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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Zolpirest-M Tablet is used in the treatment of insomnia. It contains Zolpidem and Melatonin which relaxes muscles, reduces anxiety, and helps to fall asleep. It may cause side effects such as nausea, headache, diarrhoea, drowsiness, and dizziness. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Manufacturer/Marketer :

East West Pharma India Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Zolpirest-M Tablet

Zolpirest-M Tablet is a combination medication containing 'sedative-hypnotics' used in the treatment of insomnia. Insomnia is a disorder of sleep that causes difficulty in falling asleep or staying asleep. It may be acute (short-term) or chronic (long-term) in nature due to various complications like stress, anxiety, and breathing problems.

Zolpirest-M Tablet contains Zolpidem and Melatonin, primarily used to treat insomnia. Zolpidem works by increasing the activity of GABA, which is a chemical messenger in the brain, acting as a natural nerve-calming agent, thereby inducing sleep. Melatonin is a natural hormone that helps to maintain the normal sleep cycle (waking up and falling asleep).  Thus, Zolpirest-M Tablet relaxes muscles, reduces anxiety, and helps to fall asleep.

Take Zolpirest-M Tablet as prescribed by your doctor. You are advised to take Zolpirest-M Tablet for as long as your doctor has prescribed it for you, depending upon your medical condition. Preferably take Zolpirest-M Tablet empty stomach and just before bedtime. In some cases, you may experience nausea, headache, diarrhoea, drowsiness, and dizziness. Most of these side effects of Zolpirest-M Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

If you are pregnant, planning to become pregnant, or breastfeeding, please inform your doctor before starting Zolpirest-M Tablet . Do not stop taking Zolpirest-M Tablet even if you feel better, as it may lead to unpleasant side effects. Zolpirest-M Tablet is known to cause drowsiness, so do not drive or operate machinery. Avoid consumption of alcohol as it may reduce the effectiveness of Zolpirest-M Tablet . Zolpirest-M Tablet should not be used for daily naps.

Uses of Zolpirest-M Tablet

Zolpirest-M Tablet is used in the treatment of Insomnia (sleeplessness). The detailed use of Zolpirest-M Tablet is as follows:

  • Insomnia (sleeplessness): Zolpirest-M Tablet helps initiate and maintain sleep.

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Directions for Use

  • Take Zolpirest-M Tablet with or without food or as advised by a doctor.
  • Follow your doctor’s instructions on the dosage and timing of this medication, to ensure the safety.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

Zolpirest-M Tablet is a sleeping pill used to treat insomnia (difficulty in falling or staying asleep). Zolpidem increases the activity of GABA (a chemical messenger in the brain that acts as a natural nerve-calming agent) that is involved in inducing sleep. Melatonin is a natural hormone that helps to maintain the normal sleep cycle (waking up and falling asleep). Thus, Zolpirest-M Tablet relaxes muscles, reduces anxiety, and helps to fall asleep. Appropriate lifestyle changes are recommended along with Zolpirest-M Tablet to improve the quality of sleep.

How Zolpirest-M Tablet Works

Zolpirest-M Tablet contains Zolpidem and Melatonin, primarily used to treat insomnia. Zolpidem works by increasing the activity of GABA, which is a chemical messenger in the brain, acting as a natural nerve-calming agent, thereby inducing sleep. Melatonin is a natural hormone that helps to maintain the normal sleep cycle (waking up and falling asleep).  Thus, Zolpirest-M Tablet relaxes muscles, reduces anxiety, and helps to fall asleep.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Zolpirest-M Tablet

Do not take more than the prescribed dose of Zolpirest-M Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Do not take Zolpirest-M Tablet if you are allergic to Zolpirest-M Tablet or any of its ingredients. If you notice that the tablets are not working as well as they did in the beginning of the treatment, please consult a doctor as you might have developed tolerance to Zolpirest-M Tablet , and dose adjustment may be required. Zolpirest-M Tablet contains Zolpidem, a category C pregnancy drug, and is not recommended for use during pregnancy as it may cause adverse effects in the baby after birth. If you are a breastfeeding mother, it is advised to consult a doctor before using Zolpirest-M Tablet . If you have kidney, liver, or breathing problems, severe muscle weakness, sleep apnoea (a severe condition in which breathing stops and starts repeatedly in sleep), and if you have a history of depression or mental illness, please inform your doctor before taking Zolpirest-M Tablet . Maintain a time gap of a minimum of 8 hours between taking Zolpirest-M Tablet and driving to reduce the risk of increased adverse effects.

