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compositionComposition:MIDODRINE-2.5MG
prescription
Prescription Medicine
info
XIDORIN 2.5MG TAB, 20'S
XIDORIN 2.5MG TAB, 20'S
XIDORIN 2.5MG TAB, 20'S
XIDORIN 2.5MG TAB, 20'S
XIDORIN 2.5MG TAB, 20'S

XIDORIN 2.5MG TAB is used to treat orthostatic hypotension (sudden lowering in blood pressure on standing). It contains midodrine, which works by tightening the blood vessels, thereby increasing blood pressure. In some cases, this medicine may cause side effects such as headache, nausea, heartburn, and pain during urination. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

MIDODRINE-2.5MG

Manufacturer/Marketer :

Sigmund Promedica

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About XIDORIN 2.5MG TAB

XIDORIN 2.5MG TAB belongs to a group of medicines called antihypotensives, which are used to treat low blood pressure (hypotension). Low blood pressure is when blood flow drops below normal, which can cause dizziness, weakness, fainting, and increase the risk of falls.

XIDORIN 2.5MG TAB contains midodrine hydrochloride, which works on blood vessels through the nervous system to improve blood flow. This helps relieve symptoms like dizziness, fainting, blurred vision, and weakness when sitting or standing up.

Some people may experience supine hypertension, reflex bradycardia, arrhythmias, rash, nausea, vomiting, dyspepsia, headache, and urinary retention. Most of these side effects of XIDORIN 2.5MG TAB do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

XIDORIN 2.5MG TAB is contraindicated in patients with severe organic heart disease, congestive heart failure, thyrotoxicosis, phaeochromocytoma, acute renal disease, severe renal insufficiency, urinary retention, narrow-angle glaucoma, hyperthyroidism, or known hypersensitivity to any component of the product. Inform your doctor if you are a pregnant woman or nursing mother.

Uses of XIDORIN 2.5MG TAB

XIDORIN 2.5MG TAB is used to treat low blood pressure conditions. The detailed uses of XIDORIN 2.5MG TAB include:

  • Treatment of idiopathic postural hypotension: XIDORIN 2.5MG TAB helps raise blood pressure in individuals who experience a sudden drop in blood pressure upon standing (orthostatic hypotension) without a known cause.
  • Management of general hypotension: It is used to treat persistent low blood pressure that may lead to dizziness, fainting, or fatigue, by constricting blood vessels and improving blood flow.

Key Benefits

  • XIDORIN 2.5MG TAB contains midodrine hydrochloride, which acts on the blood vessels via the sympathetic nervous system to correct imbalances of blood distribution. 
  • XIDORIN 2.5MG TAB helps to prevent symptoms like weakness, blurred vision, and fatigue caused by sudden drops in blood pressure.
  • Supports better daily functioning and safety by reducing the risk of falls related to low blood pressure.

Directions for Use

  • XIDORIN 2.5MG TAB can be taken with meals.
  • It is usually taken 2-3 times daily during the daytime, with each dose taken 3 hours apart, or as prescribed by your doctor.
  • Swallow XIDORIN 2.5MG TAB as a whole with a glass of water.
  • Do not crush, chew, or break it.

How XIDORIN 2.5MG TAB Works

XIDORIN 2.5MG TAB contains the active ingredient midodrine hydrochloride, which acts on the blood vessels via the sympathetic nervous system to correct imbalances of blood distribution. This should help relieve the symptoms you might suffer, such as dizziness, fainting, blurred vision, and weakness when sitting or standing up.
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Alcohol

Unsafe

Consuming alcohol along with XIDORIN 2.5MG TAB is not advisable as it may cause unpleasant side effects.

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Pregnancy

Consult your doctor

Please consult the doctor. There are no adequate and well-controlled studies on pregnant women.

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Breast Feeding

Consult your doctor

Consult your doctor, and there is no substantial research yet on the use of XIDORIN 2.5MG TAB in breastfeeding/nursing mothers.

