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compositionComposition:BISOPROLOL-5MG+HYDROCHLOROTHIAZIDE-12.5MG
prescription
Prescription Medicine
info
Zabesta Xlo Tablet 10's

Zabesta Xlo Tablet is used in the treatment of high blood pressure. It effectively lowers elevated blood pressure and supports better heart function. By maintaining normal blood pressure, this combination helps reduce the risk of heart attack, stroke, heart failure, and kidney complications associated with long-term hypertension.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

BISOPROLOL-5MG+HYDROCHLOROTHIAZIDE-12.5MG

Manufacturer/Marketer :

USV Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Zabesta Xlo Tablet

Zabesta Xlo Tablet is a prescription tablet used to treat high blood pressure (hypertension). By keeping your blood pressure within a healthy range, it helps reduce the risk of serious cardiovascular events like strokes and heart attacks. This medicine combines two active ingredients that work in different ways to make it easier for your heart to pump blood throughout your body.

To get the most benefit, you should take Zabesta Xlo Tablet consistently at the same time every day, exactly as directed by your doctor. It can be taken with or without food, though taking it with breakfast is a common routine that helps you remember your dose. Making healthy choices, such as reducing salt in your diet and staying physically active, can significantly improve your treatment results.

Some people may experience mild side effects, such as dizziness, lightheadedness, or feeling unusually tired. If you notice severe symptoms like a very slow heartbeat, breathing difficulties, or sudden muscle weakness, seek medical care immediately. Always let your healthcare team know if any side effects persist or worry you.

Do not take this if you have certain heart conditions, such as a very slow heart rate or severe heart failure, or if you have serious kidney or liver problems. Before starting Zabesta Xlo Tablet , tell your doctor if you have asthma, diabetes, gout, or thyroid issues. Your doctor will help determine if this treatment is safe and appropriate for your specific health history.

This medicine can interact with alcohol, which may cause your blood pressure to drop too low and make you feel dizzy. It can also interact with other blood pressure drugs, certain pain relievers, and diabetes medications. If you are pregnant, breastfeeding, or an older adult, consult your doctor to discuss the risks and benefits before taking Zabesta Xlo Tablet .

Uses of Zabesta Xlo Tablet

Zabesta Xlo Tablet is used to treat high blood pressure (hypertension). The detailed uses of Zabesta Xlo Tablet are as follows:

  • High Blood Pressure (Hypertension): Zabesta Xlo Tablet helps relax your blood vessels and lower the volume of fluid in your body, which reduces the force your heart has to use to pump blood.
  • Reduction of Cardiovascular Risks: By maintaining normal blood pressure levels, it helps lower your chances of experiencing life-threatening conditions like strokes and heart attacks.
     

Key Benefits

Zabesta Xlo Tablet helps manage high blood pressure by providing effective and sustained blood pressure control. By combining two blood pressure-lowering medicines in a single tablet, it supports long-term cardiovascular health while simplifying daily treatment.

  • Helps Maintain Healthy Blood Pressure Levels: By lowering and controlling blood pressure, Zabesta Xlo Tablet helps reduce strain on the heart and blood vessels, supporting stable blood pressure throughout the day.
  • Supports Long-Term Heart and Blood Vessel Health: Consistent blood pressure control with Zabesta Xlo Tablet helps reduce the risk of hypertension-related complications such as heart attack, stroke, and damage to vital organs, including the kidneys and brain.
  • Offers Convenient Combination Therapy: By combining two antihypertensive medicines in a single daily tablet, Zabesta Xlo Tablet simplifies treatment, supports better medication adherence, and helps maintain reliable long-term blood pressure control.
     
Side effects of Zabesta Xlo Tablet
  • Exercising regularly helps lower the risk of heart problems.
  • Maintain a healthy diet, including vegetables and fruits.
  • Rest well; get enough sleep.
  • Manage stress with yoga and meditation.
  • Limit alcohol and smoking.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Chest pain may last for a while and needs immediate medical attention as it is a significant health issue to be attended to.
  • Take rest and refrain from doing physical activity for a while, and restart after a few days.
  • Try applying an ice pack to the strained area for at least 20 minutes thrice a day. Ice pack thus helps reduce inflammation.
  • Sit upright and maintain proper posture if there is persistent chest pain. • Use extra pillows to elevate your position and prop your chest up while sleeping.
  • Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
  • Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
  • Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
  • Gently massage the swollen area with firm but not painful pressure.
  • Keep the swollen area clean and moisturized to prevent injury and infection.
  • Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
  • If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Directions for Use

