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compositionComposition:ABIRATERONE ACETATE-500MG
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Zelgor 500 mg Tablet is an anti-androgen medicine used to treat prostate cancer. It contains Abiraterone, which is in a class of medications called androgen biosynthesis inhibitors. It works by decreasing the amount of certain hormones in the body. Common side effects of Zelgor 500 mg Tablet may include nausea, dizziness, heartburn, headache, diarrhoea, muscle weakness, joint pain, confusion, hot flushes, loss of appetite, and groin pain.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ABIRATERONE ACETATE-500MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Zelgor 500 mg Tablet

Zelgor 500 mg Tablet is a prescription tablet used to treat advanced prostate cancer that has spread to other parts of the body. It is prescribed for cancer that no longer responds to surgical or medical treatments that lower testosterone, or for newly diagnosed high-risk cases that are still hormone-sensitive. It is typically taken alongside a steroid medication to help control side effects and keep your body's hormone levels balanced.

You must take Zelgor 500 mg Tablet consistently once every day, strictly following the routine set by your healthcare team. You should take this medicine on an empty stomach, meaning at least one hour before eating or two hours after eating, because food dramatically changes how it is absorbed. Incorporating gentle, doctor-approved exercise and eating a balanced diet rich in essential nutrients can also support your physical strength during this treatment.

While using this medication, you may experience common side effects such as joint pain, hot flashes, or feeling unusually tired. It is vital to seek immediate medical advice if you notice signs of liver damage, including dark urine, severe stomach discomfort, or yellowing of your eyes and skin.

Before you start taking Zelgor 500 mg Tablet , you must talk to your doctor if you have a history of heart disease, high blood pressure, low blood potassium, or liver problems. Pregnant women, or women who may become pregnant, should never take or even handle these tablets, as the active drug can cause severe harm to an unborn child.

This medication can interact with other prescriptions, over-the-counter drugs, and herbal supplements, which may change how your treatment works or increase your risk of liver damage. Because of this, you should avoid drinking alcohol during treatment, and always discuss your options with your doctor if you are managing other chronic health conditions.
 

Uses of Zelgor 500 mg Tablet

Zelgor 500 mg Tablet may be prescribed to treat the following types of advanced prostate cancer:

  • Metastatic castration-resistant prostate cancer (mCRPC): Zelgor 500 mg Tablet helps slow down the growth and spread of advanced prostate cancer cells that no longer respond to traditional testosterone-lowering treatments.
  • Metastatic high-risk castration-sensitive prostate cancer (mCSPC): Zelgor 500 mg Tablet works in combination with other hormone therapies to delay cancer progression in newly diagnosed cases that still respond to hormone reduction.
     

Key Benefits

Zelgor 500 mg Tablet offers the following benefits when used as prescribed:

  • Slowing Cancer Progression: By stopping the production of the hormones that feed cancer cells, Zelgor 500 mg Tablet helps limit the growth of tumours, offering patients more time with stable, managed disease.
  • Delaying Severe Bone Pain: As advanced prostate cancer often spreads to the bones, this medicine helps prevent or delay the onset of severe bone pain, helping you maintain better daily mobility and comfort.
  • Lowering Cancer Markers: When taken as directed, Zelgor 500 mg Tablet works effectively to lower prostate-specific antigen (PSA) levels in the blood, which is a key indicator that the therapy is successfully keeping the cancer in check.
     
Side effects of Zelgor 500 mg Tablet
  • If you have discomfort, illness, or unease after taking medication, seek medical attention.
  • Your treatment plan may be modified, including adjusting the dosage, substituting with an alternative medication, or discontinuing the medication. Additionally, certain lifestyle changes may be recommended to help manage symptoms.
  • To manage discomfort, follow your doctor's advice, like getting plenty of rest, or staying hydrated, and practising stress-reducing techniques.
  • Track your symptoms regularly and report any changes or concerns to your healthcare provider to manage the discomfort effectively.
  • Talk to your doctor about oral potassium supplements.
  • Eat potassium rich foods such as bananas, avocados, oranges, dark leafy greens, beans and peas, fish, spinach, milk and tomatoes.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.

