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  3. Zeesev 400 Tablet

Prescription drug
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Zeesev 400 Tablet, Pack of 1 Tablet
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Synonym :

SEVELAMER CARBONATE

Composition :

SEVELAMER-400MG

Manufacturer/Marketer :

Zeelab Pharmacy Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Zeesev 400 Tablet

Zeesev 400 Tablet is used to control high phosphate levels in the body (hyperphosphataemia) in adult patients on dialysis (a blood clearance technique), patients undergoing hemodialysis (using a blood filtration machine), and patients with chronic kidney disease.

Zeesev 400 Tablet contains sevelamer that works by binding phosphate in the gastrointestinal tract and decreasing absorption. It effectively reduces excess phosphate levels in the blood and prevents the unsafe build-up of phosphate in your body.

The most common side effects of Zeesev 400 Tablet are vomiting, upper abdominal pain, nausea, diarrhoea, stomach ache, indigestion, and flatulence. If any of the side effects are experienced continuously, contact your doctor immediately.

Zeesev 400 Tablet is not recommended if you are allergic to it, or if you have low phosphate levels in your blood or a blockage in your bowel. Also, if you are pregnant or breastfeeding, talk to your doctor before taking Zeesev 400 Tablet. 

Uses of Zeesev 400 Tablet

Zeesev 400 Tablet is used to control high phosphate levels in patients with kidney problems. The detailed uses of Zeesev 400 Tablet are as follows:

  • Treatment of hyperphosphatemia in dialysis patients: Used to lower high blood phosphate levels in adults undergoing haemodialysis or peritoneal dialysis.
  • Management of hyperphosphatemia in non-dialysis chronic kidney disease (CKD) patients: Prescribed for patients with chronic renal disease who do not require dialysis but have elevated serum phosphorus levels (1.78 mmol/L).
  • Prevention of bone disorders: Used in combination with calcium and vitamin D supplements to lower the risk of bone disease caused by high phosphate levels.
  • Supports phosphate balance: Zeesev 400 Tablet helps to maintain a healthy balance of minerals in the blood when the kidneys are unable to filter phosphate properly.

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Directions for Use

  • Zeesev 400 Tablet can be taken with meals or as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow the whole tablet with a glass of water.
  • Do not crush, chew, or break it.

Medicinal Benefits

  • Zeesev 400 Tablet belongs to a group of medications called phosphate binders, 
  • It works by binding phosphate in the gastrointestinal tract and decreasing its absorption. This lowers the phosphate concentration in the body. 
  • Zeesev 400 Tablet effectively reduces excess phosphate levels in the blood, prevents the unsafe buildup of phosphate in your body, helps to keep your bones strong, and decreases the risk of heart disease and strokes.
  • Zeesev 400 Tablet controls hyperphosphataemia (high blood phosphate levels) in adult patients on dialysis (a blood clearance technique), patients undergoing hemodialysis (using a blood filtration machine) or peritoneal dialysis (where the fluid is pumped into the abdomen and an internal body membrane filters the blood), and patients with chronic kidney disease.

How Zeesev 400 Tablet Works

Zeesev 400 Tablet contains sevelamer that works by binding phosphate in the gastrointestinal tract and decreasing absorption. It effectively reduces excess phosphate levels in the blood, prevents the unsafe build-up of phosphate in your body, helps keep your bones strong, and decreases the risk of heart disease and strokes.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Zeesev 400 Tablet
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
Here are the steps to manage Joint Pain caused by medication usage:
  • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
  • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
  • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.
Managing Medication-Triggered Bronchitis (Inflammation of the bronchial tubes): A Step-by-Step Guide:
  • If you experience symptoms like coughing, wheezing, chest tightness, or difficulty breathing after taking medication, seek medical attention immediately.
  • Your healthcare provider will work with you to stop the medication causing the reaction, start alternative treatments, and provide supportive therapy.
  • To manage symptoms and prevent complications, follow your doctor's advice to use inhalers or nebulizers as prescribed, practice good hygiene, avoid irritants, stay hydrated, and get plenty of rest.
  • Regularly track your symptoms and report any changes or concerns to your healthcare provider.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.

