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  3. Zoryl MS IR 1/1000 Tablet 10's

Zoryl MS IR 1/1000 Tablet 10's, Pack of 10 TabletS
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Composition :

GLIMEPIRIDE-1MG + METFORMIN-1000MG + SITAGLIPTIN-50MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Zoryl MS IR 1/1000 Tablet

Zoryl MS IR 1/1000 Tablet is an antidiabetic medicine used to treat type II diabetes. Type II Diabetes Mellitus is a serious condition wherein the body doesn’t use insulin effectively, which causes unusual blood glucose levels.

Zoryl MS IR 1/1000 Tablet contains Metformin (biguanides), which works by reducing the sugar production by cells in the liver and delays sugar absorption from the intestine; Sitagliptin (dipeptidyl peptidase-4 inhibitor), which works by increasing the amounts of certain natural substances that lower blood sugar when it is high and Glimepiride (sulfonylureas) works by stimulating beta cells in the pancreas that produce insulin. Thus, insulin helps to remove sugar from the blood.

Zoryl MS IR 1/1000 Tablet may cause certain side effects, such as vomiting, nausea, abdominal pain, headache, frequent urination, and allergic reactions. If these side effects persist or worsen, please consult your doctor. Zoryl MS IR 1/1000 Tablet should be taken as prescribed by your doctor.

Zoryl MS IR 1/1000 Tablet should be avoided if you are allergic to any of the medicines or the components in it. Inform your doctor about the medical and complete medication history you are taking, including herbs and supplements, before starting the treatment with Zoryl MS IR 1/1000 Tablet . Let your doctor know if you are pregnant or breastfeeding before taking Zoryl MS IR 1/1000 Tablet .

Uses of Zoryl MS IR 1/1000 Tablet

Zoryl MS IR 1/1000 Tablet is used in the treatment of Type II Diabetes Mellitus. The detailed uses of Zoryl MS IR 1/1000 Tablet are as follows:<br/>• Type 2 diabetes management: Zoryl MS IR 1/1000 Tablet helps manage elevated blood sugar levels when lifestyle modifications and single-drug treatments do not provide sufficient control.<br/>• Glycemic balance support: Zoryl MS IR 1/1000 Tablet controls blood sugar levels throughout the day, including after meals and during fasting periods.<br/>• Enhanced insulin function: Zoryl MS IR 1/1000 Tablet improves the body's ability to use insulin effectively by increasing insulin sensitivity and encouraging the pancreas to release insulin as needed.<br/>• Reduced liver glucose output: Zoryl MS IR 1/1000 Tablet helps decrease the amount of glucose produced by the liver, which is particularly useful for lowering blood sugar levels during early morning hours.<br/>• Prevention of complications: By maintaining stable blood sugar over time, Zoryl MS IR 1/1000 Tablet helps lower the risk of diabetes-related complications such as nerve damage, kidney issues, eye problems, and heart conditions.<br/>

Directions for Use

• Take Zoryl MS IR 1/1000 Tablet with food to reduce stomach upset or gastrointestinal side effects.• Recommended to take it once daily in the morning or as advised by your doctor.• Swallow the medicine as a whole with glass of water.• Do not crush, break, or chew it.

Medicinal Benefits

Zoryl MS IR 1/1000 Tablet  is a combination of three drugs: Sitagliptin, Metformin and Glimepiride. Zoryl MS IR 1/1000 Tablet belongs to the group of anti-diabetic medicines used to treat type-2 diabetes mellitus adjunct to diet and exercise. It removes excess sugar from the body via urine, increases the amounts of certain natural substances that lower blood sugar when it is high, reduces sugar production by cells in the liver and delays sugar absorption from the intestines. 

How Zoryl MS IR 1/1000 Tablet Works

Zoryl MS IR 1/1000 Tablet contains Metformin (biguanides), which works by reducing the sugar production by cells in the liver and delays sugar absorption from the intestine; Sitagliptin (dipeptidyl peptidase-4 inhibitor), which works by increasing the amounts of certain natural substances that lower blood sugar when it is high and Glimepiride (sulfonylureas) works by stimulating beta cells in the pancreas that produce insulin. Thus, insulin helps to remove sugar from the blood.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Zoryl MS IR 1/1000 Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Zoryl MS IR 1/1000 Tablet may include severe gastrointestinal problems, low blood sugar reactions, nausea, vomiting, lethargy, and abdominal pain. Seek immediate medical attention if you observe these symptoms or think you might have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

Zoryl MS IR 1/1000 Tablet should be avoided if you are allergic to any of the medicines or the components in it. Before starting the treatment, inform your doctor about your medical history and the medications you take, including herbs and supplements. This can help prevent unwanted effects. Zoryl MS IR 1/1000 Tablet is not recommended for use in patients with severe liver or kidney disease. It is unknown whether Zoryl MS IR 1/1000 Tablet can be given to pregnant women or breastfeeding mothers. Hence, inform your doctor if you are pregnant or breastfeeding. It is not recommended for use in children below 18 years of age. Avoid drinking alcohol while on Zoryl MS IR 1/1000 Tablet  as it increases the risk of hypoglycemia and lactic acidosis (when the lactic acid increases in the body, which impacts the functioning of various organs in the body).

