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Zoryl MP 2 Forte Tablet is used to treat type 2 diabetes. It works by reducing sugar production in the liver, delaying sugar absorption from the intestines, and removing sugar from the blood. In some cases, this medicine may cause side effects such as stomach pain, nausea, diarrhoea, vomiting, headache, metallic taste, or low blood sugar. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

GLIMEPIRIDE-2MG+METFORMIN-1000MG+PIOGLITAZONE-15MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Zoryl MP 2 Forte Tablet

Zoryl MP 2 Forte Tablet is a prescription medication used to manage and control high blood sugar levels in adults with type 2 diabetes. It is typically prescribed when a single or double treatment medicine is no longer sufficient to keep blood sugar within a target range. By keeping blood sugar levels controlled, this medication helps prevent serious, long-term complications associated with diabetes.

For the best results, you must take Zoryl MP 2 Forte Tablet regularly and consistently exactly as prescribed by your doctor. It is highly recommended to take this tablet with food, specifically with your first main meal of the day, to reduce the chances of a stomach upset. Alongside taking this medication, adopting healthy lifestyle habits such as eating a balanced, low-sugar diet and engaging in regular physical activity is essential to achieve optimal blood sugar control.

While taking Zoryl MP 2 Forte Tablet , some people may experience mild side effects like nausea, a metallic taste in the mouth, or low blood sugar. However, if you experience sudden swelling in your legs, shortness of breath, severe stomach pain, or yellowing of your skin or eyes, you must stop taking the medication and consult your doctor immediately.

Do not take this if you have severe kidney disease, active liver damage, or severe heart failure. Before starting Zoryl MP 2 Forte Tablet , it is crucial to tell your doctor if you have a history of bladder cancer, fluid retention, or heart conditions.

This medicine can interact with alcohol, which significantly increases your risk of dangerously low blood sugar and a rare but serious condition called lactic acidosis. If you are pregnant, planning to become pregnant, breastfeeding, or are an elderly individual, you must talk to your doctor or pharmacist before using this medicine, as alternative treatments may be safer.

Uses of Zoryl MP 2 Forte Tablet

It is mainly used to manage and control high blood sugar levels in adults with type 2 diabetes.

  • Type 2 Diabetes Mellitus: Zoryl MP 2 Forte Tablet helps lower blood glucose levels in adults whose high blood sugar is not adequately controlled by diet, exercise, or other single-agent medications.

Key Benefits

Taking Zoryl MP 2 Forte Tablet consistently provides several vital health benefits that help you manage your daily life with confidence:

  • Effective Blood Sugar Control: By targeting multiple pathways in the body, it helps keep your daily blood glucose readings within a stable, healthy range.
  • Prevention of Diabetes Complications: Maintaining steady blood sugar levels reduces the long-term risk of kidney damage, nerve pain, blindness, and cardiovascular problems like heart attacks or strokes.
  • No Need for Multiple Separate Pills: Since it combines three highly effective blood-sugar-lowering agents into a single convenient tablet, it simplifies your daily medication routine.
Side effects of Zoryl Mp 2mg Forte Tab
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
Here are the steps to manage Gastrointestinal Air and Swelling (GAS) caused by medication:
  • Tell your doctor about your GAS symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
  • To manage GAS symptoms, eat a balanced diet of fibre, vegetables, and fruits.
  • Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
  • Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
  • Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
  • Take medication for GAS symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
  • If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.
  • Regularly brush and floss your teeth.
  • Rinse your mouth with water and baking soda a solution to neutralize acid in the mouth. This makes your food taste as it should.
  • Drink plenty of water or non-caffeinated drinks to prevent dry mouth which may lead to altered taste.
  • Try ginger, peppermint, fruit or green teas, lemonade, ginger ale or fruit juice to help mask unpleasant tastes.
  • Try sucking on sugar-free ice pops or ice cubes to prevent dry mouth.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.

Directions for Use

  • Zoryl MP 2 Forte Tablet can be taken with food to avoid stomach upset or as advised by the doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Zoryl MP 2 Forte Tablet as a whole with a glass of water.
  • Do not chew, crush or break it.

