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compositionComposition:VINCRISTINE-1MG
prescription
Prescription Medicine
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Z-Cristin 1 mg/ml Injection is an anti-cancer drug used to treat various types of cancer such as cancer of the breast, pancreas, kidney, blood, bone and lung. It contains Vincristine, which stops the further growth and multiplication of the cancer cells. It may cause side effects such as hair loss, constipation, headache, tingling and numbness of feet and hand, stomach cramps, feeling tired or weak, back, bone, joint, or muscle pain, mouth irritation, or mouth sores.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

VINCRISTINE-1MG

Manufacturer/Marketer :

Zuvius Lifesciences Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Z-Cristin 1 mg/ml Injection

Z-Cristin 1 mg/ml Injection is an injection used as part of chemotherapy to treat various types of cancers, such as blood cancers and tumours in the lymph nodes. It works to stop abnormal cells from rapidly multiplying, which is key to managing these progressive conditions. Your medical team will determine if this medication is the right option for your specific diagnosis.


Because this medicine is given as a parenteral injection directly into a vein, it is administered on a highly structured schedule by a trained healthcare professional. Staying consistent with your clinical appointments is crucial for the treatment to work effectively. While undergoing therapy, making certain changes to your diet, such as drinking more fluids and eating fibre-rich foods, can help manage some of the challenges that come with this medicine.


While Z-Cristin 1 mg/ml Injection is highly effective, it can cause common side effects like temporary hair loss, mild nerve tingling, or stomach upset. It is very important to contact your doctor immediately if you notice more severe issues, such as sudden and severe constipation, difficulty walking, or pain at the site where the medicine was injected.


Before starting your treatment, it is vital to discuss your full medical history with your doctor, especially if you have a history of nerve disorders or liver damage. Do not take this if you have certain inherited nerve disorders, such as Charcot-Marie-Tooth syndrome, as this medicine can cause severe, irreversible nerve damage in these individuals.


Z-Cristin 1 mg/ml Injection can interact with several substances, including certain anti-seizure drugs and antifungals, which might change how well your treatments work or increase side effects. Always consult your doctor if you are pregnant, breastfeeding, or if the patient is an older adult, as specialised care plans may be required for these groups.

Uses of Z-Cristin 1 mg/ml Injection

Your doctor may prescribe Z-Cristin 1 mg/ml Injection for several serious conditions, often alongside other chemotherapy medications:

  • Acute Lymphocytic Leukaemia (ALL): Z-Cristin 1 mg/ml Injection helps stop the rapid growth of abnormal white blood cells in the bone marrow and blood.
  • Hodgkin's and Non-Hodgkin's Lymphoma: It targets and destroys cancerous cells in the lymphatic system to help bring the disease into remission.
  • Wilms' Tumour: This medicine is used to treat this specific type of kidney cancer that primarily occurs in children.
  • Neuroblastoma: It works to manage this nerve tissue cancer that typically starts in the adrenal glands.
  • Rhabdomyosarcoma: Z-Cristin 1 mg/ml Injection helps slow the growth of cancerous cells in the body's soft tissues, such as skeletal muscle.

Key Benefits

Z-Cristin 1 mg/ml Injection is a chemotherapy medicine used as part of treatment regimens for several types of cancer. It works by disrupting the process cancer cells need to divide and multiply, helping control disease progression.

  • Controls Cancer Cell Growth: Stops rapidly dividing cancer cells from completing cell division, which helps limit their growth and multiplication.
  • Supports Treatment of Different Cancers: Used in combination chemotherapy regimens for certain blood cancers and solid tumours, depending on the diagnosis and treatment plan.
  • Helps Reduce Cancer Burden: By controlling cancer cell multiplication, it may help shrink some tumours or reduce the number of cancer cells in the body.
  • Supports Remission: When used as part of an appropriate combination chemotherapy regimen, Z-Cristin 1 mg/ml Injection may contribute to achieving and maintaining remission in certain cancers. Treatment outcomes vary according to the cancer type, stage, overall health, and response to therapy.
  • Complements Combination Chemotherapy: Works through a different mechanism from many other anticancer medicines, allowing it to be combined with other treatments that target cancer cells in different ways.
Side effects of Z-Cristin 1 mg/ml Injection
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

Directions for Use

  • Follow your doctor’s recommendations on the dosage and timing of this medication to achieve optimal results.
  • Z-Cristin 1 mg/ml Injection will be administered by a healthcare professional.
  • Do not self-administer.

