ZICLAM TABLET belongs to a class of medicine known as an anti-diabetic. It is primarily used to treat Type 2 diabetes. Type 2 diabetes is a chronic or lifelong condition affecting how your body processes glucose. People with type 2 diabetes either do not produce enough insulin, or if at all the insulin is produced, it is unable to perform its function in the body (insulin resistance). Due to this, the blood glucose level increases and symptoms such as frequent urination, increased thirst and increased hunger start. It can lead to serious complications like skin infection, eye problems (retinopathy), nerve damage (neuropathy), diabetic foot (foot ulcer), kidney disease (nephropathy), high blood pressure, and even stroke.
ZICLAM TABLET is a combination of two anti-diabetic drugs: Gliclazide and Metformin. Gliclazide is a 'sulfonylurea' which acts by increasing the amount of insulin released by the pancreas. On the other hand, Metformin, which is a 'biguanide', works by lowering the glucose production in the liver, delaying glucose absorption from the intestines and increasing the body's response to insulin. In a nutshell, the two medicines prevent blood glucose levels from rising to very high levels, thus keeping your Diabetes under control. ZICLAM TABLET act together to keep your blood sugar levels under check. The strict control of blood sugars is especially important to mention the many disabling side effects of Diabetes. ZICLAM TABLET shows optimum effects when taken along with healthy lifestyle changes like weight loss, regular exercise, a healthy diet etc.
ZICLAM TABLET should be taken with food to avoid an upset stomach. ZICLAM TABLET should be taken at the same time of the day each time for best results. For better advice, your doctor will decide what dose should be taken, which can change quickly depending on your condition. A common side effect of ZICLAM TABLET is hypoglycaemia (low blood glucose levels) characterized by dizziness, sweating, palpitations, hunger pangs, dry mouth and skin etc. So, to avoid hypoglycaemia, you should not miss meals and also should carry some form of sugar along with you. Other side effects include taste change, nausea, diarrhoea, stomach pain, headache, and upper respiratory symptoms.
You should not take the ZICLAM TABLET if you have diabetic ketoacidosis (excess acids in your blood). ZICLAM TABLET should not be stopped even if you feel better without consulting your doctor as sugar levels change. If you stop taking ZICLAM TABLET abruptly, it may increase your sugar levels which could further increase the risk of eyesight loss (retinopathy), kidney (nephropathy) and nerve damage (neuropathy). ZICLAM TABLET should not be taken if you have type 1 diabetes mellitus or severe kidney or liver disease. Tell your doctor before prescribing the ZICLAM TABLET if you are a pregnant woman or nursing mother.
Type 2 Diabetes Mellitus
ZICLAM TABLET plays a vital role in decreasing the blood sugar level in the body as metformin lowers glucose production in the liver, whereas the other increases the amount of insulin released by the pancreas. ZICLAM TABLET also helps to prevent serious complications of diabetes such as kidney damage (diabetic nephropathy), blindness (diabetic retinopathy), loss of sensation in your hands and feet (diabetic neuropathy) or even loss of the foot. ZICLAM TABLET also helps to reduce your chance of having a heart attack or stroke. Being a combination of two drugs, it reduces the need to take multiple pills and hence makes it easier to remember to take the drugs.
Some diabetic patients taking ZICLAM TABLET may develop a rare but serious condition called lactic acidosis. In this condition, too much lactic acid is accumulated in the blood. So, your liver and kidney's proper functioning is required to eliminate excess lactic acid from the blood. You should not take ZICLAM TABLET if you have kidney disease, as measured by a blood test. ZICLAM TABLET may lower vitamin B12 levels, so try to have blood tests annual blood and vitamin. ZICLAM TABLET, when used with or without insulin, tends to lower the blood sugar level extremely. So, the doctor may reduce the dose of insulin. ZICLAM TABLET may lower your thyroid-stimulating hormone (TSH), so an annual check-up of TSH is suggested.
Drug-Drug Interactions: ZICLAM TABLET may interact with insulin, high blood pressure-lowering pills (e.g. hydrochlorothiazide, amlodipine), water pills/diuretics (e.g. furosemide), heart failure-related medicines (e.g. digoxin), anti-hypertensive (e.g. metoprolol), steroids (e.g. prednisolone), thyroid hormones etc. So, tell your doctor if you are using these drugs before taking the ZICLAM TABLET.
Drug-Food Interactions: Taking ZICLAM TABLET with alcoholic beverages may increase the risk of a rare but serious and potentially life-threatening condition known as lactic acidosis (build-up of lactic acid in the blood) and hypoglycaemia.
Drug-Disease Interactions: ZICLAM TABLET should be avoided in patients with vitamin B12 deficiency, kidney problems, liver problems, cardiovascular disease (heart-related issues), and low blood sugar level (hypoglycaemia) as it may worsen the condition.
You are recommended not to consume alcohol along with ZICLAM TABLET to avoid unpleasant side-effects.
Please consult the doctor. There are no adequate and well-controlled studies on pregnant women. Your doctor will prescribe only if the benefits outweigh the risks.
Let your doctor know if you are a nursing mother before taking ZICLAM TABLET; your doctor will decide whether ZICLAM TABLET can be taken by breastfeeding mothers or not.
ZICLAM TABLET may cause hypoglycaemia (low blood sugar levels), whose symptoms include unusual sleepiness, shivering, palpitations, sweating etc. This may affect your ability to drive. Use caution while driving or doing anything that requires concentration.
Tell your doctor before prescribing the ZICLAM TABLET if you have a history of liver diseases/conditions. Your doctor may adjust your dose depending upon your current liver conditions.
Tell your doctor before receiving the ZICLAM TABLET if you have a history of kidney diseases/conditions. Your doctor may adjust your dose depending upon your current liver conditions.
The safety and efficacy of ZICLAM TABLET in children have not been established. ZICLAM TABLET is not recommended in children.
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Diabetes Mellitus type 2 is a condition in which either the body stops producing enough insulin (the hormone which helps to decrease sugar levels in the blood) or there is resistance to the action of insulin. As a result, excessive insulin is produced but it fails to act on the organs of the body. Symptoms of type 2 diabetes include feeling exhausted all time, feeling thirsty, having blurry vision, and urge to urinate (pee) more often. Complications of type 2 diabetes include skin infection, eye problems (retinopathy), nerve damage (neuropathy), delayed wound healing, diabetic foot (foot ulcer), kidney disease (nephropathy), high blood pressure, and even stroke. Both low and high blood sugar levels can be dangerous and should be treated as soon as possible. Your H1bA1C below 5.7% is normal, 5.7-6.4% confirms the prediabetes stage, and 6.5% or greater states diabetes condition.
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