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compositionComposition:ZONISAMIDE-50MG
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Prescription Medicine
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Zonisep 50 Capsule is used to treat epilepsy (seizures/fits). It contains Zonisamide, which reduces the abnormal and excessive activity of nerve impulses in the brain that cause fits or seizures. In some cases, you may experience certain common side effects such as dizziness, irritability, loss of appetite, nausea, headache, or uncontrolled movements. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

ZONISAMIDE-50MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Zonisep 50 Capsule

Zonisep 50 Capsule is an oral prescription medication used to treat partial seizures in adults with epilepsy. It is typically prescribed alongside other seizure medications to help control and reduce the frequency of these episodes. By stabilising electrical activity in the brain, it supports overall seizure management.

For Zonisep 50 Capsule to work effectively, you must take it consistently every day at the same times as directed by your doctor. You can take this medication with or without food, but you should swallow the capsules whole with plenty of water. Drinking extra fluids and staying well-hydrated throughout the day can significantly lower your risk of developing kidney stones while on this treatment.

Many people taking Zonisep 50 Capsule experience mild side effects, like drowsiness, dizziness, or a loss of appetite. However, you must contact your doctor immediately if you notice serious symptoms such as severe skin rashes, difficulty breathing, decreased sweating, or sudden mood changes like depression or suicidal thoughts.

Before starting Zonisep 50 Capsule , tell your doctor if you have a history of kidney disease, liver problems, or a sulfa allergy. Do not take this medication if you have had a severe allergic reaction to sulfonamide drugs, as the active ingredient in Zonisep 50 Capsule belongs to this chemical family.

Zonisep 50 Capsule can interact with other medications that cause drowsiness, as well as alcohol, which can worsen dizziness and slow down your reaction times. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, you should discuss the risks and benefits thoroughly with your doctor before starting this medication.

Uses of Zonisep 50 Capsule

Zonisep 50 Capsule is used to treat partial seizures in adults with epilepsy. The detailed uses of Zonisep 50 Capsule are as follows:

  • Partial seizures in adults with epilepsy: Zonisep 50 Capsule is used as an add-on treatment to help control and reduce the frequency of seizures that start in one specific area of the brain.

Key Benefits

Zonisep 50 Capsule provides critical support for individuals living with epilepsy by reducing the sudden, uncontrolled electrical disturbances in the brain. Achieving better control over these episodes allows patients to experience fewer disruptions in their daily lives. Some of the key benefits patients may experience include:

  • Helps Reduce Seizure Frequency: By controlling excessive electrical activity in the brain, Zonisep 50 Capsule helps reduce the frequency of seizures, supporting more stable day-to-day functioning.
  • Supports Greater Confidence in Daily Life: Better seizure control with Zonisep 50 Capsule can help reduce the uncertainty associated with unexpected seizures, allowing you to carry out daily activities with greater confidence and peace of mind.
  • Enhances Long-Term Epilepsy Management: When used as prescribed, either alone or in combination with other anti-seizure medicines, Zonisep 50 Capsule helps provide effective long-term seizure control and supports overall epilepsy management.
Side effects of Zonisep 50 Capsule
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
  • Manage stress by practising deep breathing, yoga or meditation.
  • Participating in activities you enjoy, or exercising may also help manage agitation.
  • Get enough sleep. Maintain a regular sleep cycle.
  • Exercise regularly. Try physical activities like walking, running, or dancing.
  • Manage stress by practising deep breathing, yoga or meditation.
  • Get enough sleep. Maintain a regular sleep cycle.
  • Exercise regularly. Try physical activities like walking, running, or dancing.
  • Limit stimulants like tea, coffee and alcohol.
  • Identify triggers and try managing them.
  • Take a break by scheduling time for yourself.
  • Try creative activities like writing, dancing or painting as it helps release tension.
  • Confusion is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control confusion.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your confusion.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes.
  • Talk to your dietician and consume food that can improve your mental health.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Regular eye exams can detect conditions causing Involuntary Eye Movement.
  • Alcohol and drugs should be avoided as they can increase the symptoms of nystagmus.
  • Wearing corrective lenses for refractive errors can reduce eye strain and symptoms.
  • Stress management and getting proper sleep can help to reduce symptoms.

