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Xone SB 250 Injection is used to treat bacterial infections. It contains Ceftriaxone and Sulbactam which work by inhibiting the growth of infection-causing bacteria. In some cases, this medicine may cause side effects such as pain and swelling at the injection site, skin rash, diarrhoea, nausea, vomiting and black/tarry stools. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Xone SB 250 Injection

Xone SB 250 Injection is a prescription-only injectable antibiotic combination used under the supervision of a qualified healthcare professional to treat severe bacterial infections throughout the body. It is commonly used for serious infections such as lung infections, abdominal infections, urinary tract infections, skin and soft tissue infections, bone infections, and meningitis. This medicine works by targeting and clearing the harmful bacteria responsible for these conditions.

Since Xone SB 250 Injection is an injectable antibiotic, it is usually administered once or twice daily depending on the severity of the infection and your doctor's treatment plan. It is critical to receive this medication consistently and complete the entire course exactly as prescribed, even if you begin to feel better. Because it is given as an injection, food intake does not affect how it works, but maintaining a balanced diet and drinking plenty of water will support your body's recovery.

While taking Xone SB 250 Injection, you may experience mild side effects such as redness at the injection site or temporary diarrhea. However, you must contact your doctor immediately if you experience severe watery diarrhea, unusual bleeding, or yellowing of your skin or eyes.

Talk to your doctor before starting Xone SB 250 Injection if you have a history of kidney disease, liver disease, or gallbladder problems. Do not take this medicine if you have had a severe allergic reaction to cephalosporin or penicillin antibiotics in the past.

Let your doctor know about all other medications you are taking, as Xone SB 250 Injection can interact with certain blood thinners and calcium-containing fluids. It is also important to consult your healthcare provider if you are pregnant, breastfeeding, or managing health conditions in elderly individuals before starting treatment.

Uses of Xone SB 250 Injection

This medicine is an antibiotic combination used to treat a wide range of serious bacterial infections. It works by eliminating harmful bacteria and helping the body recover from infection. The detailed uses of Xone SB 250 Injection are as follows: 

  • Severe lung infections (pneumonia): Xone SB 250 Injection helps by clearing deep bacterial infections in the chest, making breathing easier and reducing fever.
  • Meningitis: Xone SB 250 Injection helps by crossing into the central nervous system to eliminate bacterial infections affecting the brain and spinal cord.
  • Abdominal infections: Xone SB 250 Injection helps by treating complex infections inside the stomach or intestines, preventing the spread of bacteria.
  • Urinary tract infections (UTIs): Xone SB 250 Injection helps by targeting and clearing severe, complicated infections in the kidneys and bladder.
  • Skin and soft tissue infections: Xone SB 250 Injection helps by resolving deep-seated bacterial skin infections and preventing tissue damage.
  • Bone and joint infections: Xone SB 250 Injection helps by penetrating bone tissues to eliminate stubborn bacterial growth.

Key Benefits

This medicine provides fast and effective treatment for serious bacterial infections by directly targeting and eliminating harmful bacteria. Its benefits include:

  • Reaches the site of infection quickly when given by injection, allowing faster action against bacteria.
  • Helps reduce severe infection symptoms such as high fever, body pain, and extreme weakness.
  • Works through two complementary mechanisms to improve bacterial clearance.
  • Helps treat infections caused by bacteria that may be resistant to some other antibiotics.
  • Prevents the infection from spreading further into deeper tissues and organs.
  • Supports a faster and more complete recovery from severe bacterial infections.
Side effects of Xone SB 250 Injection
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Managing Medication-Triggered Thrombophlebitis (Inflammation of a vein): A Step-by-Step Guide:
  • If you have symptoms such as pain, swelling, redness, or warmth in your veins after taking medication, contact your doctor right once. Share information about your symptoms, medication regimen, and medical history.
  • Your doctor will then assess your medication regimen to determine if it's contributing to the thrombophlebitis. This assessment will help identify the best course of action to manage your condition and prevent further complications.
  • Your doctor may suggest certain diet and lifestyle changes to help manage your condition. This may include increasing your intake of foods rich in omega-3 fatty acids, staying hydrated, exercising regularly, and maintaining a healthy weight. Your doctor may also advise medications to reduce inflammation, prevent blood clots, or manage pain if necessary.
  • If your condition does not improve or persists, consult your doctor and report your condition. Your doctor will assess your progress, adjust your treatment plan if necessary, and provide appropriate advice to ensure the best possible outcome.
  • Chest pain may last for a while and needs immediate medical attention as it is a significant health issue to be attended to.
  • Take rest and refrain from doing physical activity for a while, and restart after a few days.
  • Try applying an ice pack to the strained area for at least 20 minutes thrice a day. Ice pack thus helps reduce inflammation.
  • Sit upright and maintain proper posture if there is persistent chest pain. • Use extra pillows to elevate your position and prop your chest up while sleeping.
  • Rest well; get enough sleep.
  • Wear comfortable layers of clothes and get to a warm place.
  • Drink warm fluids like coffee, tea or hot chocolate.
  • Warm up using a blanket or heating pad.
  • Painful urination can be reduced by drinking lots of water.
  • Don't hold urine, as it can worsen the pain during urination.
  • Try taking probiotics and eating garlic, which can help reduce painful urination.
  • Sleep well and give enough rest to your body.
  • Take a balanced diet and avoid bladder-irritating foods.
  • Quit smoking and intake of alcohol.
  • Practice yoga and meditation to improve inner strength and stay healthy.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Xone SB 250 Injection will be administered by the doctor or nurse in a healthcare setting.
  • Do not self-administer.

