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  3. Zonisep 50 Capsule 10's

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Zonisep 50 Capsule 10's, Pack of 10 CAPSULES
Zonisep 50 Capsule 10's, Pack of 10 CAPSULES
Zonisep 50 Capsule 10's, Pack of 10 CAPSULES
Zonisep 50 Capsule 10's, Pack of 10 CAPSULES
Zonisep 50 Capsule 10's, Pack of 10 CAPSULES
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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

Zonisep 50 Capsule is used to treat epilepsy (seizures/fits). It contains Zonisamide, which reduces the abnormal and excessive activity of nerve impulses in the brain that cause fits or seizures. In some cases, you may experience certain common side effects such as dizziness, irritability, loss of appetite, nausea, headache, or uncontrolled movements. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

ZONISAMIDE-50MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Zonisep 50 Capsule

Zonisep 50 Capsule is used to treat epilepsy (seizures/fits). Epilepsy is a sudden rush of electricity in the brain. In epilepsy, the brain's electrical rhythms become imbalanced, resulting in recurrent seizures.

Zonisep 50 Capsule contains 'Zonisamide’ that reduces the abnormal and excessive activity of nerve impulses in the brain that cause fits or seizures. This helps in controlling seizures.

In some cases, you may experience certain common side effects such as dizziness, irritability, loss of appetite, constipation, nausea, headache, and uncontrolled movements. Talk to your doctor if you experience these side effects persistently.

Inform your doctor about your health conditions and medicines to prevent side effects. Do not take Zonisep 50 Capsule if you are pregnant or breastfeeding unless prescribed by the doctor. Zonisep 50 Capsule can cause permanent vision loss. Inform your doctor immediately if you have any eye pain, redness, or any changes in your vision.

Uses of Zonisep 50 Capsule

Zonisep 50 Capsule is used in the treatment of epilepsy/seizures. The detailed use of Zonisep 50 Capsule is as follows:

  • Seizure Management: Zonisep 50 Capsule is used as adjunctive therapy to control partial seizures in epilepsy patients by stabilising abnormal electrical activity in the brain.

Have a query?

Directions for Use

  • Zonisep 50 Capsule can be taken with or without food as advised by your doctor.
  • It is usually taken once or twice a day or as directed by the doctor.
  • Swallow Zonisep 50 Capsule as a whole with a glass of water.
  • Do not chew, crush, or break it.

Medicinal Benefits

  • Zonisep 50 Capsule belongs to a group of medicines called anti-convulsants or anti-epileptics used to treat epilepsy/seizures/fits.
  • It works by blocking the sodium and calcium currents in the brain and suppressing the abnormal and excessive activity of nerve impulses in the brain that cause fits and pain. This helps in controlling seizures.
  • Zonisep 50 Capsule is used alone or in combination to treat and prevent partial seizures and generalised seizures in adults.
  • It may be used as solo therapy or in combination to treat and prevent seizures in children above 6 years of age.
  • Zonisep 50 Capsule is not associated with any psychological or physical dependence, and there is no potential for abuse.

How Zonisep 50 Capsule Works

Zonisep 50 Capsule contains Zonisamide, which reduces the abnormal and excessive activity of nerve impulses in the brain that cause fits or seizures. This helps in controlling seizures.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Zonisep 50 Capsule
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
  • Manage stress by practising deep breathing, yoga or meditation.
  • Participating in activities you enjoy, or exercising may also help manage agitation.
  • Get enough sleep. Maintain a regular sleep cycle.
  • Exercise regularly. Try physical activities like walking, running, or dancing.
  • Manage stress by practising deep breathing, yoga or meditation.
  • Get enough sleep. Maintain a regular sleep cycle.
  • Exercise regularly. Try physical activities like walking, running, or dancing.
  • Limit stimulants like tea, coffee and alcohol.
  • Identify triggers and try managing them.
  • Take a break by scheduling time for yourself.
  • Try creative activities like writing, dancing or painting as it helps release tension.
  • Confusion is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control confusion.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your confusion.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes.
  • Talk to your dietician and consume food that can improve your mental health.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Regular eye exams can detect conditions causing Involuntary Eye Movement.
  • Alcohol and drugs should be avoided as they can increase the symptoms of nystagmus.
  • Wearing corrective lenses for refractive errors can reduce eye strain and symptoms.
  • Stress management and getting proper sleep can help to reduce symptoms.

