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compositionComposition:CEFOTAXIME-500MG+SULBACTAM-250MG
prescription
Prescription Medicine
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Xibact 500 mg/250 mg Injection is used to treat bacterial infections. It contains Cefotaxime and Sulbactam which work by killing infection-causing bacteria. In some cases, this medicine may cause side effects such as pain and swelling at the injection site, skin rash, diarrhoea, nausea and vomiting. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

CEFOTAXIME-500MG+SULBACTAM-250MG

Manufacturer/Marketer :

Galpha Laboratories Ltd

Consume Type :

Parenteral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Xibact 500 mg/250 mg Injection

Xibact 500 mg/250 mg Injection is a combination antibiotic used to treat a wide variety of severe bacterial infections in the body. It is clinically prescribed for moderate to serious infections of the lungs, skin, abdomen, and urinary tract. This medicine works by targeting and destroying the bacteria causing the illness, helping you recover safely.

This medication is injected regularly at scheduled intervals to maintain a consistent level of the active medicine in your bloodstream. Because it is given as an injection, it does not depend on meals and can be injected with or without food. To support your body during treatment, staying well-hydrated, eating balanced meals, and getting plenty of rest are highly beneficial.

While taking Xibact 500 mg/250 mg Injection, you may experience some mild side effects such as pain at the injection site, nausea, or mild diarrhoea. However, you must contact your doctor immediately if you experience severe symptoms like persistent watery diarrhoea, intense stomach cramps, yellowing of the skin, or difficulty breathing.

Before starting this treatment, inform your doctor if you have kidney problems or a history of drug allergies, particularly to penicillin-type medications. Do not take this if you have had a severe allergic reaction to cephalosporins or any other ingredients in the formula.

Additionally, Xibact 500 mg/250 mg Injection can interact with certain water pills or gout medications, which may increase the strain on your kidneys. It is also important to consult your healthcare provider if you are pregnant, breastfeeding, or managing health conditions as an elderly individual before receiving this injection.

Uses of Xibact 500 mg/250 mg Injection

Xibact 500 mg/250 mg Injection is used in the treatment of various bacterial infections. The detailed uses of Xibact 500 mg/250 mg Injection are as follows:

  • Severe respiratory tract infections: It clears deep-seated bacterial infections in the lungs, such as severe pneumonia.
  • Complicated urinary tract infections: It targets and eliminates bacteria in the kidneys and bladder to resolve painful, severe UTIs.
  • Intra-abdominal infections: It treats serious bacterial infections inside the stomach area, often occurring after abdominal surgeries.
  • Skin and soft tissue infections: It halts the spread of deep, aggressive skin infections and helps the tissues heal.
  • Gynaecological infections: It resolves severe bacterial infections within the organs of the female reproductive system.
  • Bloodstream infections: It provides rapid, systemic protection to eliminate bacteria that have entered the blood.

Key Benefits

Taking Xibact 500 mg/250 mg Injection can help treat bacterial infections effectively by stopping the growth of bacteria and helping your body's immune system clear the infection. Here are the key benefits of this treatment:

  • Starts fighting the infection quickly: Delivers the antibiotic directly into your bloodstream, allowing it to begin working soon after administration.
  • Relieves infection symptoms: Helps reduce fever, pain, swelling, and other symptoms as the bacterial infection starts to clear.
  • Treats difficult bacterial infections: Helps overcome certain bacterial defence mechanisms, making it effective against infections that may not respond well to some standard antibiotics.
  • Prevents the infection from spreading: Controls bacterial growth, reducing the risk of the infection spreading to nearby tissues or other parts of the body.
  • Promotes faster recovery: By effectively treating the infection, it helps you recover sooner and return to your normal daily activities more comfortably.
Side effects of Xibact 500 mg/250 mg Injection
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Managing Medication-Triggered Thrombophlebitis (Inflammation of a vein): A Step-by-Step Guide:
  • If you have symptoms such as pain, swelling, redness, or warmth in your veins after taking medication, contact your doctor right once. Share information about your symptoms, medication regimen, and medical history.
  • Your doctor will then assess your medication regimen to determine if it's contributing to the thrombophlebitis. This assessment will help identify the best course of action to manage your condition and prevent further complications.
  • Your doctor may suggest certain diet and lifestyle changes to help manage your condition. This may include increasing your intake of foods rich in omega-3 fatty acids, staying hydrated, exercising regularly, and maintaining a healthy weight. Your doctor may also advise medications to reduce inflammation, prevent blood clots, or manage pain if necessary.
  • If your condition does not improve or persists, consult your doctor and report your condition. Your doctor will assess your progress, adjust your treatment plan if necessary, and provide appropriate advice to ensure the best possible outcome.
  • Chest pain may last for a while and needs immediate medical attention as it is a significant health issue to be attended to.
  • Take rest and refrain from doing physical activity for a while, and restart after a few days.
  • Try applying an ice pack to the strained area for at least 20 minutes thrice a day. Ice pack thus helps reduce inflammation.
  • Sit upright and maintain proper posture if there is persistent chest pain. • Use extra pillows to elevate your position and prop your chest up while sleeping.
  • Rest well; get enough sleep.
  • Wear comfortable layers of clothes and get to a warm place.
  • Drink warm fluids like coffee, tea or hot chocolate.
  • Warm up using a blanket or heating pad.
  • Painful urination can be reduced by drinking lots of water.
  • Don't hold urine, as it can worsen the pain during urination.
  • Try taking probiotics and eating garlic, which can help reduce painful urination.
  • Sleep well and give enough rest to your body.
  • Take a balanced diet and avoid bladder-irritating foods.
  • Quit smoking and intake of alcohol.
  • Practice yoga and meditation to improve inner strength and stay healthy.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Xibact 500 mg/250 mg Injection will be administered by the doctor or nurse in a healthcare setting.
  • Do not self-administer.

