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compositionComposition:CLONAZEPAM-0.5MG+PAROXETINE-12.5MG
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Prescription Medicine
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Best Price

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XET CR PLUS 12.5MG CAPSULE is used in the treatment of depression. It contains Clonazepam and Paroxetine, which increases levels of a calming chemical in the brain and also increases the serotonin hormone levels that improve mood, behaviour and prevent symptoms of depression. It may cause common side effects such as nausea, vomiting, diarrhoea, memory impairment, uncoordinated body movements, drowsiness, low sexual desire and delayed ejaculation. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

CLONAZEPAM-0.5MG+PAROXETINE-12.5MG

Manufacturer/Marketer :

Zydus Healthcare Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About XET CR PLUS 12.5MG CAPSULE

XET CR PLUS 12.5MG CAPSULE is a prescription medicine used to treat generalized anxiety disorder, panic disorder, and anxiety associated with depression. It contains two medicines that work together to provide both rapid relief of anxiety symptoms and long-term improvement in mood and anxiety control.

For best results, take XET CR PLUS 12.5MG CAPSULE exactly as prescribed and at the same time each day. It may be taken with or without food. Maintaining healthy sleep habits, regular physical activity, and stress-management techniques may help improve treatment outcomes.

Some people may experience mild side effects such as drowsiness, dry mouth, nausea, dizziness, or changes in appetite, especially during the first few weeks of treatment. These effects are often temporary and improve as the body adjusts to the medicine.

Seek immediate medical attention if you experience suicidal thoughts, thoughts of self-harm, severe mood changes, extreme confusion, difficulty breathing, or signs of a severe allergic reaction. Contact your doctor if side effects become persistent or troublesome.

Before starting treatment, inform your doctor if you have glaucoma, liver or kidney disease, breathing problems, sleep apnea, bipolar disorder, seizures, a history of substance misuse, or allergies to similar medicines. Avoid alcohol while taking XET CR PLUS 12.5MG CAPSULE, and consult your doctor before use during pregnancy, breastfeeding, in older adults, or in children and adolescents.

Uses of XET CR PLUS 12.5MG CAPSULE

XET CR PLUS 12.5MG CAPSULE is used in the treatment of depression. The detailed uses of XET CR PLUS 12.5MG CAPSULE are as follows:

  • Depression with Anxiety: Helps improve symptoms of depression while also reducing anxiety-related symptoms.
  • Generalized Anxiety Disorder: Helps reduce excessive worry, nervousness, irritability, and physical symptoms of anxiety.
  • Panic Disorder: Helps reduce the frequency and severity of panic attacks and the fear associated with them.

Key Benefits

XET CR PLUS 12.5MG CAPSULE helps manage anxiety and related mood symptoms, supporting improved emotional well-being and daily functioning. By providing both short-term symptom relief and long-term emotional support, it helps individuals feel more comfortable and in control of their daily lives. Benefits may include:

  • Helps reduce anxiety, nervousness, and panic-related symptoms.
  • Provides early relief from anxiety symptoms while supporting long-term symptom control.
  • Helps improve mood and reduce persistent feelings of worry or emotional distress.
  • Supports emotional balance and overall mental well-being.
  • May promote better sleep by reducing anxiety-related sleep disturbances.
  • Improves daily functioning, social interactions, and overall quality of life.
Side effects of Xet Cr Plus 12.5mg Capsule
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Get enough sleep. Maintain a regular sleep cycle.
  • Eat a healthy diet and exercise regularly.
  • Manage stress with yoga or meditation.
  • Limit alcohol and caffeine.
  • Avoid driving or operating machinery unless you are alert.
  • Uncoordinated muscle movements need immediate medical attention.
  • Observe your movements and try to understand and control the particular movement.
  • Regularly do strengthening exercises to improve blood flow throughout the body and avoid involuntary movements.
  • Implement massage techniques to enhance blood flow to organs.
  • Take a balanced diet and quit smoking.
  • Practice yoga and meditation to improve thought processes and reduce uncontrolled and involuntary movements.

Directions for Use

  • Take XET CR PLUS 12.5MG CAPSULE with or without food or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.
  • Swallow the medicine as a whole with glass of water.
  • Do not crush, break, or chew it.