Directions for Use

  • Zelgor 500 mg Tablet can be taken on an empty stomach at least two hours before or after a meal as directed by the doctor.
  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Swallow Zelgor 500 mg Tablet as a whole with a glass of water.
  • Do not break, chew or crush Zelgor 500 mg Tablet .

How Zelgor 500 mg Tablet Works

Even after medical or surgical treatments to lower testosterone, your body can still produce small amounts of male hormones (androgens) in other places, such as the adrenal glands or even within the cancer cells themselves. These residual hormones can continue to support the growth of prostate cancer. Zelgor 500 mg Tablet contains abiraterone acetate. It works by blocking a key enzyme in your body called CYP17, which is responsible for making these male hormones. By blocking this enzyme, the medicine stops hormone production at three critical sources: the testes, the adrenal glands, and the tumour cells. This severely limits the supply of testosterone, depriving the cancer cells of the hormones they need to grow and helping slow their progression.
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Alcohol

Caution

Interaction of Zelgor 500 mg Tablet with alcohol is unknown. It is advisable to consult your doctor if you have concerns.

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Pregnancy

Not applicable

Not intended for women.

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Breast Feeding

Not applicable

Not intended for women.

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Driving

Caution

Zelgor 500 mg Tablet may decrease alertness or make you feel sleepy and dizzy. So, do not drive or operate heavy machinery while taking Zelgor 500 mg Tablet until your vision improves.

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Liver

Caution

Zelgor 500 mg Tablet should be used with caution, especially if you have a history of liver diseases/conditions. Your doctor may adjust the dose based on your condition.

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Kidney

Caution

Zelgor 500 mg Tablet should be used with caution, especially if you have a history of kidney diseases/conditions. Your doctor may adjust the dose based on your condition.

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Children

Unsafe

Zelgor 500 mg Tablet is not recommended for use in children as the safety and efficacy of this medicine are not established.

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Heart

Caution

Zelgor 500 mg Tablet may be used in heart patients, but it can cause high blood pressure, fluid retention, and low potassium, which may worsen cardiac conditions. Careful monitoring and management of heart function and electrolytes are essential during treatment.

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Geriatrics

Caution

Geriatric patients can take Zelgor 500 mg Tablet , but it may be more prone to high blood pressure, low potassium, and fluid retention. Regular monitoring and dose adjustments are essential to ensure safe and effective treatment.

What if I have taken an overdose of Zelgor 500 mg Tablet

If you suspect an overdose or have taken more than your prescribed amount of Zelgor 500 mg Tablet , seek emergency medical care or call a poison control centre right away.

Diet & Lifestyle Advise

  • Strictly manage your food timing: To prevent dangerous levels of the drug from entering your system, never take Zelgor 500 mg Tablet with food. Keep a strict timer for your meals and medication.
  • Monitor your blood pressure daily: Because this therapy can cause your body to hold onto water and raise your blood pressure, keep a daily record of your readings to share with your doctor.
  • Support your bones: Hormone-blocking therapies can weaken your bones. Speak with your healthcare team about getting enough calcium and vitamin D, or whether you need bone-protecting supplements.
  • Stay active with gentle movement: Regular, low-impact exercise like walking can help combat the fatigue caused by cancer treatment and preserve your muscle mass.
     
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How Soon It Starts Working

The time required for Zelgor 500 mg Tablet to start to work: The onset time of Zelgor 500 mg Tablet has not been clinically established. The time for which the effects of Zelgor 500 mg Tablet last: The duration of Zelgor 500 mg Tablet ’s effect is clinically not established.

What if you forget to take Zelgor 500 mg Tablet

If you miss a dose of Zelgor 500 mg Tablet , skip the missed dose entirely and take your normal dose the next day at your regularly scheduled time. Do not take a double dose to make up for the missed one. If you miss more than one dose, contact your doctor or pharmacist immediately for instructions.

Storage

• Store Zelgor 500 mg Tablet tablets at room temperature, between 68°F and 77°F (20°C and 25°C).

Drug Warnings

  • Do not skip your steroid medication: Zelgor 500 mg Tablet must be taken with your prescribed steroid. Stopping the steroid suddenly can cause your body to produce too much of certain hormones, leading to severe high blood pressure or fluid retention.
  • Attend all scheduled blood tests: Your doctor will need regular blood samples to closely monitor your liver function and potassium levels while you are on this medicine.
  • Use effective barrier protection: If you are sexually active with a woman who is pregnant or could become pregnant, you must use a condom during intercourse and for one week after your last dose of Zelgor 500 mg Tablet .
  • Handle tablets with care: Ensure that women who are pregnant or breastfeeding do not handle broken or crushed tablets, as the drug can easily be absorbed through the skin.
     