How Z-Cristin 1 mg/ml Injection Works

Z-Cristin 1 mg/ml Injection contains vincristine, an anticancer medicine that belongs to a class of drugs known as vinca alkaloids. It targets cells that are dividing rapidly, a key characteristic of cancer cells. Inside cells, there are tiny structural proteins called tubulin. These proteins join together to form a 'scaffold' known as microtubules that the cell needs to split and divide into two new cells. Z-Cristin 1 mg/ml Injection works by binding to these tubulin proteins and stopping the scaffold from forming. Without this structure, the cancer cell cannot complete its division process and eventually self-destructs. Because normal cells divide much more slowly than cancer cells, this treatment primarily impacts the rapidly dividing cancer cells.
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Alcohol

Caution

Avoid consumption of alcohol while taking Z-Cristin 1 mg/ml Injection as it may increase drowsiness.

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Pregnancy

Unsafe

Z-Cristin 1 mg/ml Injection is a pregnancy category D drug. It should not be used in pregnancy as it is known to cause fetal damage. Also, maintain a gap of 6 months between the last dose of Z-Cristin 1 mg/ml Injection and your next pregnancy.

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Breast Feeding

Unsafe

Z-Cristin 1 mg/ml Injection is known to pass through breast milk and it may cause harm to the baby. So, it is advised not to breastfeed while taking Z-Cristin 1 mg/ml Injection.

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Driving

Unsafe

Z-Cristin 1 mg/ml Injection may cause weakness, dizziness and drowsiness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

The safety and efficacy of Z-Cristin 1 mg/ml Injection are not known in children. It should be taken only if prescribed by a doctor.

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Heart

Unsafe

This medicine is not recommended for cardiac patients due to its adverse effects.

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Geriatrics

Caution

Z-Cristin 1 mg/ml Injection should be administered with caution in geriatric patients.

What if I have taken an overdose of Z-Cristin 1 mg/ml Injection

An overdose is highly unlikely because your medical team carefully calculates and administers the dose in a controlled medical environment. If you suspect an error has occurred or if you experience severe side effects immediately after your injection, tell your healthcare provider right away or seek emergency medical attention.

Diet & Lifestyle Advise

  • Prevent severe constipation: This medicine can significantly slow down your bowels. Eat a high-fibre diet rich in fruits, vegetables, and whole grains, and drink plenty of fluids daily. Ask your doctor if you should start a preventive stool softener.
  • Manage nerve sensitivity: Since this medicine can affect your nerves, be cautious when handling hot or sharp objects. Wear supportive, flat shoes to help maintain your balance if you experience numbness in your feet.
  • Protect against infections: Your body's defences may be lowered during treatment. Wash your hands frequently, avoid large crowds, and stay away from people who are actively sick. Avoid eating raw or undercooked foods.
  • Use gentle self-care products: Use a soft-bristled toothbrush to protect your gums from bleeding, and apply a mild moisturiser to care for sensitive skin.
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Have a query?

How Soon It Starts Working

The time required for Z-Cristin 1 mg/ml Injection to start to work: The time required for Z-Cristin 1 mg/ml Injection to show its action is unknown. The time for which the effects of Z-Cristin 1 mg/ml Injection last: The duration of action for Z-Cristin 1 mg/ml Injection is unknown.

What if you forget to take Z-Cristin 1 mg/ml Injection

Because this medicine is injected by a healthcare professional in a clinic, a missed dose is unlikely. However, if you miss an appointment for your scheduled injection, contact your clinic or doctor immediately to reschedule. Do not wait until your next scheduled visit to report the missed appointment.

Storage

•Under normal circumstances, Z-Cristin 1 mg/ml Injection is stored and prepared directly by the hospital or clinic pharmacy. •It must be stored in a refrigerator between 2°C and 8°C (36°F to 46°F).

Drug Warnings

  • Intravenous use only: This medicine must only be injected into a vein. Injection into the spinal fluid (intrathecal) is fatal and must never be done.
  • Monitor the injection site closely: Tell your nurse immediately if you feel any burning, stinging, or pain while the injection is being given. If the drug leaks outside the vein, it can cause severe tissue damage.
  • Track your bowel movements: Keep a daily log of your bowel movements. Notify your doctor right away if you go more than two days without a bowel movement or experience abdominal pain.
  • Report nerve changes early: Let your medical team know if you have trouble with fine tasks, like buttoning a shirt or picking up small items, as this could be an early sign of nerve damage.
  • Avoid live vaccines: Do not receive any live vaccines while undergoing treatment, as your weakened immune system may not react safely.