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Driving

Unsafe

If you feel dizzy or lightheaded while taking XIDORIN 2.5MG TAB, avoid driving or using machines.

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Liver

Consult your doctor

Limited information is available on the use of XIDORIN 2.5MG TAB in patients with liver disease. Please consult your doctor.

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Kidney

Consult your doctor

Limited information is available on the use of XIDORIN 2.5MG TAB in patients with Kidney disease. Please consult your doctor.

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Children

Unsafe

XIDORIN 2.5MG TAB is not recommended for children below 18 years of age.

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Heart

Unsafe

XIDORIN 2.5MG TAB is contraindicated in patients with heart conditions. Please seek medical advice before using this medicine.

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Geriatrics

Caution

XIDORIN 2.5MG TAB should be given to elderly patients only if prescribed by a doctor. If you have any concerns about using XIDORIN 2.5MG TAB in geriatrics, please consult your doctor.

What if I have taken an overdose of XIDORIN 2.5MG TAB

Take XIDORIN 2.5MG TAB only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to serious side effects such as palpitations, headache, pounding in the ears, goose bumps, blurred vision, difficulty urinating, and cold sensation. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Diet & Lifestyle Advise

  • Add foods with high vitamin B12, including eggs, fortified cereals, and nutritional yeast, to your daily diet.
  • Salty foods can increase blood pressure. Try eating canned soup, cottage cheese, olives, and pickled items.
  • Drink coffee and caffeinated tea, which may increase blood pressure by stimulating the cardiovascular system.
  • Eat small meals more frequently; large meals may drop in blood pressure as your body works harder to digest larger meals.
  • Drink more water and limit alcohol; dehydration lowers blood pressure.
  • Change body position by standing up slowly.
  • Avoid prolonged bed rest.
  • If you exercise outdoors in extreme heat, take frequent breaks.
  • Avoid spending a long time in saunas, hot tubs, and steam rooms, which cause dehydration.

Have a query?

How Soon It Starts Working

  • The time required for XIDORIN 2.5MG TAB to start to work: The time required for XIDORIN 2.5MG TAB to show its action is unknown. 
  • The time for which the effects of XIDORIN 2.5MG TAB last: XIDORIN 2.5MG TAB effect lasts for 24 hours.

What if you forget to take XIDORIN 2.5MG TAB

Take the missed dose as soon as you remember, provided it is at least 4 hours before bedtime. However, if it is time for your next dose, skip the missed dose and follow your regular dosing schedule. Do not take a double dose to make up for the missed dose.

Storage

• Store in a cool and dry place away from sunlight.• Keep XIDORIN 2.5MG TAB out of the sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • If you are known to be allergic to XIDORIN 2.5MG TAB or any other medicines, please tell your doctor.
  • If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.
  • XIDORIN 2.5MG TAB should not be used by children below 18 years.
  • XIDORIN 2.5MG TAB is contraindicated in patients with severe organic heart disease, congestive heart failure, thyrotoxicosis, pheochromocytoma, acute renal disease, severe renal insufficiency, urinary retention, narrow-angle glaucoma, and hyperthyroidism.
  • Inform your doctor if you have a history of stroke (CVA); close monitoring may be needed.
  • Avoid driving or operating heavy machinery if you feel dizzy or lightheaded.
  • Do not stop taking XIDORIN 2.5MG TAB suddenly without consulting your doctor.
  • XIDORIN 2.5MG TAB can cause high blood pressure when lying down, so regular blood pressure checks are important.

Drug-Drug Interactions

verifiedApollotooltip

Drug-drug interactions: XIDORIN 2.5MG TAB may interact with drugs used to treat depression and anxiety (e.g. duloxetine), medicines used to help control the amount of sodium and fluids in your body (e.g. fludrocortisone), and medications used to treat high blood pressure (e.g. metoprolol).

Drug-food interactions: Consuming alcohol with XIDORIN 2.5MG TAB is not advisable as it may cause unpleasant side effects.