How Xone SB 250 Injection Works

Xone SB 250 Injection contains Ceftriaxone and Sulbactam. Ceftriaxone: It is an antibiotic that blocks the formation of the bacterial cell wall. This weakens the protective structure of bacteria, causing them to break down and die, which helps stop the infection from spreading. Sulbactam: It acts as a protective agent that blocks beta-lactamase enzymes produced by some bacteria. By preventing these enzymes from breaking down the antibiotic, sulbactam helps ceftriaxone work effectively against resistant bacteria.
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Alcohol

Caution

It is advisable to avoid alcohol consumption to prevent unintended side effects.

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Pregnancy

Caution

Xone SB 250 Injection is not recommended for use in pregnancy unless absolutely necessary. Inform your doctor if you are pregnant. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

Xone SB 250 Injection is not recommended for use in breastfeeding unless absolutely necessary. Inform your doctor if you are breastfeeding. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Caution

Xone SB 250 Injection may decrease your alertness and vision or make you sleepy and dizzy. Do not drive if these symptoms occur after receiving this medicine.

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Liver

Caution

Xone SB 250 Injection should be used with caution if you have liver function impairment due to the increased risk of worsening your condition. Regular monitoring of liver function tests, appropriate dose adjustments or replacement with a suitable alternative medicine may be required in some cases based on your clinical condition.

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Kidney

Caution

Xone SB 250 Injection should be used with caution if you have a history of renal function impairment due to the increased risk of severe side effects. Close monitoring of kidney function, appropriate dose adjustments or replacement with alternative medicine may be required in some cases based on your clinical condition.

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Children

Caution

Xone SB 250 Injection is probably safe when used in children. However, your doctor may adjust the dose based on age, body weight and health condition of your child.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using Xone SB 250 Injection. Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Limited information available for use of Xone SB 250 Injection in elderly patients. Please consult your doctor.

What if I have taken an overdose of Xone SB 250 Injection

Because this medicine is typically injected by a healthcare professional, an overdose is rare. However, if you suspect an overdose or experience severe symptoms like seizures, difficulty breathing, or severe muscle spasms, seek immediate emergency medical care.

Diet & Lifestyle Advise

  • Stay hydrated: Drink plenty of water and clear broths to help your body process the medication and recover more quickly from the infection.
  • Replenish gut bacteria: Antibiotics can disrupt your natural gut flora. Consider taking a high-quality probiotic supplement or eating yogurt with active cultures a few hours after your injection to support gut health.
  • Get sufficient rest: Allow your body to rest fully during treatment. Avoid heavy physical exertion, as your immune system requires energy to fight the infection.
  • Eat nutrient-dense foods: Focus on meals rich in vitamins C and zinc, such as citrus fruits, leafy greens, and lean proteins, to support your immune defense and tissue repair.
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How Soon It Starts Working

The time required for Xone SB 250 Injection to start to work: Xone SB 250 Injection starts to show its action immediately after administration. The time for which the effects of Xone SB 250 Injection last: The duration of action for Xone SB 250 Injection is clinically unknown.

What if you forget to take Xone SB 250 Injection

If you miss a dose of Xone SB 250 Injection, contact your doctor or nurse right away to find out when you should receive your next injection. Do not inject a double dose to make up for a missed one.

Storage

• Store the dry, unmixed vials of Xone SB 250 Injection at room temperature, between 20°C to 25°C (68°F to 77°F).

