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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Zeparin 25000 Injection 5 ml is used to prevent and treat deep vein thrombosis (blood clots in leg veins), pulmonary embolism (blood clots in the lung), stroke, Transient ischaemic attack (TIA), and heart attacks. It contains Heparin, which works by inhibiting the production of fibrin (a protein that binds platelets together and forms a clot), preventing blood clot formation. Some people may experience haemorrhage (bleeding), thrombocytopenia (low platelets), hypersensitivity reactions, and elevations of liver enzyme (aminotransferase) levels. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

HEPARIN-5000IU

Manufacturer/Marketer :

Zyphar's Pharmaceuticals Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Zeparin 25000 Injection 5 ml

Zeparin 25000 Injection 5 ml belongs to a class of drugs called anticoagulants or blood thinners. Zeparin 25000 Injection 5 ml is primarily used to prevent and treat deep vein thrombosis (blood clots in leg veins), pulmonary embolism (blood clots in the lung), stroke, Transient ischaemic attack (TIA), and heart attacks. Deep vein thrombosis is a medical condition in which blood clots form in deep veins, usually in the legs. Pulmonary embolism is a condition in which a blood clot blocks the arteries in the lungs. A stroke is a condition where a blood clot restricts the flow of blood to your brain, causing brain cells to die and possibly resulting in permanent brain damage or death. Transient ischaemic attack (TIA) is a condition also called mini-strokes. These have similar symptoms to a stroke, but the effects usually last less than 24 hours. Heart attack is a condition where a blood clot blocks a blood vessel supplying your heart, starving it of oxygen and causing chest pain and sometimes death.

Blood clots are formed to stop bleeding that occurs due to tissue injury. Though blood clots are useful to stop bleeding, they may be harmful when abnormally formed within blood vessels as they block blood vessels and inhibit blood flow to essential organs such as the brain, heart, or lungs. Zeparin 25000 Injection 5 ml works by inhibiting the production of fibrin (a protein that binds platelets together and forms a clot), preventing blood clot formation.

Zeparin 25000 Injection 5 ml will be administered by a healthcare professional; do not self-administer. Some people may experience haemorrhage, thrombocytopenia (low platelets), hypersensitivity reactions, and elevations of liver enzyme (aminotransferase) levels. Most of these side effects of Zeparin 25000 Injection 5 ml do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Zeparin 25000 Injection 5 ml or any other medicines, please tell your doctor. It is not known whether Zeparin 25000 Injection 5 ml harms the baby or passes into breast milk in pregnancy and breastfeeding state. If you are pregnant or breastfeeding, it is advised to consult a doctor before using Zeparin 25000 Injection 5 ml. Zeparin 25000 Injection 5 ml is not recommended for children below 2 months of age. If you have diabetes, kidney or liver problems, bleeding problems, or are aged above 60 years, inform your doctor before taking Zeparin 25000 Injection 5 ml.

Uses of Zeparin 25000 Injection 5 ml

Prevention of blood clots.

Directions for Use

Zeparin 25000 Injection 5 ml will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Zeparin 25000 Injection 5 ml is primarily used to prevent and treat blood clots by inhibiting the production of fibrin (a protein that binds platelets together and forms a clot). Zeparin 25000 Injection 5 ml also reduces the risk of blood clots during surgeries (like heart surgery). Zeparin 25000 Injection 5 ml is used as an anticoagulant in blood transfusion and in a dialysis procedure.

How Zeparin 25000 Injection 5 ml Works

Zeparin 25000 Injection 5 ml works by inhibiting the production of fibrin (a protein that binds platelets together and forms a clot), preventing blood clot formation.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Zeparin 25000 Injection 5 ml

The overdose of Zeparin 25000 Injection 5 ml is unlikely as it is administered by a doctor. Too much heparin may cause bleeding. Therefore, if you suspect any adverse reactions or unusual symptoms or more severe bleeding while on treatment with Zeparin 25000 Injection 5 ml, please inform your doctor immediately.

