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compositionComposition:ZOLEDRONIC ACID-4MG
prescription
Prescription Medicine
info
Zoldonat 4 mg Injection 1's
Zoldonat 4 mg Injection 1's
Zoldonat 4 mg Injection 1's
Zoldonat 4 mg Injection is used to treat osteoporosis (weak and brittle bones), Paget’s disease of bone and high calcium levels caused by cancer. It contains Zoledronic acid which works by preventing the bones from breaking down and keeps them strong. In some cases, this medicine may cause side effects such as headache, fever, nausea, dizziness, vomiting, diarrhoea, swelling, or pain at the infusion site. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ZOLEDRONIC ACID-4MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Zoldonat 4 mg Injection

Zoldonat 4 mg Injection belongs to the class of medicines called 'bisphosphonates' used to treat osteoporosis (weak and brittle bones) caused by menopause or long-term steroid use. Zoldonat 4 mg Injection also treats Paget’s bone and high calcium levels caused by cancer. Osteoporosis is a bone disease that weakens and thins bones by decreasing bone density, common in post-menopausal women.  As the density of bones decreases, they weaken and are more likely to break. 

Zoldonat 4 mg Injection contains Zoledronic acid that works by binding to the bone tightly and preventing the removal of calcium by osteoclasts (a type of bone cell that destroys bone tissue). This prevents osteoclasts from breaking down the bone and keeps the bones strong and minimizes the risk of bones breaking.

A doctor or nurse will administer Zoldonat 4 mg Injection. In some cases, you may experience headache, fever, nausea, dizziness, vomiting, back pain, diarrhea, pain in the muscles, joints, or bones, swelling, or pain at the infusion site. Most of these side effects of Zoldonat 4 mg Injection do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Zoldonat 4 mg Injection or any other medicines, please tell your doctor. Avoid taking Zoldonat 4 mg Injection if you are pregnant or breastfeeding and consult a doctor. Zoldonat 4 mg Injection is not recommended for children below 18 years as the safety and effectiveness were not established. Avoid taking Zoldonat 4 mg Injection if you have hypocalcemia (low calcium levels in the blood) and severe kidney problems. Drive only if you are alert as Zoldonat 4 mg Injection may cause dizziness. Zoldonat 4 mg Injection may cause osteonecrosis of the jaw (ONJ) in some patients. Therefore, if you experience any problems with teeth or mouth such as loose teeth, swelling or pain, non-healing of sores, or discharge, consult your doctor and dentist as these might be signs of osteonecrosis of the jaw.

Uses of Zoldonat 4 mg Injection

Zoldonat 4 mg Injection is used in the treatment of Postmenopausal osteoporosis, Pagets disease, Hypercalcemia (high level of calcium) in cancer. The detailed uses of Zoldonat 4 mg Injection are as follows:

  • Osteoporosis: Zoldonat 4 mg Injection treats and prevents bone loss in postmenopausal women and men at high risk of fractures.
  • Paget’s disease of Bone: Zoldonat 4 mg Injection reduces abnormal bone turnover and strengthens weakened bones.
  • Hypercalcemia of Malignancy: Zoldonat 4 mg Injection lowers dangerously high calcium levels caused by cancer.

Key Benefits

Zoldonat 4 mg Injection contains Zoledronic acid used to treat postmenopausal osteoporosis, Paget’s disease, and hypercalcemia of malignancy (bone cancer in which excess of calcium exits). Zoldonat 4 mg Injection binds to the bone tightly and prevents calcium removal by osteoclasts (a type of bone cell that destroy bone tissue). This prevents osteoclasts from breaking down the bone, strengthening bones, and minimizing the risk of bones breaking. Also, Zoldonat 4 mg Injection may reduce calcium levels in the blood by preventing calcium reabsorption from bones to the blood. Thus, it helps in treating high calcium levels in the blood caused by cancer.

Side effects of Zoldonat 4 mg Injection
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of Zoldonat 4 mg Injection. Typically, it is administered once every 3-4 weeks.
  • Zoldonat 4 mg Injection will be administered intravenously (through the vein) by a healthcare professional in a medical setting.
  • Do not self-administer it.

