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compositionComposition:DECITABINE-50MG
prescription
Prescription Medicine
info
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XALIBO 50MG INJECTION used to treat myelodysplastic syndrome. It contains Decitabine, which works by helping the bone marrow produce normal blood cells and kills abnormal cells in the bone marrow. The most common adverse reactions of XALIBO 50MG INJECTION are injection site reactions, excessive tiredness, headache, dizziness, confusion, fast heartbeat, difficulty falling asleep or staying asleep, weakness, shortness of breath, nausea, constipation, diarrhoea, vomiting, heartburn, chest discomfort and swelling of the hands, feet, ankles, lower legs, or stomach.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DECITABINE-50MG

Manufacturer/Marketer :

Dr Reddy's Laboratories Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About XALIBO 50MG INJECTION

XALIBO 50MG INJECTION is a prescription injection used to treat myelodysplastic syndromes (MDS), which are a group of blood cancers where the bone marrow cannot make enough healthy blood cells. It is also prescribed to treat certain types of acute myeloid leukaemia (AML) in adults. This medicine works by helping your bone marrow grow normal, healthy blood cells instead of abnormal, diseased cells.

Because this medicine is given as an injection into a vein in a clinic or hospital, your medical team will manage your specific schedule. It is typically given in structured cycles of several days in a row, followed by a rest period, and keeping these appointments consistently is crucial for your treatment to work. Eating a clean, well-balanced diet and staying well-hydrated can help your body tolerate these treatment cycles more comfortably.

While receiving this treatment, you may experience common side effects such as nausea, tiredness, fever, or a temporary drop in your healthy blood cell counts. It is vital to contact your doctor immediately if you face serious side effects, such as a high fever, severe chills, unusual bleeding, or bruising.

Before starting this medicine, talk to your doctor if you have kidney disease or liver disease, as these conditions can affect how your body clears the medication. Do not take this if you have had a severe allergic reaction to this medicine or its ingredients in the past. This treatment is not recommended for pregnant women because it can cause serious harm to an unborn baby.

This medicine can interact with other drugs that weaken your immune system, which greatly increases your risk of catching severe infections. Avoid alcohol and smoking during your treatment because they can worsen liver strain and fatigue. Pregnant women, breastfeeding mothers, and elderly individuals must consult their doctor to carefully weigh the risks and benefits before starting therapy.

Uses of XALIBO 50MG INJECTION

Your doctor may prescribe XALIBO 50MG INJECTION to treat the following conditions:

  • Myelodysplastic Syndromes (MDS): XALIBO 50MG INJECTION helps treat these complex bone marrow disorders by encouraging the production of normal, functional blood cells and controlling abnormal cell growth.
  • Acute Myeloid Leukaemia (AML): In certain adult patients, XALIBO 50MG INJECTION is used to slow down the rapid growth of abnormal white blood cells, helping to manage this aggressive blood cancer.

Key Benefits

XALIBO 50MG INJECTION helps restore healthy blood cell production by reducing abnormal cells in the bone marrow. This improves the bone marrow's ability to produce normal red blood cells, white blood cells, and platelets, helping manage the disease and improve overall health.

  • Improves healthy blood cell counts: Helps the bone marrow produce normal blood cells, which may reduce the need for frequent blood or platelet transfusions.
  • Reduces the risk of infections and bleeding: By increasing healthy white blood cells and platelets, it helps strengthen the body's defence against infections and lowers the risk of easy bruising or bleeding.
  • Helps slow disease progression: Controls the growth of abnormal bone marrow cells, which may delay progression to more advanced forms of leukemia in suitable patients.
  • Enhances quality of life: Improving blood counts can reduce symptoms such as fatigue, weakness, and shortness of breath, allowing you to carry out daily activities more comfortably.

Directions for Use

  • Typically, XALIBO 50MG INJECTION is given every 8 hours for 3 days, with cycles repeated every 6 weeks, or as recommended by your doctor.
  • XALIBO 50MG INJECTION will be administered by a doctor or nurse in a healthcare facility.
  • Do not self-administer.

How XALIBO 50MG INJECTION Works

XALIBO 50MG INJECTION contains decitabine, which works as a 'hypomethylating agent.' In simple terms, it targets the DNA of rapidly dividing abnormal cells in your bone marrow. Cancerous and abnormal cells often shut down the specific genes that control normal growth and cell death. XALIBO 50MG INJECTION helps reactivate these silent genes. Once these genes are turned back on, the abnormal cells are forced to mature normally or die off, making room for healthy blood cells to grow.
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while on treatment with XALIBO 50MG INJECTION as it might cause increased dizziness.