How Xibact 500 mg/250 mg Injection Works

Xibact 500 mg/250 mg Injection works through the combined action of two distinct components that target bacteria together. Cefotaxime: It is an antibiotic that acts by interfering with the construction of the bacterial cell wall, which is essential for the bacteria to survive. Without a strong wall, the bacterial cells swell and burst, clearing the infection from your body. Sulbactam: It mainly acts as a beta-lactamase inhibitor. Some bacteria produce enzymes called beta-lactamases that can break down certain antibiotics before they work. Sulbactam blocks these enzymes, helping protect cefotaxime from being destroyed and allowing it to work more effectively against susceptible bacteria. Although sulbactam has weak antibacterial activity on its own against some bacteria, its primary role in this combination is to inhibit beta-lactamase enzymes. Together, they provide broader protection against susceptible bacterial infections.
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Alcohol

Safe if prescribed

Xibact 500 mg/250 mg Injection may not interact with alcohol.

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Pregnancy

Safe if prescribed

Xibact 500 mg/250 mg Injection is a category B medicine and may not cause harmful effects to the unborn baby. So, it is probably safe when used in pregnant women, when prescribed by a doctor.

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Breast Feeding

Safe if prescribed

Xibact 500 mg/250 mg Injection is probably safe when used in breastfeeding mothers, when prescribed by a doctor.

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Driving

Caution

Xibact 500 mg/250 mg Injection may cause dizziness, so do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Xibact 500 mg/250 mg Injection should be used with caution in patients with liver diseases. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Xibact 500 mg/250 mg Injection should be used with caution in patients with kidney diseases. The dose may have to be adjusted by your doctor.

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Children

Safe if prescribed

Xibact 500 mg/250 mg Injection is probably safe when used in children. However, the doctor may have to adjust the dose based on age, body weight and health condition.

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Heart

Caution

Xibact 500 mg/250 mg Injection should be used with extreme caution due to the risk of cardiovascular problems. Please inform your physician if you have any concerns.

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Geriatrics

Safe if prescribed

Xibact 500 mg/250 mg Injection is safe for use in elderly patients if prescribed by the physician.

What if I have taken an overdose of Xibact 500 mg/250 mg Injection

If you suspect an overdose, seek emergency medical care immediately. Symptoms of receiving too much of this medicine can include muscle twitching, shivering, or seizures. Prompt medical attention is vital to manage these effects safely.

Diet & Lifestyle Advise

  • Replenish your gut bacteria: Antibiotics can disrupt the healthy microbes in your digestive system. Eating probiotic-rich foods like yoghurt or taking a high-quality probiotic supplement a few hours after your injection can help maintain a healthy gut.
  • Increase fluid intake: Drink plenty of water throughout the day. This supports your kidneys as they filter and remove the medication from your bloodstream.
  • Prioritise restful sleep: Your body needs significant energy to fight off severe infections. Ensure you get 7 to 8 hours of sleep each night to assist your immune system.
  • Eat clean, simple foods: Avoid heavy, greasy, or highly spiced meals if you experience mild nausea from the injections. Stick to bland, nutrient-dense foods to keep your strength up.
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How Soon It Starts Working

The time required for Xibact 500 mg/250 mg Injection to start to work: The time required for Xibact 500 mg/250 mg Injection to show its action is unknown. The time for which the effects of Xibact 500 mg/250 mg Injection last: The duration of action for Xibact 500 mg/250 mg Injection is clinically unknown.

What if you forget to take Xibact 500 mg/250 mg Injection

Since this medication is usually injected by a medical professional, missing a dose is highly unlikely. If you are injecting this medicine at home and miss a dose, inject it as soon as you remember. However, if it is almost time for your next scheduled injection, skip the missed dose and resume your regular schedule. Do not inject a double dose to make up for a missed one.

Storage

•Store the dry powder vials of Xibact 500 mg/250 mg Injection at controlled room temperature, safely between 20°C to 25°C (68°F to 77°F). •Keep the medicine in its original outer carton to protect the vials from direct sunlight and moisture.