Drug Warnings

Use Zeparin 25000 Injection 5 ml cautiously in conditions with increased risk of bleeding. Use of name contraindicated in patients with HIT - Heparin-induced thrombosis (the abnormal formation of blood clots inside a blood vessel) and HITT (heparin-induced thrombocytopenia and thrombosis) might occur. Monitoring of blood coagulation tests like platelet count and haematocrit should be done in all patients receiving Zeparin 25000 Injection 5 ml. Patients should inform the doctor that they are receiving Zeparin 25000 Injection 5 ml before any surgery is scheduled.

Drug-Drug Interactions

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HeparinBazedoxifene
Critical

Drug-Drug Interactions

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How does the drug interact with Zeparin 25000 Injection 5 ml:
Taking Mifepristone with Zeparin 25000 Injection 5 ml can increase the risk of negative side effects.

How to manage the interaction:
Taking Zeparin 25000 Injection 5 ml with Mifepristone is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without a doctor's advice.
HeparinBazedoxifene
Critical
How does the drug interact with Zeparin 25000 Injection 5 ml:
When Zeparin 25000 Injection 5 ml is taken with bazedoxifene the effects of Zeparin 25000 Injection 5 ml are reduced by bazedoxifene.

How to manage the interaction:
Taking Bazedoxifene with Zeparin 25000 Injection 5 ml is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Zeparin 25000 Injection 5 ml:
Taking Ticlopidine with Zeparin 25000 Injection 5 ml can increase the risk of bleeding.

How to manage the interaction:
Taking Ticlopidine with Zeparin 25000 Injection 5 ml is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without a doctor's advice.
HeparinOritavancin
Critical
How does the drug interact with Zeparin 25000 Injection 5 ml:
Using Zeparin 25000 Injection 5 ml with Oritavancin can make Zeparin 25000 Injection 5 ml less effective as a therapy.

How to manage the interaction:
Zeparin 25000 Injection 5 ml is not recommended within 120 hours (5 days) of taking oritavancin. Oritavancin can interfere with certain of the major coagulation tests used to assess Zeparin 25000 Injection 5 ml's effectiveness and safety, it can be taken only if prescribed by a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Zeparin 25000 Injection 5 ml:
Taking Alteplase with Zeparin 25000 Injection 5 ml can increase the risk of bleeding.

How to manage the interaction:
Taking Zeparin 25000 Injection 5 ml with Alteplase is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you have unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Zeparin 25000 Injection 5 ml:
Taking Tenecteplase with Zeparin 25000 Injection 5 ml can increase the risk of bleeding.

How to manage the interaction:
Taking Zeparin 25000 Injection 5 ml with Tenecteplase is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you notice unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Zeparin 25000 Injection 5 ml:
Taking Abciximab with Zeparin 25000 Injection 5 ml may increase the risk of bleeding.

How to manage the interaction:
Co-administration of Abciximab with Zeparin 25000 Injection 5 ml can result in an interaction, but it can be taken if a doctor has advised it. However, if you notice any of these signs - bleeding, bruising, vomiting, headache, dizziness, weakness, or blood in your urine or stools, it's important to contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Zeparin 25000 Injection 5 ml:
Co-administration of Cefpodoxime with Zeparin 25000 Injection 5 ml may enhance the levels or effects of Zeparin 25000 Injection 5 ml by anticoagulation (preventing blood from clotting).

How to manage the interaction:
Although there is an interaction, Cefpodoxime can be taken with Zeparin 25000 Injection 5 ml if prescribed by the doctor. Do not stop using any medications without a doctor's advice. Do not discontinue the medication without consulting a doctor.
HeparinEdoxaban
Severe
How does the drug interact with Zeparin 25000 Injection 5 ml:
Taking Edoxaban with Zeparin 25000 Injection 5 ml may increase the risk of bleeding.

