significantly increase the blood levels of Lovastatin.

How to manage the interaction:
Taking Vonaz Injection with Lovastatin is not recommended, please consult a doctor before taking it. You should also seek immediate medical attention if you experience fever, joint pain or swelling, vomiting, dark-colored urine, and/or yellowing of the skin or eyes. Do not discontinue any medication without consulting a doctor.
VoriconazoleSilodosin
Critical
How does the drug interact with Vonaz Injection:
Co-administration of Silodosin together with Vonaz Injection, may significantly increase the blood levels and effects of Silodosin which may lead to side effects.

How to manage the interaction:
Taking Vonaz Injection and Silodosin is not recommended, but it can be taken if prescribed by a doctor. If you experience dizziness, headache, heart palpitation-call a doctor right away. Do not stop using any medications without a doctor's advice.
VoriconazoleEfavirenz
Critical
How does the drug interact with Vonaz Injection:
Coadministration of Vonaz Injection with Efavirenz can alter the blood levels and effects of both medications.

How to manage the interaction:
Taking Vonaz Injection with Efavirenz can be taken if a doctor has advised it. Contact a doctor if you experience vomiting, dizziness, difficulty concentrating. Do not discontinue any medications without consulting a doctor.
VoriconazoleSparfloxacin
Critical
How does the drug interact with Vonaz Injection:
Using Sparfloxacin together with Vonaz Injection can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Vonaz Injection with Sparfloxacin is not recommended, please consult a doctor before taking it. You should seek immediate medical attention if you develop dizziness, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIFUNGALS]

FAQs

VONAZ INJECTION is used to treat fungal infections.

VONAZ INJECTION contains Voriconazole that kills or prevents fungus by inhibiting an enzyme in fungi responsible for its normal fat metabolism, thereby interfering with the fungal cell membrane formation. As a result, fungal cells get killed, or their growth is minimized.

VONAZ INJECTION can also prevent fungal infections in people undergoing bone marrow transplants.

VONAZ INJECTION may not be suitable in patients with known hypersensitivity to any of the components present in VONAZ INJECTION; or with a hereditary intolerance for galactose, Lapp lactase deficiency, or glucose-galactose malabsorption.

You can take VONAZ INJECTION with contraceptive pills. However, some studies show a chance of an increase in the body's hormonal levels when you take VONAZ INJECTION with a combined pill. Seek your doctor's advice if any side effects occur.

Yes, fungal infection is a contagious skin condition that spreads from one person to another through direct skin-to-skin contact or by contact with contaminated soil or surfaces and infected animals. Therefore, it is recommended to avoid close direct contact until the infection is clear and avoid sharing things with the infected person, as it can also spread the infection.

VONAZ INJECTION can use women of childbearing potential; however, they must always use effective contraception during treatment.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

  • Bayyarapu Mahesh Kumar

    M Pharmacy

Santoshini Reddy GDoctor badge

Reviewed By

  • Santoshini Reddy G

    M Pharmacy

Last Updated

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Country of origin

INDIA
Other Info - VON0004
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