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compositionComposition:NIMESULIDE-100MG+PARACETAMOL-325MG
prescriptionPrescription Medicine
ZACOPAR NP TABLET

ZACOPAR NP TABLET is used to relieve mild to moderate pain in conditions such as headache, toothache, muscle pain, joint pain, menstrual cramps, and fever associated with infections. Besides this, it is also useful for dental pain, muscle pain, back pain, ear pain, and throat pain.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

NIMESULIDE-100MG+PARACETAMOL-325MG

Manufacturer/Marketer :

Gaenr Biologicals

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About ZACOPAR NP TABLET

ZACOPAR NP TABLET is primarily used to relieve pain in conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and dysmenorrhea. Besides this, it is also useful for dental pain, muscle pain, back pain, ear pain, and throat pain. 

ZACOPAR NP TABLET is composed of Nimesulide and Paracetamol, which work by blocking the effect of prostaglandins, a chemical responsible for inducing pain and inflammation in the body. It also lowers the elevated body temperature by promoting heat loss (through sweating).

The most common side effects of ZACOPAR NP TABLET include loss of appetite (in cases of liver condition), nausea, vomiting, abdominal pain, persistent tiredness, and dark/discoloured urine. It is not necessary for everyone to experience the side effects above. If you experience any discomfort, speak with your doctor.

Do not take ZACOPAR NP TABLET if you are allergic to painkillers such as aspirin, ibuprofen, naproxen, or diclofenac. It is not recommended for use in children, people with liver disease, heart disease or gastric ulcers/bleeding problems. Consult your doctor if your pain, inflammation, and fever symptoms do not improve even after 10 days.

Uses of ZACOPAR NP TABLET

ZACOPAR NP TABLET is used to provide pain relief. The detailed uses of ZACOPAR NP TABLET are as follows:

  • Pain Relief: ZACOPAR NP TABLET relieves mild to moderate pain, such as headaches, muscle aches, and joint pain.
  • Fever Reduction: ZACOPAR NP TABLET helps to reduce fever, relieving discomfort caused by high body temperature.

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Directions for Use

  • ZACOPAR NP TABLET should be taken with food.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow ZACOPAR NP TABLET as a whole with a glass of water.
  • Do not crush, break, or chew it.

Key Benefits

  • Provides effective relief from mild to moderate pain.
  • Reduces fever quickly.
  • Helps decrease inflammation and swelling.
  • Useful for conditions such as headaches, toothaches, and muscle pain.
  • Relieves joint pain and stiffness.
  • Helps ease menstrual pain (period cramps).
  • Improves comfort in fever associated with infections.

How ZACOPAR NP TABLET Works

ZACOPAR NP TABLET is composed of two medicines: nimesulide and paracetamol. • ZACOPAR NP TABLET works by blocking the effect of prostaglandins, a chemical responsible for inducing pain and inflammation in the body. • It also lowers the elevated body temperature by promoting heat loss (through sweating), which helps reset the hypothalamic thermostat. Together, ZACOPAR NP TABLET helps relieve pain.

Storage

Store in a cool and dry place away from sunlight
Side effects of Zacopar Np Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • High levels of liver enzymes need immediate medical attention.
  • Watch your diet and consume low-fat foods, like green leafy vegetables, fish, whole grains, nuts, etc.
  • Regularly do strengthening exercises to control your cholesterol levels.
  • Avoid drinking alcohol as it can affect your liver.
  • Focus on losing weight as it can help control cholesterol and maintain liver enzymes.
  • Practice yoga and meditation to improve liver functioning and overall health.

What if I have taken an overdose of ZACOPAR NP TABLET

Do not take more than the prescribed dose of ZACOPAR NP TABLET as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

  • ZACOPAR NP TABLET is contraindicated in patients with a history of hypersensitivity (allergic) reaction to ZACOPAR NP TABLET, paracetamol, nimesulide, or other pain killers.
  • Please inform your doctor before starting ZACOPAR NP TABLET if you have an active stomach ulcer, recent gastrointestinal bleeding, asthma, recent heart bypass surgery or severe kidney/liver impairment.
  • Nimesulide present in ZACOPAR NP TABLET is known to affect fertility, so if you are planning for pregnancy, contact the doctor. ZACOPAR NP TABLET should be avoided in both pregnant women (especially in the last trimester of pregnancy) and breastfeeding women, as it may pass through the milk, affecting the baby.
  • Patients with heart diseases and recent stroke (bleeding in the brain) should not take ZACOPAR NP TABLET as a substitute for aspirin.
  • It should not be given to children (below 12 years) with symptoms of fever and chills or suffering from influenza (flu) or chickenpox.
  • Inform your doctor about any bleeding disorders as nimesulide in ZACOPAR NP TABLET should be taken with care as it may interfere with the functioning of platelets.

Drug-Drug Interactions

verifiedApollotooltip
ParacetamolKetamine
Severe
ParacetamolMipomersen
Severe

Drug-Drug Interactions

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ParacetamolKetamine
Severe
How does the drug interact with Zacopar Np Tablet:
Co-administration of ketamine and Zacopar Np Tablet may decrease the effectiveness of Ketamine which could result in a higher blood level.