How Zoldonat 4 mg Injection Works

Zoldonat 4 mg Injection contains Zoledronic acid that works by binding to the bone tightly and preventing the removal of calcium by osteoclasts (a type of bone cell that destroys bone tissue). This prevents osteoclasts from breaking down the bone and keeps the bones strong and minimizes the risk of bones breaking.
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Alcohol

Caution

Interaction of alcohol with Zoldonat 4 mg Injection is unknown. Please consult a doctor before consuming alcohol with Zoldonat 4 mg Injection.

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Pregnancy

Unsafe

Zoldonat 4 mg Injection is a category D pregnancy drug and is not recommended for pregnant women as it may harm an unborn baby. Please consult a doctor if you are pregnant.

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Breast Feeding

Unsafe

Zoldonat 4 mg Injection is contraindicated in breastfeeding mothers. Therefore, please consult a doctor if you are breastfeeding.

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Driving

Caution

Zoldonat 4 mg Injection may cause dizziness. Therefore, avoid driving or operating machinery if you feel dizzy after taking Zoldonat 4 mg Injection.

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Liver

Caution

Take Zoldonat 4 mg Injection with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Zoldonat 4 mg Injection with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required. Avoid taking Zoldonat 4 mg Injection if you have severe kidney problems.

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Children

Unsafe

Zoldonat 4 mg Injection is not recommended for children below 18 years as the safety and effectiveness were not established.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using Zoldonat 4 mg Injection. Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Limited information available for use of Zoldonat 4 mg Injection in elderly patients. Please consult your doctor.

What if I have taken an overdose of Zoldonat 4 mg Injection

Overdose may cause hypocalcemia (low calcium levels in the blood), hypophosphatemia (low levels of phosphate in the blood), and hypomagnesemia (low magnesium levels). Since Zoldonat 4 mg Injection is administered by a healthcare professional, an overdose is unlikely to occur. However, seek medical attention if you experience any unusual symptoms.

Diet & Lifestyle Advise

  • Include dairy products like milk, yoghurt, cheese, or milk-based custard in your diet.
  • Eat daily a serving of broccoli, cabbage, bok choy (Chinese white cabbage), spinach, and other green leafy vegetables.
  • Snack on calcium-rich nuts like Brazil nuts or almonds.
  • Sprinkle sesame seeds over your food, vegetables, and salads. Sesame seeds are high in calcium.
  • Avoid or reduce the intake of caffeine, soft drinks, and alcohol that inhibit calcium absorption.
  • Replace the meat with tofu or tempeh for extra calcium in your food.

Health Queries

I have back problems related to a bone marrow issue; what medications or treatments should I take to manage this?

Veda Maddala

Veda Maddala

M Pharmacy

Managing back pain from a bone marrow issue depends on your specific diagnosis. Treatment typically focuses on protecting your bones and treating the underlying condition. To strengthen bones and prevent pain or fractures, doctors often prescribe bone-modifying medications like bisphosphonates (such as zoledronic acid). For pain management, options range from acetaminophen to prescribed pain-relievers, physical therapy, or supportive back braces. If the marrow issue is oncological, targeted therapies or chemotherapy will be managed by a specialist. Please consult your hematologist or oncologist, as they will tailor a safe, highly personalized treatment plan specifically for your needs.

Have a query?

How Soon It Starts Working

The time required for Zoldonat 4 mg Injection to start to work: The time required for Zoldonat 4 mg Injection to show its action is unknown. The time for which the effects of Zoldonat 4 mg Injection last: The duration of action for Zoldonat 4 mg Injection is clinically unknown.

What if you forget to take Zoldonat 4 mg Injection

If you miss a dose or appointment for Zoldonat 4 mg Injection, reach out to your healthcare provider as soon as possible to reschedule.