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines, as they may interact with Z-Cristin 1 mg/ml Injection:

  • Anti-seizure medications (like phenytoin): Z-Cristin 1 mg/ml Injection can lower the level of these medicines in your blood, which may increase your risk of having a seizure.
  • Antifungals (like itraconazole or ketoconazole): These medicines can slow down how your liver processes Z-Cristin 1 mg/ml Injection, increasing the drug's levels in your body and raising the risk of severe nerve damage.
  • Other chemotherapy drugs: Combining this medicine with other cancer treatments can increase the risk of low blood cell counts and nerve complications.
VincristineCladribine
Severe
VincristineCeritinib
Severe

Drug-Drug Interactions

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VincristineCladribine
Severe
How does the drug interact with Z-Cristin 1 mg/ml Injection:
Combining Cladribine with Z-Cristin 1 mg/ml Injection can increase the risk and severity of developing serious infections.

How to manage the interaction:
Although taking Cladribine and Z-Cristin 1 mg/ml Injection together can cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms, it's important to contact a doctor right away. These symptoms include infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you pee. Do not stop using any medications without a doctor's advice.
VincristineCeritinib
Severe
How does the drug interact with Z-Cristin 1 mg/ml Injection:
Taking Z-Cristin 1 mg/ml Injection with Ceritinib significantly increase the blood levels and effects of Z-Cristin 1 mg/ml Injection which may increase the risk of side effects.

How to manage the interaction:
There may be a possibility of interaction between Z-Cristin 1 mg/ml Injection and Ceritinib, but it can be taken if prescribed by a doctor. If you experience any of these symptoms constipation, abdominal pain or bloating, difficulty urinating, numbness or tingling in hands and feet, muscle weakness, difficulty walking, hearing loss, fits, unusual or excessive bleeding, easy bruising, paleness, weakness, fainting, infection, fever, chills, sore throat, call a doctor. Do not stop using any medications without talking to a doctor.
VincristineErythromycin
Severe
How does the drug interact with Z-Cristin 1 mg/ml Injection:
When Z-Cristin 1 mg/ml Injection is taken with Erythromycin, the amount of Z-Cristin 1 mg/ml Injection in the blood can increase.

How to manage the interaction:
Although taking Z-Cristin 1 mg/ml Injection and Erythromycin together can cause an interaction, it can be taken if your doctor has suggested it. If you're having any of these symptoms - like stomach pain, pain while urinating, or feeling weak - it's important to inform your doctor immediately. Do not stop using any medications without a doctor's advice.
VincristineClarithromycin
Severe
How does the drug interact with Z-Cristin 1 mg/ml Injection:
When Z-Cristin 1 mg/ml Injection is taken with Clarithromycin, it may increase the risk of side effects.

How to manage the interaction:
There may be a possibility of interaction between Clarithromycin and Z-Cristin 1 mg/ml Injection, but it can be taken if prescribed by a doctor. If you're having any of these symptoms like constipation, stomach pain, or difficulty peeing, it's important to let your doctor know. They can recommend other options that won't cause these problems. You should also contact your doctor right away if you notice any numbness, weakness, trouble walking, or hearing loss. Other symptoms like seizures, bleeding, fatigue, or fever should also be reported to your doctor. Do not stop using any medications without a doctor's advice.
VincristineEtanercept
Severe
How does the drug interact with Z-Cristin 1 mg/ml Injection:
When Etanercept is used with Z-Cristin 1 mg/ml Injection, the likelihood or severity of infection may increase.

How to manage the interaction:
Although there is a possible interaction between Etanercept and Z-Cristin 1 mg/ml Injection, you can take these medicines together if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
VincristineBaricitinib
Severe
How does the drug interact with Z-Cristin 1 mg/ml Injection:
Coadministration of Z-Cristin 1 mg/ml Injection with Baricitinib can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Baricitinib and Z-Cristin 1 mg/ml Injection together can cause an interaction, it can be taken if your doctor has suggested it. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate. Do not stop using any medications without a doctor's advice.
VincristineRitonavir
Severe
How does the drug interact with Z-Cristin 1 mg/ml Injection:
Taking Ritonavir and Z-Cristin 1 mg/ml Injection may significantly increase the blood levels and effects of Z-Cristin 1 mg/ml Injection.