How to manage the interaction:
Although taking Ketamine and Zacopar Np Tablet together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you're feeling very sleepy or having trouble breathing, it's important to contact your doctor right away. Do not stop using any medications without a doctor's advice.
ParacetamolMipomersen
Severe
How does the drug interact with Zacopar Np Tablet:
Co-administration of Mipomersen with Zacopar Np Tablet may increase the risk or severity of liver injury.

How to manage the interaction:
There may be a possibility of interaction between Zacopar Np Tablet and Mipomersen, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
ParacetamolOxazepam
Severe
How does the drug interact with Zacopar Np Tablet:
Co-administration of Zacopar Np Tablet may decrease the excretion rate of Oxazepam which could result in a higher serum level.

How to manage the interaction:
Although there is a possible interaction between Oxazepam and Zacopar Np Tablet, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
ParacetamolValdecoxib
Severe
How does the drug interact with Zacopar Np Tablet:
Co-administration of Zacopar Np Tablet and Valdecoxib may increase the risk or severity of adverse effects.

How to manage the interaction:
Although there is a possible interaction between Zacopar Np Tablet and Valdecoxib, you can take these medicines together if prescribed by a doctor. However, if the side effects worsen, please consult a doctor.
ParacetamolLomitapide
Severe
How does the drug interact with Zacopar Np Tablet:
Co-administration of Lomitapide and Zacopar Np Tablet may increase the risk of severity of liver injury.

How to manage the interaction:
Although there is a possible interaction between Zacopar Np Tablet and Lomitapide, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
ParacetamolLeflunomide
Severe
How does the drug interact with Zacopar Np Tablet:
Co-administration of Zacopar Np Tablet and Leflunomide may increase the risk of liver problems.

How to manage the interaction:
Although there is a possible interaction between Zacopar Np Tablet and Leflunomide, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ParacetamolTeriflunomide
Severe
How does the drug interact with Zacopar Np Tablet:
Co-administration of Teriflunomide with Zacopar Np Tablet may increase the risk or severity of Liver problems.

How to manage the interaction:
Taking Zacopar Np Tablet with Teriflunomide together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
ParacetamolKetoconazole
Severe
How does the drug interact with Zacopar Np Tablet:
Co-administration of Zacopar Np Tablet and Ketoconazole may increase the risk of liver injury.

How to manage the interaction:
Although there is a possible interaction between Zacopar Np Tablet and Ketoconazole, you can take these medicines together if prescribed by a doctor. However, if you have joint pain or swelling, fever, chills, unusual bleeding or bruising, skin rash, itching, over-tiredness, nausea, vomiting, loss of appetite, stomach pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact a doctor immediately as these may be signs and symptoms of liver damage. Do not discontinue the medication without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Diet

  • Eat light, balanced meals with fruits and vegetables to support recovery
  • Stay well hydrated by drinking plenty of water
  • Avoid alcohol, as it can increase the risk of liver damage

Lifestyle changes

  • Get adequate rest to help the body recover from pain or fever
  • Use proper posture and avoid strain during daily activities to prevent worsening pain

Physical activity

  • Prefer light activities like walking or gentle stretching to avoid worsening pain
  • Avoid heavy exercise or strenuous work until the pain and inflammation reduce
  • Gradually return to normal physical activity as symptoms improve

Habit Forming

No

Therapeutic Class

[ANALGESIC AND ANTIPYRETIC AGENT]

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Alcohol

Unsafe

Taking ZACOPAR NP TABLET with alcohol may cause dizziness or drowsiness. Besides this, it can also damage your liver if taken for a longer duration. So, avoid or limit the intake of alcoholic beverages with ZACOPAR NP TABLET.

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Pregnancy

Unsafe

Use of ZACOPAR NP TABLET during pregnancy is not recommended as taking this medicine during the last 3 months of pregnancy may harm the unborn baby. Consult your doctor for further advice.

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Breast Feeding

Unsafe

Use of ZACOPAR NP TABLET during breastfeeding is not recommended as it may pass through the milk and harm the baby. Consult your doctor for further advice.

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Driving

Unsafe

After taking ZACOPAR NP TABLET, you may notice dizziness, sleepiness, drowsiness. So, you should stop taking ZACOPAR NP TABLET and contact your doctor.

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Liver

Caution

ZACOPAR NP TABLET to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

ZACOPAR NP TABLET to be taken with caution, especially if you have a history of Kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Unsafe

ZACOPAR NP TABLET is contraindicated in children below 20 kg body weight or younger than 6 years of age. It may cause kidney problems in children and adolescents who are dehydrated.

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Heart

Unsafe

ZACOPAR NP TABLET should be avoided in cardiac patients as it can lead to serious cardiavascular risks

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Geriatrics

Caution

ZACOPAR NP TABLET should be given with caution in geriatrics due to increased risk of side effects. If you have any concerns about using ZACOPAR NP TABLET, please consult a doctor.

