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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Manufacturer/Marketer :

Jenburkt Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Zix R OD Capsule

Zix R OD Capsule is a prescription medication designed to relieve severe pain, swelling, and inflammation in the joints and muscles. It is commonly used to treat long-term painful joint conditions such as osteoarthritis and rheumatoid arthritis. The medication works by targeting the source of physical pain while simultaneously defending your digestive tract from irritation.

To achieve the best results, it is important to take this medicine consistently at the same times each day as directed by your doctor. You should swallow the tablet whole, preferably before a meal to allow its stomach-protecting properties to activate early. Incorporating gentle, low-impact exercise and maintaining a balanced weight can also significantly enhance your mobility and overall results.

While taking this medication, you may experience mild and temporary side effects such as a mild headache, nausea, or light diarrhoea. However, if you notice serious symptoms like severe abdominal pain, vomiting blood, or unusually dark stools, you must stop taking the medicine and consult your doctor immediately.

Before starting Zix R OD Capsule , you must talk to your doctor if you have a history of kidney disease, liver damage, high blood pressure, or heart issues. Do not take this if you currently have active stomach ulcers, severe heart failure, or if you have previously experienced allergic reactions to other pain relievers.

This medication can interact with other drugs, such as blood thinners or alternative pain relievers, which can increase your risk of internal bleeding. It is also important to avoid alcohol and smoking while on this treatment, as they can severely irritate your stomach lining. If you are pregnant, planning a pregnancy, breastfeeding, elderly, or considering this medicine for a child, consult your doctor before starting Zix R OD Capsule to ensure it is appropriate for your situation. This medicine is generally not recommended for children unless specifically prescribed by a healthcare professional. 

Uses of Zix R OD Capsule

Zix R OD Capsule is used to relieve pain, inflammation, and stiffness associated with various musculoskeletal and joint conditions while helping protect the stomach from irritation.

  • Osteoarthritis: Helps reduce pain, swelling, and stiffness in the joints, making daily physical movements smoother and easier.
  • Rheumatoid arthritis: Eases long-term joint inflammation, warmth, and tenderness associated with this chronic autoimmune condition.
  • Ankylosing spondylitis: Relieves painful inflammation in the spine and large joints, improving physical flexibility and overall posture.
  • Acute pain relief: Manages short-term discomfort and swelling from muscle strains, dental pain, or joint injuries while keeping your stomach safe from irritation.

Key Benefits

Zix R OD Capsule combines pain relief with stomach protection, helping manage painful inflammatory conditions while reducing the risk of stomach irritation associated with pain-relieving medicines.

  • Relieves Pain and Inflammation: Helps reduce pain, swelling, tenderness, and stiffness associated with joint and muscle conditions.
  • Protects the Stomach: Rabeprazole helps reduce stomach acid production, lowering the risk of acid reflux, indigestion, and stomach irritation.
  • Improves Mobility: By reducing pain and inflammation, it may help improve movement and make daily activities more comfortable.
  • Supports Physical Recovery: Helps patients participate more comfortably in exercise, rehabilitation, and physical therapy programmes.
  • Offers Convenient Combination Therapy: Combines pain management and stomach protection in a single medicine, making treatment easier to follow.
Side effects of Zix R OD Capsule
  • Drink warm fluids such as warm water with honey, broth, soup or herbal tea to soothe sore throat.
  • Gargle with warm salt water.
  • Suck on lozenges to increase the production of saliva and soothe your throat.
  • Use a humidifier to soothe sore throat as it adds moisture to the air and makes breathing easier.
Here are the steps to manage Gastrointestinal Air and Swelling (GAS) caused by medication:
  • Tell your doctor about your GAS symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
  • To manage GAS symptoms, eat a balanced diet of fibre, vegetables, and fruits.
  • Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
  • Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
  • Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
  • Take medication for GAS symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
  • If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.
  • Wash your hands regularly with soap and water or use a hand sanitizer to prevent the spread of infections.
  • Wear masks, gloves and other protective clothing.
  • Cover sneezes and coughs with a medical mask or tissue or your elbow.
  • Take vaccinations to enhance your immunity to specific diseases.
  • Clean your utensils, linen and surfaces regularly.
  • Do not consume spicy foods, caffeine, and alcohol.
  • Choose low-acid fruits and vegetables like apples, melons, and carrots.
  • Include whole grains like whole-wheat bread, oatmeal, and brown rice.
  • Limit processed meats like hotdogs and sausages.
  • Avoid fatty, spicy, or acidic salad dressings.
  • Limit tomatoes and tomato-based products.
  • Quit smoking to promote ulcer healing.
  • Adopt a balanced diet and lifestyle to reduce the risk of peptic ulcers.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