How to manage the interaction:
Although there is a possible interaction between Z-Cristin 1 mg/ml Injection and Ritonavir, you can take these medicines together if prescribed by your doctor. However, if you experience constipation, abdominal pain or bloating, difficulty urinating, numbness or tingling in hands and feet, muscle weakness, difficulty walking, hearing loss, fits, unusual or excessive bleeding, easy bruising, paleness, tiredness, fainting, infection, fever, chills, sore throat contact a doctor. Do not stop using any medications without a doctor's advice.
VincristineThalidomide
Severe
How does the drug interact with Z-Cristin 1 mg/ml Injection:
Taking thalidomide together with Z-Cristin 1 mg/ml Injection may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Z-Cristin 1 mg/ml Injection together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
VincristineClozapine
Severe
How does the drug interact with Z-Cristin 1 mg/ml Injection:
When Z-Cristin 1 mg/ml Injection and Clozapine are taken together, can increase the effect of Z-Cristin 1 mg/ml Injection.

How to manage the interaction:
Taking Clozapine with Z-Cristin 1 mg/ml Injection together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you're having any of these symptoms like fever, chills, sore throat, or muscle aches, it's important to contact your doctor right away. They may be able to recommend other options for you that won't cause any problems. Don't worry, there are solutions available to help you feel better. Do not stop using any medications without first talking to your doctor.
VincristineVoriconazole
Severe
How does the drug interact with Z-Cristin 1 mg/ml Injection:
Using Z-Cristin 1 mg/ml Injection together with voriconazole may significantly increase the blood levels and effects of Z-Cristin 1 mg/ml Injection.

How to manage the interaction:
Although taking Voriconazole and Z-Cristin 1 mg/ml Injection together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience abdominal pain, difficulty urinating, hearing loss, fever contact a doctor right away. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip

Certain foods and drinks may affect how Z-Cristin 1 mg/ml Injection is processed by the body and increase the risk of side effects. Important interactions include:

  • Grapefruit and grapefruit juice: Grapefruit can interfere with how your body breaks down Z-Cristin 1 mg/ml Injection, which can lead to higher levels of the drug in your body and worse side effects.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Z-Cristin 1 mg/ml Injection is used to treat various types of cancer. It is used to treat cancer of the breast, pancreas, kidney, blood, bone, lung.
Z-Cristin 1 mg/ml Injection contains Vincristine, which works by blocking DNAÂ replication (genetic material) in the cancer cells. Hence, this stops the further growth and multiplication of the cancer cells.Â
Z-Cristin 1 mg/ml Injection if not administered properly, and if it leaks from the vein, it may cause tissue damage. So, if you see any redness, pain, swelling, burning, skin sores or leaking of fluid from where the drug is going into your body, please tell your nurse.
The most common side effects of Z-Cristin 1 mg/ml Injection are hair loss, constipation, headache, peripheral neuropathy (tingling and numbness of feet and hand), stomach cramps, feeling tired or weak, back, bone, joint or muscle pain, mouth irritation or mouth sores​​​​​​​. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.Â
Z-Cristin 1 mg/ml Injection is a vesicant (irritant) and can damage the tissues and blood vessels if it is not administered correctly, which can be fatal. So, it should be given by a trained professional in the hospital.
Yes, Z-Cristin 1 mg/ml Injection is a cytotoxic (toxic to living cells) medicine. So, it is advised to be very cautious while taking Z-Cristin 1 mg/ml Injection.
This medicine is injected strictly into a vein (intravenously) by a trained healthcare professional in a hospital or clinic setting. It must never be given by any other route, as doing so can be life-threatening. Talk to your doctor if you want to understand more about your infusion process.
No, Z-Cristin 1 mg/ml Injection can harm an unborn baby. Both men and women should use highly effective birth control during treatment and for a specified time after therapy ends. Talk to your doctor if you are planning a family or have questions about fertility.
You should avoid receiving live vaccines during your treatment, as Z-Cristin 1 mg/ml Injection can lower your immune system and make the vaccine unsafe. Always talk to your doctor or pharmacist before getting any immunisations.
It is highly recommended to avoid alcohol while receiving this medication, as alcohol can place extra stress on your liver and worsen dehydration, which can make constipation and nerve symptoms worse. Talk to your doctor before consuming alcohol during your treatment cycle.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

B/108-113, Kanara Business Centre Near Everest Gardens, Link Rd, Mumbai, Maharashtra 400075
Other Info - ZCR0001
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