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  3. Zextra 600Mg Tablet

Zextra 600Mg Tablet, Pack of 10 TABLETS
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Zextra 600Mg Tablet is used to treat pain, swelling and inflammation in osteoarthritis and rheumatoid arthritis. Besides this, it can also be used to relieve pain, tenderness, swelling, and stiffness caused by juvenile rheumatoid arthritis in children two years of age and older. It contains Tolmetin, which works by blocking the release of a chemical messenger called prostaglandin, produced by COX-2, which is responsible for pain, swelling and inflammation. Thus, it effectively helps to manage pain in various conditions.

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Composition :

TOLMETIN-600MG

Manufacturer/Marketer :

Dr Reddy's Laboratories Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Zextra 600Mg Tablet

Zextra 600Mg Tablet is used to treat pain, swelling and inflammation in osteoarthritis and rheumatoid arthritis. Besides this, it can also be used to relieve pain, tenderness, swelling, and stiffness caused by juvenile rheumatoid arthritis in children two years of age and older. 

Zextra 600Mg Tablet contains Tolmetin, which works by blocking the release of a chemical messenger called prostaglandin, produced by COX-2, which is responsible for pain, swelling and inflammation. Thus, Zextra 600Mg Tablet effectively helps to manage pain in various conditions.

You should take this medicine exactly as the doctor prescribed it. The common side-effects of Zextra 600Mg Tablet are diarrhoea, constipation, gas, weight gain or loss, headache, depression, skin irritation, ringing in the ears, ulcers, bleeding, or holes in the stomach or intestine. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Before taking the Zextra 600Mg Tablet, let your doctor know about all your medical conditions, sensitivities, and medications you are using. Inform your doctor if you have ulcers or bleeding in your stomach, severe liver and/or kidney impairment, colitis (inflammation of the large intestine), uncontrolled blood pressure, or heart problems. Also, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Zextra 600Mg Tablet should not be taken around or after 20 weeks of pregnancy unless directed by your doctor. Zextra 600Mg Tablet may harm the fetus and create complications during delivery if taken about 20 weeks or later during pregnancy.

Uses of Zextra 600Mg Tablet

Zextra 600Mg Tablet is used in the treatment of Osteoarthritis, Rheumatoid arthritis, Juvenile rheumatoid arthritis (in children 2 years of age and older). The detailed uses of Zextra 600Mg Tablet are as follows:<br/>• Relief of Pain and Inflammation: Zextra 600Mg Tablet is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain, including muscle aches, joint pain, and fever. It works by blocking chemical messengers that cause inflammation and discomfort.<br/>• Osteoarthritis Management: Zextra 600Mg Tablet helps reduce joint stiffness, swelling, and tenderness in patients with osteoarthritis, a degenerative joint disease caused by cartilage breakdown.<br/>• Rheumatoid Arthritis Treatment: Zextra 600Mg Tablet is used to manage symptoms of rheumatoid arthritis, an autoimmune condition that causes chronic joint inflammation and pain.<br/>• Juvenile Rheumatoid Arthritis: Zextra 600Mg Tablet is approved for use in children aged 2 years and older to treat juvenile rheumatoid arthritis, helping control flares and improve mobility.<br/>

Directions for Use

• Take Zextra 600Mg Tablet with or without food or as advised by a doctor.• Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.• Swallow the medicine as a whole with glass of water.• Do not crush, break, or chew it.

Medicinal Benefits

Zextra 600Mg Tablet contains ‘Tolmetin’, which is a non-steroidal anti-inflammatory drug (NSAID). It acts as both an analgesic (reduces pain) and an anti-inflammatory (reduces inflammation) agent. It is a selective COX-2 inhibitor. COX-2 enzymes are responsible for converting arachidonic acid to prostaglandins, which are inflammatory mediators. The blocking of COX-2 reduces the production of prostaglandins, eventually decreasing pain and inflammation.

How Zextra 600Mg Tablet Works

Zextra 600Mg Tablet contains Tolmetin, which works by blocking the release of a chemical messenger called prostaglandin, produced by COX-2, which is responsible for pain, swelling and inflammation. Thus, Zextra 600Mg Tablet effectively helps to manage pain in various conditions.