How Zoryl MP 2 Forte Tablet Works

Zoryl MP 2 Forte Tablet is a combination of three active ingredients that work together in different ways to control your blood sugar levels efficiently. Glimepiride works by encouraging your pancreas to release more insulin, which is the natural hormone your body uses to clear sugar from your bloodstream. Metformin focuses on reducing the amount of glucose (sugar) that your liver produces and releases into your body. It also delays the absorption of sugar from your intestines and helps your muscles use the available insulin more effectively. Pioglitazone works primarily by making your body's cells much more sensitive to insulin. This allows your muscles and fat tissues to easily take up and utilise glucose from your blood, keeping your sugar levels stable.
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Alcohol

Unsafe

You are recommended to avoid consumption of alcohol with Zoryl MP 2 Forte Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

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Pregnancy

Unsafe

Zoryl MP 2 Forte Tablet is not recommended for pregnant women as it may harm an unborn baby. Please consult a doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Zoryl MP 2 Forte Tablet as it may be excreted in breastmilk and cause adverse effects in the baby. Therefore, please consult a doctor before using Zoryl MP 2 Forte Tablet if you are breastfeeding.

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Driving

Caution

Zoryl MP 2 Forte Tablet may decrease alertness in some people. Therefore, drive only if you are alert after taking Zoryl MP 2 Forte Tablet .

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Liver

Caution

Take Zoryl MP 2 Forte Tablet with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Zoryl MP 2 Forte Tablet with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Unsafe

Zoryl MP 2 Forte Tablet is not recommended for children as the safety and effectiveness were not established.

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Heart

Caution

Zoryl MP 2 Forte Tablet should be used with caution in patients with heart problems. Inform your doctor about any heart-related conditions before taking Zoryl MP 2 Forte Tablet .

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Geriatrics

Caution

Zoryl MP 2 Forte Tablet should be given with caution in elderly patients due to an increased risk of side effects. Seek medical advice before using Zoryl MP 2 Forte Tablet .

What if I have taken an overdose of Zoryl MP 2 Forte Tablet

In case of an accidental overdose, seek immediate medical attention. An overdose can cause extremely low blood sugar (which may lead to confusion, fainting, or seizures) or a dangerous acid buildup in your blood. If you are conscious and suspect low blood sugar, consume a fast-acting sugar source like fruit juice or candy while waiting for medical help.

Diet & Lifestyle Advise

  • Monitor your carbohydrates: Focus on complex carbohydrates with a low glycemic index, such as whole grains, oats, vegetables, and legumes, to prevent sudden spikes in blood sugar.
  • Stay physically active: Aim for at least 150 minutes of moderate-intensity exercise, such as brisk walking or swimming, each week. Physical activity helps your body use insulin more efficiently.
  • Keep a sugar source nearby: Because this medicine can cause low blood sugar, always carry fast-acting sweets, glucose tablets, or fruit juice with you to treat sudden symptoms of hypoglycemia.
  • Check your feet daily: Diabetes can affect blood circulation and nerve sensitivity. Inspect your feet daily for any cuts, sores, or blisters, and report any non-healing wounds to your doctor.
  • Stay hydrated: Drink plenty of water throughout the day to support your kidney function and help your body flush out excess glucose.
health query

Have a query?

How Soon It Starts Working

The time required for Zoryl MP 2 Forte Tablet to start to work: Zoryl MP 2 Forte Tablet ideally shows its action within a few hours after administration.

The time for which the effects of Zoryl MP 2 Forte Tablet last: The duration of action for Zoryl MP 2 Forte Tablet is clinically unknown.

What if you forget to take Zoryl MP 2 Forte Tablet

If you miss a dose of Zoryl MP 2 Forte Tablet , take it as soon as you remember with food. However, if it is almost time for your next scheduled dose, skip the missed dose entirely and resume your regular dosing schedule. Do not take a double dose to make up for a missed one, as this can cause your blood sugar to drop dangerously low.

Storage

• Proper storage ensures your medication remains effective and safe to use. •Keep Zoryl MP 2 Forte Tablet stored in its original packaging at room temperature, ideally below 30°C (86°F).

Drug Warnings

  • Monitor blood sugar: Check your blood sugar regularly as directed by your healthcare provider to ensure the medication is working safely.
  • Watch for swelling: Watch for sudden weight gain or swelling in your lower legs or ankles, which can indicate fluid buildup, and notify your doctor immediately.
  • Avoid alcohol: Limit or avoid alcohol consumption while taking this medication, as alcohol increases the risk of severe low blood sugar and dangerous acid buildup in the body.
  • Inform healthcare provider: Inform any doctor, dentist, or surgeon that you are taking Zoryl MP 2 Forte Tablet before undergoing any medical procedures or receiving contrast dye for imaging scans.
  • Be aware: Stress, illness, injury, or surgery can affect your blood sugar levels, and your doctor may need to temporarily adjust your treatment plan during these times.

