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About CEFIXIME+OFLOXACIN

CEFIXIME+OFLOXACIN belongs to a group of medications called 'cephalosporin antibiotics' primarily used for the treatment of a wide range of bacterial infections of the skin, ears, lungs, prostate and urinary tract. Besides this, it also treats typhoid fever and STDs (sexually transmitted diseases) like chlamydia and gonorrhoea. A bacterial infection happens when harmful bacteria enter inside the body and start multiplying. These harmful bacteria are responsible for producing toxins that can cause diseases like strep throat, urinary tract infection (UTI), bacterial food poisoning, gonorrhoea, bacterial meningitis, cellulitis, Lyme disease, and tetanus. CEFIXIME+OFLOXACIN does not work against viral infections like flu and colds.

CEFIXIME+OFLOXACIN contains 'Cefixime' (cephalosporin antibiotic) and 'Ofloxacin' (fluoroquinolone antibiotic) that works by preventing the formation of the outer covering of the bacteria (cell wall) required for their survival. CEFIXIME+OFLOXACIN prevents the release of a chemical messenger (mucopeptides) by the bacteria, thereby weakening and destroying the bacterial cell wall. CEFIXIME+OFLOXACIN is a broad range antibiotic that works against a wide range of both gram-positive and gram-negative bacteria.

Take CEFIXIME+OFLOXACIN as prescribed. Your doctor will recommend how often you take CEFIXIME+OFLOXACIN based on your medical condition. CEFIXIME+OFLOXACIN may cause some common side effects that include diarrhoea, indigestion, nausea, loose stools, abdominal pain, and vomiting. However, some of these side effects do not require medical attention and will pass within a couple of days. If side effects become get worse with time or do not pass within a couple of days, then one should consult their doctor. 

CEFIXIME+OFLOXACIN is not allowed to use in patients who are already taking any of the other antibiotics or having kidney or liver problems. This medicine can only be used in pregnant or breastfeeding women if strongly suggested by the doctor. Ofloxacin present in CEFIXIME+OFLOXACIN may cause and aggravate symptoms of existing peripheral neuropathy (nerve damage in legs), tendinitis (swelling or tearing of a tendon), myasthenia gravis (skeletal muscle weakness), and respiratory issues like bronchitis, sinusitis. People with diabetes should contact a doctor before taking CEFIXIME+OFLOXACIN as CEFIXIME+OFLOXACIN can lower your blood sugar level in some cases. Patient with central nervous system disorder or epilepsy (fits) should avoid intake of CEFIXIME+OFLOXACIN as its use is contraindicated for them.

Uses of CEFIXIME+OFLOXACIN

Bacterial infections, Typhoid fever, Urinary tract infection (UTI)

Medicinal Benefits

CEFIXIME+OFLOXACIN is a combination of cephalosporin and fluoroquinolone antibiotics that works by killing the bacteria (bactericidal). Cefixime works by stopping the growth of bacteria by inhibiting the formation of a protective layer required by the bacteria or its growth. At the same time, Ofloxacin acts by blocking the action of a chemical messenger, which helps the genetic material of bacteria to survive. The doctor usually prescribes CEFIXIME+OFLOXACIN for the treatment of typhoid fever and urinary tract infections. Besides this, it also treats bacterial infections of the prostate, skin, lungs, sexually transmitted infections like gonorrhoea (cervical/urethral), ear infections (acute otitis media), upper respiratory tract infections (URTI), lower respiratory tract infection, tonsillitis (inflammation of the tonsils) and pharyngitis (inflammation of the pharynx). 

Directions for Use

Tablet: Take it with or without food as advised by a doctor. Swallow it as a whole with a glass of water. Do not crush, chew or break it. Tablet DT: Take it with food as advised by the doctor. Disperse the tablet in a spoonful (15ml) of boiled and cooled water. Consume immediately.