Directions for Use

To get the maximum benefit from Zix R OD Capsule , follow these step-by-step instructions carefully:

  • Swallow the tablet or capsule whole with a full glass of water.
  • Do not crush, chew, break, or open the medication, as this can destroy the protective coating meant to shield your stomach.
  • Take this medication exactly as directed by your doctor. Depending on the formulation prescribed, your doctor may recommend taking this medicine before meals to allow the rabeprazole component to work effectively. 

Always follow your doctor's exact instructions regarding duration and timing, and never stop taking the medication early without consulting them first.

How Zix R OD Capsule Works

Zix R OD Capsule contains two active therapeutic components that work together to provide safe and effective relief. The first component, aceclofenac, belongs to a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). It is a pain-relieving agent that works by blocking enzymes called cyclo-oxygenase (COX) enzymes, which reduces the production of prostaglandins, the chemical messengers responsible for pain, warmth, and swelling at the site of injury or joint wear. The second component, rabeprazole, belongs to a group of medicines called proton pump inhibitors (PPIs). It is an acid-reducing agent that specifically targets the acid-producing cells in your stomach lining. By temporarily blocking these acid pumps, it lowers the overall level of stomach acid. This action helps protect your stomach lining from the potential irritation caused by the pain-relieving component, reducing the risk of stomach ulcers and acid reflux. Together, these actions help manage pain and inflammation while supporting stomach protection during treatment.
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Zix R OD Capsule . Alcohol intake along Zix R OD Capsule may cause increased drowsiness and drowsiness. It may also increase the risk of stomach bleeding. Please consult your doctor if you have any concerns regarding this.

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Pregnancy

Consult your doctor

Zix R OD Capsule is a Category C pregnancy drug and is not recommended for pregnant women, especially in the third trimester, as it may cause adverse effects in the baby. However, please consult a doctor if you are pregnant or planning for pregnancy before taking Zix R OD Capsule .

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Zix R OD Capsule as it may be excreted in breast milk and cause adverse effects in the baby. Please consult a doctor if you are breastfeeding.

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Driving

Caution

Zix R OD Capsule may cause drowsiness, dizziness, or abnormal vision. Do not drive or operate heavy machinery if you feel dizzy or drowsy.

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Liver

Caution

Dose adjustment may be needed in patients with severe liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Take Zix R OD Capsule with caution, especially if you have a history of kidney disease. The dose may be adjusted by your doctor as required. Avoid taking Zix R OD Capsule if you have severe kidney disease.

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Children

Unsafe

Zix R OD Capsule is not recommended for children below 18 years of age, as the safety and effectiveness were not established.

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Heart

Caution

Zix R OD Capsule should be used under caution in heart patients if prescribed by the physician. Please consult your physician if you have any concerns.

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Geriatrics

Caution

Geriatric patients can take Zix R OD Capsule if prescribed by the physician. It's important to use it under close medical supervision with tailored dosing and regular monitoring.

