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  3. ZAVEDOS INJECTION 5MG

ZAVEDOS INJECTION 5MG, Pack of 1 INJECTION
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

ZAVEDOS INJECTION 5MG is used to treat cancer. It contains Idarubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, destroying DNA and RNA synthesis. Thus, ZAVEDOS INJECTION 5MG stops the multiplication of abnormal cells, leads to the growth of cells in an unbalanced way and causes cancer cell death. ZAVEDOS INJECTION 5MG is used in combination with other medicines for the treatment of acute myeloid leukaemia.

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Composition :

IDARUBICIN-5MG

Manufacturer/Marketer :

Pfizer Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About ZAVEDOS INJECTION 5MG

ZAVEDOS INJECTION 5MG is an antineoplastic medicine used in the treatment of cancer. Cancer is a disease where the cells grow abnormally and divide uncontrollably. ZAVEDOS INJECTION 5MG is used in the treatment of Acute Myeloid Leukemia. Leukemia, also known as blood cancer, is the cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections.

ZAVEDOS INJECTION 5MG contains Idarubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, destroying DNA and RNA synthesis. Thus, ZAVEDOS INJECTION 5MG stops the multiplication of abnormal cells, leads to the growth of cells in an unbalanced way and causes cancer cell death. ZAVEDOS INJECTION 5MG is used in combination with other medicines for the treatment of acute myeloid leukemia.

ZAVEDOS INJECTION 5MG may cause certain side effects such as vomiting, nausea, mouth ulcers, loss of appetite, diarrhea, dizziness, weakness, stomach pain, headache, pale skin, difficulty urinating, fever, and pain at the site of injection. Most of these side effects of ZAVEDOS INJECTION 5MG do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. ZAVEDOS INJECTION 5MG is a parenteral preparation and will be administered by the oncology doctor. Hence, do not self-administer. Your doctor will decide the dose of the medicine based on the severity of the condition.

ZAVEDOS INJECTION 5MG should be avoided if you are allergic to it or any other component present in it. Inform your doctor about your complete medical and medication history before starting treatment with ZAVEDOS INJECTION 5MG. ZAVEDOS INJECTION 5MG is contraindicated for pregnant women due to serious embryo-fetal toxicity. Inform your doctor if you are pregnant, planning to become pregnant or breastfeeding. Inform your doctor if you have /had any pre-existing liver or kidney disease, bone marrow suppression, or heart disease, as it may cause serious adverse effects or worsen the condition. Avoid alcohol consumption with ZAVEDOS INJECTION 5MG as it may increase the risk of liver damage. This medicine is not recommended for children as safety and efficacy are not established.

Uses of ZAVEDOS INJECTION 5MG

ZAVEDOS INJECTION 5MG is used in the treatment of acute myeloid leukemia (AML). The detailed uses of ZAVEDOS INJECTION 5MG are as follows:<br/>• Treatment of acute myeloid leukemia (AML): ZAVEDOS INJECTION 5MG is used in combination with other medications to treat acute myelogenous leukemia, a cancer of the white blood cells.<br/>• Inhibits cancer cell growth: ZAVEDOS INJECTION 5MG belongs to the anthracycline class of drugs and works by slowing or stopping the growth of cancer cells in the body.<br/>

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.• ZAVEDOS INJECTION 5MG will be administered by the doctor or healthcare professional.• Do not self-administer.

Medicinal Benefits

ZAVEDOS INJECTION 5MG contains Idarubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, destroying DNA and RNA synthesis. Thus, ZAVEDOS INJECTION 5MG stops the multiplication of abnormal cells, leads to the growth of cells in an unbalanced way and causes cancer cell death.

How ZAVEDOS INJECTION 5MG Works

ZAVEDOS INJECTION 5MG contains Idarubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, destroying DNA and RNA synthesis. Thus, ZAVEDOS INJECTION 5MG stops the multiplication of abnormal cells, leads to the growth of cells in an unbalanced way and causes cancer cell death. ZAVEDOS INJECTION 5MG is used in combination with other medicines for the treatment of acute myeloid leukemia.