Directions for Use

  • Zonisep 50 Capsule can be taken with or without food as advised by your doctor.
  • It is usually taken once or twice a day or as directed by the doctor.
  • Swallow Zonisep 50 Capsule as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Zonisep 50 Capsule Works

Zonisep 50 Capsule contains zonisamide. It works by stabilising the electrical activity in your brain. Under normal conditions, brain cells communicate using controlled electrical signals. During a seizure, these signals become hyperactive and disorganised. The active zonisamide compound in Zonisep 50 Capsule helps block certain sodium and calcium channels in brain cells, which stops the rapid and repetitive firing of these electrical signals. By calming this overactivity, the medication helps prevent a seizure from starting or spreading to other parts of the brain.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Zonisep 50 Capsule as it may increase dizziness and sleepiness.

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Pregnancy

Caution

Avoid taking Zonisep 50 Capsule if you are pregnant unless prescribed by a doctor to lead to serious birth defects/congenital disabilities. Please consult your doctor if you have any concerns regarding this. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Zonisep 50 Capsule should not be taken by breastfeeding mothers as it passes into breast milk and could lead to side-effects for breastfed babies.

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Driving

Unsafe

Zonisep 50 Capsule causes drowsiness, sleepiness, and tiredness. Do not drive or operate machinery unless you are alert.

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Liver

Consult your doctor

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Consult your doctor

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks.

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Children

Safe if prescribed

Zonisep 50 Capsule can be given to children above 6 years if prescribed by the doctor. The dose will be adjusted by the doctor depending upon the child's body weight.

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Heart

Consult your doctor

Please inform your doctor if you have any pre-existing heart problems

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Geriatrics

Consult your doctor

Limited information available for use of Zonisep 50 Capsule in elderly patients. Please consult your doctor.

What if I have taken an overdose of Zonisep 50 Capsule

If you take too much Zonisep 50 Capsule , seek emergency medical attention or call your local hospital immediately. Symptoms of an overdose may include extreme drowsiness, slow heart rate, shallow breathing, or fainting.

Diet & Lifestyle Advise

  • Stay highly hydrated: Drink at least 6 to 8 glasses of water daily. This is critical to lower your risk of developing kidney stones, which is a known risk with zonisamide therapy.
  • Avoid overheating: Since Zonisep 50 Capsule can reduce your ability to sweat, avoid extreme heat, saunas, and intense exercise in hot weather. Dress in cool layers and stay in air-conditioned spaces when temperatures rise.
  • Maintain a consistent sleep schedule: Lack of sleep is a well-known trigger for seizures. Aim for 7 to 9 hours of quality sleep each night.
  • Limit alcohol consumption: Alcohol can increase the sedative effects of Zonisep 50 Capsule , making you dangerously drowsy or dizzy, and can also trigger seizures.
  • Keep a seizure diary: Track when your seizures occur, what you were doing, and any side effects you experience. This information is incredibly valuable for your doctor during check-ups.

Health Queries

Can Rolandic epilepsy treated with Zonisep 50 disappear with age?

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

Indeed, when a child gets older, Rolandic epilepsy frequently becomes better and may even go away entirely by adolescence. During this time, medications like Zonisep 50 assist manage seizures, but they don't alter the condition's normal progression. Once they are seizure-free for an extended period of time, many kids can gradually stop taking their medicine under a doctor's supervision.
health query

Have a query?

How Soon It Starts Working

  • The time required for Zonisep 50 Capsule to start to work: The time required for Zonisep 50 Capsule to show its action is not clinically established.
  • The time for which the effects of Zonisep 50 Capsule last: The duration of action for Zonisep 50 Capsule is not clinically established.

What if you forget to take Zonisep 50 Capsule

If you miss a dose of Zonisep 50 Capsule , take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and return to your regular schedule. Do not take two doses at the same time to make up for a missed one. If you miss multiple doses, talk to your doctor or pharmacist for guidance.

