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compositionComposition:MISOPROSTOL-25MCG
prescription
Prescription Medicine
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Zitotec 25 mg Tablet 10's is used in medical abortion and post-delivery bleeding. It is also used to treat gastric ulcers. It contains Misoprostol, which increases the womb's (uterus) contraction and dilates the cervix, thereby expelling the pregnancy. Thus, it can cause termination of pregnancy. It can also prevent post-delivery bleeding due to poor contraction of the uterus. You may experience menorrhagia (heavy menstrual bleeding), nausea, vomiting, diarrhea, uterine contractions, and stomach cramps. Before taking this medicine, you should tell your doctor if you are allergic to any of its components and about all the medications you are taking and pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

MISOPROSTOL-25MCG

Manufacturer/Marketer :

SUN SPECTRA

Consume Type :

Oral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Zitotec 25 mg Tablet 10's

Zitotec 25 mg Tablet 10's is a prescription medicine used primarily to prevent ulcers in the stomach and upper part of the intestines in people who need long-term treatment with nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen or naproxen. It helps protect the stomach lining, reducing the risk of ulcers and serious stomach bleeding. Most people tolerate Zitotec 25 mg Tablet 10's well when it is taken as directed with food.

To get the best results, you should take Zitotec 25 mg Tablet 10's consistently at the exact times prescribed by your doctor. It is typically taken multiple times a day, and you should always take each dose with food and at bedtime to help prevent stomach upset. Making simple lifestyle adjustments, like eating smaller, more frequent meals and avoiding highly spicy foods, can also help protect your stomach while using this medication.

While taking Zitotec 25 mg Tablet 10's, you may experience some common side effects, such as mild stomach cramps or diarrhoea. These symptoms are usually temporary, but if they become severe, persistent, or if you notice signs of dehydration, you must contact your doctor immediately. If you experience unusual vaginal bleeding, seek medical advice right away.

Talk to your doctor or pharmacist before starting Zitotec 25 mg Tablet 10's if you have a history of inflammatory bowel disease, severe heart disease, liver or kidney problems. Do not take this medicine if you are allergic to misoprostol, other prostaglandins, or any of its ingredients. Do not take this medicine if you are pregnant or planning to become pregnant, as it can cause serious pregnancy complications, including miscarriage or premature birth. Older adults and people with liver or kidney problems may require closer monitoring during treatment.

This medicine can interact with certain other products, such as magnesium-containing antacids, which can make diarrhoea much worse. It is also important to limit alcohol consumption and avoid smoking, as both can irritate your stomach lining and make you more prone to ulcers. If you are breastfeeding or are an older adult, talk to your doctor or pharmacist to make sure this medication is safe for you.

Uses of Zitotec 25 mg Tablet 10's

Under medical supervision, Zitotec 25 mg Tablet 10's may be prescribed for the following conditions:

  • Prevention of stomach ulcers: Zitotec 25 mg Tablet 10's protects the stomach lining from damage caused by long-term use of pain-relieving medicines (NSAIDs), reducing the risk of bleeding and ulcer formation.
  • Obstetric and gynaecological indications: Under strict specialist or hospital supervision, Zitotec 25 mg Tablet 10's may also be used for approved indications such as medical abortion, cervical ripening before procedures, induction of labour, and the prevention or treatment of postpartum haemorrhage. These uses require different doses, routes of administration, and monitoring than those used for stomach ulcer prevention.

Key Benefits

Zitotec 25 mg Tablet 10's helps protect the stomach lining and is also used for specific obstetric and gynaecological purposes under medical supervision. It works by reducing the risk of stomach ulcers caused by certain pain medicines and by promoting uterine contractions when indicated.

  • Protects the Stomach Lining: Helps prevent stomach and duodenal ulcers, particularly in people taking long-term nonsteroidal anti-inflammatory drugs (NSAIDs).
  • Reduces the Risk of Ulcer Complications: Lowers the risk of ulcer-related bleeding and other serious gastrointestinal complications.
  • Supports Continued Pain Management: Helps patients continue necessary NSAID treatment for conditions such as arthritis while reducing the risk of stomach injury.
  • Promotes Healing and Comfort: Helps maintain the stomach's natural protective barrier, reducing stomach discomfort associated with NSAID use.
  • Used in Obstetric and Gynaecological Care: Under strict hospital or specialist supervision, Zitotec 25 mg Tablet 10's may also be used for approved indications such as medical abortion, cervical ripening before procedures, induction of labour, and the prevention or treatment of postpartum haemorrhage. These uses require different doses, routes of administration, and monitoring than those used for stomach ulcer prevention.
     