Storage

• Store in a cool and dry place away from sunlight.
• Keep Zextra 600Mg Tablet out of reach and sight of children.
• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Zextra 600Mg Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the steps to manage Gastrointestinal Air and Swelling (GAS) caused by medication:
  • Tell your doctor about your GAS symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
  • To manage GAS symptoms, eat a balanced diet of fibre, vegetables, and fruits.
  • Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
  • Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
  • Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
  • Take medication for GAS symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
  • If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

What if I have taken an overdose of Zextra 600Mg Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Zextra 600Mg Tablet may include severe stomach pain, vomit, extreme drowsiness, slow/shallow breathing, and seizures. Seek immediate medical attention if you observe these symptoms or think you might have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

Before taking Zextra 600Mg Tablet, inform your doctor if you have a history of stomach ulcers or bleeding, asthma, oedema (fluid retention), GI toxicity, rash, renal toxicities, and thrombosis (blood clots block your blood vessels). If you have recently had a heart attack, do not take an NSAID such as tolmetin unless your doctor tells you to. Inform your doctor if you or someone in your family has or has ever had heart disease, a heart attack, or a stroke, if you smoke, and if you have or have ever had high cholesterol, high blood pressure, or diabetes. If you have any of the following symptoms, seek emergency medical attention right away: chest pain, shortness of breath, weakness in one area or side of the body, or slurred speech.

Drug-Drug Interactions

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TolmetinKetorolac
Critical
TolmetinDabigatran etexilate
Severe

Drug-Drug Interactions

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TolmetinKetorolac
Critical
How does the drug interact with Zextra 600Mg Tablet:
Using ketorolac together with Zextra 600Mg Tablet may increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding and ulceration.

How to manage the interaction:
Taking Ketorolac with Zextra 600Mg Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience any unusual bleeding, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not discontinue any medications without consulting a doctor.
TolmetinDabigatran etexilate
Severe
How does the drug interact with Zextra 600Mg Tablet:
Taking Dabigatran etexilate with Zextra 600Mg Tablet can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Dabigatran etexilate with Zextra 600Mg Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
TolmetinFondaparinux
Severe
How does the drug interact with Zextra 600Mg Tablet:
Taking Zextra 600Mg Tablet with fondaparinux can increase the risk of bleeding.

How to manage the interaction:
Although there is an interaction between Fondaparinux and Zextra 600Mg Tablet, they can be taken together if prescribed by your doctor. However, if you experience bleeding, severe back pain, dizziness, black or red stools, severe headache, weakness, and vomiting contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
TolmetinIbuprofen
Severe
How does the drug interact with Zextra 600Mg Tablet:
The combined use of Zextra 600Mg Tablet and Ibuprofen can increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding, ulceration, and rarely, perforation.

How to manage the interaction:
Co-administration of Zextra 600Mg Tablet and Ibuprofen can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
TolmetinApixaban
Severe
How does the drug interact with Zextra 600Mg Tablet:
Coadministration of Zextra 600Mg Tablet and Apixaban co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Zextra 600Mg Tablet and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
TolmetinEtodolac
Severe
How does the drug interact with Zextra 600Mg Tablet:
When Zextra 600Mg Tablet is used with etodolac, there is an increased risk of significant gastrointestinal toxicity (inflammation, bleeding, ulceration, and perforation).

How to manage the interaction:
Taking Etodolac with Zextra 600Mg Tablet together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
TolmetinPrasugrel
Severe
How does the drug interact with Zextra 600Mg Tablet:
Co-administration of Zextra 600Mg Tablet with Prasugrel can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Co-administration of Prasugrel with Zextra 600Mg Tablet can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
TolmetinDiclofenac
Severe
How does the drug interact with Zextra 600Mg Tablet:
Taking Diclofenac with Zextra 600Mg Tablet may increase the risk of side effects.

How to manage the interaction:
There may be a possible interaction between Diclofenac and Zextra 600Mg Tablet but can be taken if prescribed by doctor. However, consult your doctor immediately if you experience any unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop any medications without consulting a doctor.
TolmetinFlurbiprofen
Severe
How does the drug interact with Zextra 600Mg Tablet:
Taking Zextra 600Mg Tablet with Flurbiprofen can increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding and ulceration.

How to manage the interaction:
Co-administration of Flurbiprofen with Zextra 600Mg Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any unusual bleeding or bruising, or have other signs and symptoms of bleeding such as dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache and weakness contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
TolmetinPiroxicam
Severe
How does the drug interact with Zextra 600Mg Tablet:
Coadministration of Zextra 600Mg Tablet with Piroxicam can increase the risk of side effects (inflammation, bleeding, ulceration, and rarely, perforation).

