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  3. Zapixaban-5 mg Tablet 10's

Zapixaban-5 mg Tablet 10's, Pack of 10
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Zapixaban-5 mg Tablet 10's is used to prevent and treat deep vein thrombosis (blood clots in leg veins) and pulmonary embolism (blood clots in the lung). Additionally, it is used to prevent blood clots in patients with atrial fibrillation (irregular heartbeat). It contains Apixaban, which works by inhibiting the action of blood clotting factor and prevents the conversion of fibrinogen (soluble protein) to fibrin (insoluble protein). Thus, it helps in preventing blood clot formation. Some people may experience side effects such as nausea, anaemia (lack of blood), and unusual bleeding, including swelling and bruising. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

APIXABAN-5MG

Manufacturer/Marketer :

Brandog Pharmaceuticals

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Zapixaban-5 mg Tablet 10's

Zapixaban-5 mg Tablet 10's is used to prevent and treat deep vein thrombosis (blood clots in leg veins) and pulmonary embolism (blood clots in the lung). Deep vein thrombosis is a condition in which blood clots form in deep veins, usually in the legs. Pulmonary embolism is a condition in which a blood clot blocks the arteries in the lungs. 

Zapixaban-5 mg Tablet 10's contains Apixaban, which works by inhibiting the action of blood clotting factor (Xa), which is an important element of blood clotting.

Not everyone who is taking Zapixaban-5 mg Tablet 10's will get these side effects. Some people may experience nausea, anaemia, unusual bleeding, swelling and bruising. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Take this medication by mouth with or without food as directed by your doctor. The dosage is based on your medical condition and response to treatment. To help you remember, take it at the same time each day.

If you are known to be allergic to Zapixaban-5 mg Tablet 10's or any other medicines, please tell your doctor. Inform your doctor if you have a stomach ulcer, recent bleeding in the brain, kidney or liver problems, high blood pressure, or bleeding issues. If you are pregnant or a nursing mother, you are advised to consult a doctor before taking Zapixaban-5 mg Tablet 10's.

Uses of Zapixaban-5 mg Tablet 10's

Zapixaban-5 mg Tablet 10's used to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. The detailed uses of Zapixaban-5 mg Tablet 10's are as follows:<br/>

  • Prevention of Stroke and Systemic Embolism: Zapixaban-5 mg Tablet 10's reduces the risk of stroke and systemic embolism in patients with non-valvular atrial fibrillation.<br/>
  • Treatment of DVT and PE: Zapixaban-5 mg Tablet 10's treats and prevents deep vein thrombosis (DVT) and pulmonary embolism (PE).<br/>
  • Prevention of DVT and PE after Surgery: Zapixaban-5 mg Tablet 10's also prevents DVT and PE in patients who have undergone hip or knee replacement surgery.<br/>

Directions for Use

• Take Zapixaban-5 mg Tablet 10's with or without food or as advised by a doctor. • Recommended to take the medicine twice a day or as advised by your doctor. • Swallow the medicine as a whole with glass of water. Do not break or chew it. • If you have difficulty swallowing the Zapixaban-5 mg Tablet 10's, you can crush them and mix the powder with water, apple juice, or applesauce. Be sure to consume the mixture immediately after preparation.

Medicinal Benefits

  • Zapixaban-5 mg Tablet 10's is primarily used to prevent and treat blood clots in the body by inhibiting the action of the clotting factor Xa, which is a crucial element in blood clotting.
  • Zapixaban-5 mg Tablet 10's is used to prevent blood clots in patients with atrial fibrillation (irregular heartbeat).
  • Zapixaban-5 mg Tablet 10's prevents the conversion of fibrinogen (soluble protein) to fibrin (insoluble protein) and helps in preventing blood clot formation.

How Zapixaban-5 mg Tablet 10's Works

Zapixaban-5 mg Tablet 10's contains Apixaban, which works by inhibiting the action of blood clotting factor (X a), which is an important element of blood clotting. Thereby, it prevents the conversion of fibrinogen (soluble protein) to fibrin (insoluble protein) and helps in preventing blood clot formation.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Zapixaban-5 mg Tablet
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Stay hydrated by taking fluids like water, juices and soups etc.
  • Eat fruits and vegetables which contain vitamins.
  • Take iron rich food like dry fruits, green leafy vegetables and sea food etc.
  • Reduce intake of milk, cheese, yogurt, soy, chocolate, ice cream, Grapes, Popcorn, canned salmon, pomegranate.
  • Regular exercise like walking, jogging is helpful.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.

