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  3. ZOMETA 4MG INJECTION 1's

ZOMETA 4MG INJECTION 1's, Pack of 1 INJECTION
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Composition :

ZOLEDRONIC ACID-4MG

Manufacturer/Marketer :

Novartis India Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About ZOMETA 4MG INJECTION

ZOMETA 4MG INJECTION belongs to the class of medicines called 'bisphosphonates' used to treat osteoporosis (weak and brittle bones) caused by menopause or long-term steroid use. ZOMETA 4MG INJECTION also treats Paget’s bone and high calcium levels caused by cancer. Osteoporosis is a bone disease that weakens and thins bones by decreasing bone density, common in post-menopausal women.  As the density of bones decreases, they weaken and are more likely to break. 

ZOMETA 4MG INJECTION contains Zoledronic acid that works by binding to the bone tightly and preventing the removal of calcium by osteoclasts (a type of bone cell that destroys bone tissue). This prevents osteoclasts from breaking down the bone and keeps the bones strong and minimizes the risk of bones breaking.

A doctor or nurse will administer ZOMETA 4MG INJECTION. In some cases, you may experience headache, fever, nausea, dizziness, vomiting, back pain, diarrhea, pain in the muscles, joints, or bones, swelling, or pain at the infusion site. Most of these side effects of ZOMETA 4MG INJECTION do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to ZOMETA 4MG INJECTION or any other medicines, please tell your doctor. Avoid taking ZOMETA 4MG INJECTION if you are pregnant or breastfeeding and consult a doctor. ZOMETA 4MG INJECTION is not recommended for children below 18 years as the safety and effectiveness were not established. Avoid taking ZOMETA 4MG INJECTION if you have hypocalcemia (low calcium levels in the blood) and severe kidney problems. Drive only if you are alert as ZOMETA 4MG INJECTION may cause dizziness. ZOMETA 4MG INJECTION may cause osteonecrosis of the jaw (ONJ) in some patients. Therefore, if you experience any problems with teeth or mouth such as loose teeth, swelling or pain, non-healing of sores, or discharge, consult your doctor and dentist as these might be signs of osteonecrosis of the jaw.

Uses of ZOMETA 4MG INJECTION

Treatment of Postmenopausal osteoporosis, Pagets disease, Hypercalcemia (high level of calcium) in cancer

Directions for Use

• Follow your doctor's instructions on the dosage and timing of ZOMETA 4MG INJECTION. Typically, it is administered once every 3-4 weeks.• ZOMETA 4MG INJECTION will be administered intravenously (through the vein) by a healthcare professional in a medical setting. • Do not self-administer it.

Medicinal Benefits

ZOMETA 4MG INJECTION contains Zoledronic acid used to treat postmenopausal osteoporosis, Paget’s disease, and hypercalcemia of malignancy (bone cancer in which excess of calcium exits). ZOMETA 4MG INJECTION binds to the bone tightly and prevents calcium removal by osteoclasts (a type of bone cell that destroy bone tissue). This prevents osteoclasts from breaking down the bone, strengthening bones, and minimizing the risk of bones breaking. Also, ZOMETA 4MG INJECTION may reduce calcium levels in the blood by preventing calcium reabsorption from bones to the blood. Thus, it helps in treating high calcium levels in the blood caused by cancer.

How ZOMETA 4MG INJECTION Works

ZOMETA 4MG INJECTION contains Zoledronic acid that works by binding to the bone tightly and preventing the removal of calcium by osteoclasts (a type of bone cell that destroys bone tissue). This prevents osteoclasts from breaking down the bone and keeps the bones strong and minimizes the risk of bones breaking.

Storage

Store in a cool and dry place away from sunlight
Side effects of Zometa 4mg Injection
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.

What if I have taken an overdose of ZOMETA 4MG INJECTION

Overdose may cause hypocalcemia (low calcium levels in the blood), hypophosphatemia (low levels of phosphate in the blood), and hypomagnesemia (low magnesium levels). Since ZOMETA 4MG INJECTION is administered by a healthcare professional, an overdose is unlikely to occur. However, seek medical attention if you experience any unusual symptoms.

