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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

X-Out 21 Tablet is used for contraception and treating dysmenorrhea (irregular and painful periods). It contains Ethinylestradiol and Levonorgestrel, which maintains a normal menstrual cycle (periods) in women. It works by fulfilling the deficiency of estrogen hormone, thereby preventing symptoms like night sweats, hot flashes, and mood swings. Also, it prevents the release of an egg from the ovary (female reproductive cells) or prevents fertilization of an egg by sperm (male reproductive cells). It may also change the lining of the uterus to prevent the development of a pregnancy. It may cause side effects such as stomach pain, headache, nausea, breast pain, weight gain, and irregular uterine bleeding. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Manufacturer/Marketer :

Depsons Healthcare

Consume Type :

Oral

Expires on or after :

Return Policy :

Not Returnable

About X-Out 21 Tablet

X-Out 21 Tablet belongs to a group of medications called 'hormonal contraceptives' primarily used for contraception and treating dysmenorrhea (irregular and painful periods). Contraception is a procedure that aims to prevent unwanted pregnancy for safe family planning. Dysmenorrhea is an irregular and painful menstrual period leading to abdominal pain, mood swings, digestion problems, fainting, vomiting, and nausea.

X-Out 21 Tablet is a combination of two medications: Ethinylestradiol and Levonorgestrel. Ethinylestradiol is a synthetic female hormone (estrogen) that maintains a normal menstrual cycle (periods) in women. It works by fulfilling the deficiency of estrogen hormone, thereby preventing symptoms like night sweats, hot flashes, and mood swings. Levonorgestrel is a progestin (female sex hormones) that prevents the release of an egg from the ovary (female reproductive cells) or prevents fertilization of an egg by sperm (male reproductive cells). X-Out 21 Tablet may also change the lining of the uterus to prevent the development of a pregnancy. Thus, together, X-Out 21 Tablet helps prevent pregnancy.

Take X-Out 21 Tablet  as prescribed by your doctor. X-Out 21 Tablet can be taken with or without food but take it simultaneously every day for best results. Depending on your medical condition, you are advised to take X-Out 21 Tablet for as long as your doctor has prescribed it for you. You may experience stomach pain, headache, nausea, breast pain, weight gain, and irregular uterine bleeding. Most of these side effects of X-Out 21 Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor. Do not use X-Out 21 Tablet if you are pregnant or have recently delivered a baby.

Inform your doctor before starting to X-Out 21 Tablet if you are over 35 years or ever have a heart problem, cancer (breast, uterus, or vagina), uterine bleeding, liver, or kidney problems. Do not take X-Out 21 Tablet if you are pregnant already or a breastfeeding mother. X-Out 21 Tablet does not prevent the transmission of any sexually transmitted disease (STD), so use some other form of contraception (condom) during sexual intercourse if you have any STD or AIDS (acquired immunodeficiency syndrome).

Uses of X-Out 21 Tablet

X-Out 21 Tablet is used to treat Contraception, Dysmenorrhea (irregular menstrual periods). The detailed uses of X-Out 21 Tablet are as follows:

  • Hormonal Birth Control: X-Out 21 Tablet is a form of hormonal birth control that prevents pregnancy by inhibiting ovulation and changing the uterine lining.
  • Regulating Menstrual Cycle: X-Out 21 Tablet can help in regulating menstrual cycles by balancing hormones.
  • Treatment of Menstrual Disorders: X-Out 21 Tablet may be prescribed to treat menstrual disorders like dysmenorrhea by reducing symptoms of painful periods.
  • Acne Management: X-Out 21 Tablet can help manage acne by regulating hormonal imbalances that contribute to breakouts.
  • Polycystic Ovary Syndrome (PCOS): X-Out 21 Tablet can be used to help manage PCOS symptoms by regulating menstrual cycles and balancing hormones.

Have a query?

Directions for Use

  • Take X-Out 21 Tablet without food or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.
  • Swallow the medicine as a whole with glass of water.
  • Do not crush, break, or chew it.