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Pregnancy

Unsafe

XALIBO 50MG INJECTION should not be used during pregnancy. So, inform your doctor if you are pregnant or suspect pregnancy. You or your partner must use a reliable form of contraception to prevent pregnancy while taking these medications.

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Breast Feeding

Unsafe

XALIBO 50MG INJECTION should not be used in breastfeeding. Discuss with your doctor if you have any concerns.

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Driving

Unsafe

XALIBO 50MG INJECTION may cause dizziness, sleepiness, and blurred vision. Do not drive or operate heavy machinery unless you are alert.

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Liver

Caution

Inform your doctor before receiving the XALIBO 50MG INJECTION if you have had a liver impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Inform your doctor before receiving the XALIBO 50MG INJECTION if you have had a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Unsafe

XALIBO 50MG INJECTION is not recommended for children below 18 years as the safety and effectiveness have not been established.

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Heart

Caution

XALIBO 50MG INJECTION may be used in patients with heart problems, but only under strict medical supervision. It pose risks like cardiomyopathy and heart failure, so close monitoring is essential.

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Geriatrics

Caution

Geriatric patients can receive XALIBO 50MG INJECTION, but they may be more vulnerable to side effects like low blood counts or heart complications. Close medical supervision and dose adjustments are often necessary.

What if I have taken an overdose of XALIBO 50MG INJECTION

Since a trained medical professional calculates and injects this medication, an overdose is highly unlikely. However, if you suspect an error or experience severe side effects immediately after an injection, notify your healthcare provider right away or seek emergency medical attention.

Diet & Lifestyle Advise

  • Follow a low-microbe diet: Since this medicine lowers your white blood cell count, avoid raw or undercooked meats, unpasteurized dairy, and unwashed raw fruits and vegetables to lower your risk of foodborne infections.
  • Stay well-hydrated: Drink plenty of water and clear fluids, especially during your injection days, to help your kidneys flush out waste products and manage mild nausea.
  • Practice strict hand hygiene: Wash your hands frequently with warm water and soap, and avoid crowded places or people who are sick to protect your compromised immune system.
  • Use a soft-bristle toothbrush: This helps prevent gum bleeding, which is a common risk when your platelet counts are low during treatment.
health query

Have a query?

How Soon It Starts Working

The time required for XALIBO 50MG INJECTION to start to work: The exact onset time of XALIBO 50MG INJECTION has not been clinically established. The time for which the effects of XALIBO 50MG INJECTION last: The duration of XALIBO 50MG INJECTION’s effect is clinically not established.

What if you forget to take XALIBO 50MG INJECTION

Because this medicine is given by a healthcare professional at a clinic, missing an appointment disrupts your treatment cycle. If you miss or have to postpone a scheduled injection, call your clinic or doctor immediately to reschedule the appointment.

Storage

•Before the dry powder vials of XALIBO 50MG INJECTION are mixed, they are stored at room temperature between 20°C to 25°C (68°F to 77°F).

Drug Warnings

  • Check the solution: Before your injection starts, ensure the prepared liquid is clear and free of visible particles or discoloration.
  • Monitor the injection site: Tell your nurse immediately if you feel pain, burning, coldness, or swelling around the vein where the needle is inserted.
  • Get regular blood tests: You will need frequent blood tests to monitor your blood cell counts before and during each treatment cycle.
  • Avoid live vaccines: Do not receive any live vaccines (such as the shingles or measles vaccine) while using this medicine, as your weakened immune system may not be able to handle them.
  • Use effective birth control: Both men and women must use reliable birth control during treatment and for several months afterward to prevent pregnancy and birth defects.

Drug-Drug Interactions

verifiedApollotooltip
  • Immunosuppressants and other chemotherapy drugs: Combining these with XALIBO 50MG INJECTION may severely lower your blood cell counts, further increasing the risk of life-threatening infections and bleeding.
  • Live vaccines: Taking live vaccines while undergoing treatment may cause the vaccine virus to replicate and cause active illness due to your weakened immune system.
DecitabineLeflunomide
Severe

Drug-Drug Interactions

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DecitabineLeflunomide
Severe
How does the drug interact with Xalibo 50mg Injection:
Combining Xalibo 50mg Injection with Leflunomide can increase the risk of negative side effects.