Storage

• Store in a cool and dry place away from sunlight.• Keep ZAVEDOS INJECTION 5MG out of the sight and reach of children. • Cold chain - To be stored in cold places at 2ºC to 8ºC.
Side effects of Zavedos Injection 5mg
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Severe leukopenia needs immediate medical attention if the levels of WBC drop.
  • Boost your immunity by including immune-rich foods and stay hydrated.
  • Get sufficient sleep and manage stress, which helps improve white blood cell count.
  • Consult your doctor for effective treatment to improve your blood cell count and get regular body checks to monitor changes in the count.
  • Try to prevent the factors that cause severe leukopenia and may lead to impaired immunity.
  • Eat well-cooked food to minimize infection risk.
  • Practice good hand hygiene to prevent infections.
  • Avoid crowds and people with illnesses to reduce exposure.
  • Wear a mask when necessary to lower infection risk.
  • Rest adequately to support your body's healing process.
  • Stay hydrated by drinking plenty of water.
  • Regularly monitor blood cell counts for changes.
  • Seek immediate medical help if symptoms like fever, chills, or fatigue occur.
  • Consult your doctor right away if concerning symptoms arise.
  • Follow your doctor's guidance on managing myelosuppression and infection prevention.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Heart failure needs immediate medical attention. To manage this effect, the doctor's instructions must be followed strictly.
  • Take care of change in your weight as there can be sudden changes.
  • Rest and refrain from physical activity, and restart after a few days.
  • Reduce your salt intake and control your diet with the help of a dietician.
  • Track your symptoms and keep your follow-up appointments to manage severe side effects.
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.

What if I have taken an overdose of ZAVEDOS INJECTION 5MG

As ZAVEDOS INJECTION 5MG is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away. Overdose of ZAVEDOS INJECTION 5MG may cause nausea, vomiting, severe stomach pain, sores in the mouth and throat, unusual bleeding or bruising, fever, sore throat, chills, or other signs of infection, black and tarry stools, and red blood in stools.

Drug Warnings

ZAVEDOS INJECTION 5MG should be avoided if you are allergic to it or any other component present in it. Inform your doctor about your complete medical and medication history before starting treatment with ZAVEDOS INJECTION 5MG. ZAVEDOS INJECTION 5MG is contraindicated for pregnant women and breastfeeding women due to serious embryo-fetal toxicity. Inform your doctor if you are pregnant, planning to become pregnant or breastfeeding. Inform your doctor if you have /had any pre-existing liver or kidney disease, pre-existing bone marrow suppression, or pre-existing heart disease, as it may cause serious adverse effects or worsen the condition. Avoid alcohol consumption with ZAVEDOS INJECTION 5MG as it may increase the risk of liver damage. This medicine is not recommended for children as safety and efficacy are not established.

Drug-Drug Interactions

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IdarubicinPimozide
Critical
IdarubicinSparfloxacin
Critical

Drug-Drug Interactions

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IdarubicinPimozide
Critical
How does the drug interact with Zavedos Injection 5mg:
Taking Zavedos Injection 5mg and Pimozide together can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Zavedos Injection 5mg and Pimozide together is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
IdarubicinSparfloxacin
Critical
How does the drug interact with Zavedos Injection 5mg:
Co-administration of Sparfloxacin with Zavedos Injection 5mg may prolong the QT interval.

How to manage the interaction:
Taking Zavedos Injection 5mg with Sparfloxacin is not recommended, please consult a doctor before taking it.
IdarubicinZiprasidone
Severe
How does the drug interact with Zavedos Injection 5mg:
Taking Zavedos Injection 5mg and Ziprasidone together can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Zavedos Injection 5mg and Ziprasidone together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
IdarubicinYellow fever vaccine
Severe
How does the drug interact with Zavedos Injection 5mg:
Taking Yellow fever vaccine with Zavedos Injection 5mg can increase the risk of infection or may reduce the effectiveness of the vaccine.

How to manage the interaction:
Although taking Zavedos Injection 5mg and Yellow fever vaccine together can cause an interaction, it can be taken if a doctor has suggested it. If you notice any unusual symptoms, it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
IdarubicinDolasetron
Severe
How does the drug interact with Zavedos Injection 5mg:
Taking Zavedos Injection 5mg and Dolasetron together can increase the chance of a serious abnormal heart rhythm. If you suffer from any cardiac conditions, or electrolyte disturbances (such as magnesium or potassium deficiency brought on by severe or prolonged diarrhea or vomiting), you may be at higher risk.

How to manage the interaction:
Taking Zavedos Injection 5mg and Dolasetron together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
IdarubicinMethadone
Severe
How does the drug interact with Zavedos Injection 5mg:
Taking Zavedos Injection 5mg and Methadone together can increase the chance of a serious abnormal heart rhythm. If you suffer from any cardiac conditions, or electrolyte disturbances (such as magnesium or potassium deficiency brought on by severe or prolonged diarrhea or vomiting), you may be at higher risk.