How XET CR PLUS 12.5MG CAPSULE Works

XET CR PLUS 12.5MG CAPSULE contains Paroxetine and Clonazepam. • Paroxetine: It helps improve mood and emotional well-being by balancing certain chemicals in the brain. It helps reduce symptoms of anxiety, depression, excessive worry, and panic over time. • Clonazepam: It helps calm the brain and nervous system, reducing symptoms such as anxiety, panic, restlessness, nervousness, and muscle tension. It provides relatively quick relief from anxiety-related symptoms.
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Alcohol

Caution

Avoid consumption of alcohol while taking XET CR PLUS 12.5MG CAPSULE as it may cause an increased sedative effect.

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Pregnancy

Unsafe

XET CR PLUS 12.5MG CAPSULE may cause toxic effects to the fetus. So, it is not recommended for use in women who are pregnant or planning to become pregnant.

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Breast Feeding

Caution

XET CR PLUS 12.5MG CAPSULE should be used with caution in breastfeeding mothers. Your doctor may advise you to stop breastfeeding while taking this medication.

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Driving

Caution

Do not drive or operate heavy machinery as XET CR PLUS 12.5MG CAPSULE may cause drowsiness.

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Liver

Caution

XET CR PLUS 12.5MG CAPSULE should be used with caution in patients with severe liver impairment. Dose adjustments may be required in such cases.

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Kidney

Caution

XET CR PLUS 12.5MG CAPSULE should be used with caution in patients with kidney problems. Dose adjustments may be required in such cases. If you have any concerns regarding the use of XET CR PLUS 12.5MG CAPSULE in patients with kidney problems, please consult a doctor.

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Children

Caution

XET CR PLUS 12.5MG CAPSULE should not be used in children unless prescribed by a child specialist.

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Heart

Caution

XET CR PLUS 12.5MG CAPSULE should be taken with extreme caution in patients with heart disease. Please consult your physician.

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Geriatrics

Caution

XET CR PLUS 12.5MG CAPSULE can be given in elderly patients with extreme caution due to increased risk of adverse effects.

What if I have taken an overdose of XET CR PLUS 12.5MG CAPSULE

If you take more than your prescribed dose, seek emergency medical attention immediately. Symptoms of an overdose may include severe drowsiness, confusion, slow reflexes, shallow breathing, or loss of consciousness.

Diet & Lifestyle Advise

  • Avoid alcohol and limit caffeine: Alcohol can cause dangerous drowsiness when combined with XET CR PLUS 12.5MG CAPSULE, while caffeine can trigger panic attacks and worsen anxiety.
  • Eat high-fiber foods: Paroxetine can occasionally cause mild constipation. Eating fruits, vegetables, and whole grains while drinking plenty of water can keep your digestion smooth.
  • Maintain a consistent sleep routine: Go to bed and wake up at the same time daily to help support your brain's natural rhythms and maximize the calming effects of the medication.
  • Engage in low-impact exercise: Regular, gentle physical activities like walking, swimming, or stretching can help reduce stress and naturally boost your mood.
     
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How Soon It Starts Working

The time required for XET CR PLUS 12.5MG CAPSULE to start to work: The time required for XET CR PLUS 12.5MG CAPSULE to show its action is unknown. 

The time for which the effects of XET CR PLUS 12.5MG CAPSULE last: The duration of action for XET CR PLUS 12.5MG CAPSULE is unknown.

What if you forget to take XET CR PLUS 12.5MG CAPSULE

If you miss a dose, take it as soon as you remember. However, if your next scheduled dose is only a few hours away, skip the missed dose and resume your regular schedule. Do not take two doses at the same time to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Use caution during activities requiring alertness: XET CR PLUS 12.5MG CAPSULE may cause significant drowsiness, dizziness, and slowed reflexes. Avoid driving, riding a bicycle, operating machinery, or performing hazardous tasks until you know how the medicine affects you.
  • Do not stop treatment abruptly: Never stop taking XET CR PLUS 12.5MG CAPSULE suddenly, as this may cause withdrawal symptoms such as dizziness, anxiety, irritability, sleep disturbances, sweating, shaking, flu-like symptoms, or electric shock-like sensations. Your doctor will advise a gradual dose reduction when treatment needs to be stopped.
  • Use the medicine exactly as prescribed: XET CR PLUS 12.5MG CAPSULE may cause physical dependence, especially when used for a long time. Do not increase the dose, use it more frequently than prescribed, or share it with anyone else.
  • Monitor for mood and behavior changes: Paroxetine carries a warning for an increased risk of suicidal thoughts and behavior in children, adolescents, and young adults, especially during the first few months of treatment or after dose changes. Close monitoring by family members, caregivers, and healthcare professionals is recommended during these periods.
  • Inform your doctor about all other medicines: Always tell your doctor or pharmacist about any prescription medicines, over-the-counter pain relievers, cough and cold products, or herbal supplements you are using, as many can interact with XET CR PLUS 12.5MG CAPSULE.
  • Follow your treatment plan carefully: XET CR PLUS 12.5MG CAPSULE is often used for short-term symptom relief. The duration of treatment will depend on your condition and response to therapy, as determined by your doctor.