Key Benefits

X-Out 21 Tablet is an oral hormonal combination drug, Ethinylestradiol and Levonorgestrel, primarily used for contraception. X-Out 21 Tablet contains two female sex hormones, progestin (levonorgestrel) and estrogen (ethinylestradiol), which help prevent pregnancy in multiple ways. It prevents the release of an egg from the ovaries and makes the fluid present in the cervix difficult for sperm to enter the womb. In addition, it prevents the thickening of the uterus's inner wall, which is necessary for an egg to grow and multiply. X-Out 21 Tablet is generally taken for 21 days starting from day one of the menstrual cycle, and then for the next seven days, it is not taken, and the same course is repeated.

How X-Out 21 Tablet Works

X-Out 21 Tablet is a combination of two medications: Ethinylestradiol and Levonorgestrel. Ethinylestradiol is a synthetic female hormone (estrogen) that maintains a normal menstrual cycle (periods) in women. It works by fulfilling the deficiency of estrogen hormone, thereby preventing symptoms like night sweats, hot flashes, and mood swings. Levonorgestrel is a progestin (female sex hormones) that prevents the release of an egg from the ovary (female reproductive cells) or prevents fertilization of an egg by sperm (male reproductive cells). X-Out 21 Tablet may also change the lining of the uterus to prevent the development of a pregnancy. Thus, together, X-Out 21 Tablet helps prevent pregnancy.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of X-Out 21 Tablet

Do not take more than the prescribed dose of X-Out 21 Tablet as it may cause overdose. The symptoms of overdose include vomiting, nausea, drowsiness, fatigue (overtired) and withdrawal bleeding in females. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Please inform your doctor if you have ever had heart disease, hypertension, obesity, cancer (breast, cervix, or uterus), diabetes mellitus, liver or kidney disease, or abnormal uterine bleeding as X-Out 21 Tablet is known to contra-indicate. Check your breast every month for changes, such as if you feel lumps or see anything odd, please inform your doctor. Smoking may increase the risk of cardiovascular disease in women over 35 years when taking X-Out 21 Tablet . X-Out 21 Tablet does not protect against any sexually transmitted disease or HIV. If pregnancy occurs while you are taking X-Out 21 Tablet , please consult your doctor. Do not start using a new medication without telling your doctor. Sometimes, you may experience spotting or bleeding in between missed periods or menstrual periods. If the spotting persists, please consult your doctor. Do not use X-Out 21 Tablet if you are pregnant or have recently delivered a baby. If you have missed a dose or are late by 12 hours, please wear a condom for two days while sexual intercourse to avoid unwanted pregnancy. Do not take medicine if you are pregnant already or breastfeeding. If you have migraines, please inform your doctor, as taking X-Out 21 Tablet may increase your headache.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with X-Out 21 Tablet:
Taking X-Out 21 Tablet with Tranexamic acid may increase the risk of blood clot formation.

How to manage the interaction:
Taking X-Out 21 Tablet with Tranexamic acid is not recommended, as it can lead to an interaction, but can be taken if a doctor has prescribed it. However, if you suffer from chest discomfort, shortness of breath, blood in the urine, blood in the cough, sudden loss of vision, and pain, redness, or swelling in your arm or leg, consult doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with X-Out 21 Tablet:
Coadministration of Acitretin with X-Out 21 Tablet can increase the risk and severity of birth defects in unborn when taken by a pregnant woman.

How to manage the interaction:
Taking Acitretin with X-Out 21 Tablet together is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. Consult a doctor if you get pregnant while taking these medications. Never use acitretin if you are pregnant. Do not stop using any medications without talking to a doctor.
LevonorgestrelEtretinate
Critical
How does the drug interact with X-Out 21 Tablet:
Using etretinate and X-Out 21 Tablet can cause severe birth defects.

How to manage the interaction:
Taking Etretinate with X-Out 21 Tablet can cause an interaction, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
How does the drug interact with X-Out 21 Tablet:
Taking X-Out 21 Tablet with Tranexamic acid may increase the risk of blood clot formation which can lead to serious conditions such as heart problems and kidney failure.

How to manage the interaction:
Taking Tranexamic acid with X-Out 21 Tablet may leads to an interaction but can be taken if prescribed by the doctor. However, if you experience chest pain; shortness of breath; coughing up blood; blood in the urine; sudden loss of vision; and pain, redness, or swelling in your arm or leg, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with X-Out 21 Tablet:
When used with X-Out 21 Tablet, the effectiveness of Exemestane might be reduced.