  • Zabesta Xlo Tablet can be taken with or without food as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Zabesta Xlo Tablet as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Zabesta Xlo Tablet Works

This medication combines two active ingredients, bisoprolol and hydrochlorothiazide, which work together to control high blood pressure. Bisoprolol is a beta-blocker. It works by targeting specific receptors in your heart and blood vessels. This slows down your heart rate and allows the heart to beat more softly and regularly, reducing the effort needed to pump blood. Hydrochlorothiazide is a diuretic, often called a 'water pill'. It helps your kidneys remove excess water and salt from your body through your urine. Reducing the amount of fluid circulating in your blood vessels lowers the overall pressure against your artery walls.
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Alcohol

Unsafe

You are recommended not to consume alcohol along with Zabesta Xlo Tablet to avoid unpleasant side effects.

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Pregnancy

Consult your doctor

It is not known whether this Zabesta Xlo Tablet will harm an unborn baby. Inform your doctor if you are pregnant or plan to become pregnant.

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Breast Feeding

Unsafe

Zabesta Xlo Tablet can pass into breast milk and may harm newborn babies. You should not breast-feed while using this Zabesta Xlo Tablet .

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Driving

Caution

It is not recommended to drive after taking Zabesta Xlo Tablet as it may occasionally cause drowsiness or fatigue.

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Liver

Caution

Zabesta Xlo Tablet to be taken with caution, especially if you have a history of liver diseases. Your doctor may adjust your dose depending on your current liver conditions.

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Kidney

Caution

Zabesta Xlo Tablet to be taken with caution, especially if you have a history of Kidney diseases. Your doctor may adjust your dose depending on your current kidney conditions.

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Children

Unsafe

Zabesta Xlo Tablet is not recommended for children below 18 years.

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Heart

Safe if prescribed

Zabesta Xlo Tablet is safe for use in heart patients if recommended by the physician.

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Geriatrics

Caution

Zabesta Xlo Tablet should be used under caution in geriatric patients. Please consult your physician.

What if I have taken an overdose of Zabesta Xlo Tablet

In case of an accidental overdose, seek immediate emergency medical attention. Symptoms of an overdose may include extreme dizziness, feeling faint, a very slow heart rate, or severe muscle weakness.

Diet & Lifestyle Advise

  • Limit sodium intake: Reducing the amount of salt in your meals helps the diuretic component work more effectively and naturally lowers blood pressure.
  • Monitor potassium levels: Hydrochlorothiazide can cause your body to lose potassium. Eat potassium-rich foods like bananas, leafy greens, and potatoes if advised by your doctor.
  • Stay moderately active: Engage in regular, low-impact exercises like walking or cycling, as recommended by your doctor, to strengthen your cardiovascular system.
  • Avoid excessive alcohol: Restricting alcohol intake helps prevent unsafe drops in blood pressure and reduces the risk of dizziness.
  • Maintain a healthy weight: Working toward a healthy weight range puts less strain on your heart and improves the efficiency of your blood pressure medication.
     

Have a query?

How Soon It Starts Working

  • The time required for Zabesta Xlo Tablet to start to work: The time required for Zabesta Xlo Tablet to start to work is 1-2 hours after administration.
  • The time for which the effects of Zabesta Xlo Tablet last: The effect of Zabesta Xlo Tablet lasts for 12-24 hours.

What if you forget to take Zabesta Xlo Tablet

If you miss a dose of Zabesta Xlo Tablet , take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for a missed one.

Storage

•Store Zabesta Xlo Tablet at room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Rise slowly from a sitting or lying position to minimise dizziness and prevent falls.
  • Check your blood pressure and heart rate regularly at home and keep a log for your doctor.
  • This medication can make your skin more sensitive to the sun; wear protective clothing and use sunscreen when outdoors.
  • Avoid driving or operating machinery when you first start taking Zabesta Xlo Tablet until you know how it affects your alertness.
  • Inform your dentist or surgeon that you are taking this medication before undergoing any procedures.
     

Drug-Drug Interactions

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Drug-Drug Interactions

  • Other blood pressure medications: Combining Zabesta Xlo Tablet with other blood pressure drugs can sometimes cause your blood pressure to drop too low.
  • NSAID pain relievers: Medications like ibuprofen or naproxen can reduce the effectiveness of Zabesta Xlo Tablet and increase the risk of kidney strain.
  • Lithium: The diuretic component in Zabesta Xlo Tablet can raise lithium levels in your blood to unsafe limits.
  • Diabetes medicines: This drug may interact with insulin or oral diabetes treatments, requiring your doctor to adjust your diabetes dosages.


