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  3. Zatrofix OF Dry Syrup

Zatrofix OF Dry Syrup, Pack of 1 Syrup
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Zatrofix OF Dry Syrup is used for the treatment of a wide range of bacterial infections of the skin, ears, lungs, prostate and urinary tract. Besides this, it also treats typhoid fever and STDs (sexually transmitted diseases) like chlamydia and gonorrhoea. It contains Cefixime and Ofloxacin, which works by preventing the formation of the outer covering of the bacteria (cell wall) required for their survival. It prevents the release of a chemical messenger (mucopeptides) by the bacteria, thereby weakening and destroying the bacterial cell wall. It may cause some common side effects such as diarrhoea, indigestion, nausea, loose stools, abdominal pain, and vomiting.
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Composition :

CEFIXIME-50MG + OFLOXACIN-50MG

Manufacturer/Marketer :

Zatropha Pharma

Consume Type :

ORAL

Return Policy :

Not Returnable

About Zatrofix OF Dry Syrup

Zatrofix OF Dry Syrup belongs to a group of medications called 'cephalosporin antibiotics' primarily used for the treatment of a wide range of bacterial infections of the skin, ears, lungs, prostate and urinary tract. Besides this, it also treats typhoid fever and STDs (sexually transmitted diseases) like chlamydia and gonorrhoea. A bacterial infection happens when harmful bacteria enter inside the body and start multiplying. These harmful bacteria are responsible for producing toxins that can cause diseases like strep throat, urinary tract infection (UTI), bacterial food poisoning, gonorrhoea, bacterial meningitis, cellulitis, Lyme disease, and tetanus. Zatrofix OF Dry Syrup does not work against viral infections like flu and colds.

Zatrofix OF Dry Syrup contains 'Cefixime' (cephalosporin antibiotic) and 'Ofloxacin' (fluoroquinolone antibiotic) that works by preventing the formation of the outer covering of the bacteria (cell wall) required for their survival. Zatrofix OF Dry Syrup prevents the release of a chemical messenger (mucopeptides) by the bacteria, thereby weakening and destroying the bacterial cell wall. Zatrofix OF Dry Syrup is a broad range antibiotic that works against a wide range of both gram-positive and gram-negative bacteria.

Take Zatrofix OF Dry Syrup as prescribed. Your doctor will recommend how often you take Zatrofix OF Dry Syrup based on your medical condition. Zatrofix OF Dry Syrup may cause some common side effects that include diarrhoea, indigestion, nausea, loose stools, abdominal pain, and vomiting. However, some of these side effects do not require medical attention and will pass within a couple of days. If side effects become get worse with time or do not pass within a couple of days, then one should consult their doctor. 

Zatrofix OF Dry Syrup is not allowed to use in patients who are already taking any of the other antibiotics or having kidney or liver problems. This medicine can only be used in pregnant or breastfeeding women if strongly suggested by the doctor. Ofloxacin present in Zatrofix OF Dry Syrup may cause and aggravate symptoms of existing peripheral neuropathy (nerve damage in legs), tendinitis (swelling or tearing of a tendon), myasthenia gravis (skeletal muscle weakness), and respiratory issues like bronchitis, sinusitis. People with diabetes should contact a doctor before taking Zatrofix OF Dry Syrup as Zatrofix OF Dry Syrup can lower your blood sugar level in some cases. Patient with central nervous system disorder or epilepsy (fits) should avoid intake of Zatrofix OF Dry Syrup as its use is contraindicated for them.

Uses of Zatrofix OF Dry Syrup

Treatment of Bacterial infections, Typhoid fever, Urinary tract infection (UTI)

Directions for Use

Tablet: Take it with or without food as advised by a doctor. Swallow it as a whole with a glass of water. Do not crush, chew or break it.Tablet DT: Take it with food as advised by the doctor. Disperse the tablet in a spoonful (15ml) of boiled and cooled water. Consume immediately.

Medicinal Benefits

Zatrofix OF Dry Syrup is a combination of cephalosporin and fluoroquinolone antibiotics that works by killing the bacteria (bactericidal). Cefixime works by stopping the growth of bacteria by inhibiting the formation of a protective layer required by the bacteria or its growth. At the same time, Ofloxacin acts by blocking the action of a chemical messenger, which helps the genetic material of bacteria to survive. The doctor usually prescribes Zatrofix OF Dry Syrup for the treatment of typhoid fever and urinary tract infections. Besides this, it also treats bacterial infections of the prostate, skin, lungs, sexually transmitted infections like gonorrhoea (cervical/urethral), ear infections (acute otitis media), upper respiratory tract infections (URTI), lower respiratory tract infection, tonsillitis (inflammation of the tonsils) and pharyngitis (inflammation of the pharynx). 