How to manage the interaction:
Although taking Exemestane and X-Out 21 Tablet together can cause an interaction, it can be taken if a doctor has suggested it. Do not stop using any medications without a doctor's advice.
How does the drug interact with X-Out 21 Tablet:
Phenytoin may lower ethinyl estradiol levels in the blood and its effects. You may be more likely to experience breakthrough bleeding and unexpected pregnancy if you use low-dose oral contraceptives.

How to manage the interaction:
Although taking Phenytoin and X-Out 21 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. If you are on hormone replacement therapy for menopause, inform a doctor if your symptoms are no longer being controlled or if you are experiencing abnormal bleeding. Do not stop using any medications without a doctor's advice.
How does the drug interact with X-Out 21 Tablet:
Coadministration of X-Out 21 Tablet with Mycophenolic acid may lower the blood levels and effects of X-Out 21 Tablet, making it less effective as a form of birth control.

How to manage the interaction:
There could be a possible interaction between Mycophenolic acid and X-Out 21 Tablet, but they can be taken together if a doctor has prescribed them. However, if you are taking hormone replacement therapy for menopause, and you notice an increase in the frequency or severity of your symptoms, such as hot flashes, vaginal dryness, or irregular bleeding, consult a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with X-Out 21 Tablet:
Carfilzomib can cause serious blood clots and taking it with ethinyl estradiol may enhance the risk.

How to manage the interaction:
There may be a possibility of interaction between Carfilzomib and X-Out 21 Tablet, but it can be taken if prescribed by a doctor. However, if you experience chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness, or swelling in an arm or leg, or numbness or weakness on one side of the body, you should consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with X-Out 21 Tablet:
When X-Out 21 Tablet is taken with phenobarbital, X-Out 21 Tablet may become les effective.

How to manage the interaction:
Although taking phenobarbital and X-Out 21 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you use hormone replacement therapy for menopause, inform a doctor if your symptoms are no longer controlled or if you experience unusual bleeding. Do not stop using any medications without talking to a doctor.
Severe
How does the drug interact with X-Out 21 Tablet:
Dantrolene's beneficial effectiveness can be reduced when used with X-Out 21 Tablet.

How to manage the interaction:
Co-administration of X-Out 21 Tablet with Dantrolene can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience a fever, chills, joint pain or swelling, severe fatigue or weakness, unusual bleeding or bruising, skin rash or itching, lack of appetite, nausea, vomiting, or yellowing of the skin or whites of your eyes, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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ETHINYLESTRADIOL-0.05MG+LEVONORGESTREL-0.25MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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ETHINYLESTRADIOL-0.05MG+LEVONORGESTREL-0.25MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit, Grapefruit Juice

How to manage the interaction:
Taking Grapefruit or Grapefruit juice while on the treatment with Ethinylestradiol, Levonorgestrel can lead to increase in blood levels of Ethinylestradiol, Levonorgestrel. Avoid or limit the consumption of grapefruit and grapefruit juice during treatment with Ethinylestradiol, Levonorgestrel.

Diet & Lifestyle Advise

  • ​​Keep your weight under control with a body mass index (BMI) of 19.5-24.9.
  • Opt for a diet rich in whole grains, fruits, veggies, and low-fat dairy products.
  • Including heart-healthy omega-3 fatty acid-containing food drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.
  • Do regular exercise to maintain weight fluctuations caused due to X-Out 21 Tablet .
  • Avoid chronic stress and exercise like running, as it might increase vaginal bleeding.
  • Monitor your blood pressure daily and if there is too much fluctuation, immediately contact your doctor.
  • Monitor your blood sugar level and blood pressure regularly to avoid any complications.
  • Quitting smoking and not drinking alcohol is the best strategy to lower the risk of any complications.

Habit Forming

No

Therapeutic Class

[CONTRACEPTIVES]

All Substitutes & Brand Comparisons

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Alcohol

Safe if prescribed

You are recommended not to consume alcohol along with X-Out 21 Tablet to avoid unpleasant side effects.

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Pregnancy

Consult your doctor

Caution should be exercised. Hormonal medicines can affect the developing baby. It is advisable to consult a doctor before using it.

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Breast Feeding

Consult your doctor

Not safe; this X-Out 21 Tablet may pass into breast milk. They may harm the baby and also may affect the production of milk. So, this X-Out 21 Tablet is unsafe for breastfeeding mothers.