What if I have taken an overdose of Zapixaban-5 mg Tablet 10's

Do not take more than the prescribed dose of Zapixaban-5 mg Tablet 10's as it may cause overdose. The symptoms of overdose include unusual bleeding or bruising, red/black/tarry stools, red/brown/pink urine and coughing up or vomiting blood or material that looks like coffee grounds. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

  • Inform your doctor if you are allergic to it or any other components present in it.
  • Blood tests are recommended before and during Zapixaban-5 mg Tablet 10's use to monitor kidney and liver function.
  • Inform your doctor if you are pregnant or breastfeeding before taking Zapixaban-5 mg Tablet 10's.
  • If you have a stomach ulcer, recent bleeding in the brain, kidney, or liver problems, high blood pressure, or bleeding disorders, or antiphospholipid syndrome (an immune system disorder that increases the risk of blood clots), inform your doctor before taking Zapixaban-5 mg Tablet 10's.
  • Your doctor may suggest a blood test called the 'international normalized ratio' (INR) to check how quickly your blood is clotting. This test result will help your doctor determine the exact time to start taking Zapixaban-5 mg Tablet 10's.

Drug-Drug Interactions

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ApixabanMifepristone
Critical
ApixabanDefibrotide
Critical

Drug-Drug Interactions

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ApixabanMifepristone
Critical
How does the drug interact with Zapixaban-5 mg Tablet:
Mifepristone and Zapixaban-5 mg Tablet co-administration have been associated with more severe vaginal bleeding in women.

How to manage the interaction:
Taking Zapixaban-5 mg Tablet with Mifepristone together is not generally recommended as it may lead to an interaction, but it can be taken if prescribed by a doctor. However, if you experience persistent, excessive bleeding, consult the doctor. Without consulting a doctor, never stop taking any medication.
ApixabanDefibrotide
Critical
How does the drug interact with Zapixaban-5 mg Tablet:
Coadministration of Defibrotide and Zapixaban-5 mg Tablet co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Defibrotide and Zapixaban-5 mg Tablet may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
ApixabanTiclopidine
Severe
How does the drug interact with Zapixaban-5 mg Tablet:
Co-administration Ticlopidine and Zapixaban-5 mg Tablet may raise the risk of bleeding.

How to manage the interaction:
Even though combining Ticlopidine and Zapixaban-5 mg Tablet may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
ApixabanTenecteplase
Severe
How does the drug interact with Zapixaban-5 mg Tablet:
Coadministration of Tenecteplase and Zapixaban-5 mg Tablet co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Tenecteplase and Zapixaban-5 mg Tablet may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
ApixabanStreptokinase
Severe
How does the drug interact with Zapixaban-5 mg Tablet:
Coadministration of Streptokinase and Zapixaban-5 mg Tablet co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Streptokinase and Zapixaban-5 mg Tablet may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
ApixabanWarfarin
Severe
How does the drug interact with Zapixaban-5 mg Tablet:
Coadministration of Warfarin and Zapixaban-5 mg Tablet may raise the risk of bleeding.

How to manage the interaction:
Even though combining Warfarin and Zapixaban-5 mg Tablet may cause an interaction, it is still possible to take it if a doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
ApixabanFlurbiprofen
Severe
How does the drug interact with Zapixaban-5 mg Tablet:
Coadministration of Flurbiprofen and Zapixaban-5 mg Tablet co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Flurbiprofen and Zapixaban-5 mg Tablet may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
ApixabanAntithrombin iii
Severe
How does the drug interact with Zapixaban-5 mg Tablet:
Coadministration of Defibrotide and Antithrombin iii co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Antithrombin iii and Zapixaban-5 mg Tablet may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
ApixabanPonatinib
Severe
How does the drug interact with Zapixaban-5 mg Tablet:
Coadministration of Ponatinib and Zapixaban-5 mg Tablet co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Ponatinib and Zapixaban-5 mg Tablet may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
ApixabanAnagrelide
Severe
How does the drug interact with Zapixaban-5 mg Tablet:
Coadministration of Defibrotide and Zapixaban-5 mg Tablet co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Defibrotide and Zapixaban-5 mg Tablet may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid vitamin K-rich foods such as coriander, cabbage, spinach, broccoli, collard greens, kale (leaf cabbage), black liquorice, turnip greens, avocados, Brussels sprouts, as they may decrease the effectiveness of Zapixaban-5 mg Tablet 10's.
  • Do regular exercise, as it helps to dissolve blood clots, especially in obese people.
  • Do not consume more than 14 units of alcohol per week, as excess alcohol intake may increase the risk of bleeding and quit smoking.

Habit Forming

No

Therapeutic Class

ANTICOAGULANT/ANTITHROMBOTIC

Zapixaban-5 mg Tablet 10's Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

You are recommended not to consume more than 14 units per week as exceeding this may increase the risk of bleeding.