Side effects of Zitotec 25 mg Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Vaginal bleeding can be abnormal if it is not related to menstruation, and needs immediate attention and cannot be ignored.
  • Get a physical examination and follow your doctor's instructions to get relief from bleeding.
  • Avoid using vaginal sprays or perfumed soaps that increase itching and irritation.
  • Prefer practicing yoga and meditation to reduce stress and anxiety, as it can worsen vaginal bleeding.
  • Take a balanced diet and manage your weight.
  • Drink plenty of fluids and stay hydrated.
  • Avoid foods containing sugars, salts and processed food.
  • Avoid consumption of alcohol.
  • Take healthy diet containing fiber, carbohydrates and lean proteins.
  • Exercise regularly and maintain a healthy lifestyle.
  • Drink a lot of water to help reduce bloating and cramping.
  • Reduce stress with relaxation techniques such as yoga or meditation.
  • Apply a warm compress if you are experiencing cramps in your lower belly.
  • Keep a record of your menstrual cycle and any irregularities.

Directions for Use

  • Recommended to take Zitotec 25 mg Tablet 10's with food at bedtime or as advised by a doctor.
  • Recommended to take the medicine 4 times a day or as advised by your doctor.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Zitotec 25 mg Tablet 10's Works

Zitotec 25 mg Tablet 10's contains misoprostol, a synthetic prostaglandin analogue that works by replacing the natural prostaglandins in the body. Non-steroidal anti-inflammatory drugs (NSAIDs) reduce the production of these protective prostaglandins, which normally help decrease stomach acid and maintain a protective mucus layer over the stomach lining. By mimicking the action of these natural substances, misoprostol reduces stomach acid production and increases the secretion of protective mucus, helping protect the stomach lining from acid-related damage and ulcers.
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Alcohol

Unsafe

Alcohol is known to cause excessive dizziness and if taken along with Zitotec 25 mg Tablet 10's and increase uterine bleeding.

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Pregnancy

Unsafe

Zitotec 25 mg Tablet 10's is used for medical abortion. If taken in pregnancy, it can lead to abortion.

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Breast Feeding

Unsafe

Zitotec 25 mg Tablet 10's should not be taken if breastfeeding as it may pass through the milk to the baby.

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Driving

Caution

Dizziness has been reported after taking Zitotec 25 mg Tablet 10's. Be cautious when driving or operating machinery until you know how the Zitotec 25 mg Tablet 10's affects you.

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Liver

Caution

Zitotec 25 mg Tablet 10's to be taken with caution, especially if you have a history of Liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Zitotec 25 mg Tablet 10's to be taken with caution, especially if you have a history of Kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Unsafe

Zitotec 25 mg Tablet 10's is not recommended for children below 18 years.

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Heart

Caution

Zitotec 25 mg Tablet 10's should be used with caution in patients with cardiac problems.

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Geriatrics

Safe if prescribed

Zitotec 25 mg Tablet 10's is safe for use in geriatric patients if prescribed by the physician.

What if I have taken an overdose of Zitotec 25 mg Tablet 10's

If you take too much of this medication, seek immediate medical attention or contact a poison control centre right away. Symptoms of an overdose may include severe stomach cramps, diarrhoea, fever, a fast heartbeat, or confusion.

Diet & Lifestyle Advise

  • Take with meals: Always take your dose with food or milk to slow down how quickly the medicine enters your system, which significantly reduces the chance of diarrhoea.
  • Choose your antacids carefully: If you need to take an antacid for indigestion, choose one that contains aluminium or calcium rather than magnesium, as magnesium can worsen diarrhoea.
  • Avoid stomach irritants: Limit your intake of caffeine, highly spiced foods, and acidic foods, which can irritate your stomach lining.
  • Stay hydrated: Drink plenty of water throughout the day to prevent dehydration, especially if you experience mild diarrhoea.
health query

Have a query?

How Soon It Starts Working

The time required for Zitotec 25 mg Tablet 10's to start to work: Zitotec 25 mg Tablet 10's ideally shows its action within 2 to 3 hours after administration. The time for which the effects of Zitotec 25 mg Tablet 10's last: The effect of Zitotec 25 mg Tablet 10's lasts for 3 to 5 hours.