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Driving

Safe if prescribed

X-Out 21 Tablet has no or negligible influence on the ability to drive or use machines.

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Liver

Consult your doctor

X-Out 21 Tablet to be taken with caution, especially if you have a history of Liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Consult your doctor

X-Out 21 Tablet to be taken with caution, especially if you have a history of Kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Safe if prescribed

X-Out 21 Tablet is not recommended for children. Safety and efficacy of X-Out 21 Tablet are established in women of reproductive age. But sufficient studies have not been performed on women less than 16 years of age. So, take X-Out 21 Tablet only when prescribed by a doctor.

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Heart

X-Out 21 Tablet is not recommended for use in heart patients as it can lead to side effects like heart attack, blood clots, or stroke in some patients.

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Geriatrics

Consult your doctor

X-Out 21 Tablet is not recommended for use in elderly patients and postmenopausal women.

FAQs

X-Out 21 Tablet is used for contraception and treating dysmenorrhea (irregular and painful periods).

Yes, X-Out 21 Tablet can cause spotting in between the regular periods. Usually, it does not persist, but if spotting does not, please inform your doctor, as medical attention may be required.

Yes, X-Out 21 Tablet is known to cause weight gain. So, avoid weight gain, exercise regularly, and eat home-cooked food.

No, the X-Out 21 Tablet does not protect against sexually transmitted diseases (STDs). It is an oral form of contraception that does not protect against STDs. So, use some other form of contraception, like condoms, to avoid transmission.

You will usually get your period within three days after taking the last pill. If you have not followed the dosing schedule like you have missed one or two pills or started taking them a day after, you should have the probability of pregnancy at the time of the first missed period, and you should contact your doctor.

Do not take X-Out 21 Tablet if you have a heart fitted with an artificial valve, heart diseases like high blood pressure or high blood cholesterol levels (increased fat in your blood), confirmed or suspected ectopic pregnancy, have asthma, have blood clot problems, have a bleeding disorder, have liver or kidney disease, have anaemia (low haemoglobin) or otherwise malnourished. Taking X-Out 21 Tablet in these conditions can cause life-threatening conditions in an individual.

If you forget to take one tablet of X-Out 21 Tablet , take it as soon as you remember, even if it means taking two tablets at the same time and then follow the usual dosing schedule. However, if you forget to take two or more doses, you may not be completely protected against pregnancy. In this case, start taking the X-Out 21 Tablet as soon as you remember and use a non-hormonal method of contraception such as condoms for at least the next 7 days to prevent pregnancy. Frequent missing doses may cause spotting (bloodstain) or unexpected vaginal bleeding. If this persists, contact your doctor.

X-Out 21 Tablet is contraindicated in women with a history of breast and cervical cancer. Women with known or suspected carcinoma of the breast or personal history of breast cancer should not use X-Out 21 Tablet because breast cancer is usually a hormonally-sensitive tumor, and X-Out 21 Tablet slightly increases your risk of breast cancer.Therefore, inform your doctor if you have had a history of breast cancer before taking X-Out 21 Tablet .

Yes, X-Out 21 Tablet is a 21-day oral contraceptive pill used for regulating periods and preventing pregnancy.

To take X-Out 21 Tablet , swallow the tablet whole with a glass of water. Do not chew, crush, or break it. Your doctor will determine the correct dose based on your medical condition. If you have any concerns, please consult your doctor.

Smokers over 35 should avoid taking X-Out 21 Tablet due to increased risks of blood clots, stroke, and heart attack. If you're a smoker, consult your doctor for guidance on safer alternatives or to discuss any concerns.

If you vomit within 3-4 hours of taking X-Out 21 Tablet , take another tablet as soon as possible to maintain effectiveness. However, please consult a doctor if vomiting persists or worsens.

The common side effects of X-Out 21 Tablet include stomach pain, nausea, headache, breast tenderness, weight gain, and irregular menstrual bleeding. Most of these side effects are temporary and resolve on their own. However, if they persist, consult your doctor for guidance.

Country of origin

India

Manufacturer/Marketer address

A-104, Fairdeal House, Near Swastik Cross Roads, Ahmedabad, India, 380009
Other Info - XOU0001

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