Drug-Drug Interactions

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Drug-Drug Interactions

  • Monoamine oxidase inhibitors (MAOIs) (e.g., phenelzine, tranylcypromine): Taking these medicines alongside XET CR PLUS 12.5MG CAPSULE can cause a life-threatening condition called serotonin syndrome. Do not use these medicines within 14 days of each other.
  • Pain relievers (e.g., aspirin, ibuprofen): Combining these with XET CR PLUS 12.5MG CAPSULE may increase the risk of bruising, stomach bleeding, or internal bleeding.
  • Blood thinners (e.g., warfarin): Taking these medicines alongside XET CR PLUS 12.5MG CAPSULE may increase the risk of serious bleeding and may require closer monitoring.
  • Selective Estrogen Receptor Modulators (hormone therapy )(e.g., Tamoxifen): Paroxetine may reduce the effectiveness of tamoxifen, a medicine used to treat breast cancer.
  • Sleeping pills, muscle relaxants, and opioid pain relievers: Taking these alongside XET CR PLUS 12.5MG CAPSULE may cause excessive drowsiness, severe sedation, and dangerously slow breathing.

Drug-Food Interactions

Alcohol: Avoid consuming alcohol while taking XET CR PLUS 12.5MG CAPSULE, as it can greatly increase drowsiness, dizziness, impaired coordination, and breathing problems.

Drug-Disease Interactions

  • Narrow-angle glaucoma: XET CR PLUS 12.5MG CAPSULE may worsen symptoms in patients with narrow-angle glaucoma and should be used with caution.
  • Liver disease: Patients with liver impairment may process XET CR PLUS 12.5MG CAPSULE more slowly, increasing the risk of side effects due to drug accumulation.
  • Kidney disease: Reduced kidney function may affect the removal of XET CR PLUS 12.5MG CAPSULE from the body, increasing the likelihood of side effects.
  • Breathing disorders (e.g., asthma, sleep apnea, chronic lung disease): XET CR PLUS 12.5MG CAPSULE may further suppress breathing and should be used with caution in patients with respiratory conditions.
Paroxetine + ClonazepamThioridazine
Critical
Paroxetine + ClonazepamProcarbazine
Critical

Drug-Drug Interactions

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Paroxetine + ClonazepamThioridazine
Critical
How does the drug interact with Xet Cr Plus 12.5mg Capsule:
Co-administration of Paroxetine and Clonazepam with Thioridazine can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Paroxetine and Clonazepam with Thioridazine is not recommended, as it can lead to an interaction, but can be taken if advised by a doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Paroxetine + ClonazepamProcarbazine
Critical
How does the drug interact with Xet Cr Plus 12.5mg Capsule:
Using Paroxetine and Clonazepam together with procarbazine can increase the risk of a serious condition called the serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Paroxetine and Clonazepam with Procarbazine is not recommended, as it can lead to an interaction, but can be taken if advised by a doctor. However, if you experience confusion, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Paroxetine + ClonazepamTranylcypromine
Critical
How does the drug interact with Xet Cr Plus 12.5mg Capsule:
Co-administration of Paroxetine and Clonazepam with Tranylcypromine, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Paroxetine and Clonazepam with Tranylcypromine is not recommended as it can possibly lead to an interaction but it can be taken if your doctor has advised it. If you notice any of these symptoms like confusion, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramps, nausea, vomiting, diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Paroxetine + ClonazepamPimozide
Critical
How does the drug interact with Xet Cr Plus 12.5mg Capsule:
Combining Paroxetine and Clonazepam with Pimozide can effect the rhythm of the heart.