Drug Warnings

  • Check the medicine before use: Make sure the solution is clear before each injection. Do not use it if it has changed colour or contains particles.
  • Rotate injection sites: If you are receiving injections into a muscle, use a different injection site each time. This helps reduce pain, swelling, and scarring.
  • Use new injection supplies: Never reuse needles, syringes, or IV tubing. Dispose of used sharps safely in a puncture-proof container.
  • Watch for allergic reactions: Contact your doctor immediately if you develop a rash, hives, or severe itching during treatment. These may be signs of an allergic reaction.
  • Do not share your medicine: Never share Xibact 500 mg/250 mg Injection with anyone else, even if they have similar symptoms. It should only be used by the person for whom it was prescribed.

Drug-Drug Interactions

verifiedApollotooltip
  • Water pills (e.g., furosemide): Combining these medicines with Xibact 500 mg/250 mg Injection may increase the risk of experiencing kidney damage.
  • Gout medicines (e.g., probenecid): These medicines can delay the removal of Xibact 500 mg/250 mg Injection from your body, leading to higher levels of the antibiotic in your blood.
  • Live bacterial vaccines (e.g., oral typhoid vaccine): Xibact 500 mg/250 mg Injection can kill the active bacteria in the vaccine, rendering it less effective.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant interactions with food or drinks are known because Xibact 500 mg/250 mg Injection is given by injection.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIBIOTICS]

FAQs

Xibact 500 mg/250 mg Injection is used to treat bacterial infections.
Xibact 500 mg/250 mg Injection contains Cefotaxime and Sulbactam. Cefotaxime reduces the infection by inhibiting bacterial growth. It disrupts the formation of the cell wall (outer layer), which is essential for bacteria's survival. Sulbactam inhibits the action of beta-lactamase, an enzyme produced by the bacteria to destroy antibiotics (cefotaxime).
People allergic to penicillin should not take Xibact 500 mg/250 mg Injection as they may develop cross-sensitivity (sensitivity to drugs with similar structures). Xibact 500 mg/250 mg Injection contains cefotaxime, which has a similar structure to that of penicillin.
The common side-effects of Xibact 500 mg/250 mg Injection are pain and swelling at the injection site, skin rash, diarrhoea, nausea, and vomiting. These side-effects usually don't require medical attention. However, inform your doctor immediately if any of these side-effects persist or get worse.
In individuals who have kidney problems, have diabetes and are on a low-salt diet, Xibact 500 mg/250 mg Injection should be used with caution as this medicine may worsen the condition.
It is advised to let your doctor know that you are taking Xibact 500 mg/250 mg Injection before undergoing any laboratory tests or having a blood transfusion. Xibact 500 mg/250 mg Injection may cause dizziness, so do not drive or operate heavy machinery if you feel dizzy.
Xibact 500 mg/250 mg Injection may cause diarrhoea in some cases. Consult the doctor if you experience diarrhoea during treatment with Xibact 500 mg/250 mg Injection.
Xibact 500 mg/250 mg Injection starts working almost immediately after administering. However, it might take a few days to notice its full effects. To treat your condition effectively complete the duration of treatment.
Consult the doctor if you do not get better or if your condition persists even after completing the duration of treatment with Xibact 500 mg/250 mg Injection.
The common side effects of Xibact 500 mg/250 mg Injection are pain and swelling at the injection site, skin rash, diarrhoea, nausea and vomiting. These side effects are usually mild and temporary. However, if any of these side effects persist or worsen, inform your doctor immediately.
It is generally best to avoid alcohol while receiving Xibact 500 mg/250 mg Injection. Alcohol may worsen dehydration, increase certain side effects such as dizziness or stomach upset, and may slow your overall recovery from a serious infection. Although cefotaxime is not commonly associated with the disulfiram-like reaction seen with some other cephalosporins, you should still consult your doctor about alcohol use during treatment.
This medication should only be used during pregnancy if it is absolutely necessary and prescribed by a specialist. Your healthcare provider will weigh the benefits of treating the infection against any potential risks to your developing baby. Talk to your doctor if you are pregnant or planning a pregnancy.
No, Xibact 500 mg/250 mg Injection is strictly an antibiotic designed to fight bacterial infections. It has no effect on viruses, which cause colds, flu, or bronchitis. Talk to your doctor for an accurate diagnosis of your symptoms.
Stopping your treatment early, even if you feel completely better, can allow the strongest bacteria to survive and become resistant to antibiotics. This can cause the infection to return and make it much harder to treat in the future. Talk to your doctor or pharmacist if you have concerns about your treatment duration.
While mild soreness is expected, a site that becomes increasingly red, swollen, hot to the touch, or painful could indicate a localised reaction or a new infection. You should contact your doctor or nurse immediately to have the site evaluated. Talk to your doctor.
Yes, taking probiotics can help restore the natural balance of bacteria in your gut. To prevent the antibiotic from destroying the beneficial probiotics, space them out by at least 2 hours from your injection. Talk to your doctor or pharmacist for specific product recommendations.
Yes, because antibiotics kill both bad and good bacteria, they can allow naturally occurring yeast to grow out of control. This can lead to oral thrush or vaginal yeast infections during or after your treatment. Talk to your doctor if you notice white spots in your mouth or experience vaginal itching.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

205, P N Kothari Industrial Estate, L B S Marg, Bhandup(W), Mumbai - 400078
Other Info - XI69541
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