What if you forget to take Zitotec 25 mg Tablet 10's

If you miss a dose, take it as soon as you remember with food. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

•Store Zitotec 25 mg Tablet 10's at room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Never use this medicine if you are pregnant: This medication carries a strict warning because it can cause miscarriage, birth defects, or premature labour.
  • Use reliable birth control: Women of childbearing age must use an effective form of contraception while taking this medicine and for at least one month after stopping it.
  • Do not share this medicine: Never share Zitotec 25 mg Tablet 10's with anyone else, especially women of childbearing potential, as it can cause severe harm to an unborn baby.
  • Check your symptoms: Contact your doctor promptly if you develop severe diarrhoea or if it lasts for more than a few days. Do not stop taking Zitotec 25 mg Tablet 10's without medical advice unless your doctor tells you to do so.
  • Confirm You Are Not Pregnant: If you are of childbearing age and are taking Zitotec 25 mg Tablet 10's to prevent NSAID-related ulcers, your doctor may advise confirming that you are not pregnant before starting treatment and using effective contraception during treatment.

Drug-Drug Interactions

verifiedApollotooltip

Zitotec 25 mg Tablet 10's may interact with certain medicines, affecting its safety or increasing the risk of side effects. Inform your doctor if you are taking any of the following:

  • Magnesium-containing antacids: Taking these together with Zitotec 25 mg Tablet 10's can cause severe diarrhoea. Talk to your doctor or pharmacist about safer antacid alternatives.
  • Oxytocin: Using Zitotec 25 mg Tablet 10's together with oxytocin may increase uterine contractions and should only be done under close medical supervision for obstetric indications. 
MisoprostolDinoprostone
Severe
MisoprostolOxytocin
Severe

Drug-Drug Interactions

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MisoprostolDinoprostone
Severe
How does the drug interact with Zitotec 25 mg Tablet:
Combined use of Zitotec 25 mg Tablet and Dinoprostone can affect the metabolism of Zitotec 25 mg Tablet.

How to manage the interaction:
Taking Zitotec 25 mg Tablet and Dinoprostone together can possibly result in an interaction, it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
MisoprostolOxytocin
Severe
How does the drug interact with Zitotec 25 mg Tablet:
Coadministration of Zitotec 25 mg Tablet and Oxytocin can enhance the action of oxytocin. This can increase the risk or severity of side effects.

How to manage the interaction:
Taking Zitotec 25 mg Tablet and Oxytocin together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden or severe stomach pain, unexplained vaginal bleeding, Fast heart rate or low blood pressure in the pregnant person, diarrhea, or dehydration, consult to a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip

Food and certain products may influence how Zitotec 25 mg Tablet 10's works or affect its tolerability. Keep the following in mind:
 

  • Food: Taking this medication with food is highly beneficial as it slows down absorption and helps prevent stomach upset and diarrhoea.
  • Alcohol: Alcohol may irritate the stomach lining and increase the risk of stomach irritation or ulcers. It is best to avoid or limit alcohol while taking Zitotec 25 mg Tablet 10's.
  • Smoking: Smoking may delay healing of stomach ulcers and increase stomach irritation. Quitting smoking may improve treatment outcomes.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ABORTIFACIENT, CERVICAL RIPENING AGENTS]