Storage

• Store in a cool and dry place away from sunlight. • Keep Zoldonat 4 mg Injection out of reach and sight of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

If you are allergic to Zoldonat 4 mg Injection or any other medicines, please tell your doctor. Avoid taking Zoldonat 4 mg Injection if you are pregnant or breastfeeding and consult a doctor. Zoldonat 4 mg Injection is not recommended for children below 18 years as the safety and effectiveness were not established. Avoid taking Zoldonat 4 mg Injection if you have hypocalcemia (low calcium levels in the blood) and severe kidney problems. Drive only if you are alert as Zoldonat 4 mg Injection may cause dizziness. If you are not able to take daily calcium supplements, have had sections of the intestine or some or all of the parathyroid glands in the neck surgically removed, have cancer, gum disease, poor dental health, or planned tooth extraction or kidney problem, inform your doctor before taking Zoldonat 4 mg Injection. If you are a smoker, inform your doctor before receiving Zoldonat 4 mg Injection as it may increase the risk of dental problems. Zoldonat 4 mg Injection may cause osteonecrosis of the jaw (ONJ) in some patients. Therefore, if you experience any problems with teeth or mouth such as loose teeth, swelling or pain, non-healing of sores, or discharge, consult your doctor and dentist as these might be signs of osteonecrosis of the jaw. You are recommended to drink at least 2 glasses of fluids before and after treatment with Zoldonat 4 mg Injection as advised by your doctor to prevent dehydration. Take calcium and vitamin D supplements as prescribed by your doctor as Zoldonat 4 mg Injection may reduce calcium levels in the blood.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interaction: Zoldonat 4 mg Injection may interact with antibiotics (gentamicin) and water pills (furosemide).

Drug-Food Interaction: No interactions found.

Drug-Disease Interaction: Avoid taking Zoldonat 4 mg Injection if you have hypocalcemia (low calcium levels in the blood) and severe kidney problems. If you have cancer, gum disease, poor dental health, or planned tooth extraction or kidney problem, inform your doctor before taking Zoldonat 4 mg Injection.

Zoledronic acidCidofovir
Critical
Zoledronic acidHuman immunoglobulin
Severe

Drug-Drug Interactions

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Zoledronic acidCidofovir
Critical
How does the drug interact with Zoldonat 4 mg Injection:
Co-administration of Cidofovir and Zoldonat 4 mg Injection can increase the risk of kidney problems.

How to manage the interaction:
Taking Cidofovir and Zoldonat 4 mg Injection together is not recommended as it can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Zoledronic acidHuman immunoglobulin
Severe
How does the drug interact with Zoldonat 4 mg Injection:
Co-administration of Human immunoglobulin with Zoldonat 4 mg Injection, may raise the risk of kidney problems.

How to manage the interaction:
There may be a possibility of interaction between Human immunoglobulin and Zoldonat 4 mg Injection, but it can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
Zoledronic acidSirolimus
Severe
How does the drug interact with Zoldonat 4 mg Injection:
Co-administration of Sirolimus and Zoldonat 4 mg Injection can increase the risk or severity of kidney problems.

How to manage the interaction:
Taking Sirolimus and Zoldonat 4 mg Injection together can lead to an interaction, but it can be taken if a doctor advises. However, if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Zoledronic acidTacrolimus
Severe
How does the drug interact with Zoldonat 4 mg Injection:
Taking Tacrolimus with Zoldonat 4 mg Injection may increase risk of kidney problems.

How to manage the interaction:
Although taking Tacrolimus and Zoldonat 4 mg Injection together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
Zoledronic acidDeferasirox
Severe
How does the drug interact with Zoldonat 4 mg Injection:
Co-administration of Zoldonat 4 mg Injection (oral form) with Deferasirox can increase the risk of bleeding and ulcers in the stomach and intestines.

How to manage the interaction:
Although taking Zoldonat 4 mg Injection and Deferasirox together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm, seek immediate medical attention. Drink plenty of water if you experience diarrhoea or vomiting while taking these medications, as dehydration can potentially affect the kidneys. Do not discontinue any medications without a doctor's advice.
Zoledronic acidTenofovir alafenamide
Severe
How does the drug interact with Zoldonat 4 mg Injection:
Co-administration of Zoldonat 4 mg Injection and Tenofovir alafenamide can increase the risk of kidney problems.