What if I have taken an overdose of Zeesev 400 Tablet

Do not take more than the prescribed dose of Zeesev 400 Tablet as it may cause serious adverse effects. If you suspect you have taken an overdose, please consult a doctor immediately.

Drug Warnings

  • You should avoid taking Zeesev 400 Tablet if you are allergic to it or any of its ingredients.
  • Speak to your doctor if you have swallowing disorders, digestive tract surgery, severe constipation, have undergone major surgery on your stomach or bowel, or have serious inflammatory bowel disease.
  • If you are pregnant or breastfeeding, consult your doctor before using Zeesev 400 Tablet.
  • Avoid alcohol consumption while taking Zeesev 400 Tablet as it might cause unpleasant side effects.
  • Zeesev 400 Tablet contains lactose (milk sugar). If you have an intolerance to some sugars, contact your doctor before taking Zeesev 400 Tablet.
  • Regular monitoring of serum phosphate levels, vitamin D, A, E, K, and folic acid is advised while taking Zeesev 400 Tablet.

Drug-Drug Interactions

verifiedApollotooltip
SevelamerGemifloxacin
Severe
SevelamerEnoxacin
Severe

Drug-Drug Interactions

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SevelamerGemifloxacin
Severe
How does the drug interact with Zeesev 400 Tablet:
Gemifloxacin's efficiency can be decreased by Zeesev 400 Tablet if it prevents the drug from being absorbed into the bloodstream. this is caused by the combined use of gemifloxacin and Zeesev 400 Tablet.

How to manage the interaction:
Co-administration of enoxacin and Zeesev 400 Tablet can lead to an interaction, but it can be taken if your doctor advises. It has been advised to separate the dosing of these medications by at least 4 hours and consult the doctor if your symptoms do not improve. Do not stop using any medications without a doctor's advice.
SevelamerEnoxacin
Severe
How does the drug interact with Zeesev 400 Tablet:
Co-administration of Enoxacin and Zeesev 400 Tablet can decrease the blood levels and effectiveness of Enoxacin.

How to manage the interaction:
Co-administration of Enoxacin and Zeesev 400 Tablet can lead to an interaction, but it can be taken if advised by your doctor. Do not stop using any medications without a doctor's advice.
SevelamerErgocalciferol
Severe
How does the drug interact with Zeesev 400 Tablet:
Co-administration of Zeesev 400 Tablet with Ergocalciferol can decrease the effects of Ergocalciferol.

How to manage the interaction:
Co-administration of Zeesev 400 Tablet with Ergocalciferol can lead to an interaction, but they can be taken if advised by your doctor. Consult the doctor if your symptoms worsen. Do not stop using any drugs without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Take fresh fruits, vegetables, rice, milk, unenriched corn and rice cereals, and soda without phosphate additives in your regular diet.
  • Avoid or limit high-phosphorus addictive foods (processed meats, instant puddings, sauces, spreadable cheeses, and beverage products).
  • Avoid intake of alcoholic beverages with Zeesev 400 Tablet as it can make you dehydrated and may increase the side effects.
  • Make sure you drink plenty of fluids. This will help you clear out the extra phosphate and help you overcome some of the issues.

Habit Forming

No

Therapeutic Class

HYPOPHOSPHATEMIC AGENT

Zeesev 400 Tablet Substitute

Substitutes safety advice
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Zeesev 400 Tablet to avoid unpleasant side effects.

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Pregnancy

Consult your doctor

Zeesev 400 Tablet is not absorbed by the body and is not expected to reach the baby. If you are pregnant or planning to become pregnant, tell your doctor. They will advise you whether you should take Zeesev 400 Tablet during this time.