Storage

Store in a cool and dry place away from sunlight

Side Effects of CEFIXIME+OFLOXACIN

  • Diarrhoea
  • Nausea
  • Dyspepsia (Indigestion)
  • Loose stools
  • Abdominal pain
  • Vomiting

In-Depth Precautions and Warning

Drug Warnings

You should avoid taking CEFIXIME+OFLOXACIN if you are hypersensitive to ofloxacin, cefixime or other macrolide antibiotics as it may lead to overdose and toxicity. The use of CEFIXIME+OFLOXACIN is only allowed in pregnancy or breastfeeding if clearly suggested by the doctor. Tell your doctor if you are pregnant, or breastfeeding before using CEFIXIME+OFLOXACIN. Ofloxacin present in CEFIXIME+OFLOXACIN may cause and aggravate symptoms of existing peripheral neuropathy (nerve damage in legs), tendinitis (swelling or tearing of a tendon), myasthenia gravis (skeletal muscle weakness), and respiratory issues like bronchitis, sinusitis. People with diabetes should contact a doctor before taking CEFIXIME+OFLOXACIN as CEFIXIME+OFLOXACIN can lower your blood sugar level in some cases. Patient with central nervous system disorder or epilepsy (fits) should avoid intake of CEFIXIME+OFLOXACIN as its use is contraindicated for them. 

Drug Interactions

Drug-Drug Interaction: CEFIXIME+OFLOXACIN should be avoided to be taken with vaccines including typhoid vaccine, cholera vaccine, and Bacillus Calmette Guerin (BCG vaccine), antiepileptic (carbamazepine), blood thinner (warfarin), antacid and ulcer treating medicine (aluminium hydroxide, magnesium hydroxide, cimetidine, sucralfate), medicine to treat excess uric acid (probenecid), medicines for arthritis (methotrexate), diuretics/water pills (furosemide), asthma medicine (theophylline) and pain killers (fenbufen, ibuprofen). 

Drug-Food Interaction: A person should limit the consumption of eating a high-fat meal as this makes it harder for your body to absorb CEFIXIME+OFLOXACIN. Do not consume grapefruit during antibiotics treatment can prevent the body from utilizing CEFIXIME+OFLOXACIN properly. So, prevent intake of grapefruit or grapefruit juice with the antibiotic. Avoid consuming calcium enriched foods and drinks as it might affect the working of CEFIXIME+OFLOXACIN. 

Drug-Disease Interaction: People affected with diabetes mellitus, renal dysfunction, liver disease, seizure disorders, colitis (bowel disease that affects the large intestine, causing irritation, inflammation, and ulcers in the colon) should not take CEFIXIME+OFLOXACIN.

Drug-Drug Interactions Checker List:

  • FUROSEMIDE
  • BACILLUS CALMETTE-GUERIN(BCG) VACCINE
  • CHOLERA VACCINE
  • TYPHOID VACCINE
  • CARBAMAZEPINE
  • WARFARIN
  • CIMETIDINE
  • SUCRALFATE
  • METHOTREXATE
  • THEOPHYLLINE
  • IBUPROFEN
  • MAGNESIUM HYDROXIDE
  • ALUMINUM HYDROXIDE
  • LORATADINE
  • Safety Advice

    • Safety Warning

      Alcohol

      caution

      It is best to limit the consumption of alcohol as it may worsen the side effects of CEFIXIME+OFLOXACIN.

    • Safety Warning

      Pregnancy

      caution

      CEFIXIME+OFLOXACIN should only be given in pregnancy if clearly suggested by the doctor after weighing the benefits and potential risks of medication.

    • Safety Warning

      Breast Feeding

      unsafe

      CEFIXIME+OFLOXACIN should be suggested to breastfeeding mothers only if the doctor has judged it to outweigh the potential risks to the infant. Hence one should consult with their doctor before taking CEFIXIME+OFLOXACIN.

    • Safety Warning

      Driving

      caution

      A person should avoid driving as it may cause impaired vision and affect thinking ability.