How to manage the interaction:
Taking Zoldonat 4 mg Injection and Tenofovir alafenamide together can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[BONE ENHANCERS]

FAQs

Zoldonat 4 mg Injection is used to treat osteoporosis (weak and brittle bones) and Paget's bone.
Zoldonat 4 mg Injection contains Zoledronic acid that works by binding to the bone tightly and preventing the removal of calcium by osteoclasts (a type of bone cells that destroy bone tissue). This prevents osteoclasts from breaking down the bone and keeps the bones strong and minimizes the risk of bones breaking.
You are not recommended to take Zoldonat 4 mg Injection if you have hypocalcemia (low levels of calcium in the blood) as it may worsen the condition. However, the levels of calcium and vitamin D may be checked before starting treatment with Zoldonat 4 mg Injection.
Zoldonat 4 mg Injection may cause osteonecrosis (bone damage) of the jaw. Therefore, to prevent such condition, maintain good oral hygiene and have regular dental check-ups while taking Zoldonat 4 mg Injection. Also, is you wear dentures, make sure they fit properly. However, if you experience any problems with teeth or mouth such as loose teeth, swelling or pain, non-healing of sores or discharge, consult your doctor and dentist as these might be signs of osteonecrosis of the jaw.
You are not recommended to take Zoldonat 4 mg Injection with gentamicin as co-administration of these two medicines may increase the risk of very low calcium levels in the blood. However, please consult a doctor before taking Zoldonat 4 mg Injection with other medicines.
Zoldonat 4 mg Injection may reduce calcium levels in the blood by preventing calcium reabsorption from bones to the blood. Therefore, your doctor may prescribe calcium and vitamin D supplements, and you may be advised to take them for at least 10 days after receiving Zoldonat 4 mg Injection.
Zoldonat 4 mg Injection may cause flu-like symptoms (chills, tiredness, muscle and joint pain) in some patients as a common side effect. However, if the symptoms persist or worsen even after 2 weeks, please consult a doctor.
Osteonecrosis of the jaw (ONJ) is a condition where part of the jawbone doesn't get enough blood, causing it to die. This can happen after dental work or on its own, often linked to certain medications used for osteoporosis and cancer. Symptoms include pain, swelling, exposed bone, and trouble chewing.
In Paget’s disease, bone remodeling (removal of old bone and replacement with new bone material) is too quick, and new bone is formed in a disordered manner making it weaker than normal. If left untreated, the bone may become deformed, painful, and broken.
No, Zoldonat 4 mg Injection is not a habit-forming medication. It is used to treat osteoporosis and high blood calcium levels, and it does not cause physical or psychological dependence.
Zoldonat 4 mg Injection belongs to the class of medicines called 'bisphosphonates' that contains Zolendronic acid.
Your doctor will evaluate your individual needs and determine the appropriate treatment duration, confirming personalized care and best results. Zoldonat 4 mg Injection will be administered by a healthcare professional in a clinical setting. Always follow your doctor's instructions regarding treatment duration.
Zoldonat 4 mg Injection is administered through an intravenous (IV) infusion by a healthcare professional. This medication is given directly into your vein, and self-administration is not allowed.
Zoldonat 4 mg Injection is generally considered safe when we exactly follow our doctor's instructions. However, like all medications, it can have side effects and potential interactions with other drugs. It's important to follow your doctor's instructions and inform them of any pre-existing and existing medical conditions or medication history to avoid negative complications.
To keep your bones healthy, you should exercise regularly, eat a diet rich in calcium and vitamin D, stop smoking, limit alcohol, stay hydrated, and make your home safer to prevent falls. These simple changes can make a big difference in maintaining strong bones.
The common side effects of the Zoldonat 4 mg Injection are headache, fever, nausea, dizziness, vomiting, back pain, diarrhea, pain in the muscles, joints, or bones, swelling, or pain at the infusion site. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

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Country of origin

India

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - ZOL0033

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