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  3. Vortuxi 500 mg Injection 50 ml

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Vortuxi 500 mg Injection 50 ml, Pack of 1 INJECTION
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Composition :

RITUXIMAB-500MG

Manufacturer/Marketer :

Cadila Healthcare Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Vortuxi 500 mg Injection

Vortuxi 500 mg Injection belongs to a class of medicines called monoclonal antibodies used in the treatment of non-Hodgkin’s disease and chronic lymphocytic leukaemia. This medicine is also used in treating rheumatoid arthritis in combination with methotrexate and granulomatosis in combination with glucocorticoids. It is also used to treat Pemphigus Vulgaris (PV) and mature B-cell acute leukaemia (B-AL).

Vortuxi 500 mg Injection contains Rituximab, which works by inhibiting the DNA and RNA transcription that is essential for cancer cell growth. This helps prevent the growth and further spread of cancerous or non-cancerous cells. On the other hand, Vortuxi 500 mg Injection works by interfering with the immune system process that causes inflammation in the joint tissues. Thus, it reduces pain and inflammation and prevents joint damage and disease progression over time

Vortuxi 500 mg Injection may cause certain side effects, such as pale skin, painful urination, night sweats, flushing, back pain, nausea, vomiting, diarrhoea, stomach pain, mouth sores, peeling of skin, injection site reactions and pain at the site of injection. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. Vortuxi 500 mg Injection is a parenteral preparation. A trained healthcare professional will administer it. Hence, do not self-administer.

Vortuxi 500 mg Injection should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Also, inform your doctor if you have liver/kidney disease, hepatitis B virus infection, cardiac disorders, any active infections, or gastrointestinal disorders before receiving this injection. Vortuxi 500 mg Injection may cause bowel obstruction and perforation, reactivation of Hepatitis B infection, Cardiac arrhythmias, tumour lysis syndrome, and angina in some patients. Hence, careful monitoring should be done during the entire treatment. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Uses of Vortuxi 500 mg Injection

Vortuxi 500 mg Injection is used in the treatment of Non-Hodgkin's disease, rheumatoid arthritis, chronic lymphocytic leukaemia, granulomatosis and pemphigus vulgaris. The detailed uses of Vortuxi 500 mg Injection are as follows:<br/>• Non-Hodgkin’s Lymphoma (NHL): Vortuxi 500 mg Injection is used to treat Non-Hodgkin’s Lymphoma alone or with chemotherapy.<br/>• Chronic Lymphocytic Leukemia (CLL): Vortuxi 500 mg Injection is used in the treatment of Chronic Lymphocytic Leukemia (CLL) and B-cell Acute Lymphoblastic Leukemia (B-ALL.<br/>• Rheumatoid Arthritis (RA): Vortuxi 500 mg Injection is used in the treatment of rheumatoid arthritis.<br/>• Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA): Vortuxi 500 mg Injection helps to treat Granulomatosis with Polyangiitis and Microscopic Polyangiitis.<br/>• Pemphigus Vulgaris: Vortuxi 500 mg Injection is used to treat pemphigus vulgaris for moderate to severe cases.<br/>

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Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.• Vortuxi 500 mg Injection will be administered by the doctor or healthcare professional.• Do not self-administer.

Medicinal Benefits

Vortuxi 500 mg Injection contains Rituximab, which belongs to the class of monoclonal antibodies. It works by inhibiting the DNA and RNA transcription that is essential for cancer cell growth. This helps prevent the growth and further spread of cancerous or non-cancerous cells. On the other hand, Vortuxi 500 mg Injection works by interfering with the immune system process that causes inflammation in the joint tissues. Thus, it reduces pain and inflammation and prevents joint damage and disease progression over time.

How Vortuxi 500 mg Injection Works

Vortuxi 500 mg Injection contains Rituximab, which works by inhibiting the DNA and RNA transcription that is essential for cancer cell growth. This helps prevent the growth and further spread of cancerous or non-cancerous cells. On the other hand, Vortuxi 500 mg Injection works by interfering with the immune system process that causes inflammation in the joint tissues. Thus, it reduces pain and inflammation and prevents joint damage and disease progression over time.