Drug-Drug Interactions

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ZolpidemSodium oxybate
Critical

Drug-Drug Interactions

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ZolpidemSodium oxybate
Critical
How does the drug interact with Zolpirest-M Tablet:
Using sodium oxybate together with Zolpirest-M Tablet can significantly increase the risk of severity of low blood pressure, breathing difficulties, fainting and unconsciousness.

How to manage the interaction:
Taking Sodium oxybate with Zolpirest-M Tablet is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate consult a doctor immediately. You should refrain from operating any dangerous machinery or driving a car. Do not stop using any medications without talking to a doctor.
How does the drug interact with Zolpirest-M Tablet:
Coadministration of Zolpirest-M Tablet with ciprofloxacin can increase the blood levels and effects of Zolpirest-M Tablet. This can increase the risk or severity of side effects.

How to manage the interaction:
Although taking ciprofloxacin and Zolpirest-M Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience drowsiness, dizziness, or sleep disturbances, consult a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Zolpirest-M Tablet:
Using Zolpirest-M Tablet together with Butorphanol can cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Butorphanol and Zolpirest-M Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience dizziness, drowsiness, difficulty concentrating, and impairment in judgment, or reaction speed, avoid driving or operating hazardous machinery consult a doctor. Do not stop using any medications without a doctor's advice.
ZolpidemHydrocodone
Severe
How does the drug interact with Zolpirest-M Tablet:
Using Zolpirest-M Tablet together with Hydrocodone can cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Hydrocodone and Zolpirest-M Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience dizziness, drowsiness, difficulty concentrating, impairment in judgment, or reaction speed, consult a doctor. You should refrain from using dangerous machinery or driving a car. Do not discontinue any medications without consulting a doctor.
ZolpidemPindolol
Severe
How does the drug interact with Zolpirest-M Tablet:
Taking Zolpirest-M Tablet with Pindolol may increase the risk of low blood pressure.

How to manage the interaction:
Although taking Pindolol and Zolpirest-M Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate, consult a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Zolpirest-M Tablet:
Taking Zolpirest-M Tablet with Buprenorphine can cause central nervous system depression, leading to breathing difficulty and unconsciousness.

How to manage the interaction:
Although taking Buprenorphine and Zolpirest-M Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience dizziness, drowsiness, difficulty concentrating, and impairment in judgment, or reaction speed, consult a doctor. You should avoid driving or operating dangerous machinery. Do not stop using any medications without a doctor's advice.
ZolpidemPethidine
Severe
How does the drug interact with Zolpirest-M Tablet:
Taking Zolpirest-M Tablet with Pethidine may increase the risk of central nervous system depression, which can lead to breathing difficulty and unconsciousness.

How to manage the interaction:
Although taking Pethidine and Zolpirest-M Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience dizziness, drowsiness, difficulty concentrating, impairment in judgment, or reaction speed, consult a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Zolpirest-M Tablet:
Using Zolpirest-M Tablet together with Fentanyl can cause central nervous system depression.

How to manage the interaction:
Although taking Fentanyl and Zolpirest-M Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor if you experience dizziness, sleepiness, difficulty concentrating, and impaired judgment. Do not discontinue any medications without consulting a doctor.
ZolpidemEsketamine
Severe
How does the drug interact with Zolpirest-M Tablet:
Taking Zolpirest-M Tablet with Esketamine increases the effects of Zolpirest-M Tablet. This can increase the risk or severity of side effects.

How to manage the interaction:
Although taking Esketamine and Zolpirest-M Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience dizziness, drowsiness, difficulty concentrating, impairment in judgment, or reaction speed, consult a doctor. You should wait until the following day to operate any dangerous machinery or drive a car. Do not discontinue any medications without consulting a doctor.
ZolpidemSufentanil
Severe
How does the drug interact with Zolpirest-M Tablet:
Using Zolpirest-M Tablet together with Sufentanil can cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Sufentanil and Zolpirest-M Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience dizziness, drowsiness, difficulty concentrating, impairment in judgment, or reaction speed, consult a doctor. You should refrain from using dangerous machinery or driving a car. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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MELATONIN-3MG+ZOLPIDEM-10MGCaffeine containing foods/drinks
Moderate

Drug-Food Interactions

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MELATONIN-3MG+ZOLPIDEM-10MGCaffeine containing foods/drinks
Moderate
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Taking caffeine with Zolpirest-M Tablet may increase the blood levels and effects of Zolpirest-M Tablet. Avoid excessive caffeine consumption while being treated with Zolpirest-M Tablet.

