Walagyl 12.5mg Syrup
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About Walagyl 12.5mg Syrup
Walagyl 12.5mg Syrup belongs to the class of medications called ‘antibiotics’ used to treat bacterial infections caused by susceptible Gram-negative bacteria. Bacterial infections are caused by the multiplication of harmful bacteria inside or on the body. These harmful bacteria produce chemicals known as toxins, which can damage tissue and make you sick. Symptoms of bacterial infection vary depending on the organ affected by bacteria.
Walagyl 12.5mg Syrup contains Colistin Sulphate. Colistin effectively solubilizes the bacterial cell membrane, resulting in bacterial cell death. As a result, Walagyl 12.5mg Syrup destroys the bacteria and successfully treats the infection.
Take Walagyl 12.5mg Syrup as prescribed by your doctor. Depending on your medical condition, you are advised to take Walagyl 12.5mg Syrup for as long as your doctor prescribes it. Sometimes, you may experience common side effects like dizziness, upset stomach, rash, diarrhoea, vertigo (spinning sensation), paresthesia (tingling or pricking sensation) and slurred speech. But these side effects are usually in the initial phase and resolve over time. However, if these side effects persist, let your doctor know.
Before receiving Walagyl 12.5mg Syrup, let your doctor know about all your medical conditions, sensitivities, and all medications you are using. And also, inform your doctor if you are pregnant, planning pregnancy, or breastfeeding. Walagyl 12.5mg Syrup can cause blurred vision and dizziness in some people; if this occurs, do not drive or operate tools or machinery. It is recommended not to consume any alcoholic beverages while on treatment with this medicine.
Uses of Walagyl 12.5mg Syrup
Walagyl 12.5mg Syrup is used in the treatment of severe bacterial infections. The detailed uses of Walagyl 12.5mg Syrup are as follows:
- Treats Multidrug-Resistant Gram-Negative Bacterial Infections: Walagyl 12.5mg Syrup is effective against severe infections caused by gram-negative bacteria (GNB) that are resistant to regular antibiotics, such as Klebsiella, Pseudomonas, Acinetobacter, and Enterobacteriaceae species.
- Manages Intestinal Infections: Walagyl 12.5mg Syrup may be used to treat intestinal infections caused by susceptible bacteria, especially in cases of diarrhoea or dysentery due to GNB like Escherichia coli or Shigella.
- Used as Part of the Selective Digestive Tract Decontamination: Walagyl 12.5mg Syrup is used to reduce the risk of secondary bacterial infections in critically ill patients by suppressing the growth of harmful bacteria in the gut.
Key Benefits
Walagyl 12.5mg Syrup contains Colistin Sulphate, which is used for treating acute or chronic infections due to sensitive strains of certain gram-negative bacilli, particularly Pseudomonas aeruginosa. Colistin sulphate effectively solubilizes the bacterial cell membrane, resulting in bacterial cell death. As a result, Walagyl 12.5mg Syrup destroys the bacteria and successfully treats the infection.
Directions for Use
- Walagyl 12.5mg Syrup can be taken with or without food as advised by your doctor.
- Follow your doctor's instructions regarding the dosage and duration of the medication.
- Check the label for instructions. Mix Walagyl 12.5mg Syrup with the recommended amount of water, stir well, and administer the prescribed dose.
- Shake well before use.
How Walagyl 12.5mg Syrup Works
Alcohol
Caution
Walagyl 12.5mg Syrup is known to cause drowsiness. Taking alcohol along with it may increase drowsiness and cause excessive sleepiness.
Pregnancy
Caution
Walagyl 12.5mg Syrup should not be used in pregnancy unless necessary. Inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Walagyl 12.5mg Syrup.
Breast Feeding
Caution
Walagyl 12.5mg Syrup should not be used in breastfeeding unless necessary. Inform your doctor if you are a breastfeeding mother. Your doctor will weigh the benefits and potential risks before prescribing Walagyl 12.5mg Syrup.
Driving
Caution
Walagyl 12.5mg Syrup may cause dizziness, so do not drive or operate heavy machinery if you feel dizzy.
Liver
Consult your doctor
Walagyl 12.5mg Syrup should be used with caution if you have liver disease. Your doctor may adjust the dose based on your condition.
Kidney
Consult your doctor
Walagyl 12.5mg Syrup should be used with caution if you have kidney disease. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.
Children
Caution
Walagyl 12.5mg Syrup is probably safe when used in children who are above 40 kgs in weight. However, your child's doctor will adjust the dose based on the age, body weight and health condition of your child.
Heart
Caution
Walagyl 12.5mg Syrup should be taken with caution in patients with heart disease. Close monitoring of the patients should be done.
Geriatrics
Caution
Walagyl 12.5mg Syrup can be given in elderly patients with extreme caution, due to the cause of adverse effects like liver/kidney problems,or gastrointestinal problems.
What if I have taken an overdose of Walagyl 12.5mg Syrup
Diet & Lifestyle Advise
- After taking the full course of Walagyl 12.5mg Syrup, probiotics should be taken to restore some of the healthy bacteria in the intestine that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yoghurt, cheese, sauerkraut and kimchi can restore the intestine's good bacteria stink.
- Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria, which helps stimulate their growth. Thus fibre foods may help restore healthy gut bacteria after taking a course of antibiotics. Whole grains, like whole-grain bread and brown rice, should be included in your diet.
- Avoid taking many calcium-enriched foods and drinks as it might affect the working of Walagyl 12.5mg Syrup.
- Avoid intake of alcoholic beverages with Walagyl 12.5mg Syrup as it can make you dehydrated and affect your sleep. This can make it harder for your body to aid the Walagyl 12.5mg Syrup in fighting off infections.

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Drug Warnings
Before taking the Walagyl 12.5mg Syrup, let your doctor know about all your medical conditions, sensitivities, and all medications you are using. Inform your doctor if you are pregnant, planning to become pregnant, or are breastfeeding before receiving Walagyl 12.5mg Syrup. Also, inform your doctor if you have chronic kidney disease, myasthenia gravis (muscle disorder), and porphyria (a blood disorder). Do not abruptly discontinue taking the prescription since this may result in antibiotic resistance, a condition in which bacteria develop resistance to antibiotics.
Drug-Drug Interaction Summary:
Walagyl 12.5mg Syrup is known to interact with selective skeletal muscle relaxants (e.g. cyclobenzaprine, metaxalone), antifungals (e.g. amphotericin B) and aminoglycosides (e.g. capreomycin, vancomycin)
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Drug-Food Interaction Summary:
Walagyl 12.5mg Syrup is known to interact with alcohol and Grapefruit.
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Reference
- MedlinePlus. A682860 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
- Colistin sulphate. [Accessed on 28 Mar. 2019]Check here
- Colistin Sulphate Colistin Sulphate. [Accessed on 15 Apr. 2026]Check here
- Ministry of Health and Family Welfare. National Formulary of India (NFI) 2021. 6th ed. New Delhi, India: IPC; 2021. Clinical Drug Monographs: Walamycin Suspension