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines, as they may interact.

  • Blood pressure medicines (such as beta-blockers or ACE inhibitors): They may hide the warning signs of low blood sugar, like a racing heart, or increase the risk of hypoglycemia.
  • Water pills (diuretics) and corticosteroids: It May raise your blood sugar levels, making Zoryl MP 2 Forte Tablet less effective.
  • Certain pain relievers (like NSAIDs): They can increase the risk of kidney strain when taken alongside this medication.
Metformin + Pioglitazone + GlimepirideMetrizamide
Critical
Metformin + Pioglitazone + GlimepirideGatifloxacin
Critical

Drug-Drug Interactions

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Metformin + Pioglitazone + GlimepirideMetrizamide
Critical
How does the drug interact with Zoryl Mp 2mg Forte Tab:
Co-administration of Metformin and Metrizamide together can cause the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Metformin with Metrizamide is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience headaches, nausea, vomiting, diarrhea, muscle cramps or pain, body weakness, extreme fatigue, and visual disturbances, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Metformin + Pioglitazone + GlimepirideGatifloxacin
Critical
How does the drug interact with Zoryl Mp 2mg Forte Tab:
Taking Glimepiride with Gatifloxacin may cause both low blood glucose and, less frequently, high blood glucose.

How to manage the interaction:
Gatifloxacin is not recommended for patients with diabetes, however, it can be taken if advised by a doctor. Consult the prescriber if you experience symptoms such as nervousness, confusion, headache, dizziness, drowsiness, tremors, nausea, hunger, weakness, perspiration, palpitation, rapid heartbeat, increased urination, increased thirst, and increased hunger. Do not discontinue the medications without consulting a doctor.
Metformin + Pioglitazone + GlimepirideIomeprol
Critical
How does the drug interact with Zoryl Mp 2mg Forte Tab:
Co-administration of Iomeprol with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Metformin with Iomeprol is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Metformin + Pioglitazone + GlimepirideIodixanol
Critical
How does the drug interact with Zoryl Mp 2mg Forte Tab:
Co-administration of Iodixanol with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Metformin with Iodixanol is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Metformin + Pioglitazone + GlimepirideIodamide
Critical
How does the drug interact with Zoryl Mp 2mg Forte Tab:
Co-administration of Metformin and Iodamide can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Metformin with Iodamide is generally avoided as it can result in an interaction, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Metformin + Pioglitazone + GlimepirideIopamidol
Critical
How does the drug interact with Zoryl Mp 2mg Forte Tab:
Co-administration of Iopamidol with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Metformin with Iopamidol is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Metformin + Pioglitazone + GlimepirideIopromide
Critical
How does the drug interact with Zoryl Mp 2mg Forte Tab:
Co-administration of Iopromide with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Iopromide with Metformin is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Metformin + Pioglitazone + GlimepirideLevofloxacin
Severe
How does the drug interact with Zoryl Mp 2mg Forte Tab:
Co-administration of Glimepiride with Levofloxacin can cause both hyperglycemia (high blood glucose) and, less frequently, hypoglycemia (low blood glucose).

How to manage the interaction:
Co-administration of Levofloxacin with Glimepiride can result in an interaction, it can be taken if a doctor has advised it. Consult the prescriber if you experience dizziness, drowsiness, headache, nervousness, confusion, tremors, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat, increased urination, increased thirst, or increased hunger. Monitoring of blood glucose levels is advised. Do not discontinue the medications without consulting a doctor.
Metformin + Pioglitazone + GlimepirideTeriflunomide
Severe
How does the drug interact with Zoryl Mp 2mg Forte Tab:
Co-administration of Teriflunomide and Pioglitazone may increase the risk of liver damage.

How to manage the interaction:
Although taking Pioglitazone and Teriflunomide together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, nausea, vomiting, dark urine, light stools, and skin or eye yellowing, decreased hunger, consult the doctor. Do not stop using any medications without talking to the doctor.
Metformin + Pioglitazone + GlimepirideClopidogrel
Severe
How does the drug interact with Zoryl Mp 2mg Forte Tab:
Taking Pioglitazone with Clopidogrel can increases the blood levels of Pioglitazone, this may lead to hypoglycemia (low blood sugar).