What if I have taken an overdose of Zonisep 50 Capsule

Do not take more than the prescribed dose of Zonisep 50 Capsule as it may cause serious side effects. The symptoms of overdose include slow heart rate, fainting, feeling lightheaded, and shallow or slow breathing. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

  • Do not take Zonisep 50 Capsule if you are allergic to it or any of its contents.
  • Avoid intake of Zonisep 50 Capsule if you are pregnant or planning for pregnancy unless prescribed by the doctor.
  • Breastfeeding mothers should consult the doctor before using Zonisep 50 Capsule .
  • Zonisep 50 Capsule should not be given to children unless prescribed.
  • Inform your doctor before taking Zonisep 50 Capsule if you have or have had kidney and liver problems, glaucoma, high levels of ammonia, osteoporosis, depression, heart problems, or if you have low levels of bicarbonate in your blood, or if you have previously suffered from kidney stones.
  • Do not stop taking Zonisep 50 Capsule without consulting your doctor to avoid worsening of seizure episodes.
  • Zonisep 50 Capsule causes drowsiness and dizziness, so drive only if you are alert.
  • Avoid consuming alcohol along with Zonisep 50 Capsule as it could lead to increased dizziness and sleepiness.
  • Consult your doctor immediately if you experience mood swings or suicidal tendencies.
  • Zonisep 50 Capsule can cause permanent vision loss. If you experience any eye pain, redness, or vision changes, inform your doctor immediately.

Drug-Drug Interactions

verifiedApollotooltip
ZonisamideCariprazine
Severe
ZonisamideClemastine
Severe

Drug-Drug Interactions

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ZonisamideCariprazine
Severe
How does the drug interact with Zonisep 50 Capsule:
Coadministration of Cariprazine with Zonisep 50 Capsule can increase the risk or severity of Zonisep 50 Capsule side effects like increased body temperature and decreased sweating.

How to manage the interaction:
Taking Cariprazine with Zonisep 50 Capsule together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience changes in blood pressure, increased heart rate, fever, or excessive sweating, contact a doctor immediately. Make sure to hydrate yourself during warm weather or after exercise. Do not discontinue any medications without consulting a doctor.
ZonisamideClemastine
Severe
How does the drug interact with Zonisep 50 Capsule:
Coadministration of Clemastine with Zonisep 50 Capsule can increase the risk or severity of Zonisep 50 Capsule side effects like increased body temperature and decreased sweating especially in warm weather.

How to manage the interaction:
Taking Clemastine with Zonisep 50 Capsule together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience changes in blood pressure, increased heart rate, fever, or excessive sweating, contact a doctor immediately. Make sure to hydrate yourself during warm weather or after exercise. Do not discontinue any medications without consulting a doctor.
ZonisamideCyclobenzaprine
Severe
How does the drug interact with Zonisep 50 Capsule:
Coadministration of Zonisep 50 Capsule with Cyclobenzaprine can cause increased body temperature and decrease sweating.

How to manage the interaction:
Taking Cyclobenzaprine with Zonisep 50 Capsule together is generally avoided as it can result in an interaction, it can be taken only if your doctor has advised it. However, if you experience changes in fever, shortness of breath, or excessive sweating, contact a doctor immediately. Make sure to hydrate yourself during warm weather or after exercise. Do not discontinue any medications without consulting a doctor.
ZonisamideTripelennamine
Severe
How does the drug interact with Zonisep 50 Capsule:
Coadministration of Zonisep 50 Capsule with Tripelennamine can cause increased body temperature and decreased sweating.

How to manage the interaction:
Although there is a possible interaction between Tripelennamine and Zonisep 50 Capsule, you can take these medicines together if prescribed by your doctor. If you're having any of these symptoms like feeling too hot, feeling sleepy, or dizzy, your doctor can help you find other options for your treatment that won't cause these problems. Make sure to call a doctor right away if you experience any of these symptoms. Do not discontinue any medications without consulting a doctor.
ZonisamideDiphenhydramine
Severe
How does the drug interact with Zonisep 50 Capsule:
Coadministration of Zonisep 50 Capsule with Diphenhydramine can induce elevated body temperature and decreased sweating.

How to manage the interaction:
Although taking Diphenhydramine with Zonisep 50 Capsule can result in an interaction, they can be taken together if prescribed by your doctor. It is essential to stay hydrated by drinking enough fluids, especially in hot weather and when doing physical activity. Contact a doctor immediately if you notice decreased sweating, fever, dizziness, drowsy, or lightheadedness. Do not discontinue using any medications without consulting a doctor.
ZonisamidePropantheline
Severe
How does the drug interact with Zonisep 50 Capsule:
Coadministration of Propantheline with Zonisep 50 Capsule can increase the risk or severity of Zonisep 50 Capsule side effects like increased body temperature and decreased sweating especially in warm weather.