How Zatrofix OF Dry Syrup Works

Zatrofix OF Dry Syrup contains 'Cefixime' (cephalosporin antibiotic) and 'Ofloxacin' (fluoroquinolone antibiotic) that works by preventing the formation of the outer covering of the bacteria (cell wall) required for their survival. Zatrofix OF Dry Syrup prevents the release of a chemical messenger (mucopeptides) by the bacteria, thereby weakening and destroying the bacterial cell wall. Zatrofix OF Dry Syrup is a broad range antibiotic that works against a wide range of both gram-positive and gram-negative bacteria.

Storage

Keep Zatrofix OF Dry Syrup out of the sight and reach of children.
Side effects of Zatrofix OF Dry Syrup
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
  • Avoid trigger foods that can cause allergic reactions, such as nuts, shellfish, or dairy products.
  • Keep a food diary to track potential food allergens.
  • Include omega-3 rich foods like salmon and walnuts to reduce inflammation.
  • Wear loose, comfortable clothing made from soft fabrics like cotton.
  • Apply cool compresses or take cool baths to reduce itching.
  • Use gentle soaps and avoid harsh skin products.
  • Reduce stress through relaxation techniques like meditation or deep breathing.
  • Notify your doctor about the fever caused by medication and follow their guidance to adjust or stop the medication.
  • Drink plenty of fluids, like water or electrolyte-rich beverages, and eat healthy food.
  • Get plenty of rest to help your body recover or adjust to the medication.
  • Track your temperature and report changes to your doctor.
  • Use fever-reducing medications like acetaminophen if recommended.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
Here are the steps to manage angioedema (Swelling Under The Skin) as a side effect of medication:
  • If you experience angioedema, inform your doctor immediately. Treatment can help keep the swelling under control.
  • Seek medical attention if symptoms are severe, such as difficulty breathing or swallowing.
  • Follow your doctor's instructions to manage symptoms, which may include stopping or adjusting the medication that triggered angioedema.
  • Your doctor may also recommend antihistamines, steroids, or other treatments to reduce swelling and inflammation.
  • Make dietary and lifestyle changes as recommended, such as avoiding trigger foods or reducing stress.
  • Monitor your condition closely and track your symptoms to report them to your doctor.
  • Consult your doctor again if symptoms worsen or do not improve or if you experience any new or concerning symptoms.
  • Let your doctor know if there are unsual symptoms after taking the medication, such as red patches on your skin.
  • Your doctor may change your medication, lower the dose, or stop the treatment to help manage the symptoms.
  • Avoid heavy physical activity and get plenty of rest to prevent further worsening of the symptoms.
  • Apply cold packs to the affected areas for relief.
  • Keep yourself hydrated or take supplements to get enough vitamins.
  • Over-the-counter pain relievers can help with discomfort.

What if I have taken an overdose of Zatrofix OF Dry Syrup

Do not take more than the prescribed dose of Zatrofix OF Dry Syrup as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

You should avoid taking Zatrofix OF Dry Syrup if you are hypersensitive to ofloxacin, cefixime or other macrolide antibiotics as it may lead to overdose and toxicity. The use of Zatrofix OF Dry Syrup is only allowed in pregnancy or breastfeeding if clearly suggested by the doctor. Tell your doctor if you are pregnant, or breastfeeding before using Zatrofix OF Dry Syrup. Ofloxacin present in Zatrofix OF Dry Syrup may cause and aggravate symptoms of existing peripheral neuropathy (nerve damage in legs), tendinitis (swelling or tearing of a tendon), myasthenia gravis (skeletal muscle weakness), and respiratory issues like bronchitis, sinusitis. People with diabetes should contact a doctor before taking Zatrofix OF Dry Syrup as Zatrofix OF Dry Syrup can lower your blood sugar level in some cases. Patient with central nervous system disorder or epilepsy (fits) should avoid intake of Zatrofix OF Dry Syrup as its use is contraindicated for them. 