How to manage the interaction:
Co-administration of Zeparin 25000 Injection 5 ml with Edoxaban can result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor, if you experience any unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop using any medications without a doctor's advice.
HeparinPiperacillin
Severe
How does the drug interact with Zeparin 25000 Injection 5 ml:
When used together Piperacillin will raise the amount of anticoagulant(blood thinners, are chemical substances that prevent or reduce clotting of blood) effect of Zeparin 25000 Injection 5 ml.

How to manage the interaction:
Although there is a possible interaction between Piperacillin and Zeparin 25000 Injection 5 ml, you can take these medicines together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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HEPARIN-5000IUHerbal products/medicines
Moderate

Drug-Food Interactions

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HEPARIN-5000IUHerbal products/medicines
Moderate
Common Foods to Avoid:
Garlic Pill

How to manage the interaction:
Taking Zeparin 25000 Injection 5 ml along with herbs and supplements such as garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba can lead to an increased risk of bleeding Avoid taking herbs and supplements such as garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba while taking Zeparin 25000 Injection 5 ml.

Habit Forming

No

Therapeutic Class

ANTICOAGULANTS / ANTITHROMBOTICS. ANTICONVULSANTS
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Alcohol

Caution

You are recommended to avoid consumption of alcohol with Zeparin 25000 Injection 5 ml as it may cause severe bleeding in the stomach and harmful side effects to the liver.

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Pregnancy

Caution

Zeparin 25000 Injection 5 ml is a Category C pregnancy drug and should be given to pregnant women only if clearly needed and has more benefits than risks. Preservative-free forms are preferred in pregnant women as preservatives such as benzyl alcohol may cross the placenta.

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Breast Feeding

Caution

Zeparin 25000 Injection 5 ml should be given to breastfeeding mothers only if clearly needed and has more benefits than risks.

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Driving

Safe if prescribed

Zeparin 25000 Injection 5 ml usually does not affect your ability to drive or operate machinery.

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Liver

Caution

Zeparin 25000 Injection 5 ml should be given with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Zeparin 25000 Injection 5 ml should be given with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Caution

Zeparin 25000 Injection 5 ml is not recommended for children below 2 months.

Have a query?

FAQs

Zeparin 25000 Injection 5 ml is used to prevent and treat deep vein thrombosis (blood clots in leg veins), pulmonary embolism (blood clots in the lung), stroke, Transient ischaemic attack (TIA), and heart attacks.

Zeparin 25000 Injection 5 ml works by inhibiting the production of fibrin (a protein that binds platelets together and forms a clot). Thereby, preventing blood clot formation.

No, you are not recommended to take ibuprofen with Zeparin 25000 Injection 5 ml as co-administration of these two medicines may increase the risk of bleeding more easily. However, please consult a doctor before taking other medicines with Zeparin 25000 Injection 5 ml.

Yes, Zeparin 25000 Injection 5 ml may increase potassium levels in the blood (hyperkalaemia), especially when given for a long period. Therefore, it is advised to inform your doctor if you are taking any medicines that increase potassium levels in the blood.

Yes, Zeparin 25000 Injection 5 ml may cause bleeding. If you notice purple spots on the skin or unusual bruising, blood in urine, black tarry stools, unusual bleeding from gums or nose, please inform your doctor immediately as these are signs of bleeding more easily.

Yes, Zeparin 25000 Injection 5 ml may cause allergic reactions such as fever, chills, difficulty in breathing, wheezing, blue shade to the lips, swelling of lips, and eyes. It is not necessary for everyone taking Zeparin 25000 Injection 5 ml to experience an allergic reaction. However, if you notice any of these signs, please inform your doctor immediately.

Country of origin

India

Manufacturer/Marketer address

102/103, Park Plaza, Opp. Kamla Nehru Park, Off. Bhandarkar Road, Pune - 411004, Maharashtra (India)
Other Info - ZEP0140

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