What if I have taken an overdose of Zix R OD Capsule

Do not take more than the prescribed dose of Zix R OD Capsule as it may cause serious adverse effects. If you suspect you have taken overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Avoid Stomach-Irritating Foods: Limit spicy, acidic, fried, and greasy foods that may worsen stomach irritation or acid reflux.
  • Stay Well-Hydrated: Drink plenty of water throughout the day to support kidney health and overall well-being.
  • Maintain a Healthy Weight: Keeping a healthy weight may reduce pressure on weight-bearing joints such as the knees and hips.
  • Stay Physically Active: Engage in low-impact activities such as walking, cycling, or swimming to help maintain joint flexibility and strength.
  • Limit Caffeine and Fizzy Drinks: Reduce intake of caffeinated and carbonated beverages, as they may increase stomach acid production and discomfort.

Have a query?

How Soon It Starts Working

  • The time required for Zix R OD Capsule to start to work: The time required for Zix R OD Capsule to show its action is unknown.
  • The time for which the effects of Zix R OD Capsule last: The duration of action for Zix R OD Capsule is unknown.

What if you forget to take Zix R OD Capsule

If you miss a dose of Zix R OD Capsule , take it as soon as you remember. However, if it is almost time for the next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Storage

•Store Zix R OD Capsule at room temperature, ideally between 20°C and 25°C (68°F to 77°F). •Keep the medication in its original blister packaging to protect it from moisture and direct sunlight.

Drug Warnings

  • Check Before Use: Inspect the blister pack before taking the medicine and do not use it if the packaging is damaged or tampered with.
  • Do Not Share Your Medicine: Never give Zix R OD Capsule to another person, even if they have similar symptoms.
  • Avoid Additional Pain Relievers: Do not take other non-prescription pain medicines such as ibuprofen or aspirin unless advised by your doctor, as this may increase the risk of stomach ulcers and bleeding.
  • Use Caution During Activities: Avoid driving, cycling, or operating machinery until you know how this medicine affects you, as it may occasionally cause dizziness.
  • Inform Healthcare Providers: Tell your doctor, dentist, or surgeon that you are taking Zix R OD Capsule before any medical or dental procedure.

Drug-Drug Interactions

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Drug-Drug Interactions

The following medicines may interact with Zix R OD Capsule and may require dose adjustments or additional monitoring:

  • Blood thinners (such as warfarin): May significantly increase the risk of severe stomach bleeding.
  • Other pain medicines (such as ibuprofen or naproxen): Can increase the risk of developing stomach ulcers and bleeding.
  • Water pills (diuretics) and blood pressure medications: Zix R OD Capsule may reduce their physical effectiveness and increase the risk of kidney damage.
  • Lithium or Methotrexate: This medication can raise the concentration of these drugs in your blood, increasing the likelihood of serious side effects.

Drug-Food Interactions

Alcohol: Avoid alcohol while taking this medicine, as combining them can severely irritate your stomach lining and increase the risk of liver damage and bleeding.

Drug-Disease Interactions

Inform your doctor if you have any of the following conditions before taking Zix R OD Capsule , as special precautions may be required:

  • Active stomach ulcers: Do not take this medication if you have a history of bleeding ulcers or active digestive tract bleeding.
  • Kidney or liver damage: May worsen kidney or liver function; requires close medical monitoring and possible dose adjustments.
  • Heart conditions: Use with extreme caution, as it can cause fluid retention and may increase the risk of heart-related events in predisposed individuals.
  • NSAID Allergy or Hypersensitivity: Do not take this medicine if you have previously experienced asthma, severe allergic reactions, or skin reactions after taking aspirin or other NSAIDs. 
Critical

Drug-Drug Interactions

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How does the drug interact with Zix R OD Capsule:
When used in combination with erlotinib, Zix R OD Capsule may prevent the absorption of erlotinib into the circulation, which might make erlotinib less effective in treating cancer.