Drug Warnings

  • Check the Vial Before Use: Always check the liquid vial before injecting. Discard it immediately if the solution is cloudy, discolored, or contains visible particles.
  • Rotate Injection Sites: If the medicine is injected into a muscle, rotate the injection sites each time to reduce soreness and protect the tissue.
  • Use New Needles and Syringes: Never reuse needles or syringes, as this can increase the risk of serious bloodstream infections or skin abscesses.
  • Avoid Calcium-Containing IV Fluids: Avoid using IV fluids containing calcium through the same line as Xone SB 250 Injection, as this may cause harmful particles to form in the veins.
  • Newborn Safety: CEFTRIAXONE should not be used in newborns who require calcium-containing intravenous fluids because of the risk of dangerous deposits forming in the bloodstream, lungs, or kidneys. Always inform the paediatrician about all fluids and medicines being given to a newborn.
  • Inform About Urine Tests: Inform your laboratory technician or doctor that you are using Xone SB 250 Injection before urine tests, as it may cause false-positive results for glucose in urine.

Drug-Drug Interactions

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  • Calcium-containing IV fluids: CEFTRIAXONE can react with calcium-containing solutions and form harmful crystalline deposits. This interaction is especially dangerous in newborn babies, where the combination is contraindicated because it may lead to serious complications affecting the lungs and kidneys. Inform your doctor if calcium-containing intravenous fluids are being used during treatment.
  • Blood thinners (like warfarin): May increase the risk of bleeding by enhancing the blood-thinning effects.
  • Live vaccines (like oral typhoid vaccine): May decrease the effectiveness of the vaccine by killing the active bacteria.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No clinically significant food interactions are known with Xone SB 250 Injection when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIBIOTICS]

FAQs

Xone SB 250 Injection is used to treat bacterial infections.
Xone SB 250 Injection contains Ceftriaxone and Sulbactam. Ceftriaxone reduces the infection by inhibiting bacterial growth. It disrupts the formation of the cell wall (outer layer), which is essential for bacteria's survival. Sulbactam inhibits the action of beta-lactamase, an enzyme bacteria produce to destroy antibiotics. Sulbactam enhances the activity of ceftriaxone.
Common side effects of Xone SB 250 Injection are pain and swelling at the injection site, skin rash, diarrhea, nausea, vomiting and black/tarry stools. These side effects are usually mild and temporary. However, if any of these side effects persist or worsen, inform your doctor immediately.
Xone SB 250 Injection should be avoided in conditions like gastrointestinal diseases, liver diseases, kidney diseases, seizure disorders, bleeding disorders, antibiotic resistance and bleeding disorders.
Do not stop taking Xone SB 250 Injection suddenly because your symptoms may improve before the infection is completely cured. Complete the full course of treatment even if you feel better.
People allergic to penicillin should not take Xone SB 250 Injection as they may develop cross-sensitivity (sensitivity to drugs with similar structures). Xone SB 250 Injection contains ceftriaxone, which has a similar structure to that of penicillin.
Xone SB 250 Injection may cause allergic reactions, such as skin rashes, swelling, difficulty breathing, or in rare cases, anaphylaxis (a severe, rapid allergic reaction). If you have a history of allergies to antibiotics, please inform your doctor before using Xone SB 250 Injection.
Xone SB 250 Injection may cause diarrhoea as a side effect. Like other antibiotics, it can disrupt the normal balance of bacteria in your gut. To help manage antibiotic-related diarrhoea, make sure to stay hydrated, consider taking probiotics, avoid dairy, and limit high-fibre foods. If diarrhoea is severe or persistent, please consult your doctor.
Xone SB 250 Injection usually starts working within a few hours after you take it. However, you will likely notice an improvement in your symptoms within the first few days of treatment, depending on the severity of the infection.
If you don't get better after using Xone SB 250 Injection, it could mean that the infection is resistant to the antibiotic or there might be complications. Please contact your doctor so they can assess your condition and adjust your treatment if needed. The doctor may test for antibiotic resistance, try a different antibiotic, or investigate other possible causes.
Yes, Xone SB 250 Injection can sometimes be injected at home if you or a caregiver have been properly trained by a healthcare professional. However, the first dose is typically given in a clinic to monitor for allergic reactions. Talk to your doctor.
Xone SB 250 Injection is generally used during pregnancy only when clearly needed and prescribed by a doctor. Your healthcare provider will weigh the benefits against any potential risks to the baby. Talk to your doctor.
While there is no direct chemical interaction between alcohol and Xone SB 250 Injection, it is highly recommended to avoid alcohol while recovering from a severe infection, as alcohol can weaken your immune system and slow down recovery. Talk to your doctor.
Stopping the treatment early can leave surviving, stronger bacteria behind. These bacteria can adapt, multiply, and become resistant to the antibiotic, causing the infection to return and making it much harder to treat next time. Talk to your doctor.
No, Xone SB 250 Injection should not be mixed or infused through the same IV line with other medications, particularly those containing calcium, as this can cause physical particles to form, which is dangerous. Talk to your doctor.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - XON0025
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