Storage

• Store in a cool and dry place away from sunlight.• Keep Vortuxi 500 mg Injection out of the sight and reach of children. • Cold chain - To be stored in cold places at 2ºC to 8ºC.
Side effects of Vortuxi 500 mg Injection 50 ml
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
  • Nourish your body with a balanced diet with protein-rich foods like fish, eggs, and beans. Fruits, vegetables, and nuts provide essential vitamins and minerals. If necessary, consider vitamin B12 and folate supplements.
  • Practice good hygiene to protect yourself from infections. Wash your hands often, stay up-to-date on vaccinations, avoid crowded areas, and take care when handling food, pets, and diapers.
  • Aim for a good night's sleep, targeting 8 hours of sleep. Find calm through stress-reducing practices like yoga, meditation, or deep breathing. Regular physical activity can also help.
  • Stay healthy by drinking plenty of water, eating probiotic-rich foods like yoghurt, and limiting processed foods and sugars. Consult your doctor, if you are having difficulties or concerns.
  • Rest well; get enough sleep.
  • Wear comfortable layers of clothes and get to a warm place.
  • Drink warm fluids like coffee, tea or hot chocolate.
  • Warm up using a blanket or heating pad.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the steps to manage the medication-triggered Common Cold:
  • Inform your doctor about the common cold symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Drink plenty of fluids, such as warm water or soup, to help thin out mucus.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

What if I have taken an overdose of Vortuxi 500 mg Injection

Since Vortuxi 500 mg Injection is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.

Drug Warnings

Vortuxi 500 mg Injection should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before administration, inform your doctor if you have liver/kidney disease, hepatitis B Virus infection, cardiac disorders, any active infections, or gastrointestinal disorders. Vortuxi 500 mg Injection may cause bowel obstruction and perforation, reactivation of Hepatitis B infection, Cardiac arrhythmias, tumour lysis syndrome (tumour cells release their contents into the bloodstream), and angina in some patients. Hence, careful monitoring should be done during the entire treatment. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Drug-Drug Interactions

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RituximabRotavirus vaccine
Critical
RituximabBaricitinib
Severe

Drug-Drug Interactions

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RituximabRotavirus vaccine
Critical
How does the drug interact with Vortuxi 500 mg Injection 50 ml:
Taking Vortuxi 500 mg Injection 50 ml and Rotavirus vaccine together may increase risk of side effects.

How to manage the interaction:
Taking Vortuxi 500 mg Injection 50 ml with Rotavirus vaccine is not recommended as it can possibly result in an interaction, it can be taken if a doctor has prescribed it. In case you experience any unusual symptoms, consult a doctor. Do not stop using any medications without consulting a doctor.
RituximabBaricitinib
Severe
How does the drug interact with Vortuxi 500 mg Injection 50 ml:
Taking Vortuxi 500 mg Injection 50 ml with Baricitinib may significantly increases the risk of infections.

How to manage the interaction:
Although taking Vortuxi 500 mg Injection 50 ml and Baricitinib together can cause an interaction, it can be taken if A doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, loose stools, sore throat, muscle aches, breathing difficulty, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
RituximabLeflunomide
Severe
How does the drug interact with Vortuxi 500 mg Injection 50 ml:
Taking Vortuxi 500 mg Injection 50 ml with Leflunomide can increase the risk of infections.

How to manage the interaction:
Taking Vortuxi 500 mg Injection 50 ml with Leflunomide together can result in an interaction, it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, loose stools, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
RituximabNatalizumab
Severe
How does the drug interact with Vortuxi 500 mg Injection 50 ml:
Combining Vortuxi 500 mg Injection 50 ml with Natalizumab may increase the risk of infections.

How to manage the interaction:
Although taking Vortuxi 500 mg Injection 50 ml and Natalizumab together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, loose stools, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
RituximabTofacitinib
Severe
How does the drug interact with Vortuxi 500 mg Injection 50 ml:
Taking Vortuxi 500 mg Injection 50 ml and Tofacitinib may increase the risk infections.

How to manage the interaction:
Taking Tofacitinib with Vortuxi 500 mg Injection 50 ml together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, loose stools, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
RituximabDeferiprone
Severe
How does the drug interact with Vortuxi 500 mg Injection 50 ml:
Taking Vortuxi 500 mg Injection 50 ml with Deferiprone may increase the risk of infections.

