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Zidavi Infusion 1's, Pack of 1 Infusion
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Zidavi Infusion is an antibiotic used in treating bacterial infections. This medicine stops the growth of bacteria and thereby helps reduce various bacterial infections of the urinary tract, respiratory tract and abdomen. This medicine is not effective for treating viral infections. Common side effects include diarrhoea, nausea & vomiting. This medicine is not effective for the treatment of viral infections.
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Composition :

AVIBACTAM-0.5GM + CEFTAZIDIME-2GM

Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Zidavi Infusion

Zidavi Infusion belongs to a class of medicines called antibiotics used in the treatment of bacterial infections of the urinary tract, respiratory tract and abdomen. A bacterial infection is a condition in which harmful bacteria grow in the body and cause infection. Bacteremia is the presence of bacteria in the blood.

Zidavi Infusion contains Ceftazidime and Avibactam. Ceftazidime works by interfering with the formation of the bacterial cell wall (a protective covering) that is necessary for their survival. Avibactam decreases bacterial resistance and enhances the activity of Ceftazidime against the bacteria. Together, Zidavi Infusion helps to treat bacterial infections.

In some cases, you may experience redness and swelling at the site of injection, and/or nausea and diarrhoea. Most of these side effects of Zidavi Infusion do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Zidavi Infusion or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, please inform your doctor before taking Zidavi Infusion. Drive only if you are alert as Zidavi Infusion may cause dizziness. Zidavi Infusion should be used with caution in those with renal impairment and Clostridium difficile-associated diarrhoea.

Uses of Zidavi Infusion

Treatment of Bacterial infections. The detailed uses of Zidavi Infusion are as follows:<br/>• Treatment of bacterial infections: Zidavi Infusion is used to treat serious, drug-resistant bacterial infections, especially those caused by Gram-negative organisms.<br/>• Complicated urinary tract infections (cUTIs): Zidavi Infusion is used in the treatment of complicated urinary tract infections, including pyelonephritis.<br/>• Complicated intra-abdominal infections (cIAIs): Zidavi Infusion is used to treat complicated intra-abdominal infections.<br/>• Treatment of pneumonia: Zidavi Infusion is used to treat hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP).<br/>• Bloodstream infections (bacteremia): Zidavi Infusion helps to treat bloodstream infections caused by multidrug-resistant bacteria.<br/>

Directions for Use

• Follow your doctor's instructions regarding dosage and timing of Zidavi Infusion.• Zidavi Infusion will be administered by a healthcare professional.• Do not self-administer.

Medicinal Benefits

Zidavi Infusion contains Ceftazidime and Avibactam; they act against both aerobic (grow in the presence of oxygen) and anaerobic (grow in the absence of oxygen) gram-negative and gram-positive bacteria. It is used in the treatment of bacterial infections of the urinary tract, respiratory tract, and abdomen. Ceftazidime inhibits enzymes that regulate the formation of the bacterial cell wall, thereby arresting bacterial development. Avibactam is a beta-lactamase inhibitor. Beta-lactamase is an enzyme that inactivates antibiotics and builds up a drug resistance. By inhibiting beta-lactamase, avibactam makes the bacteria more susceptible to antibiotic action. Zidavi Infusion damages the bacterial cell wall, kills bacteria and makes the bacteria more sensitive to the action of the antibiotic. Hence Zidavi Infusion finds widespread use in treating complicated bacterial infections.

How Zidavi Infusion Works

Zidavi Infusion contains Ceftazidime and Avibactam. Ceftazidime works by interfering with the formation of the bacterial cell wall (a protective covering) that is necessary for their survival. Avibactam decreases bacterial resistance and enhances the activity of Ceftazidime against the bacteria. Together, Zidavi Infusion helps to treat bacterial infections.