Drug-Drug Interactions

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OfloxacinMesoridazine
Critical
OfloxacinSaquinavir
Critical

Drug-Drug Interactions

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OfloxacinMesoridazine
Critical
How does the drug interact with Zatrofix OF Dry Syrup:
Using Mesoridazine together with Zatrofix OF Dry Syrup can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Mesoridazine with Zatrofix OF Dry Syrup is not recommended, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.
OfloxacinSaquinavir
Critical
How does the drug interact with Zatrofix OF Dry Syrup:
Coadministration of Zatrofix OF Dry Syrup with Saquinavir can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Zatrofix OF Dry Syrup with Saquinavir together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
OfloxacinDronedarone
Critical
How does the drug interact with Zatrofix OF Dry Syrup:
Coadministration of Zatrofix OF Dry Syrup with Dronedarone can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Zatrofix OF Dry Syrup with Dronedarone together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
OfloxacinDisopyramide
Critical
How does the drug interact with Zatrofix OF Dry Syrup:
Coadministration of Zatrofix OF Dry Syrup with Disopyramide can increase the risk of irregular heart rhythms.

How to manage the interaction:
Taking Zatrofix OF Dry Syrup with Disopyramide together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
OfloxacinHalofantrine
Critical
How does the drug interact with Zatrofix OF Dry Syrup:
Using halofantrine together with Zatrofix OF Dry Syrup can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Zatrofix OF Dry Syrup with Halofantrine can cause an interaction, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.
OfloxacinQuinidine
Critical
How does the drug interact with Zatrofix OF Dry Syrup:
Coadministration of Zatrofix OF Dry Syrup with Quinidine can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Zatrofix OF Dry Syrup with Quinidine together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
OfloxacinThioridazine
Critical
How does the drug interact with Zatrofix OF Dry Syrup:
Coadministration of Zatrofix OF Dry Syrup with Thioridazine can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Zatrofix OF Dry Syrup with Thioridazine together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
OfloxacinBepridil
Critical
How does the drug interact with Zatrofix OF Dry Syrup:
Using bepridil together with Zatrofix OF Dry Syrup drugs can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Zatrofix OF Dry Syrup with Bepridil can cause an interaction, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats. Do not stop using any medications without consulting a doctor.
OfloxacinAmiodarone
Critical
How does the drug interact with Zatrofix OF Dry Syrup:
The combination of Amiodarone and Zatrofix OF Dry Syrup may significantly increase the risk of an abnormal heart rhythm.

How to manage the interaction:
Although Amiodarone and Zatrofix OF Dry Syrup interact, it can be taken if prescribed by a doctor. If you get dizziness, lightheadedness, fainting, or fast or racing heartbeats, consult a doctor. Do not stop taking any medications without consulting a doctor.
OfloxacinSotalol
Critical
How does the drug interact with Zatrofix OF Dry Syrup:
Coadministration of Zatrofix OF Dry Syrup with Sotalol can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Zatrofix OF Dry Syrup with Sotalol together is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. If you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include probiotics in your diet as probiotics contain healthy bacteria that are good for the intestines and can recover the killed bacteria.
  • Taking probiotics after completing the antibiotics course can minimize the chances of antibiotic-associated diarrhoea. Foods that are high in probiotics include yoghurt, cheese, sauerkraut, and kimchi so consume them to restore the good bacteria of the intestine. 
  • Try to take more fibre-enriched food as it will help the food to digest properly and helps to stimulate the growth of gut bacteria.
  • Include whole grains like whole-grain bread, brown rice to include fibre in your diet.
  • Try to consume less calcium, iron-enriched foods, and drinks as it may slow down the working of Zatrofix OF Dry Syrup. 
  • Try to limit the consumption of alcoholic beverages as it can cause worsening of side effects and make your body dehydrated and affect your sleep. This also makes it difficult for your body to aid the Zatrofix OF Dry Syrup in fighting off infections.

Habit Forming

No

Therapeutic Class

ANTI- BACTERIALS

Zatrofix OF Dry Syrup Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

It is best to limit the consumption of alcohol as it may worsen the side effects of Zatrofix OF Dry Syrup.

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Pregnancy

Caution

Zatrofix OF Dry Syrup should only be given in pregnancy if clearly suggested by the doctor after weighing the benefits and potential risks of medication.

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Breast Feeding

Unsafe

Zatrofix OF Dry Syrup should be suggested to breastfeeding mothers only if the doctor has judged it to outweigh the potential risks to the infant. Hence one should consult with their doctor before taking Zatrofix OF Dry Syrup.

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Driving

Caution

A person should avoid driving as it may cause impaired vision and affect thinking ability.

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Liver

Caution

Zatrofix OF Dry Syrup should be taken with caution in patients having a history of liver diseases/conditions. The doctor may suggest lower doses initially.