Storage

•Store Zonisep 50 Capsule capsules at room temperature, ideally between 20°C and 25°C (68°F to 77°F). •Keep the medication in its original container, tightly closed, to protect it from moisture and direct light.

Drug Warnings

  • Check your skin daily. Contact your doctor immediately if you notice any new rash, itching, or skin peeling, as this medication can cause rare but life-threatening skin reactions.
  • Do not drive or operate heavy machinery until you know how Zonisep 50 Capsule affects you, as it can cause significant drowsiness and slow your reflexes.
  • Monitor your mood closely. Have a family member or caregiver watch for sudden changes in your behaviour, depressive thoughts, or signs of self-harm.
  • Tell all healthcare providers, including your dentist, that you are taking Zonisep 50 Capsule before undergoing any medical procedures or starting new prescriptions.
  • Never stop taking this medicine abruptly. Doing so can cause a severe, continuous state of seizures that can be dangerous.

Drug-Drug Interactions

verifiedApollotooltip
  • Other carbonic anhydrase inhibitors (like topiramate or acetazolamide): Taking these alongside Zonisep 50 Capsule can increase the risk of metabolic acidosis (too much acid in the blood) and kidney stones.
  • Sedatives and sleep aids: Medicines that cause drowsiness, such as benzodiazepines or muscle relaxants, can cause extreme sleepiness when taken with Zonisep 50 Capsule .
  • Certain seizure medications (like phenytoin, carbamazepine, or phenobarbital): These drugs can speed up how your body processes Zonisep 50 Capsule , potentially lowering its effectiveness.
ZonisamideAripiprazole
Severe
ZonisamideAmitriptyline
Severe

Drug-Drug Interactions

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ZonisamideAripiprazole
Severe
How does the drug interact with Zonisep 50 Capsule:
Coadministration of Aripiprazole with Zonisep 50 Capsule can increase the risk or severity of Zonisep 50 Capsule side effects like increased body temperature and decreased sweating especially in warm weather.

How to manage the interaction:
Taking Aripiprazole with Zonisep 50 Capsule together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience changes in blood pressure, increased heart rate, fever, or excessive sweating, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ZonisamideAmitriptyline
Severe
How does the drug interact with Zonisep 50 Capsule:
Coadministration of Amitriptyline and Zonisep 50 Capsule both increase body temperature while decreasing sweating.

How to manage the interaction:
Zonisep 50 Capsule and Amitriptyline interact, however, if prescribed by a doctor, they can both be used. Some people may experience heat stroke and need to be hospitalized, especially in warm weather and while engaging in intense exercise. Children are especially at risk. If you feel sleepy, uneasy, or lightheaded after taking these medications combined, consult a doctor. Without consulting a doctor, never stop taking medicines.
ZonisamideHaloperidol
Severe
How does the drug interact with Zonisep 50 Capsule:
Coadministration of Haloperidol with Zonisep 50 Capsule can increase the risk or severity of developing Zonisep 50 Capsule side effects like increased body temperature and decreased sweating especially in warm weather.

How to manage the interaction:
Taking Haloperidol with Zonisep 50 Capsule together is not recommended as it can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience changes in blood pressure, increased heart rate, fever, or excessive sweating, contact a doctor immediately. Make sure to hydrate yourself during warm weather or after exercise. Do not discontinue any medications without consulting a doctor.
ZonisamideRisperidone
Severe
How does the drug interact with Zonisep 50 Capsule:
Coadministration of Risperidone with Zonisep 50 Capsule can increase the risk of Zonisep 50 Capsule side effects.

How to manage the interaction:
Taking Risperidone with Zonisep 50 Capsule together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience changes in blood pressure, increased heart rate, fever, or excessive sweating, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ZonisamidePromethazine
Severe
How does the drug interact with Zonisep 50 Capsule:
Coadministration of Promethazine with Zonisep 50 Capsule can increase the risk or severity of Zonisep 50 Capsule side effects like increased body temperature and decreased sweating especially in warm weather.