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines before using Zelgor 500 mg Tablet :

  • CYP2D6 substrates: Zelgor 500 mg Tablet can increase the levels of certain medications processed by your liver, such as specific blood pressure drugs, antidepressants, or pain relievers, raising the risk of side effects.
  • Strong CYP3A4 inducers: Medicines like rifampin or phenytoin can speed up how quickly your body breaks down Zelgor 500 mg Tablet , making it less effective against your cancer.
     
AbirateroneMesoridazine
Critical
AbirateroneZiprasidone
Critical

Drug-Drug Interactions

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AbirateroneMesoridazine
Critical
How does the drug interact with Zelgor 500 mg Tablet:
Taking Zelgor 500 mg Tablet with Mesoridazine can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Zelgor 500 mg Tablet and Mesoridazine together is not recommended as it can result in an interaction. It can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat. Do not discontinue any medications without consulting a doctor.
AbirateroneZiprasidone
Critical
How does the drug interact with Zelgor 500 mg Tablet:
Taking Zelgor 500 mg Tablet with ziprasidone can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Although there is an interaction between Zelgor 500 mg Tablet and ziprasidone, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
AbirateroneThioridazine
Critical
How does the drug interact with Zelgor 500 mg Tablet:
Taking Zelgor 500 mg Tablet with Thioridazine can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Zelgor 500 mg Tablet and Thioridazine together is not recommended and can result in an interaction; it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or a rapid heartbeat. Do not discontinue any medications without consulting a doctor.
AbirateroneEliglustat
Critical
How does the drug interact with Zelgor 500 mg Tablet:
Coadministration of Zelgor 500 mg Tablet with Eliglustat can increase the levels of Eliglustat in the body. This increases the risk or severity of side effects.

How to manage the interaction:
Taking Zelgor 500 mg Tablet with Eliglustat is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, slow heart rate, weak pulse, or heart palpitations. Do not discontinue any medications without consulting a doctor.
AbirateroneSaquinavir
Critical
How does the drug interact with Zelgor 500 mg Tablet:
Taking Zelgor 500 mg Tablet with Saquinavir can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Zelgor 500 mg Tablet and Saquinavir together is not recommended as it can result in an interaction; it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.
AbirateroneEscitalopram
Severe
How does the drug interact with Zelgor 500 mg Tablet:
Using escitalopram together with Zelgor 500 mg Tablet can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although taking Escitalopram with Zelgor 500 mg Tablet can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience dizziness, irregular heartbeat, drowsiness, lightheadedness, shortness of breath, vomiting, or shortness of breath, consult a doctor immediately. Do not stop using any medications without consulting a doctor.
AbirateroneOxycodone
Severe
How does the drug interact with Zelgor 500 mg Tablet:
Coadministration of Zelgor 500 mg Tablet with Oxycodone can increase the levels of Oxycodone in the body. This increases the risk or severity of side effects.

How to manage the interaction:
Taking Zelgor 500 mg Tablet with Oxycodone together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience dizziness, fainting, confusion, excessive drowsiness, slow heart rate, and/or shallow or difficult breathing, contact a doctor immediately. Avoid activities requiring mental alertness such as driving or operating hazardous machinery while taking these medications. Do not discontinue any medications without consulting a doctor.
AbirateroneVenetoclax
Severe
How does the drug interact with Zelgor 500 mg Tablet:
Coadministration of Zelgor 500 mg Tablet with Venetoclax can increase the levels of Venetoclax in the body. This increases the risk or severity of side effects like bleeding problems, kidney injury, and the risk of developing serious infections.

How to manage the interaction:
Taking Zelgor 500 mg Tablet with Venetoclax together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.
AbirateroneCeritinib
Severe
How does the drug interact with Zelgor 500 mg Tablet:
Taking Zelgor 500 mg Tablet with Ceritinib can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Zelgor 500 mg Tablet with Ceritinib together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.
AbirateronePrimidone
Severe
How does the drug interact with Zelgor 500 mg Tablet:
Taking Zelgor 500 mg Tablet with primidone can significantly reduce the blood levels of Zelgor 500 mg Tablet, which may lower the treatment outcomes.