FAQs

ZACOPAR NP TABLET is used to relieve pain in conditions like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and dysmenorrhea. Besides this, it is also useful for dental pain, muscle pain, back pain, ear pain, and throat pain.

ZACOPAR NP TABLET works by blocking the effects of prostaglandins, chemicals that induce pain and inflammation in the body. It also lowers the elevated body temperature by promoting heat loss (through sweating), which helps reset the hypothalamic thermostat. Together, ZACOPAR NP TABLET helps relieve pain.

No, ZACOPAR NP TABLET is not indicated for stomach pain. If you have stomach pain post-ingestion, it may be a sign of a stomach ulcer or gastric bleeding. Do not take ZACOPAR NP TABLET in this condition. It is better to inform your doctor if you experience stomach pain after ingesting this medication.

No, ZACOPAR NP TABLET should not be taken as a long-term medication as it may lead to stomach ulcers/bleeding and kidney problems. For best results, take it at the doses and for the duration advised by your doctor.

Yes, ZACOPAR NP TABLET should preferably be taken with food to avoid an upset stomach. If taken on an empty stomach, it may cause stomach irritation and upset.

You should not take ZACOPAR NP TABLET if you have a history of peptic ulceration, a history of gastrointestinal haemorrhage, Crohn's disease or ulcerative colitis.

No, ZACOPAR NP TABLET should not be taken if you plan to get pregnant, as it contains nimesulide, which may cause birth defects. So, before starting ZACOPAR NP TABLET, please consult your doctor if you are pregnant or planning a pregnancy.

Though ZACOPAR NP TABLET may be used for tooth pain, it should not be used in children unless advised by the doctor. Please consult the doctor before using ZACOPAR NP TABLET in children; the doctor will prescribe appropriate medicine based on the child’s condition.

ZACOPAR NP TABLET is a combination medication that belongs to the class of painkillers called non-steroidal anti-inflammatory drugs. It is mainly prescribed to treat pain and relieve discomfort caused by tooth pain, arthritis, period pain, and other types of short-term pain.

As ZACOPAR NP TABLET is indicated for short-term pain relief, it can be discontinued once pain relief is achieved. However, it is advised to take ZACOPAR NP TABLET for the prescribed duration to effectively treat your condition.

Taking ZACOPAR NP TABLET may cause nausea and vomiting. If you feel sick, talk to your doctor or pharmacist for help. To cope with nausea and vomiting, take your medicine with food or milk, eat small meals, and stay hydrated. Avoid spicy foods and lying down after taking the medicine. Try ginger products like ginger tea or candies. If your symptoms are severe, ask your doctor for help.

Don't take ZACOPAR NP TABLET if you're allergic to it or other painkillers, have stomach ulcers or bleeding, asthma, recent heart surgery, severe kidney or liver problems. Consult the doctor if you are pregnant or breastfeeding.

ZACOPAR NP TABLET can be taken with vitamin B-complex if prescribed by your doctor. Please consult your doctor if you have any concerns.

ZACOPAR NP TABLET may cause harm to the liver, especially if used for a longer duration or in higher doses. So, do not take a higher dose than the recommended dose of ZACOPAR NP TABLET.

Taking more than the recommended dose of ZACOPAR NP TABLET is dangerous. Overuse of ZACOPAR NP TABLET can harm your liver and kidneys, which can be life-threatening. Always follow the dosage instructions as advised by the doctor.

ZACOPAR NP TABLET should be stored in a cool, dry place away from sunlight. Keep away from children and pets.

Though ZACOPAR NP TABLET may help lower body temperature, it is primarily used for pain relief. Consult your doctor before taking ZACOPAR NP TABLET for fever or if you have any concerns.

Follow your doctor's advice and take the right amount of medicine. Inform your doctor about any health problems, allergies, or other drugs you're taking. Be aware of side effects and take care of yourself. If you're pregnant while on treatment, inform your doctor immediately. Don't take other medications unless instructed by the doctor. Alcohol consumption should be avoided. By following these precautions, you'll benefit most from your medicine and stay safe.

You are recommended to consult your doctor before taking other medications while using ZACOPAR NP TABLET to avoid drug interactions.

If you suspect an overdose of ZACOPAR NP TABLET, seek medical help immediately. Quick action can help prevent serious harm, so don’t wait to seek medical attention.

The common side effects of ZACOPAR NP TABLET include loss of appetite, nausea, vomiting, abdominal pain, persistent tiredness, or dark or discoloured urine. Not everyone experiences the side effects above. If you experience any discomfort, speak with your doctor.

Country of origin

India

Manufacturer/Marketer address

Gaenr Biotec, Amit Shur(Managing Director), SCO- 47, 1st Floor Pipli Wala Town, Manimajra, Chandigarh - 160101, India
Other Info - ZAC0018

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Santoshini Reddy GDoctor badge

Reviewed By

Santoshini Reddy G

M Pharmacy

Last Updated

Mar 23, 2026 | 7:20 AM IST

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