Drug-disease interactions: XIDORIN 2.5MG TAB should be used with caution in patients with heart disease/ hypertensive effects, kidney or liver dysfunction and diabetes.

MidodrineDihydroergotamine
Critical
MidodrineLinezolid
Severe

Drug-Drug Interactions

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MidodrineDihydroergotamine
Critical
How does the drug interact with Xidorin 2.5mg Tab,:
Coadministration of Dihydroergotamine with Xidorin 2.5mg Tab, can increase the risk or severity of high blood pressure.

How to manage the interaction:
Taking Dihydroergotamine with Xidorin 2.5mg Tab, together is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you notice any of these symptoms like headaches, abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discolouration of fingers or toes, pale or cold skin, chest pain or tightness, severe or throbbing headache, irregular heartbeat, shortness of breath, blurred vision, eye redness, confusion, or slurred speech, consult a doctor right away. Do not discontinue any medications without consulting a doctor.
MidodrineLinezolid
Severe
How does the drug interact with Xidorin 2.5mg Tab,:
Taking Xidorin 2.5mg Tab, along with linezolid could increase the risk or severity of high blood pressure.

How to manage the interaction:
Although taking linezolid with Xidorin 2.5mg Tab, together can result in an interaction, they can be taken if a doctor has prescribed it. However, if you experience abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discoloration of fingers or toes, pale or cold skin, chest pain or tightness, severe or throbbing headache, irregular heartbeat, shortness of breath, blurred vision, confusion, and/or slurred speech, contact a doctor immediately. Do not discontinue any medication without consulting a doctor.
MidodrineDoxapram
Severe
How does the drug interact with Xidorin 2.5mg Tab,:
Coadministration of Xidorin 2.5mg Tab, with doxapram can increase effect of Doxapram.

How to manage the interaction:
Taking Doxapram with Xidorin 2.5mg Tab, together can result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.
MidodrineErgotamine
Severe
How does the drug interact with Xidorin 2.5mg Tab,:
Using ergotamine together with Xidorin 2.5mg Tab, can increase the risk or severity of high blood pressure.

How to manage the interaction:
There may be a possibility of interaction between Xidorin 2.5mg Tab, and Ergotamine, but it can be taken if prescribed by a doctor. If you're having any of these symptoms like abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discolouration of fingers or toes, pale or cold skin, chest pain or tightness, severe or throbbing headache, irregular heartbeat, shortness of breath, blurred vision, confusion, and/or slurred speech, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
MidodrineMethysergide
Severe
How does the drug interact with Xidorin 2.5mg Tab,:
Using methysergide maleate together with Xidorin 2.5mg Tab, may cause significant increases in blood pressure.

How to manage the interaction:
Co-administration of Xidorin 2.5mg Tab, with Methysergide can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discolouration of fingers or toes, pale or cold skin, chest pain or tightness, severe or throbbing headache, irregular heartbeat, shortness of breath, blurred vision, confusion, and/or slurred speech, contact a doctor immediately. Do not discontinue any medications without first consulting a doctor.
MidodrineIobenguane (131i)
Severe
How does the drug interact with Xidorin 2.5mg Tab,:
Coadministration of Xidorin 2.5mg Tab, with Iobenguane can cause a decrease in the absorption of Iobenguane resulting in a low treatment outcomes.

How to manage the interaction:
Co-administration of Xidorin 2.5mg Tab, with Iobenguane (131i) can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIHYPOTENSIVES]