How to manage the interaction:
Taking Propantheline with Zonisep 50 Capsule together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience changes in blood pressure, increased heart rate, fever, or excessive sweating, contact a doctor immediately. Make sure to hydrate yourself during warm weather or after exercise. Do not discontinue any medications without consulting a doctor.
ZonisamideClomipramine
Severe
How does the drug interact with Zonisep 50 Capsule:
Co-administration of Clomipramine with Zonisep 50 Capsule can increase the risk or severity of Zonisep 50 Capsule

How to manage the interaction:
Taking Clomipramine with Zonisep 50 Capsule together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience increased heart rate, fever, or excessive sweating, contact a doctor immediately. Make sure to hydrate yourself during warm weather or after exercise. Do not discontinue any medications without consulting a doctor.
ZonisamideQuetiapine
Severe
How does the drug interact with Zonisep 50 Capsule:
Coadministration of Quetiapine with Zonisep 50 Capsule can increase the risk or severity of Zonisep 50 Capsule side effects like increased body temperature and decreased sweating especially in warm weather.

How to manage the interaction:
Taking Quetiapine with Zonisep 50 Capsule together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience changes in blood pressure, increased heart rate, fever, or excessive sweating, contact a doctor immediately. Make sure to hydrate yourself during warm weather or after exercise. Do not discontinue any medications without consulting a doctor.
ZonisamideRisperidone
Severe
How does the drug interact with Zonisep 50 Capsule:
Coadministration of Risperidone with Zonisep 50 Capsule can increase the risk of Zonisep 50 Capsule side effects.

How to manage the interaction:
Taking Risperidone with Zonisep 50 Capsule together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience changes in blood pressure, increased heart rate, fever, or excessive sweating, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ZonisamideOlanzapine
Severe
How does the drug interact with Zonisep 50 Capsule:
Coadministration of Olanzapine with Zonisep 50 Capsule can increase the risk or severity of Zonisep 50 Capsule side effects like increased body temperature and decreased sweating especially in warm weather.

How to manage the interaction:
Taking Olanzapine with Zonisep 50 Capsule together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience changes in blood pressure, increased heart rate, fever, or excessive sweating, contact a doctor immediately. Make sure to hydrate yourself during warm weather or after exercise. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps in utilising fat instead of glucose for the generation of energy.
  • Atkins diet (high fat and controlled carbohydrates) is recommended for adolescents and adults.
  • Rest well, get plenty of sleep.
  • Avoid smoking and alcohol consumption.
  • Exercise, meditation, and yoga can help lower stress, decrease pain sensitivity, and improve coping skills.
  • Prepare your living area; small changes may reduce the risk of physical injury during a seizure.
  • Install an alarm or emergency device to get assistance during a seizure attack.

Habit Forming

No

Therapeutic Class

ANTICONVULSANT

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Zonisep 50 Capsule as it may increase dizziness and sleepiness.

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Pregnancy

Caution

Avoid taking Zonisep 50 Capsule if you are pregnant unless prescribed by a doctor to lead to serious birth defects/congenital disabilities. Please consult your doctor if you have any concerns regarding this. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Zonisep 50 Capsule should not be taken by breastfeeding mothers as it passes into breast milk and could lead to side-effects for breastfed babies.

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Driving

Unsafe

Zonisep 50 Capsule causes drowsiness, sleepiness, and tiredness. Do not drive or operate machinery unless you are alert.

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Liver

Consult your doctor

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Consult your doctor

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks.

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Children

Safe if prescribed

Zonisep 50 Capsule can be given to children above 6 years if prescribed by the doctor. The dose will be adjusted by the doctor depending upon the child's body weight.

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Heart

Consult your doctor

Please inform your doctor if you have any pre-existing heart problems

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Geriatrics

Consult your doctor

Limited information available for use of Zonisep 50 Capsule in elderly patients. Please consult your doctor.

FAQs

Zonisep 50 Capsule belongs to a group of medicines called anti-convulsants or anti-epileptics used to treat epilepsy (seizures/fits).

Zonisep 50 Capsule consists of zonisamide, which decreases the brain's excessive and abnormal nerve activity by blocking sodium and calcium currents in your brain and body. This reduces abnormal electrical activity between your nerve cells.

Consult your doctor before taking Zonisep 50 Capsule if you are pregnant or planning a pregnancy. Your doctor will prescribe Zonisep 50 Capsule only if the benefits outweigh the risks. If you are planning for pregnancy, use contraception while taking Zonisep 50 Capsule .

Zonisep 50 Capsule should be used with caution during hot weather, as it may increase the chance of having a heat stroke. Inform your doctor if you have heat intolerance or fever. To avoid this condition, it is advisable to drink a lot of cold fluid and water and move to a cooler place, especially in summer.

No, Zonisep 50 Capsule is not a habit-forming drug. However, it can cause side effects, especially when you stop taking it suddenly.

Country of origin

India

Manufacturer/Marketer address

90, Delhi - Jaipur Road, Sector 32, Gurugram, Haryana 122001
Other Info - ZON0004

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Dec 3, 2025 | 7:35 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.medicines.org.uk/emc/files/pil.72.pdf
  2. https://www.drugs.com/mtm/zonisamide.html
  3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/020789s034lbl.pdf

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