How to manage the interaction:
Taking Zavedos Injection 5mg and Methadone together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
IdarubicinEfavirenz
Severe
How does the drug interact with Zavedos Injection 5mg:
Taking Zavedos Injection 5mg and Efavirenz together can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Zavedos Injection 5mg and Efavirenz together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue any medication without consulting a doctor.
IdarubicinToremifene
Severe
How does the drug interact with Zavedos Injection 5mg:
Taking Zavedos Injection 5mg and Toremifene together can increase the chance of a serious abnormal heart rhythm. If you suffer from any cardiac conditions, or electrolyte disturbances (such as magnesium or potassium deficiency brought on by severe or prolonged diarrhea or vomiting), you may be at higher risk.

How to manage the interaction:
Taking Zavedos Injection 5mg and Toremifene together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
IdarubicinSotalol
Severe
How does the drug interact with Zavedos Injection 5mg:
Taking sotalol and Zavedos Injection 5mg can increase the risk or severity of irregular heart rhythms which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Although there is a possible interaction between Sotalol and Zavedos Injection 5mg, you can take these medicines together if prescribed by a doctor. If you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations consult a doctor. Do not stop using any medications without talking to a doctor.
IdarubicinArsenic trioxide
Severe
How does the drug interact with Zavedos Injection 5mg:
Taking Zavedos Injection 5mg and Arsenic trioxide together can increase the chance of a serious abnormal heart rhythm. If you suffer from any heart conditions, or electrolyte disturbances (such as magnesium or potassium deficiency brought on by severe or prolonged diarrhea or vomiting), you may be at higher risk.

How to manage the interaction:
Taking Zavedos Injection 5mg and Arsenic trioxide together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a balanced diet including fruits and vegetables rich in nutrients and low-fat proteins like lean meats, fish and poultry.
  • Drink plenty of water daily while taking ZAVEDOS INJECTION 5MG as some cancer therapies may cause dehydration.
  • Exercise regularly and maintain a healthy body weight.
  • Regularly wash your hands and avoid contact with people having infections.
  • Quit smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

ZAVEDOS INJECTION 5MG Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid consumption of alcohol with ZAVEDOS INJECTION 5MG as it may increase the risk of liver damage.

bannner image

Pregnancy

Unsafe

It is not recommended for use in pregnancy as it may harm your foetus. If you are pregnant or planning pregnancy, inform your doctor before receiving ZAVEDOS INJECTION 5MG. Use effective contraception to avoid pregnancy while on treatment with this medicine.

bannner image

Breast Feeding

Unsafe

It is not recommended for use in breastfeeding as it may pass into breast milk and harm your infant. Because of the possibility of major adverse events in nursing infants from the medicine, women should quit nursing prior to taking the drug and refrain from breastfeeding during treatment and for 14 days after the final dosage.

bannner image

Driving

Unsafe

ZAVEDOS INJECTION 5MG causes dizziness and may alter the ability to drive or operate machines. Hence, avoid driving or operating machines after taking ZAVEDOS INJECTION 5MG.

bannner image

Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving ZAVEDOS INJECTION 5MG. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition. Your doctor may also suggest liver function tests while on treatment with ZAVEDOS INJECTION 5MG.

bannner image

Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving ZAVEDOS INJECTION 5MG. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition. Your doctor may also suggest renal function tests while on treatment with ZAVEDOS INJECTION 5MG.

bannner image

Children

Unsafe

ZAVEDOS INJECTION 5MG is not recommended for use in children as the safety and efficacy have not been established.

Have a query?

FAQs

ZAVEDOS INJECTION 5MG is used to treat Acute Myeloid Leukemia.

ZAVEDOS INJECTION 5MG contains Idarubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, destroying DNA and RNA synthesis.

If you are about to receive any vaccinations, especially live vaccines such as measles, mumps, rubella and polio vaccines, it is advised to inform your doctor that you are on treatment with ZAVEDOS INJECTION 5MG as it may cause infections.

Yes, ZAVEDOS INJECTION 5MG is a vesicant. Vesicants are drugs that can cause severe tissue damage and blistering if they leak out of the vein during administration (a process known as extravasation). Always ensure ZAVEDOS INJECTION 5MG should be administered by trained healthcare professionals to minimize risks.

The side effects of ZAVEDOS INJECTION 5MG include nausea, vomiting, mouth ulcers, loss of appetite, diarrhoea, dizziness, weakness, stomach pain, headache, pale skin, difficulty urinating, fever, and pain at the injection site. Consult the doctor if any of these symptoms persist or worsen.

Country of origin

India

Manufacturer/Marketer address

The Capital, 1802, 18th Floor , Plot No. C-70, ‘G’ Block , Bandra Kurla Complex, Bandra East , Mumbai – 400051.
Other Info - ZAV0003

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:20 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/050734s027lbl.pdf
  2. https://medlineplus.gov/druginfo/meds/a691004.html
  3. https://reference.medscape.com/drug/idarubicin-342123
  4. https://go.drugbank.com/drugs/DB01177

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