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Breast Feeding

Consult your doctor

Zeesev 400 Tablet is not absorbed by the body and is not expected to pass into breast milk. If you are breastfeeding or plan to breastfeed, tell your doctor. They will advise you if you should take Zeesev 400 Tablet while breastfeeding.

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Driving

Safe if prescribed

Zeesev 400 Tablet has no or negligible influence on the ability to drive or operate any machinery.

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Liver

Consult your doctor

Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Consult your doctor

Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Zeesev 400 Tablet is not recommended for children below 6 years as its safety and effectiveness are not known.

FAQs

Zeesev 400 Tablet is used to control high phosphate levels in the body (hyperphosphataemia)‚ in adult patients on dialysis (a blood clearance technique), patients undergoing hemodialysis (using a blood filtration machine), and patients with chronic kidney disease. It is also used for the treatment of bone disease.

Zeesev 400 Tablet works by holding onto phosphate from the food so that it can pass out of your body. Decreasing blood phosphate levels can help keep your bones strong, prevent unsafe buildup of minerals in your body, and possibly decrease the risk of heart disease and strokes that can result from high phosphate levels.

No, ciprofloxacin may interfere with the working of Zeesev 400 Tablet; therefore, it should not be taken simultaneously with Zeesev 400 Tablet.

Yes, constipation is a common side effect of Zeesev 400 Tablet, though it does not occur in everyone. Please consult your doctor if the side effects become severe and disturb you.

Yes, serum phosphate levels should be monitored regularly while you are taking Zeesev 400 Tablet. The use of Zeesev 400 Tablet may decrease the levels of vitamin D, A, E, K, and folic acid, and hence, the levels need to be monitored during the treatment.

No, do not stop taking Zeesev 400 Tablet on your own. If you stop taking Zeesev 400 Tablet, your phosphate levels may elevate again. Please consult your doctor.

The side effects of Zeesev 400 Tablet include diarrhoea, headache, stomach upset, and constipation. If these side effects persist or worsen, please consult your doctor.

Take Zeesev 400 Tablet for as long as it is prescribed by your doctor. The dose and duration will depend on the response to treatment. Follow your doctor's instructions and do not stop taking Zeesev 400 Tablet on your own.

No, Zeesev 400 Tablet does not contain a steroid. It contains Sevelamer, which belongs to the class of drugs called phosphate binders.

Yes, Zeesev 400 Tablet can be taken with food as it works by binding to phosphate from food. Take it exactly as prescribed by your doctor.

It is important to take Zeesev 400 Tablet as phosphate levels in the blood cannot be controlled in patients undergoing dialysis, especially after a meal. When the phosphate level exceeds the range in the blood, it may cause problems such as red eyes, itchy skin, high blood pressure, bone pain, and also increase the risk of fractures. Zeesev 400 Tablet lowers these increased serum phosphate levels by binding phosphate from food in the digestive tract.

Zeesev 400 Tablet should be avoided by patients who are allergic to it and who have low phosphate levels in blood. Additionally, patients having intestinal obstruction should also avoid taking Zeesev 400 Tablet.

You are recommended to consult your doctor before taking other medicines with Zeesev 400 Tablet to avoid drug interactions.

If you miss a dose of Zeesev 400 Tablet, do not worry. Take it as soon as you remember. But, if it is time for your next dose, skip the missed dose and take your regular dose. Do not take a double dose to make up for the missed dose.

Country of origin

India
Other Info - ZE94494

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Author Details

Santoshini Reddy GDoctor badge

Reviewed By

Santoshini Reddy G

M Pharmacy

Last Updated

Sep 16, 2025 | 7:42 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.8784.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/022127s019,022318s021lbl.pdf
  3. https://www.medicines.org.uk/emc/files/pil.3681.pdf
  4. https://www.drugs.com/pro/sevelamer-suspension.html#s-34068-7
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