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Kidney

Caution

Zatrofix OF Dry Syrup to be taken with caution, especially in persons having a history of Kidney disorders. The doctor may initially suggest a lower dose of initially.

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Children

Caution

Zatrofix OF Dry Syrup to be given to children below the age of 12 with caution only if clearly prescribed by a doctor.

Have a query?

FAQs

Zatrofix OF Dry Syrup is used for the treatment of a wide range of bacterial infections of the skin, ears, lungs, prostate and urinary tract. Besides this, it also treats typhoid fever and STDs (sexually transmitted diseases) like chlamydia and gonorrhoea.

No, you should not double the dose if you forget to take Zatrofix OF Dry Syrup, then take it as soon as you remember or skip it if it's time for the next dose.

Yes, some patients may experience diarrhoea, after taking this medicine so it is better to take this drug after a meal which reduces the risk of stomach discomfort. However, If you are noticing diarrhoea that is watery or bloody, then immediately ask your doctor. Do not try to take self-medication for diarrhoea without asking the doctor.

Yes, this medicine is prescribed for the treatment of urinary tract infection (UTI). Take Zatrofix OF Dry Syrup only if the doctor has prescribed you this medicine.

You should avoid driving as this medicine may cause impaired vision or affect the thinking ability so avoid such a task that needs a clear vision.

You should avoid taking Zatrofix OF Dry Syrup if you have peripheral neuropathy (nerve damage in legs), tendinitis (swelling or tearing of a tendon), myasthenia gravis (skeletal muscle weakness), respiratory issues like bronchitis, sinusitis, diabetes, central nervous system disorder, or epilepsy (fits).

No, Zatrofix OF Dry Syrup is not advised for viral infections, such as the common cold. It is a strong antibiotic used to treat severe bacterial infections.

You are advised to take Zatrofix OF Dry Syrup as recommended by your doctor. Complete the full treatment as prescribed to show its effectiveness, as discontinuing suddenly may cause antibiotic resistance.

No, Zatrofix OF Dry Syrup is not recommended for viral infections. Zatrofix OF Dry Syrup is an antibiotic used to treat bacterial infections. Do not self-medicate.

Zatrofix OF Dry Syrup doesn’t respond against the viral infections such as cough. Therefore, if you have cough, consult your doctor for appropriate medication.

Yes, cefix contains cefixime as its active substance and is an antibiotic used to treat bacterial infections of urinary tract, lungs, throat, airways, tonsils, middle ear, and cervical or urethral regions.

Take Zatrofix OF Dry Syrup as recommended by your doctor. Taking Zatrofix OF Dry Syrup with milk may potentially affect its effectiveness.

No, do not take Zatrofix OF Dry Syrup for stomach infections as it could be due to various reasons. Also, avoid taking Zatrofix OF Dry Syrup for any infection without doctor’s advice.

Yes, Zatrofix OF Dry Syrup is a strong antibiotic that can treat various bacterial infections. Do not self-medicate.

Zatrofix OF Dry Syrup can be used for sinus infections (sinusitis) if caused by bacteria and if it is advised by a doctor. However, please consult a doctor as it varies for everyone based on your health condition.

No, do not take Zatrofix OF Dry Syrup on your own as inappropriate usage of antibiotics may cause failure of the treatment in future.

The dosage of Zatrofix OF Dry Syrup treatment vary based on the specific condition and patient response to the medication. If you do not notice any improvement within 3-4 days of starting the treatment, please consult your doctor. Do not self-medicate.

Zatrofix OF Dry Syrup contains Cefixime (cephalosporin antibiotic) and Ofloxacin (fluoroquinolone antibiotic) as its active substances.

Consult your doctor if you don’t get better after using Zatrofix OF Dry Syrup. Also, inform about the unwanted effects and the symptoms that worsen while using Zatrofix OF Dry Syrup.

UTIs are usually treated with antibiotics. To prevent UTIs, it's important to stay hydrated, urinate after sex, avoid irritating female hygiene products, and wear cotton underwear. For frequent UTIs, doctors may recommend low-dose antibiotics or other preventive options, including probiotics.

Store Zatrofix OF Dry Syrup at room temperature. Protect from light. Keep it out of reach from children. Disposal of Zatrofix OF Dry Syrup is done by following the local guidelines.

Country of origin

India
Other Info - ZA65495

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:38 AM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/202091s005,203195s006lbl.pdf
  2. https://www.drugs.com/drug-interactions/cefixime.html
  3. https://www.ciplamed.com/content/omnix-o-tablets
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