FAQs

XIDORIN 2.5MG TAB is used to treat idiopathic postural hypotension or hypotension (low blood pressure)
XIDORIN 2.5MG TAB contains the active ingredient midodrine hydrochloride, which acts on the blood vessels via the sympathetic nervous system to correct imbalances of blood distribution. This should help relieve the symptoms you might suffer, such as dizziness, fainting, blurred vision, and weakness when sitting or standing up.
Do not stop taking XIDORIN 2.5MG TAB on your own. Depending on your medical condition, you are advised to take XIDORIN 2.5MG TAB for as long as your doctor has prescribed it for you. Do not hesitate to speak with your doctor if you experience difficulty while taking XIDORIN 2.5MG TAB.
XIDORIN 2.5MG TAB is contraindicated in patients with severe organic heart disease, congestive heart failure, thyrotoxicosis, phaeochromocytoma, acute renal disease, severe renal insufficiency, urinary retention, narrow-angle glaucoma, hyperthyroidism, known hypersensitivity to any component of the product. And also, Patients with a history of CVA should be monitored closely.
XIDORIN 2.5MG TAB is metabolised to desglymidodrine, an active metabolite that activates alpha-1-adrenergic receptors on arterioles and venules, causing smooth muscle contraction and blood pressure increase. Midodrine may cause a drop in heart rate due to the vagal reflex.
The side effects of XIDORIN 2.5MG TAB include nausea, vomiting, indigestion, supine hypertension (high blood pressure while lying down), and dysuria (painful or uncomfortable urination). If these side effects persist or worsen, please consult your doctor.
Yes, XIDORIN 2.5MG TAB may cause high blood pressure when you are lying flat on your back (supine hypertension). XIDORIN 2.5MG TAB should only be used by people whose low blood pressure affects their daily activities and in people who could not be treated successfully with other therapies.
You are advised not to lie down immediately after taking XIDORIN 2.5MG TAB due to the risk of supine hypertension (high blood pressure when you are lying flat on your back). Therefore, it is recommended to take the final dose of the day at least 4 hours before bedtime. By elevating the head, you can reduce the risk of supine hypertension during the night.
XIDORIN 2.5MG TAB may take about 1 hour to show its effects. Though the effect lasts for about 2-3 hours, the action lasts for a short time only.
Take XIDORIN 2.5MG TAB exactly as advised by your doctor. It is taken orally with or without food. Swallow it as a whole with a glass of water. Do not break, crush or chew it.
XIDORIN 2.5MG TAB is not recommended for patients who are allergic to any of its components, who have unusually slow heart rate, severe heart disease, high blood pressure, conditions causing tightening of the arteries, urinary retention (when the bladder cannot empty properly), overactive thyroid, enlarged prostate gland, pheochromocytoma (tumour of the adrenal medulla), acute or severe kidney disease, poor vision as a result of diabetes and narrow-angle glaucoma (elevated pressure in the eye).
Before starting XIDORIN 2.5MG TAB, you may need to get your liver and kidney function tests done and check your blood pressure. After starting the treatment, keep a constant track of your heart rate and blood pressure, especially after lying down.
Symptoms of supine hypertension include shortness of breath, chest pain, palpitations (abnormalities of heartbeat), blurred vision, and headache. If you develop these symptoms, consult your doctor immediately. The doctor may lower the dose of XIDORIN 2.5MG TAB or discontinue treatment if the symptoms persists.
You should be cautious while using XIDORIN 2.5MG TAB and metoprolol together as it can decrease your heart rate significantly. If you experience dizziness, fainting and slow pulse, inform your doctor as the dose of these medicines may need to be adjusted. However, please consult your doctor before using other medicines with XIDORIN 2.5MG TAB.

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Reference

  1. National Health Service (NHS). Midodrine Information Leaflet - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026] Check here
  2. Electronic Medicines Compendium (EMC). Product Summary of Product Characteristics (SmPC). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  3. Electronic Medicines Compendium (EMC). Pil.12496 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  4. Drugs.com Clinical Review Team. Midodrine Drug Interactions Reference. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  5. Midodrine hydrochloride [Product Information]. 2023. [Accessed on 05 Mar. 2025] Check here
  6. Midodrine Hydrochloride [Product Information]. 2024. [Accessed on 05 Mar. 2025] Check here
  7. Midodrine 2.5 Tablets - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 13 June 2025]Check here

Country of origin

India

Manufacturer/Marketer address

Karl Marx Rd, Moghalrajpuram, Sitharamapuram, Vijayawada, Andhra Pradesh 520002
Other Info - XID0002

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