How to manage the interaction:
Taking Promethazine with Zonisep 50 Capsule together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience changes in blood pressure, increased heart rate, fever, or excessive sweating, contact a doctor immediately. Make sure to hydrate yourself during warm weather or after exercise. Do not discontinue any medications without consulting a doctor.
ZonisamideBenzatropine
Severe
How does the drug interact with Zonisep 50 Capsule:
Zonisep 50 Capsule can cause Benzatropine to be eliminated from the body faster, leading to lower levels in the blood and possibly reducing its effectiveness.

How to manage the interaction:
Taking Benzatropine with Zonisep 50 Capsule together can result in an interaction, but it can be taken if your doctor has advised it. If you're having any of these symptoms like feeling too hot, not sweating enough, feeling very tired, dizzy, or lightheaded, it's important to call a doctor right away. They may be able to recommend other options for you that won't cause these problems. Do not discontinue any medications without consulting a doctor.
ZonisamideFlavoxate
Severe
How does the drug interact with Zonisep 50 Capsule:
Co-administration of Flavoxate and Zonisep 50 Capsule may increase body temperature and decrease sweating.

How to manage the interaction:
If you are supposed to take Flavoxate and Zonisep 50 Capsule together, a doctor may adjust the dose or monitor you more frequently to safely use both medications. Drink plenty of fluids during warm weather and when exercising and contact a doctor if you have decreased sweating or a fever. Avoid activities requiring mental alertness such as driving or operating hazardous machinery, until you know how the medications affect you. Do not discontinue any medication without consulting a doctor.
ZonisamideCyproheptadine
Severe
How does the drug interact with Zonisep 50 Capsule:
Coadministration of Cyproheptadine with Zonisep 50 Capsule can lead to increased body temperature and decreased sweating especially in warm weather.

How to manage the interaction:
Taking Cyproheptadine with Zonisep 50 Capsule together is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience changes in blood pressure, increased heart rate, fever, or excessive sweating, contact a doctor immediately. Make sure to hydrate yourself during warm weather or after exercise. Do not discontinue any medications without consulting a doctor.
ZonisamideMetformin
Severe
How does the drug interact with Zonisep 50 Capsule:
The combined use of Metformin with Zonisep 50 Capsule may increase the risk of Lactic acidosis (excessive lactic acid production in the blood).

How to manage the interaction:
Co-administration Metformin with Zonisep 50 Capsule can lead to an interaction, it can be taken if prescribed by a doctor. However, if you experience any symptoms such as weakness, muscle pain, respiratory distress, consult a doctor immediately. Do not stop using any medication without a doctor's advice.
ZonisamideTrihexyphenidyl
Severe
How does the drug interact with Zonisep 50 Capsule:
Coadministration of Trihexyphenidyl with Zonisep 50 Capsule can increase the risk or severity of Zonisep 50 Capsule side effects like increased body temperature and decreased sweating especially in warm weather.

How to manage the interaction:
Taking Trihexyphenidyl with Zonisep 50 Capsule together is not recommended as it can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience increased heart rate, fever, or excessive sweating, contact a doctor immediately. Make sure to hydrate yourself during warm weather or after exercise. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Drinking alcohol while taking Zonisep 50 Capsule can severely increase central nervous system side effects like dizziness, confusion, and drowsiness.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTICONVULSANT]