How to manage the interaction:
Taking Paroxetine and Clonazepam with Pimozide is not recommended, as it can lead to an interaction, but can be taken if advised by a doctor. However, if you experience chest tightness, irregular heartbeat, blurred vision and nausea contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Paroxetine + ClonazepamFurazolidone
Critical
How does the drug interact with Xet Cr Plus 12.5mg Capsule:
Taking Paroxetine and Clonazepam with Furazolidone, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Paroxetine and Clonazepam with Furazolidone is not recommended, as it can lead to an interaction, but can be taken if advised by a doctor. However, if you experience confusion, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Paroxetine + ClonazepamEliglustat
Critical
How does the drug interact with Xet Cr Plus 12.5mg Capsule:
Co-administration of Paroxetine and Clonazepam with eliglustat can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Paroxetine and Clonazepam with Eliglustat is not recommended, as it can lead to an interaction, but can be taken if advised by a doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, slow heart rate, weak pulse, or heart palpitations, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Paroxetine + ClonazepamPhenelzine
Critical
How does the drug interact with Xet Cr Plus 12.5mg Capsule:
When Paroxetine and Clonazepam are taken with phenelzine, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Paroxetine and Clonazepam with phenelzine is not recommended as it can possibly lead to an interaction but it can be taken if your doctor has advised it. If you notice any of these symptoms like confusion, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramps, nausea, vomiting, diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Paroxetine + ClonazepamSelegiline
Critical
How does the drug interact with Xet Cr Plus 12.5mg Capsule:
Taking Paroxetine and Clonazepam with Selegiline, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Paroxetine and Clonazepam with Selegiline is not recommended as it can possibly lead to an interaction but it can be taken if your doctor has advised it. If you notice any of these symptoms like confusion, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramps, nausea, vomiting, diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Paroxetine + ClonazepamIsocarboxazid
Critical
How does the drug interact with Xet Cr Plus 12.5mg Capsule:
Taking Paroxetine and Clonazepam with Isocarboxazid, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Paroxetine and Clonazepam with Isocarboxazid is not recommended as it can possibly lead to an interaction but it can be taken if your doctor has advised it. If you notice any of these symptoms like confusion, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramps, nausea, vomiting, diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Paroxetine + ClonazepamLinezolid
Critical
How does the drug interact with Xet Cr Plus 12.5mg Capsule:
Co-administration of Paroxetine and Clonazepam with Linezolid, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Paroxetine and Clonazepam with Linezolid is not recommended but should be taken if advised by a doctor. However, if you experience confusion, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

Yes

Therapeutic Class

[ANTIDEPRESSANT]

FAQs

XET CR PLUS 12.5MG CAPSULE is used in the treatment of depression.
XET CR PLUS 12.5MG CAPSULE causes sleepiness, drowsiness, and dizziness. Do not drive or operate machinery if you experience these symptoms after taking XET CR PLUS 12.5MG CAPSULE.
XET CR PLUS 12.5MG CAPSULE causes weight gain due to increased appetite. Eat a healthy diet and exercise regularly to maintain a healthy weight.
Do not discontinue XET CR PLUS 12.5MG CAPSULE without consulting your doctor as it could lead to recurring symptoms. To treat your condition effectually continue taking XET CR PLUS 12.5MG CAPSULE for as long as prescribed. Moreover, stopping this medicine suddenly may result in withdrawal symptoms. Do not be reluctant to speak with your doctor if you feel any difficulty while taking XET CR PLUS 12.5MG CAPSULE.
XET CR PLUS 12.5MG CAPSULE may cause decreased sex-drive, problems with erection and orgasm. Consult your doctor if you have any concerns regarding this.
Dry mouth could be a side-effect of XET CR PLUS 12.5MG CAPSULE. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.
Some patients experienced increased suicidal thoughts or actions in the first few months of the treatment with XET CR PLUS 12.5MG CAPSULE. Report to your doctor immediately if you notice any changes in your behaviour or mood while on this medication.
Yes, the use of XET CR PLUS 12.5MG CAPSULE can cause sleepiness as a side effect. It's important to avoid driving or operating heavy machinery until you know how XET CR PLUS 12.5MG CAPSULE affects you.
No, it's not safe to drink alcohol while taking XET CR PLUS 12.5MG CAPSULE. Alcohol can increase the sedative effects of XET CR PLUS 12.5MG CAPSULE, leading to increased drowsiness and dizziness. It's best to avoid alcohol to prevent these increased side effects.
XET CR PLUS 12.5MG CAPSULE typically takes several weeks to show full effects, but it may differ from person to person. However, it’s important to complete the full course of treatment as prescribed by your doctor.
Store the XET CR PLUS 12.5MG CAPSULE at room temperature protected from light and moisture. Keep it out of reach of children.
The common side effects of XET CR PLUS 12.5MG CAPSULE are nausea, vomiting, diarrhoea, memory impairment, uncoordinated body movements, drowsiness, low sexual desire and delayed ejaculation. If any of these side effects persist or worsen, please consult doctor.

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Country of origin

India

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads,Ahmedabad – 380015 Gujarat, India.
Other Info - XET0006

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