Drug Warnings

If you are allergic to ZOMETA 4MG INJECTION or any other medicines, please tell your doctor. Avoid taking ZOMETA 4MG INJECTION if you are pregnant or breastfeeding and consult a doctor. ZOMETA 4MG INJECTION is not recommended for children below 18 years as the safety and effectiveness were not established. Avoid taking ZOMETA 4MG INJECTION if you have hypocalcemia (low calcium levels in the blood) and severe kidney problems. Drive only if you are alert as ZOMETA 4MG INJECTION may cause dizziness. If you are not able to take daily calcium supplements, have had sections of the intestine or some or all of the parathyroid glands in the neck surgically removed, have cancer, gum disease, poor dental health, or planned tooth extraction or kidney problem, inform your doctor before taking ZOMETA 4MG INJECTION. If you are a smoker, inform your doctor before receiving ZOMETA 4MG INJECTION as it may increase the risk of dental problems. ZOMETA 4MG INJECTION may cause osteonecrosis of the jaw (ONJ) in some patients. Therefore, if you experience any problems with teeth or mouth such as loose teeth, swelling or pain, non-healing of sores, or discharge, consult your doctor and dentist as these might be signs of osteonecrosis of the jaw. You are recommended to drink at least 2 glasses of fluids before and after treatment with ZOMETA 4MG INJECTION as advised by your doctor to prevent dehydration. Take calcium and vitamin D supplements as prescribed by your doctor as ZOMETA 4MG INJECTION may reduce calcium levels in the blood.

Drug-Drug Interactions

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Zoledronic acidCidofovir
Critical
Zoledronic acidTenofovir alafenamide
Severe

Drug-Drug Interactions

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Zoledronic acidCidofovir
Critical
How does the drug interact with Zometa 4mg Injection:
Co-administration of Cidofovir and Zometa 4mg Injection can increase the risk of kidney problems.

How to manage the interaction:
Taking Cidofovir and Zometa 4mg Injection together is not recommended as it can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Zoledronic acidTenofovir alafenamide
Severe
How does the drug interact with Zometa 4mg Injection:
Co-administration of Zometa 4mg Injection and Tenofovir alafenamide can increase the risk of kidney problems.

How to manage the interaction:
Taking Zometa 4mg Injection and Tenofovir alafenamide together can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Zoledronic acidDeferasirox
Severe
How does the drug interact with Zometa 4mg Injection:
Co-administration of Zometa 4mg Injection (oral form) with Deferasirox can increase the risk of bleeding and ulcers in the stomach and intestines.

How to manage the interaction:
Although taking Zometa 4mg Injection and Deferasirox together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm, seek immediate medical attention. Drink plenty of water if you experience diarrhoea or vomiting while taking these medications, as dehydration can potentially affect the kidneys. Do not discontinue any medications without a doctor's advice.
Zoledronic acidTacrolimus
Severe
How does the drug interact with Zometa 4mg Injection:
Taking Tacrolimus with Zometa 4mg Injection may increase risk of kidney problems.

How to manage the interaction:
Although taking Tacrolimus and Zometa 4mg Injection together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
Zoledronic acidSirolimus
Severe
How does the drug interact with Zometa 4mg Injection:
Co-administration of Sirolimus and Zometa 4mg Injection can increase the risk or severity of kidney problems.

How to manage the interaction:
Taking Sirolimus and Zometa 4mg Injection together can lead to an interaction, but it can be taken if a doctor advises. However, if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Zoledronic acidHuman immunoglobulin
Severe
How does the drug interact with Zometa 4mg Injection:
Co-administration of Human immunoglobulin with Zometa 4mg Injection, may raise the risk of kidney problems.

How to manage the interaction:
There may be a possibility of interaction between Human immunoglobulin and Zometa 4mg Injection, but it can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include dairy products like milk, yoghurt, cheese, or milk-based custard in your diet.
  • Eat daily a serving of broccoli, cabbage, bok choy (Chinese white cabbage), spinach, and other green leafy vegetables.
  • Snack on calcium-rich nuts like Brazil nuts or almonds.
  • Sprinkle sesame seeds over your food, vegetables, and salads. Sesame seeds are high in calcium.
  • Avoid or reduce the intake of caffeine, soft drinks, and alcohol that inhibit calcium absorption.
  • Replace the meat with tofu or tempeh for extra calcium in your food.

Habit Forming

No

Therapeutic Class

BONE ENHANCERS

ZOMETA 4MG INJECTION Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

Interaction of alcohol with ZOMETA 4MG INJECTION is unknown. Please consult a doctor before consuming alcohol with ZOMETA 4MG INJECTION.

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Pregnancy

Unsafe

ZOMETA 4MG INJECTION is a category D pregnancy drug and is not recommended for pregnant women as it may harm an unborn baby. Please consult a doctor if you are pregnant.

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Breast Feeding

Unsafe

ZOMETA 4MG INJECTION is contraindicated in breastfeeding mothers. Therefore, please consult a doctor if you are breastfeeding.