How to manage the interaction:
There may be a possibility of interaction between Piroxicam and Zextra 600Mg Tablet, but it can be taken if prescribed by a doctor. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a healthy body weight because obesity can lead to joint pain. Please avoid strenuous exercise as it may aggravate your arthritis-related joint pain. Instead, you can stretch and engage in low-impact aerobic exercises such as treadmill walking, biking, and swimming. Lifting light weights can also help to improve your muscle strength.
  • Increase your intake of glucosamine, chondroitin sulphate, vitamin D, and calcium-rich supplements. Turmeric and fish oils can also help reduce tissue inflammation.
  • If you have arthritis or joint pain, include fish such as salmon, trout, tuna, and sardines in your diet. These fish are high in omega-3 fatty acids, which aid in reducing inflammation (redness and swelling) and protecting the heart.
  • Your sitting posture is critical, especially if you suffer from pain or inflammation. Try to sit as little as possible and only for a short period of time (10-15 min). Place a rolled-up towel at the back of your curve to alleviate pain. In addition, a footrest can be used if necessary.
  • Follow heat or cold therapy by regularly applying a cold or hot compress to the joints for 15-20 minutes.
  • Relax by meditating, reading, taking a bubble bath, or listening to calming music.
  • Avoid drinking alcohol and quit smoking.

Habit Forming

No

Therapeutic Class

NON-STEROIDAL DRUG

Zextra 600Mg Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Consuming alcohol along with Zextra 600Mg Tablet is not advisable.

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Pregnancy

Caution

Zextra 600Mg Tablet should not be used when pregnancy unless clearly necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Zextra 600Mg Tablet.

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Breast Feeding

Caution

Inform your doctor if you are breastfeeding. A decision should be made whether to discontinue nursing or to discontinue the medicine, taking into account the importance of the medicine to the mother.

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Driving

Caution

Zextra 600Mg Tablet may cause dizziness. So, you should not drive or operate heavy machinery after taking Zextra 600Mg Tablet.

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Liver

Caution

Zextra 600Mg Tablet should be used with caution in patients with liver diseases. Your doctor will weigh the benefits and potential risks before prescribing Zextra 600Mg Tablet. So, do not take Zextra 600Mg Tablet unless instructed by the doctor if you have a liver impairment/disorder history.

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Kidney

Caution

Zextra 600Mg Tablet should be used with caution in patients with kidney diseases. Dosage adjustments may be necessary for patients with severe renal impairment. So, do not take Zextra 600Mg Tablet unless instructed by the doctor if you have a kidney impairment/disorder history.

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Children

Caution

Zextra 600Mg Tablet can be used in children two years and older to treat Juvenile rheumatoid arthritis.

Have a query?

FAQs

Zextra 600Mg Tablet is used to treat pain, swelling and inflammation in osteoarthritis and rheumatoid arthritis. Besides this, it can also be used to relieve pain, tenderness, swelling, and stiffness caused by juvenile rheumatoid arthritis in children two years of age and older.

Zextra 600Mg Tablet contains ‘Tolmetin’, which is a non-steroidal anti-inflammatory drug (NSAID). It is a COX-2 inhibitor. COX-2 enzyme produces prostaglandins that cause pain, swelling and inflammation.

Zextra 600Mg Tablet is not recommended for the longer term, especially in higher doses, as it increases the risk of heart attack and stroke.

Zextra 600Mg Tablet should not be taken before or after a coronary artery bypass graft (CABG; a form of cardiac surgery).

Zextra 600Mg Tablet is a pain reliever that helps in the relief of pain and inflammation associated with joint disorders. However, taking it without the advice of a doctor is not advised.

Zextra 600Mg Tablet is not recommended for the longer term, especially in higher doses, as it increases the risk of heart attack and stroke.

Inform your doctor before taking the Zextra 600Mg Tablet if you are going to take any immunizations/vaccinations. Your doctor will decide.

Zextra 600Mg Tablet is a nonsteroidal anti-inflammatory drug (NSAID) that contains the active ingredient Tolmetin. It is used to relieve pain, inflammation, and stiffness caused by conditions such as osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.

No, Zextra 600Mg Tablet is not a narcotic drug. It is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and stiffness caused by various conditions.

The common side of Zextra 600Mg Tablet in some individuals may include diarrhea, constipation, gas, weight gain or loss, headache, depression, skin irritation, ringing in the ears, ulcers, bleeding, or holes in the stomach or intestine. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Country of origin

India

Manufacturer/Marketer address

Dr. Reddy's Laboratories Ltd., 8-2-337, Road No. 3, Banjara Hills, Hyderabad, Telangana 500034, INDIA
Other Info - ZEX0005

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 9:22 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://medlineplus.gov/druginfo/meds/a681033.html
  2. https://go.drugbank.com/drugs/DB00500
  3. https://www.drugs.com/drug-interactions/tolmetin-index.html

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