How to manage the interaction:
Taking Vortuxi 500 mg Injection 50 ml with Deferiprone together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, loose stools, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
RituximabInfliximab
Severe
How does the drug interact with Vortuxi 500 mg Injection 50 ml:
Taking Infliximab with Vortuxi 500 mg Injection 50 ml may increase the risk of infections.

How to manage the interaction:
Taking Vortuxi 500 mg Injection 50 ml with Infliximab together can result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, loose stools, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without talking to a doctor.
RituximabProcarbazine
Severe
How does the drug interact with Vortuxi 500 mg Injection 50 ml:
Combining Vortuxi 500 mg Injection 50 ml with Procarbazine can increase risk of side effects.

How to manage the interaction:
There may be a possibility of interaction between Procarbazine and Vortuxi 500 mg Injection 50 ml, but it can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
RituximabAdalimumab
Severe
How does the drug interact with Vortuxi 500 mg Injection 50 ml:
Taking adalimumab with Vortuxi 500 mg Injection 50 ml may increase the risk of infections.

How to manage the interaction:
Co-administration of Vortuxi 500 mg Injection 50 ml with Adalimumab can result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, loose stools, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
RituximabCladribine
Severe
How does the drug interact with Vortuxi 500 mg Injection 50 ml:
Combining Vortuxi 500 mg Injection 50 ml with Cladribine can increase the risk of infections.

How to manage the interaction:
Co-administration of Cladribine with Vortuxi 500 mg Injection 50 ml can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult your doctor if you experience fever, chills, loose stools, sore throat, muscle aches, difficulty breathing, and pain or burning sensation while urinating. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • After your treatment begins, dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals to take during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans, and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast and fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Vortuxi 500 mg Injection Substitute

Substitutes safety advice
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Alcohol

Consult your doctor

It is not known if alcohol interacts with Vortuxi 500 mg Injection. Please consult the doctor.

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Pregnancy

Caution

If you are pregnant or planning pregnancy, inform your doctor before receiving Vortuxi 500 mg Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

If you are a nursing mother, inform your doctor before receiving Vortuxi 500 mg Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Not applicable

Vortuxi 500 mg Injection will be administered in the hospital setting. Hence, avoid driving.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Vortuxi 500 mg Injection. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Vortuxi 500 mg Injection. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition.

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Children

Consult your doctor

Vortuxi 500 mg Injection will be given to the children only if needed. If administered, careful monitoring of the child is needed.

FAQs

Vortuxi 500 mg Injection is used to treat Non-Hodgkin’s disease, rheumatoid arthritis, chronic lymphocytic leukaemia, granulomatosis and pemphigus vulgaris.

Vortuxi 500 mg Injection contains Rituximab, which works by inhibiting the DNA and RNA transcription that is essential for cancer cell growth.

Vortuxi 500 mg Injection may cause bowel obstruction and perforation, reactivation of Hepatitis B infection, Cardiac arrhythmias, tumour lysis syndrome, and angina in some patients. Hence, inform your oncologist about your complete medical history, including current medication, to rule out any side effects/interactions.

Vortuxi 500 mg Injection contains the active substance rituximab. This is a type of protein called a monoclonal antibody.

The common side effects of Vortuxi 500 mg Injection are pale skin, painful urination, night sweats, flushing, back pain, nausea, vomiting, diarrhoea, stomach pain, mouth sores, peeling of skin, injection site reactions and pain at the site of injection. If any of these side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads, Ahmedabad €“ 380015, Gujarat, India.
Other Info - VOR0079

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Author Details

Santoshini Reddy GDoctor badge

Reviewed By

Santoshini Reddy G

M Pharmacy

Last Updated

Jul 18, 2025 | 7:05 AM IST

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Reference

  1. https://medlineplus.gov/druginfo/meds/a607038.html
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/103705s5367s5388lbl.pdf
  3. https://www.ncbi.nlm.nih.gov/books/NBK564374/
  4. https://reference.medscape.com/drug/rituxan-truxima-rituximab-342243
  5. https://www.rituxan.com/

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