Drug-Food Interactions

  • Alcohol: Drinking alcohol while on this medication can dangerously increase the blood pressure-lowering effect, causing severe lightheadedness or fainting.
  • Liquorice: Natural black liquorice can lower potassium levels in your body, compounding the diuretic effect of this medication.


Drug-Disease Interactions

  • Asthma and chronic lung diseases: The beta-blocker component can cause airway tightening, making breathing difficulties worse.
  • Diabetes: This medication can mask the signs of low blood sugar, such as a rapid heart rate, and can alter blood sugar control.
  • Severe kidney or liver disease: Fluid and electrolyte shifts caused by this medicine can worsen these conditions.
  • Gout: The diuretic component can raise uric acid levels, potentially triggering a gout attack.
     
Bisoprolol + HydrochlorothiazideDofetilide
Critical
Bisoprolol + HydrochlorothiazideCisapride
Critical

Drug-Drug Interactions

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Bisoprolol + HydrochlorothiazideDofetilide
Critical
How does the drug interact with Zabesta Xlo Tablet:
Taking Dofetilide and Zabesta Xlo Tablet can increase the risk of an irregular heart rhythm which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Dofetilide and Zabesta Xlo Tablet together is not recommended as it can possibly result in an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Bisoprolol + HydrochlorothiazideCisapride
Critical
How does the drug interact with Zabesta Xlo Tablet:
Taking Cisapride and Hydrochlorothiazide can increase the risk of an irregular heart rhythm which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Cisapride and Hydrochlorothiazide together is generally avoided as it can possibly result in an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, or fast or pounding heartbeats, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
Bisoprolol + HydrochlorothiazideZiprasidone
Severe
How does the drug interact with Zabesta Xlo Tablet:
Taking Ziprasidone and Zabesta Xlo Tablet can increase the risk of an irregular heart rhythm which can be severe.

How to manage the interaction:
Taking Ziprasidone and Zabesta Xlo Tablet together is avoided as it can possibly result in an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
Bisoprolol + HydrochlorothiazidePimozide
Severe
How does the drug interact with Zabesta Xlo Tablet:
Taking Pimozide and Zabesta Xlo Tablet can increase the risk of an irregular heart rhythm which can be severe.

How to manage the interaction:
Taking Pimozide and Zabesta Xlo Tablet together can possibly result in an interaction, but it can be taken if advised by your doctor. However, consult the doctor immediately if you experience any symptoms like dizziness, lightheadedness, fainting, fast heartbeats, weakness, tiredness, drowsiness, confusion, muscle pain, cramps, nausea, or vomiting. Do not stop using any medications without a doctor's advice.
Bisoprolol + HydrochlorothiazideDisopyramide
Severe
How does the drug interact with Zabesta Xlo Tablet:
Co-administration of Zabesta Xlo Tablet with Disopyramide may increase the effects of Disopyramide.

How to manage the interaction:
Although there may be an interaction, Zabesta Xlo Tablet can be taken with Disopyramide if prescribed by the doctor. Consult the prescriber if you experience dizziness, palpitations, fainting, slow or fast pulse, or irregular heartbeats. Do not discontinue the medication without consulting a doctor.
Bisoprolol + HydrochlorothiazideTheophylline
Severe
How does the drug interact with Zabesta Xlo Tablet:
Co-administration of Zabesta Xlo Tablet with Theophylline may cause Bisoprolol to be less effective and increase the effects of Theophylline.

How to manage the interaction:
Although there may be an interaction, Zabesta Xlo Tablet can be taken with Theophylline if prescribed by the doctor. Consult the prescriber if you experience nausea, vomiting, insomnia, shaking hands and legs, restlessness, uneven heartbeats, or difficulty breathing. Do not discontinue the medication without consulting a doctor.
Bisoprolol + HydrochlorothiazideAminophylline
Severe
How does the drug interact with Zabesta Xlo Tablet:
Co-administration of Aminophylline with Bisoprolol could reduce the metabolism of Aminophylline which increased the levels and enhance the effects of Aminophylline.

How to manage the interaction:
Taking aminophylline and bisoprolol together can result in an interaction; it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, insomnia, tremors, restlessness, uneven heartbeats, or difficulty breathing, Contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Bisoprolol + HydrochlorothiazideLithium
Severe
How does the drug interact with Zabesta Xlo Tablet:
Co-administration of Lithium and Zabesta Xlo Tablet can increase the effects of lithium.