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Pregnancy

Consult your doctor

Zapixaban-5 mg Tablet 10's is a Category B pregnancy drug and is given to pregnant women only if doctor thinks benefits outweigh risks.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Zapixaban-5 mg Tablet 10's as it may be excreted in breast milk and cause adverse effects in the baby.

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Driving

Safe if prescribed

Zapixaban-5 mg Tablet 10's usually does not affect your ability to drive or operate machinery.

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Liver

Caution

Take Zapixaban-5 mg Tablet 10's with caution, especially if you have a history of liver disease. The dose may be adjusted by your doctor as required.

bannner image

Kidney

Caution

Take Zapixaban-5 mg Tablet 10's with caution, especially if you have a history of kidney disease. The dose may be adjusted by your doctor as required.

bannner image

Children

Unsafe

Zapixaban-5 mg Tablet 10's is not recommended for children below 18 years of age as the safety and efficacy is not mentioned.

Have a query?

FAQs

Zapixaban-5 mg Tablet 10's is used to prevent and treat deep vein thrombosis (blood clots in leg veins) and pulmonary embolism (blood clots in the lung). Additionally, it is used to prevent blood clots in patients with atrial fibrillation (irregular heartbeat). Zapixaban-5 mg Tablet 10's works by inhibiting the action of blood clotting factor (X a), which is an important element of blood clotting.

No, you are not recommended to take ibuprofen with Zapixaban-5 mg Tablet 10's as co-administration of these two medicines may increase the risk of bleeding more easily. However, if you notice blood in urine or stools, dizziness, unusual bleeding or bruising, red or black tarry stools, vomiting, weakness or headache, please consult a doctor immediately. If you are supposed to use these medicines together, you are advised to contact your doctor so that the dose may be adjusted appropriately to use safely.

No, you are usually not advised to have a tattoo or body piercing while taking Zapixaban-5 mg Tablet 10's as it may increase the risk of bleeding and infection. If you still wish to proceed further, contact your doctor so that the dose may be adjusted or any antibiotics may be prescribed and let the piercer or tattooist know in advance that you are on treatment with a blood thinner.

Yes, you are advised to stop taking Zapixaban-5 mg Tablet 10's a few days before surgery or procedure as Zapixaban-5 mg Tablet 10's may increase the risk of bleeding. Therefore, before having any procedure or any surgery, please inform your doctor that you are taking Zapixaban-5 mg Tablet 10's.

Yes, Zapixaban-5 mg Tablet 10's helps in reducing the risk of stroke and heart attack by preventing blood clots. Stroke is caused as blood clots break off and travel to brain.

No, you are not recommended to stop taking Zapixaban-5 mg Tablet 10's without consulting your doctor as it may worsen the condition. Therefore, take Zapixaban-5 mg Tablet 10's for as long as your doctor has prescribed it.

If you have difficulty swallowing the tablet whole, please consult your doctor about alternative methods for taking Zapixaban-5 mg Tablet 10's. The tablet can be crushed and mixed with water, 5% glucose in water, apple juice, or apple puree just before consumption.

If you miss a dose of Zapixaban-5 mg Tablet 10's, take it as soon as you remember. Take the next dose of Zapixaban-5 mg Tablet 10's at the usual time and then continue as normal.

Side effects of Zapixaban-5 mg Tablet 10's include nausea, anaemia (lack of blood), and unusual bleeding, including swelling and bruising. Most of these side effects may not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you have atrial fibrillation (a condition in which the heart beats irregularly) and are taking Zapixaban-5 mg Tablet 10's to help prevent strokes or serious blood clots, in that case, you may be at a higher risk of having a stroke if you stop taking this medication. Besides this, you may be at risk of having a blood clot form in or around your spine that could cause paralysis if you have epidural or spinal anaesthesia or a spinal puncture while taking a blood thinner such as Zapixaban-5 mg Tablet 10's.

Yes, Zapixaban-5 mg Tablet 10's is a blood thinner. It belongs to the class of medicines known as factor Xa inhibitors which help prevent the formation of blood clots.

Symptoms of Zapixaban-5 mg Tablet 10's overdose are unusual bleeding or bruising; red, brown, or pink urine; red or black, tarry stools; and coughing up or vomiting blood or material that looks like coffee grounds. Consult the doctor if you experience these symptoms or if you have taken an overdose.

Country of origin

India
Other Info - ZAP0080

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 23, 2025 | 1:37 PM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.4756.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/202155s000lbl.pdf
  3. https://www.drugs.com/mtm/apixaban.html
  4. https://www.nhs.uk/medicines/apixaban/
  5. https://www.eliquis.bmscustomerconnect.com/home?consumer=true
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