    • Safety Warning

      Liver

      caution

      CEFIXIME+OFLOXACIN should be taken with caution in patients having a history of liver diseases/conditions. The doctor may suggest lower doses initially.

    • Safety Warning

      Kidney

      caution

      CEFIXIME+OFLOXACIN to be taken with caution, especially in persons having a history of Kidney disorders. The doctor may initially suggest a lower dose of initially.

    • Safety Warning

      Children

      caution

      CEFIXIME+OFLOXACIN to be given to children below the age of 12 with caution only if clearly prescribed by a doctor.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Include probiotics in your diet as probiotics contain healthy bacteria that are good for the intestines and can recover the killed bacteria.
    • Taking probiotics after completing the antibiotics course can minimize the chances of antibiotic-associated diarrhoea. Foods that are high in probiotics include yoghurt, cheese, sauerkraut, and kimchi so consume them to restore the good bacteria of the intestine. 
    • Try to take more fibre-enriched food as it will help the food to digest properly and helps to stimulate the growth of gut bacteria.
    • Include whole grains like whole-grain bread, brown rice to include fibre in your diet.
    • Try to consume less calcium, iron-enriched foods, and drinks as it may slow down the working of CEFIXIME+OFLOXACIN. 
    • Try to limit the consumption of alcoholic beverages as it can cause worsening of side effects and make your body dehydrated and affect your sleep. This also makes it difficult for your body to aid the CEFIXIME+OFLOXACIN in fighting off infections.

    Special Advise

    If you experience diarrhoea or CDAD (C. difficile-associated disease) immediately contact a doctor or nearby clinic as you might require sufficient electrolyte and other interventions for preventing water loss or dehydration. 

    Patients Concern

    Disease/Condition Glossary

    Bacterial infection: The bacterial infection occurs when harmful bacteria enter, and get multiplied, and cause sickness inside the body. Common symptoms of bacterial infection may vary depending upon the type of infection and bacteria, causing it. Some other symptoms of a bacterial infection include fever, feeling tired, swollen lymph nodes, headache, nausea, or vomiting. Bacteria are single-celled small microorganisms found in different shapes and structures like spherical, rod, and spiral-shaped.  Some harmful bacteria that can affect a human's body include Streptococcus, Staphylococcus, and E. coli. Bacterial infection can infect anyone persons with a weak immune system or already taking immunosuppressive drugs are at higher risk of bacterial infection. 

    FAQs

    I forget to take CEFIXIME+OFLOXACIN, should I double the dose next time?

    No, you should not double the dose if you forget to take CEFIXIME+OFLOXACIN, then take it as soon as you remember or skip it if it's time for the next dose.

    Can CEFIXIME+OFLOXACIN cause diarrhea?

    Yes, some patients may experience diarrhoea, after taking this medicine so it is better to take this drug after a meal which reduces the risk of stomach discomfort. However, If you are noticing diarrhoea that is watery or bloody, then immediately ask your doctor. Do not try to take self-medication for diarrhoea without asking the doctor.

    Is CEFIXIME+OFLOXACIN used for UTI?

    Yes, this medicine is prescribed for the treatment of urinary tract infection (UTI). Take CEFIXIME+OFLOXACIN only if the doctor has prescribed you this medicine.

    Can I drive after taking CEFIXIME+OFLOXACIN?

    You should avoid driving as this medicine may cause impaired vision or affect the thinking ability so avoid such a task that needs a clear vision.

    In which conditions or disease I should avoid taking CEFIXIME+OFLOXACIN?

    You should avoid taking CEFIXIME+OFLOXACIN if you have peripheral neuropathy (nerve damage in legs), tendinitis (swelling or tearing of a tendon), myasthenia gravis (skeletal muscle weakness), respiratory issues like bronchitis, sinusitis, diabetes, central nervous system disorder, or epilepsy (fits).

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    CEFIXIME+OFLOXACIN

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