How to manage the interaction:
Taking Lithium and Zabesta Xlo Tablet together can possibly result in an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like loose stools, vomiting, drowsiness, shaking of hands and legs, thirst, increased urination, lack of coordination, or muscle weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
Bisoprolol + HydrochlorothiazideAmiodarone
Severe
How does the drug interact with Zabesta Xlo Tablet:
Coadministration of Amiodarone together with Hydrochlorothiazide may raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Even though Amiodarone and Hydrochlorothiazide interact, they can be used if prescribed by a doctor. If you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, Weakness, tiredness, drowsiness, confusion, painful muscle cramping, dizziness, nausea, or vomiting, get medical attention. Do not discontinue any medications without consulting a doctor.
Bisoprolol + HydrochlorothiazideDroperidol
Severe
How does the drug interact with Zabesta Xlo Tablet:
Co-administration of Droperidol and Zabesta Xlo Tablet can increase the risk of an irregular heart rhythm which can be severe.

How to manage the interaction:
Taking Droperidol and Zabesta Xlo Tablet together can possibly result in an interaction, but they can be taken if advised by your doctor. However, consult the doctor immediately if you experience any symptoms like dizziness, lightheadedness, fainting, fast heartbeats, weakness, tiredness, drowsiness, confusion, muscle pain, cramps, nausea, or vomiting. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTI- HYPERTENSIVES]

FAQs

Zabesta Xlo Tablet is used to treat high blood pressure.
Zabesta Xlo Tablet is a combination medication containing Hydrochlorothiazide, a diuretic that helps remove excess fluid and lower blood pressure, and bisoprolol, a beta-blocker that slows the heart rate and reduces blood pressure by blocking certain stress hormones. Together, they help manage hypertension and improve heart function.
Your doctor may probably tell you to stop taking Zabesta Xlo Tablet as it lowers blood pressure (hypotension) when combined with general anaesthesia before surgery. So, please inform your doctor before surgery if you are taking Zabesta Xlo Tablet .
Avoid drinking alcohol it may cause dizziness. Avoid standing suddenly from a lying or sitting position, or you may feel dizzy. Get up slowly and stabilise yourself to avoid a fall.
No, Zabesta Xlo Tablet and Metoprolol are not the same. Zabesta Xlo Tablet contains bisoprolol, a beta-blocker combined with a diuretic, whereas Metoprolol is a beta-blocker used alone. Although both medications are beta-blockers, they have different effects. Always consult your doctor before making any changes to your medication.
The common side effects of Zabesta Xlo Tablet include weakness or fatigue, dizziness, nausea, diarrhoea, indigestion, headache, and cough. Most of these side effects do not require medical attention and gradually resolve over time. However, consult a doctor if any of these symptoms persist or worsen.
It is not known whether Zabesta Xlo Tablet will harm an unborn baby. Therefore, consult a doctor if you are pregnant or plan to become pregnant before taking Zabesta Xlo Tablet .
Yes, Zabesta Xlo Tablet can cause photosensitivity reactions by making your skin more sensitive to sunlight, sunlamps, and tanning beds. This can result in severe sunburn, blisters, or swelling. Use sunscreen, wear protective clothing, and avoid prolonged sun exposure to minimise the risk.
Yes, Zabesta Xlo Tablet may impair your ability to drive. It can cause side effects such as dizziness, fatigue, or drowsiness, which can reduce your alertness. If you experience these symptoms, avoid driving or operating heavy machinery until you know how the medication affects you.
No, you should not stop taking Zabesta Xlo Tablet suddenly. High blood pressure is a chronic condition, and stopping your medication abruptly can cause your blood pressure to spike dangerously. Talk to your doctor before making any changes.
Yes, because it contains a diuretic, this medicine helps your body eliminate excess water, which increases urination. Taking it in the morning helps prevent having to get up during the night. Talk to your doctor if this becomes problematic.
Yes, this medicine can affect your blood glucose levels and may mask the physical symptoms of low blood sugar, like a fast heart rate. Monitor your blood sugar closely and talk to your doctor about any adjustments you might need.
Muscle cramps or unusual weakness can be a sign of low potassium levels caused by the diuretic. Do not ignore these symptoms. Talk to your doctor immediately so they can check your electrolyte levels.
Regular use of pain relievers like ibuprofen can reduce how well Zabesta Xlo Tablet works and may put extra stress on your kidneys. Talk to your doctor or pharmacist for advice on safe pain relief alternatives.

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While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Arvind Vithal Gandhi Chowk, BSD Marg, Station Road, Govandi East, Mumbai - 400 088. , India.
Other Info - ZAB0003

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