FAQs

Zitotec 25 mg Tablet 10's is used in medical abortion and post-delivery bleeding. It is also used to treat gastric ulcers.
No, studies have shown that this Zitotec 25 mg Tablet 10's does not damage the fertility of the women. Your future chances of getting pregnant are as equal as those who have not taken this Zitotec 25 mg Tablet 10's.
For medical termination of pregnancy, you may experience diarrhea, abdominal cramping, nausea, and stomach pain, and immediately after taking Zitotec 25 mg Tablet 10's. You may also have vaginal bleeding within 4 hours of taking Zitotec 25 mg Tablet 10's. You may also be asked to stay at the clinic at least 3 hours after taking this Zitotec 25 mg Tablet 10's. After 14 days of taking Zitotec 25 mg Tablet 10's (pill you took before Zitotec 25 mg Tablet 10's), your gynecologist may run some blood tests or perform ultrasonography to check whether pregnancy has been terminated or not.
If you take too many tablets, contact your doctor or accident and emergency department straight away.
No, Zitotec 25 mg Tablet 10's should be taken in the dose and duration as advised by the doctor. If you take it in more than the recommended dose, it might cause unpleasant side effects like excessive uterine or vaginal bleeding.
Ask your doctor before using an antacid and use only your doctor's advice. Some antacids can enhance your risk of diarrhea while you are taking Zitotec 25 mg Tablet 10's.
Zitotec 25 mg Tablet 10's contains misoprostol as its active substance. Zitotec 25 mg Tablet 10's is a prostaglandin, it belongs to a group of medicines known as antiulcer agents.
Zitotec 25 mg Tablet 10's should be taken as advised by the doctor. Swallow it as a whole with a glass of water. Do not crush or chew it. Follow your doctor's prescribed dose and duration for the best results. Do not self-medicate.
After taking Zitotec 25 mg Tablet 10's, you may experience side effects such as abdominal cramping, diarrhoea, stomach pain, nausea, and possibly vaginal bleeding. Vaginal bleeding may occur within a few hours of taking Zitotec 25 mg Tablet 10's.
Zitotec 25 mg Tablet 10's does not affect your future chances of getting pregnant. Side effects like congenital disabilities, premature birth, miscarriage, or infant death are uncommon. Long-term emotional problems after an abortion are rare, similar to those after giving birth. Always consult a doctor if you have any concerns.
Zitotec 25 mg Tablet 10's causes side effects such as menorrhagia (heavy menstrual bleeding), nausea, vomiting, diarrhoea, and stomach cramps (pain). However, these side effects are temporary and do not require any medical attention, as they will gradually reduce over time. Please, contact a doctor if these persist for longer durations.
No, you must not take Zitotec 25 mg Tablet 10's if you are pregnant. It can cause miscarriage, premature birth, or severe birth defects. Talk to your doctor immediately if you suspect you are pregnant.
Diarrhoea is a common side effect because the medicine stimulates movement in your digestive tract. This symptom is usually mild and can be managed by taking the tablet with food. Talk to your doctor if it becomes severe.
You can lower your risk of diarrhoea by taking each dose of Zitotec 25 mg Tablet 10's directly with a meal or snack, and by avoiding antacids that contain magnesium. Talk to your doctor or pharmacist for more advice.
Yes, but you must avoid antacids containing magnesium, as they can cause severe diarrhoea when combined with this medicine. Choose antacids containing aluminium or calcium instead, and talk to your pharmacist to be sure.
You should always take Zitotec 25 mg Tablet 10's with food. Taking it with meals slows down how the medicine is absorbed, which greatly helps to prevent stomach pain and diarrhoea.
Unusual or heavy vaginal bleeding is a serious side effect. Stop taking the medicine and contact your doctor or seek medical help immediately.
It is best to avoid or limit alcohol while taking Zitotec 25 mg Tablet 10's. Alcohol can irritate your stomach lining, increasing your risk of developing stomach ulcers and bleeding. Talk to your doctor for personalised advice.It is best to avoid or limit alcohol while taking Zitotec 25 mg Tablet 10's. Alcohol can irritate your stomach lining, increasing your risk of developing stomach ulcers and bleeding. Talk to your doctor for personalised advice.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Drugs.com Clinical Review Team. Misoprostol Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Pil.1642 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. U.S. Food and Drug Administration (FDA). 019268Orig1S049Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  4. Misoprostol Misoprostol. 2013. [Accessed on 24 Jan. 2019]Check here
  5. Misoprostil Misoprostil. 2012. [Accessed on 03 Apr. 2019]Check here
  6. Raymond EG, Shannon C, Weaver MA, Winikoff B. First-trimester medical abortion with mifepristone 200 mg and misoprostol: a systematic review. Contraception. PubMed, January 2013. [Accessed on 31st January 2023]Check here
  7. Sun Pharmaceutical Industries Europe. Mifepristone, Misoprostol. Electronic Medicines Compendium (EMC). [Revised in August 2021] [Accessed on 31st January 2023]Check here

Country of origin

India

Manufacturer/Marketer address

No. 6, Kasaba hobali, Nelmangala, Tumkur Rd Nelamangala Bangalore Rural Karnataka India 562123.
Other Info - ZIT0060
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