How to manage the interaction:
Taking Clopidogrel together with Pioglitazone may lead to interaction, but it can be taken if prescribed by a doctor. Consult a doctor immediately if you experience any symptoms like headache, dizziness, drowsiness, nervousness, weakness, shakings, nausea, hunger, sweating, and palpitation. Do not discontinue any medication without consulting the doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Dramatically increases the risk of low blood sugar and can trigger a dangerous buildup of lactic acid in the blood.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIDIABETICS]

FAQs

Zoryl MP 2 Forte Tablet is used in the treatment of type 2 diabetes, especially in patients whose blood sugar levels are not controlled by diet and exercise alone.
Zoryl MP 2 Forte Tablet contains Glimepiride, Metformin, and Pioglitazone. Glimepiride lowers blood sugar by causing the pancreas to produce insulin. Metformin reduces the production of sugar in the liver and delays sugar absorption from the intestines. Pioglitazone increases the body's sensitivity to insulin. Thereby, Zoryl MP 2 Forte Tablet helps to control blood sugar levels.
You are not recommended to take Zoryl MP 2 Forte Tablet with pregabalin as it may cause weight gain and fluid retention that could lead to heart failure. However, please consult a doctor before using Zoryl MP 2 Forte Tablet with other medicines.
In type 1 diabetes, the body does not produce insulin as the islet cells (insulin-producing cells) in the pancreas are completely destroyed. In type 2 diabetes, though islet cells are working, the body does not respond to insulin as the body becomes resistant to it.
You are not recommended to stop taking Zoryl MP 2 Forte Tablet on your own, as discontinuing Zoryl MP 2 Forte Tablet suddenly may cause recurring symptoms or worsen the condition. However, if you experience any difficulty while taking Zoryl MP 2 Forte Tablet , please consult your doctor so that alternative medicine may be prescribed.
Yes, Zoryl MP 2 Forte Tablet may cause stomach upset as a side effect. Drink water/fluids in small, frequent amounts and chew the food properly while eating.
Inform the doctor if you are taking any other medicines, have any other medical conditions, and if you are pregnant or breastfeeding.
Yes, Zoryl MP 2 Forte Tablet may lead to vitamin B12 deficiency, particularly on long-term use. Consult the doctor if you experience symptoms of vitamin b12 deficiency such as headache, loss of appetite, fatigue, mental impairment, pins and needle sensation, and pale skin.
Store Zoryl MP 2 Forte Tablet at room temperature, in a dry place. Keep out of sight and reach of children.
Zoryl MP 2 Forte Tablet may cause side effects like stomach pain, nausea, diarrhoea, vomiting, headache, metallic taste, or low blood sugar. If the side effects persist or worsen, please consult your doctor.
No, you should avoid or highly limit alcohol while taking this medicine. Alcohol increases your risk of developing dangerously low blood sugar and a rare but severe condition called lactic acidosis. Talk to your doctor if you have questions about alcohol use.
Yes, some individuals may experience mild weight gain while taking this medication. This can be due to improved blood sugar control or fluid retention. If you notice sudden or rapid weight gain, talk to your doctor.
If you experience symptoms of low blood sugar (shakiness, sweating, dizziness), eat or drink 15 grams of fast-acting sugar, such as half a cup of fruit juice, three to four glucose tablets, or hard candy. If symptoms persist after 15 minutes, repeat this step and talk to your doctor.
No, this medication is generally not recommended during pregnancy or breastfeeding as it may not be safe for the developing baby. If you are pregnant or planning to conceive, talk to your doctor to discuss safer alternatives for managing your blood sugar.
Taking this medicine with your main meal helps reduce common digestive side effects, such as nausea, stomach upset, or gas, and prevents your blood sugar from dropping too quickly after taking the pill. Talk to your doctor if stomach upset persists.
No, Zoryl MP 2 Forte Tablet does not cure diabetes. It helps manage and control your blood sugar levels to prevent long-term complications. You must continue taking it consistently as prescribed, along with maintaining a healthy diet and exercise routine. Talk to your doctor before making any changes.
While this medicine does not directly cause kidney damage, it is cleared from your body through your kidneys. If you already have severe kidney disease, this medicine can build up and cause serious side effects. Your doctor will monitor your kidney function regularly. Talk to your doctor if you have concerns about your kidney health.

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Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - ZOR0063
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