How to manage the interaction:
Taking Zix R OD Capsule with Erlotinib is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience any unusual symptoms, consult the doctor. Do not stop using any medications without consulting a doctor.
Critical
How does the drug interact with Zix R OD Capsule:
Co-administration of Zix R OD Capsule can make Rilpivirine less effective by reducing its absorption in the body.

How to manage the interaction:
Taking Zix R OD Capsule with Rilpivirine is not recommended, but can be taken if prescribed by the doctor. However, if you experience any unusual symptoms, consult the doctor. Do not discontinue the medications without consulting a doctor.
How does the drug interact with Zix R OD Capsule:
Taking Clopidogrel with Zix R OD Capsule can reduce the effectiveness of Clopidogrel.

How to manage the interaction:
Taking Clopidogrel and Zix R OD Capsule together possibly has an interaction, but you can take these medications together if a doctor has advised it. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Zix R OD Capsule:
Taking Zix R OD Capsule together with Acalabrutinib results in a decreased effectiveness of Acalabrutinib.

How to manage the interaction:
Although taking Zix R OD Capsule and Acalabrutinib together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience any unusual symptoms, consult the doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Zix R OD Capsule:
Taking Zix R OD Capsule together with Dasatinib results in decreased levels of Dasatinib and its effectiveness.

How to manage the interaction:
Although taking Zix R OD Capsule and Dasatinib together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience any unusual symptoms, consult. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Zix R OD Capsule:
Co-administration of Methotrexate with Zix R OD Capsule can increase the blood levels and side effects of Methotrexate.

How to manage the interaction:
Although there is a possible interaction between Zix R OD Capsule and Methotrexate, you can take these medicines together if prescribed by a doctor. However, if you experience any unusual symptoms, consult the doctor. Do not stop using any medications without consulting a doctor.
How does the drug interact with Zix R OD Capsule:
Co-administration of Atenolol with Zix R OD Capsule could increase the risk of high blood pressure.

How to manage the interaction:
Although there is a possible interaction between Atenolol and Zix R OD Capsule, you can take these medicines together if prescribed by a doctor. However, if you experience any unusual symptoms, consult the doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Zix R OD Capsule:
When Zix R OD Capsule and Idelalisib are taken in combination, it can increase the risk of side effects.

How to manage the interaction:
Although taking Zix R OD Capsule and Idelalisib together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience any unusual symptoms, consult the doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Zix R OD Capsule:
Taking Zix R OD Capsule with Dacomitinib may decrease the effectiveness of Dacomitinib.

How to manage the interaction:
Although using Zix R OD Capsule with Dacomitinib may lead to an interaction, it can be taken if prescribed by the doctor. However, if you experience any unusual symptoms, consult the doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Zix R OD Capsule:
Taking Zix R OD Capsule together with Pazopanib can result in a decreased effectiveness of Pazopanib in treating the disease.

How to manage the interaction:
Although taking Zix R OD Capsule and Pazopanib together can result in an interaction, but can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTI- INFLAMMATORY AGENTS]

FAQs

Zix R OD Capsule is used to reduce and relieve pain and inflammation (swelling) associated with osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. It may also be indicated in the treatment of pain associated with post-traumatic and post-operative cases.

Zix R OD Capsule contains Aceclofenac and Rabeprazole. Aceclofenac is a pain killer called NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) which works by blocking the effect of chemical messengers (prostaglandin), thereby helping in reducing pain, and inflammation. Rabeprazole works by blocking the action of an enzyme called a proton pump, which is responsible for the production of stomach acid. Thus, the combination used for pain relief, decrease stiffness in joints and reduces the release of excess stomach acid caused by aceclofenac.

Zix R OD Capsule is not recommended for asthma patients as it may worsen the condition. Therefore, please inform your doctor if you have asthma or a history of asthma due to the use of aspirin or any other non-steroidal drugs.