How to manage the interaction:
Taking Zelgor 500 mg Tablet with Primidone together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience shortness of breath, chest pain or tightness, rapid heartbeat, bloating or swelling of the face, arms, hands, lower legs, or feet, low urine output, or blurred vision, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip

The following food interactions should be considered while taking Zelgor 500 mg Tablet :

  • Food and meals: Taking Zelgor 500 mg Tablet with food, especially high-fat meals, can drastically increase the absorption of the drug, which can lead to severe and dangerous side effects.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Zelgor 500 mg Tablet is used to treat Prostate Cancer.
Zelgor 500 mg Tablet contains Abiraterone acetate, which belongs to the class of androgen biosynthesis inhibitors. It works by inhibiting the production of the testosterone hormone and thus stops the growth and spread of cancer.
The common side-effects of Zelgor 500 mg Tablet are nausea, dizziness, heartburn, headache, diarrhoea, muscle weakness, joint pain, confusion, hot flushes, loss of appetite, and groin pain. These side effects usually do not require any medical attention.
Inform your doctor if you have a pre-existing or a history of liver/kidney disease, hypoglycemia, hypokalemia, bone disorders, adrenocortical insufficiency, fluid retention and cardiovascular conditions before taking Zelgor 500 mg Tablet .
Zelgor 500 mg Tablet is not a cure for prostate cancer. However, it helps manage advanced stages by blocking testosterone production, thereby slowing the growth and progression of the cancer.
No, Zelgor 500 mg Tablet is not a chemotherapy drug. Zelgor 500 mg Tablet is a hormonal therapy that lowers testosterone levels to reduce the growth of prostate cancer.
You need to take prednisolone with Zelgor 500 mg Tablet to reduce the risk of high blood pressure, fluid retention (too much water in your body), and low potassium levels in your blood which may be caused by Zelgor 500 mg Tablet .
Yes, Zelgor 500 mg Tablet can affect the liver. Your healthcare provider will perform blood tests to check your liver function before and during treatment.
Liver function tests (investigation) should be conducted before starting Zelgor 500 mg Tablet and periodically during treatment, as advised by your healthcare provider.
Zelgor 500 mg Tablet should be taken once daily on an empty stomach, at least two hours after eating or one hour before eating. Swallow Zelgor 500 mg Tablet whole with a glass of water; do not chew, crush, or break it. Always follow the recommended dose.
No, you must never take Zelgor 500 mg Tablet with any food or snacks. Even a small amount of food can cause your body to absorb too much of the medicine, which increases your risk of dangerous side effects. Take it on an empty stomach, and talk to your doctor if you struggle with stomach upset.
Women who are pregnant, or who may become pregnant, should never handle Zelgor 500 mg Tablet tablets without wearing protective gloves. The medication can be absorbed through the skin and cause serious harm to a developing baby. Talk to your doctor if you have concerns about handling safety.
You will need frequent blood tests, especially during the first few months of treatment, to check your liver function and potassium levels. Your doctor will determine the exact schedule for these tests based on your health. Talk to your doctor to learn more about your monitoring schedule.
If you miss a dose, skip it and take your regular dose the next day at your usual time. Never take two doses on the same day to make up for a missed one. If you miss more than one dose, talk to your doctor right away.
It is best to avoid alcohol while taking this medicine. Both alcohol and Zelgor 500 mg Tablet are processed by your liver, and combining them can increase your risk of liver damage. Talk to your doctor about safe lifestyle choices.
Your medical team will monitor how well the treatment is working by tracking your symptoms, performing imaging scans, and checking your prostate-specific antigen (PSA) levels through regular blood tests. Talk to your doctor for updates on your progress.
Yes, hormone treatments like Zelgor 500 mg Tablet can cause bone thinning over time, which increases the risk of fractures. Your doctor may recommend calcium and vitamin D supplements or other medications to help protect your bones. Talk to your doctor about the best ways to support your bone health.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

INDIA

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., Sun House, Cts No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - ZEL0046
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