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Driving

Caution

ZOMETA 4MG INJECTION may cause dizziness. Therefore, avoid driving or operating machinery if you feel dizzy after taking ZOMETA 4MG INJECTION.

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Liver

Caution

Take ZOMETA 4MG INJECTION with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take ZOMETA 4MG INJECTION with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required. Avoid taking ZOMETA 4MG INJECTION if you have severe kidney problems.

bannner image

Children

Unsafe

ZOMETA 4MG INJECTION is not recommended for children below 18 years as the safety and effectiveness were not established.

Have a query?

FAQs

ZOMETA 4MG INJECTION is used to treat osteoporosis (weak and brittle bones) and Paget's bone.

ZOMETA 4MG INJECTION contains Zoledronic acid that works by binding to the bone tightly and preventing the removal of calcium by osteoclasts (a type of bone cells that destroy bone tissue). This prevents osteoclasts from breaking down the bone and keeps the bones strong and minimizes the risk of bones breaking.

You are not recommended to take ZOMETA 4MG INJECTION if you have hypocalcemia (low levels of calcium in the blood) as it may worsen the condition. However, the levels of calcium and vitamin D may be checked before starting treatment with ZOMETA 4MG INJECTION.

ZOMETA 4MG INJECTION may cause osteonecrosis (bone damage) of the jaw. Therefore, to prevent such condition, maintain good oral hygiene and have regular dental check-ups while taking ZOMETA 4MG INJECTION. Also, is you wear dentures, make sure they fit properly. However, if you experience any problems with teeth or mouth such as loose teeth, swelling or pain, non-healing of sores or discharge, consult your doctor and dentist as these might be signs of osteonecrosis of the jaw.

You are not recommended to take ZOMETA 4MG INJECTION with gentamicin as co-administration of these two medicines may increase the risk of very low calcium levels in the blood. However, please consult a doctor before taking ZOMETA 4MG INJECTION with other medicines.

ZOMETA 4MG INJECTION may reduce calcium levels in the blood by preventing calcium reabsorption from bones to the blood. Therefore, your doctor may prescribe calcium and vitamin D supplements, and you may be advised to take them for at least 10 days after receiving ZOMETA 4MG INJECTION.

ZOMETA 4MG INJECTION may cause flu-like symptoms (chills, tiredness, muscle and joint pain) in some patients as a common side effect. However, if the symptoms persist or worsen even after 2 weeks, please consult a doctor.

Osteonecrosis of the jaw (ONJ) is a condition where part of the jawbone doesn't get enough blood, causing it to die. This can happen after dental work or on its own, often linked to certain medications used for osteoporosis and cancer. Symptoms include pain, swelling, exposed bone, and trouble chewing.

In Paget’s disease, bone remodeling (removal of old bone and replacement with new bone material) is too quick, and new bone is formed in a disordered manner making it weaker than normal. If left untreated, the bone may become deformed, painful, and broken.

No, ZOMETA 4MG INJECTION is not a habit-forming medication. It is used to treat osteoporosis and high blood calcium levels, and it does not cause physical or psychological dependence.

ZOMETA 4MG INJECTION belongs to the class of medicines called 'bisphosphonates' that contains Zolendronic acid.

Your doctor will evaluate your individual needs and determine the appropriate treatment duration, confirming personalized care and best results. ZOMETA 4MG INJECTION will be administered by a healthcare professional in a clinical setting. Always follow your doctor's instructions regarding treatment duration.

ZOMETA 4MG INJECTION is administered through an intravenous (IV) infusion by a healthcare professional. This medication is given directly into your vein, and self-administration is not allowed.

ZOMETA 4MG INJECTION is generally considered safe when we exactly follow our doctor's instructions. However, like all medications, it can have side effects and potential interactions with other drugs. It's important to follow your doctor's instructions and inform them of any pre-existing and existing medical conditions or medication history to avoid negative complications.

To keep your bones healthy, you should exercise regularly, eat a diet rich in calcium and vitamin D, stop smoking, limit alcohol, stay hydrated, and make your home safer to prevent falls. These simple changes can make a big difference in maintaining strong bones.

The common side effects of the ZOMETA 4MG INJECTION are headache, fever, nausea, dizziness, vomiting, back pain, diarrhea, pain in the muscles, joints, or bones, swelling, or pain at the infusion site. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Country of origin

Switzerland

Manufacturer/Marketer address

Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India
Other Info - ZOM0003

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:47 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.210.pdf
  2. https://www.drugs.com/zometa.html

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