You are not recommended to take Zix R OD Capsule with warfarin as co-administration of these two medicines may increase the risk of bleeding more easily. However, if you notice blood in urine or stools, dizziness, unusual bleeding or bruising, vomiting, weakness or headache, please consult a doctor immediately. If you are supposed to use these medicines together, you are advised to contact your doctor so that the dose may be adjusted appropriately to use safely.

Aceclofenac in Zix R OD Capsule may increase the risk of heart problems such as heart attack, especially when used in high doses or for prolonged duration and in patients who are smokers, have high blood pressure, diabetes or high cholesterol. It is advised to inform your doctor if you have any of these conditions or have a history of heart problems or stroke before taking Zix R OD Capsule . However, taking Zix R OD Capsule in the dose and for the duration, as prescribed by your doctor, is recommended.

Zix R OD Capsule may impair fertility in females and make it more difficult to conceive. Therefore, if you are pregnant, planning for pregnancy or have difficulties conceiving, please consult your doctor before taking Zix R OD Capsule .

Do not discontinue Zix R OD Capsule without consulting your doctor. To treat your condition effectively, keep taking Zix R OD Capsule for the prescribed duration.

Nausea and vomiting could be side effects of Zix R OD Capsule . Drink enough fluids by taking frequent sips and eat small, frequent meals. If the condition persists or worsens, consult the doctor.

Store Zix R OD Capsule at room temperature, in a dry place. Keep it out of sight and reach of children.

Zix R OD Capsule may cause side effects such as indigestion, stomach pain, constipation, dizziness, nausea, and diarrhoea. Most of the side effects of Zix R OD Capsule do not require medical attention and resolve gradually over time. However, if the side effects persist or worsen, please consult your doctor.

Zix R OD Capsule can be taken with vitamin B-complex if advised by the doctor. Talk to the doctor if you have any concerns.

Yes, it is generally best to take Zix R OD Capsule before a meal so the stomach-protecting component can work effectively. However, if you experience mild stomach upset, your doctor may advise you to adjust the timing. Talk to your doctor or pharmacist for personalised advice.

You may notice initial pain relief within a few hours of taking your first dose. However, for chronic swelling and joint stiffness, it may take a few days of consistent use to feel the full therapeutic benefits. Talk to your doctor if your pain does not improve.

You should avoid taking Zix R OD Capsule during pregnancy, especially in the last three months, as it can harm the unborn baby or cause complications during delivery. Always talk to your doctor before taking any medication if you are pregnant or planning to conceive.

No, you should avoid drinking alcohol while taking Zix R OD Capsule . Alcohol can increase your risk of severe stomach irritation, ulcers, and bleeding, and can also put extra strain on your liver. Talk to your doctor if you have concerns.

Yes, some people may experience dizziness, sleepiness, or lightheadedness while taking Zix R OD Capsule . If you feel dizzy, do not drive, ride a bicycle, or operate machinery. Talk to your doctor if these symptoms persist.

You should not take other pain relievers, especially non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or aspirin, alongside Zix R OD Capsule . Doing so greatly increases the risk of stomach ulcers and bleeding. Talk to your doctor before combining any medications.

Stop taking Zix R OD Capsule immediately and seek urgent medical care if you develop severe stomach pain, black or tarry stools, or if you vomit blood. These are warning signs of serious stomach bleeding. Talk to your doctor right away.

Zix R OD Capsule is typically prescribed for the shortest duration possible to manage your symptoms safely. Long-term use requires regular check-ups with your doctor to monitor your kidney, liver, and stomach health. Talk to your doctor to discuss your specific treatment plan.

This medicine is generally not recommended for children unless specifically prescribed by a doctor. The safety and suitability of this combination depend on the child's age, condition, and medical history. Consult a paediatrician before giving this medicine to a child.

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Country of origin

INDIA

Manufacturer/Marketer address

Nirmala Apartments,93, Jayprakash Road, Andheri (West),Mumbai - 400 058. India.
Other Info - ZIX0006
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