FAQs

Zonisep 50 Capsule belongs to a group of medicines called anti-convulsants or anti-epileptics used to treat epilepsy (seizures/fits).
Zonisep 50 Capsule consists of zonisamide, which decreases the brain's excessive and abnormal nerve activity by blocking sodium and calcium currents in your brain and body. This reduces abnormal electrical activity between your nerve cells.
Zonisep 50 Capsule should be used with caution during hot weather, as it may increase the chance of having a heat stroke. Inform your doctor if you have heat intolerance or fever. To avoid this condition, it is advisable to drink a lot of cold fluid and water and move to a cooler place, especially in summer.
No, Zonisep 50 Capsule is not a habit-forming drug. However, it can cause side effects, especially when you stop taking it suddenly.
Consult your doctor before taking Zonisep 50 Capsule if you have had kidney stones. Your doctor will prescribe Zonisep 50 Capsule only if the benefits outweigh the risks. Zonisep 50 Capsule should be taken with caution in patients with kidney stones. You may be at increased risk of developing more kidney stones. Reduce the risk of kidney stones by drinking sufficient water.
Consult your doctor before taking Zonisep 50 Capsule if you have glaucoma. Zonisep 50 Capsule is contraindicated in patients with narrow-angle glaucoma. Zonisep 50 Capsule may cause blindness on long-term use in the case of patients with narrow-angle glaucoma.
Zonisep 50 Capsule contains Zonisamide as an active ingredient.
If you suddenly stop taking Zonisep 50 Capsule , your seizures may become worse. If required, your doctor will probably decrease your dose gradually.
In patients taking Zonisep 50 Capsule , severe muscle pain and/or weakness develop either in the presence or absence of a fever. It is recommended that you consult your doctor; they will perform specific tests to evaluate muscle damage and treat it accordingly.
Although the Food and Drug Administration (FDA) has not officially approved Zonisep 50 Capsule for children, quite a few research studies have shown that it has been given to children of various ages (even infants) with generally good results. However, it should be provided under the supervision of a doctor.
No, it does not impact on birth control pills. No reported interactions have been established as of now.
Zonisep 50 Capsule is excreted by the kidneys; patients with renal impairment or renal disease should be treated cautiously.
In some cases, you may experience certain common side effects such as dizziness, irritability, loss of appetite, memory impairment, double vision, confusion, depression, constipation, nausea, headache, and uncontrolled movements. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
Symptoms of overdose may include slow heartbeat, slowed breathing, dizziness, fainting and coma (loss of consciousness for a period of time).
Zonisep 50 Capsule may help control your condition but will not cure it. It may take two weeks or longer before you feel the full benefit of Zonisep 50 Capsule .
Before using this medication, you should inform your doctor about your medical history, including any ongoing medicines, to avoid potential interactions and minimize side effects.
Take the missed dose as soon as you remember unless it's almost time for your next dose. In this case, skip the missed dose and take your next dose at the regular time. Never take a double dose to make up for a missed one.
Taking more than the recommended dosage does not provide additional benefits and can increase the risk of adverse effects.
Avoid consuming alcohol along with Zonisep 50 Capsule as it could lead to increased dizziness and sleepiness.
Yes, some people experience a loss of appetite and subsequent weight loss while taking Zonisep 50 Capsule . If you notice a significant or sudden drop in weight, talk to your doctor to manage this effect safely.
No, you must never stop taking Zonisep 50 Capsule suddenly, even if you feel completely well. Stopping abruptly can cause your seizures to return more frequently or become harder to control. Talk to your doctor before making any changes to your medication schedule.
Yes, Zonisep 50 Capsule can increase your risk of developing kidney stones. To help prevent this, it is very important to drink plenty of water throughout the day. Talk to your doctor immediately if you experience sharp pain in your back or side or see blood in your urine.
Taking Zonisep 50 Capsule during pregnancy may pose risks to an unborn baby, including developmental issues. However, uncontrolled seizures also present serious risks to both the mother and baby. If you are pregnant or planning to become pregnant, talk to your doctor immediately to discuss the safest treatment plan.
You should contact your doctor right away or seek emergency medical care if you develop any skin rash, peeling, or hives while taking Zonisep 50 Capsule . This medicine can cause rare but severe, life-threatening allergic skin reactions. Talk to your doctor or pharmacist if you notice any skin changes.
Yes, Zonisep 50 Capsule can cause mood changes, depression, anxiety, or even thoughts of self-harm in some patients. It is vital to monitor your emotional well-being closely and have loved ones look out for changes in your behaviour. Talk to your doctor immediately if you experience new or worsening mental health symptoms.

Disclaimer

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Country of origin

India

Manufacturer/Marketer address

90, Delhi - Jaipur Road, Sector 32, Gurugram, Haryana 122001
Other Info - ZON0004

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