Storage

• Store in a cool and dry place away from sunlight.• Keep Zidavi Infusion out of the sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Zidavi Infusion
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
  • Eosinophil levels can be lowered by eating fruits and vegetables, avoiding smoking, and consuming alcohol in moderation.
  • Several foods, such as ginger, garlic, pepper, turmeric, and honey, might boost immunity.
  • Avoid dairy products, including cheese, yoghurt, and milk.
  • Drink water and keep yourself hydrated.
  • Eat a balanced diet rich in fruits, vegetables, whole grains, lean protein, and healthy fats.
  • Boost fiber, fruits, vegetables, omega-3 fatty acids, and vitamin K-rich foods.
  • Limit red meat, processed foods, sugary drinks, and excessive alcohol.
  • Exercise regularly with moderate-intensity activities for healthy blood flow.
  • Stay hydrated by drinking plenty of water.
  • Quit smoking to reduce blood clot risk.
  • Practice stress-reducing techniques like yoga or meditation.
  • Maintain a healthy weight to lower cardiovascular risk.
  • Always seek guidance from a healthcare professional before implementing major changes to your diet or lifestyle.
  • High levels of liver enzymes need immediate medical attention.
  • Watch your diet and consume low-fat foods, like green leafy vegetables, fish, whole grains, nuts, etc.
  • Regularly do strengthening exercises to control your cholesterol levels.
  • Avoid drinking alcohol as it can affect your liver.
  • Focus on losing weight as it can help control cholesterol and maintain liver enzymes.
  • Practice yoga and meditation to improve liver functioning and overall health.
  • Injection site reaction can include numbness or redness.
  • Get a physical examination, follow your doctor's instructions, if it worsens or gets swollen.
  • Apply cold compress for pain relief.
  • Practice good hygiene and keep the injection site away from heat and pressure.

What if I have taken an overdose of Zidavi Infusion

The overdose of Zidavi Infusion is unlikely as it is administered by a doctor. However, if you suspect any adverse reactions or unusual symptoms while on treatment with Zidavi Infusion, please inform your doctor immediately.

Drug Warnings

If you are allergic to Zidavi Infusion or any other medicines, please tell your doctor. If you have kidney problems or diabetes, inform your doctor before taking Zidavi Infusion. Consult your doctor if you are pregnant or breastfeeding. If you are on a controlled sodium diet, inform your doctor before taking Zidavi Infusion. Zidavi Infusion should not be administered if you are currently on any vaccinations or are scheduled for the same. If you have a widespread rash with peeling skin and blisters, please consult a doctor immediately as these might be signs of Stevens-Johnson syndrome. Drive only if you are alert as Zidavi Infusion may cause dizziness. You are recommended to complete the full course of Zidavi Infusion as prescribed by your doctor for effective results.

Drug-Drug Interactions

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CeftizoximeCholera, live attenuated
Severe
CeftizoximeCholera vaccines
Severe

Drug-Drug Interactions

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CeftizoximeCholera, live attenuated
Severe
How does the drug interact with Zidavi Infusion:
Taking the cholera vaccine after or along with Zidavi Infusion may reduce the activity of the vaccine.

How to manage the interaction:
Taking Zidavi Infusion with Cholera, live attenuated together can possibly result in an interaction, but it can be taken if your doctor has advised it. You should wait at least 14 days after finishing your antibiotic treatment before receiving the cholera vaccine in order to ensure an appropriate immune response. In case of any unusual symptoms, consult a doctor. Do not discontinue any medications without first consulting your doctor.
CeftizoximeCholera vaccines
Severe
How does the drug interact with Zidavi Infusion:
Taking the cholera vaccine after or along with Zidavi Infusion may reduce the activity of the vaccine.

How to manage the interaction:
Co-administration of Zidavi Infusion with Cholera vaccines can possibly result in an interaction, but it can be taken if your doctor has advised it. You should wait at least 14 days after finishing your antibiotic treatment before receiving the cholera vaccine in order to ensure an appropriate immune response. In case you experience any unusual symptoms, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Take probiotics after completing the full course of Zidavi Infusion to restore some healthy bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like cheese, yoghurt, kombucha, sauerkraut and kimchi can help to restore the good bacteria of the intestine.
  • Include fibre-rich foods, as they can be easily digested by your gut bacteria, which helps stimulate their growth. Whole grains such as whole-grain bread, brown rice should be included in your diet.
  • Make sure you drink plenty of water or other fluids every day while you are taking Zidavi Infusion.
  • Avoid alcohol consumption as it may increase adverse effects.

Habit Forming

No

Therapeutic Class

ANTIBIOTICS

Zidavi Infusion Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

The interaction of Zidavi Infusion with alcohol is unknown. Please consult a doctor before consuming alcohol while using Zidavi Infusion.