How to manage the interaction:
Taking Leflunomide with Xalibo 50mg Injection together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms, it's important to contact your doctor right away: infection, complications, fever, chills, diarrhea, sore throat, muscle aches, trouble breathing, losing weight, or pain/burning when you pee. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with XALIBO 50MG INJECTION when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[MISCELLANEOUS, CHEMOTHERAPY]

FAQs

XALIBO 50MG INJECTION is used to treat Myelodysplastic syndrome.
XALIBO 50MG INJECTION contains Decitabine, which works by helping the bone marrow produce normal blood cells and by killing abnormal cells in the bone marrow.
Decitabine therapy should usually be given as a three- or five-day regimen based on your medical condition and response to the treatment. Do not stop taking XALIBO 50MG INJECTION on your own. Do not be reluctant to speak with your doctor if you experience any difficulty while taking XALIBO 50MG INJECTION.
XALIBO 50MG INJECTION can be used to treat blood cancer known as acute myeloid leukemia (AML).
XALIBO 50MG INJECTION therapy may cause a change in skin colour or pale skin or red spots on the skin. Consult your doctor immediately if you notice these symptoms persistently.
XALIBO 50MG INJECTION might cause neutropenia (low white blood cells) and thrombocytopenia (low platelets). Blood count should be checked regularly during treatment with XALIBO 50MG INJECTION.
Decitabine may raise blood sugar. If you have high blood sugar (diabetes), talk with your doctor.
No, XALIBO 50MG INJECTION is not a vesicant. It is an anti-cancer drug that is not known to cause severe tissue damage when it leaks from the injection site into surrounding tissues. It belongs to the group of medications called hypo methylation agents used to treat myelodysplastic syndrome.
XALIBO 50MG INJECTION effectively treats myelodysplastic syndrome, a group of disorders in which the bone marrow produces misshapen blood cells and insufficient healthy blood cells. It works by promoting the production of normal blood cells in the bone marrow and eliminating abnormal cells. However, the degree of effectiveness varies among individuals based on their medical condition.
Yes, XALIBO 50MG INJECTION may cause hair loss as a common side effect. To cope with hair loss, manage stress, maintain a healthy diet, avoid harsh hair treatments, use gentle hair care products, and consider medical treatments or therapies as advised by a doctor.
XALIBO 50MG INJECTION is administered through an intravenous route (into a vein) slowly over 3 hours by the doctor or nurse. It is usually administered every 8 hours for 3 days depending on the prescribed dose and treatment plan.
The side effects of XALIBO 50MG INJECTION include vomiting, nausea, injection site reactions, excessive tiredness, headache, dizziness, confusion, fast heartbeat, difficulty falling asleep or staying asleep, weakness, shortness of breath, constipation, diarrhoea, heartburn, chest discomfort and swelling of the hands, feet, ankles, lower legs, or stomach. Consult the doctor if any of these side effects persist or worsen.
It is highly recommended to avoid alcohol while receiving XALIBO 50MG INJECTION. Alcohol can increase strain on your liver and worsen side effects like fatigue, nausea, and dehydration. Talk to your doctor before consuming alcohol.
If you get a fever of 100.4°F (38°C) or higher, call your healthcare provider immediately or go to the nearest emergency room. A fever can be a sign of a serious infection because your white blood cells may be very low. Talk to your doctor right away if you feel unwell.
No, XALIBO 50MG INJECTION can cause severe harm or birth defects to an unborn baby. Both men and women should use effective birth control while receiving this medicine and for a recommended time after treatment ends. Talk to your doctor about safe family planning options.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. DrugBank Online. Db01262 Clinical & Chemical Summary. Edmonton, AB: DrugBank; 2026. [Accessed on 02 Jun. 2026]Check here
  2. MedlinePlus. A608009 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  3. ScienceDirect Topics. Decitabine - Research & Medical Applications Summary. Amsterdam, Netherlands: Elsevier; 2025. [Accessed on 02 Jun. 2026]Check here
  4. U.S. Food and Drug Administration (FDA). 021790S021Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  5. Drugs.com Clinical Review Team. Decitabine Drug Interactions Reference. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  6. Decitabine Decitabine. 2012. [Accessed on 26 Mar. 2019]Check here
  7. Decitabine Decitabine. 2006. [Accessed on 26 Mar. 2019]Check here

Country of origin

India

Manufacturer/Marketer address

Dr. Reddy's Laboratories Ltd., 8-2-337, Road No. 3, Banjara Hills, Hyderabad, Telangana 500034, INDIA
Other Info - XAL0004
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