Diet & Lifestyle Advise

  • Do regular exercise during day time.
  • Do not take a nap during day time. Set regular timings to go to bed and wake up.
  • Relax at least 1 hour before bedtime by bathing with warm water, listening to music, or reading a book.
  • Make the bedroom dark and quiet, and ensure that your pillows and mattresses are comfortable.
  • Avoid watching tv, using mobiles or laptops just before bedtime.
  • Limit caffeine intake, including tea, coffee, hot chocolate, cola, and energy drinks, as it may reduce the effectiveness of Zolpirest-M Tablet .
  • Avoid alcohol consumption as it may increase the risk of psychomotor impairment (slowdown of thought process and reduced physical movements), dependence, sleepwalking, or sleep-driving.

Habit Forming

Yes

Therapeutic Class

SEDATIVE-HYPNOTIC DRUGS
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Alcohol

Unsafe

Avoid consumption of alcohol with Zolpirest-M Tablet as it may increase the risk of dependence, psychomotor impairment (slowdown of thought process, and reduced physical movements), sleepwalking, or sleep-driving.

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Pregnancy

Unsafe

Zolpirest-M Tablet contains Zolpidem, a Category C pregnancy drug, and is not recommended for use during pregnancy as it may cause adverse effects in the baby after birth.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Zolpirest-M Tablet as it may be excreted in breast milk.

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Driving

Unsafe

You may experience dizziness, drowsiness, confusion, decreased alertness, blurred, or double vision, especially the day after taking Zolpirest-M Tablet . Therefore, avoid driving if you feel drowsy or dizzy after taking Zolpirest-M Tablet .

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Liver

Caution

Take Zolpirest-M Tablet with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Zolpirest-M Tablet with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Caution

Zolpirest-M Tablet is not recommended for children below 18 years of age.

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Heart

Caution

Zolpirest-M Tablet should be taken with extreme caution in patients with heart disease. Please consult your physician.

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Geriatrics

Unsafe

Zolpirest-M Tablet is not safe for use in elderly patients due to its serious side effects.

FAQs

Zolpirest-M Tablet is used in the treatment of insomnia.

Zolpirest-M Tablet is a sleeping pill used to treat insomnia (difficulty in falling or staying asleep). Zolpidem increases the activity of GABA (a chemical messenger in the brain that acts as a natural nerve-calming agent) that is involved in inducing sleep. Melatonin is a natural hormone that helps to maintain the normal sleep cycle (waking up and falling asleep)

No, Zolpirest-M Tablet is not recommended for depression patients as it may worsen the condition and increase self-harming or suicidal thoughts. Therefore, if you are suffering from depression or have a history of depression, please inform your doctor before taking Zolpirest-M Tablet .

You are recommended to take Zolpirest-M Tablet just before bedtime as it helps to sleep quickly and improves sleep quality. If you forget to take Zolpirest-M Tablet at night, do not take it in the day time as it may cause drowsiness, confusion and dizziness.

No, you are not recommended to take Zolpirest-M Tablet with hydrocodone or other opioid pain killers such as oxycodone, naloxone, and tramadol as co-administration of these medicines with Zolpirest-M Tablet may increase the risk of difficulty in breathing, drowsiness, coma, and even death. However, before using Zolpirest-M Tablet with any other medicines, you are advised to contact your doctor so that the dose may be adjusted to use safely.

Yes, Zolpirest-M Tablet may cause dependence (mental and physical effects caused due to compulsion of taking Zolpirest-M Tablet ) if used in high doses and for a prolonged time. This risk of dependency on Zolpirest-M Tablet increases in patients who have a history of drug or alcohol abuse.

Country of origin

India

Manufacturer/Marketer address

16Th Floor, Godrej Bkc, Plot C, G Block, Bandra-Kurla Complex, Bandra (East), Mumbai 400 051, India.
Other Info - ZOL0279

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