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Pregnancy

Caution

Please consult a doctor if you are pregnant or planning for pregnancy. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Zidavi Infusion may be excreted in human milk in small amounts. Therefore, it is given to breastfeeding mothers only if the doctor thinks benefits are greater than risks. Please consult a doctor if you are breastfeeding.

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Driving

Caution

Zidavi Infusion may cause dizziness. Therefore, avoid driving if you feel dizzy after taking Zidavi Infusion.

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Liver

Caution

Take Zidavi Infusion with caution, especially if you have a history of liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Zidavi Infusion with caution, especially if you have a history of kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Caution

Zidavi Infusion should be used in children only in doses as prescribed by a doctor. Zidavi Infusion is not recommended for use in children below 3months.

Have a query?

FAQs

Zidavi Infusion belongs to a class of medicines called antibiotics used in the treatment of bacterial infections of the urinary tract, respiratory tract and abdomen.

Zidavi Infusion works by damaging the bacterial cell wall (protective covering) that is necessary for their survival and by increasing bacterial sensitivity.

Zidavi Infusion may cause diarrhoea as a common side effect. However, if the condition persists, worsens or if you notice blood or mucus in stools, avoid taking Zidavi Infusion and consult a doctor immediately.

Exercise caution while taking Zidavi Infusion with diuretics/water tablets. You are not advised to take Zidavi Infusion with a diuretic called furosemide as co-administration of these two medicines may increase the risk of kidney problems, especially in patients with kidney impairment and also when Zidavi Infusion is given in high doses. However, please consult your doctor before taking Zidavi Infusion with other medicines.

Zidavi Infusion is not used to treat viral infections. Zidavi Infusion is an antibiotic that is used to treat only bacterial infections.

Zidavi Infusion is given through an IV (intravenous) line, which means it is injected directly into a vein. A healthcare provider administers it in a hospital or clinic, with the dose and duration depending on the specific infection being treated. It should not be self-administered.

Zidavi Infusion is safe for children when used at the prescribed doses by a doctor. However, it is not recommended for children under 3 months of age.

Before receiving Zidavi Infusion, you must inform your doctor if you are allergic to foods or medicines. You should also inform your doctor if you have kidney problems or diabetes or if you are pregnant or breastfeeding. If you are on a controlled sodium diet, let your doctor know before starting the medication. Also, inform your doctor if you are receiving or scheduled to receive any vaccinations.

The common side effects of Zidavi Infusion include nausea, diarrhoea, and redness and swelling at the site of injection. These side effects are usually temporary, and not everyone will experience them. In most cases, they resolve on their own without the need for medical treatment. However, if the side effects persist or worsen, please consult your doctor for further advice and management.

If a bacterial infection is not treated, the bacteria can continue to grow and spread throughout the body. This may lead to serious health complications, such as damage to vital organs or tissues. In severe cases, it can result in sepsis (a life-threatening, body-wide infection). Additionally, the infection may become harder to treat over time, as the bacteria can develop resistance to antibiotics. It is important to seek medical treatment to prevent these risks and help your body recover.

Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - ZID0060

Disclaimer

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:56 AM IST

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Reference

  1. https://journals.asm.org/doi/full/10.1128/AAC.03057-14
  2. https://www.medicines.org.uk/emc/medicine/33061#gref
  3. https://en.wikipedia.org/wiki/Ceftazidime
  4. https://www.ema.europa.eu/en/documents/product-information/zavicefta-epar-product-information_en.pdf
  5. https://en.wikipedia.org/wiki/Ceftazidime/avibactam
  6. https://pubmed.ncbi.nlm.nih.gov/29671219/
  7. https://www.avycaz.com/
  8. https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206494s000lbl.pdf
  9. https://pubmed.ncbi.nlm.nih.gov/25022578/#:~:text=Avibactam%20has%20an%20unusual%20mechanism,inhibitors%2C%20this%20reaction%20is%20reversible.
  10. https://journals.asm.org/doi/full/10.1128/AAC.03057-14
  11. https://www.medicines.org.uk/emc/files/pil.275.pdf
  12. https://www.drugs.com/cdi/ceftazidime.html
  13. https://www.webmd.com/drugs/2/drug-1769/ceftazidime-injection/details
  14. https://www.webmd.com/drugs/2/drug-167890/ceftazidime-avibactam-intravenous/details

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