Drug-Drug Interactions

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SitagliptinGatifloxacin
Critical
MetforminIodixanol
Critical

Drug-Drug Interactions

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SitagliptinGatifloxacin
Critical
How does the drug interact with Zoryl MS IR 1/1000 Tablet:
Co-administration of Zoryl MS IR 1/1000 Tablet with Gatifloxacin may sometimes affect blood glucose levels. Both high blood glucose and, less frequently, low blood glucose have been reported.

How to manage the interaction:
Taking Zoryl MS IR 1/1000 Tablet with Gatifloxacin is not recommended as it can lead to a possible interaction, However, it can be taken if advised by the doctor. Consult the prescriber if you experience symptoms such as nervousness, confusion, headache, dizziness, drowsiness, tremors, nausea, hunger, weakness, perspiration, palpitation, rapid heartbeat, increased urination, increased thirst, and increased hunger. Maintaining blood glucose levels is advised. Do not stop using any medications without a doctor's advice.
MetforminIodixanol
Critical
How does the drug interact with Zoryl MS IR 1/1000 Tablet:
Co-administration of Iodixanol with Zoryl MS IR 1/1000 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Zoryl MS IR 1/1000 Tablet with Iodixanol is not recommended, please consult a doctor before taking it. Do not discontinue the medications without consulting a doctor.
MetforminIobenzamic acid
Critical
How does the drug interact with Zoryl MS IR 1/1000 Tablet:
Co-administration of Zoryl MS IR 1/1000 Tablet and Iobenzamic acid can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Zoryl MS IR 1/1000 Tablet with Iobenzamic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIodamide
Critical
How does the drug interact with Zoryl MS IR 1/1000 Tablet:
Co-administration of Zoryl MS IR 1/1000 Tablet and Iodamide can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Zoryl MS IR 1/1000 Tablet with Iodamide is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIoglycamic acid
Critical
How does the drug interact with Zoryl MS IR 1/1000 Tablet:
Co-administration of Ioglycamic acid with Zoryl MS IR 1/1000 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Zoryl MS IR 1/1000 Tablet with Ioglycamic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIopamidol
Critical
How does the drug interact with Zoryl MS IR 1/1000 Tablet:
Co-administration of Iopamidol with Zoryl MS IR 1/1000 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Zoryl MS IR 1/1000 Tablet with Iopamidol is not recommended, please consult a doctor before taking it. Do not discontinue the medications without consulting a doctor.
MetforminMetrizamide
Critical
How does the drug interact with Zoryl MS IR 1/1000 Tablet:
Co-administration of Zoryl MS IR 1/1000 Tablet with Metrizamide together can cause the risk of lactic acidosis (when the body produces too much lactic acid ).

How to manage the interaction:
Taking Zoryl MS IR 1/1000 Tablet with Metrizamide is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. However, if you experience headaches, muscle cramps or pain, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MetforminIoxitalamic acid
Critical
How does the drug interact with Zoryl MS IR 1/1000 Tablet:
Co-administration of Zoryl MS IR 1/1000 Tablet and Ioxitalamic acid can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Zoryl MS IR 1/1000 Tablet with Ioxitalamic acid is not recommended, please consult your doctor before taking it.
MetforminIotroxic acid
Critical
How does the drug interact with Zoryl MS IR 1/1000 Tablet:
Co-administration of Iotroxic acid with Zoryl MS IR 1/1000 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Zoryl MS IR 1/1000 Tablet with Iotroxic acid is not recommended, please consult your doctor before taking it.
MetforminIocarmic acid
Critical
How does the drug interact with Zoryl MS IR 1/1000 Tablet:
Co-administration of Zoryl MS IR 1/1000 Tablet and Iocarmic acid can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Zoryl MS IR 1/1000 Tablet with Iocarmic acid is generally avoided as it can result in an interaction. please consult your doctor before taking it.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

ANTIDIABETICS

Zoryl MS IR 1/1000 Tablet Substitute

Substitutes safety advice

Product Substitutes

bannner image

Alcohol

Unsafe

Alcohol increases the impact of metformin on lactate metabolism. Hence, you should not consume excessive amounts of alcohol, either temporarily or permanently, while taking Zoryl MS IR 1/1000 Tablet .

bannner image

Pregnancy

Caution

There are no adequate studies on the effect of Zoryl MS IR 1/1000 Tablet in pregnancy. If you are pregnant or planning pregnancy, inform your doctor before taking Zoryl MS IR 1/1000 Tablet .

bannner image

Breast Feeding

Caution

Zoryl MS IR 1/1000 Tablet is generally not recommended in breastfeeding. Hence, if you are breastfeeding, inform your doctor before using Zoryl MS IR 1/1000 Tablet .

bannner image

Driving

Safe

Zoryl MS IR 1/1000 Tablet usually does not affect your ability to drive or operate machinery.

bannner image

Liver

Caution

Zoryl MS IR 1/1000 Tablet may cause lactic acidosis due to metformin accumulation. The risk increases with hepatic insufficiency. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

bannner image

Kidney

Caution

Renal impairment also increases the risk of lactic acidosis. Hence, Zoryl MS IR 1/1000 Tablet should be used cautiously if you have kidney problems. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

bannner image

Children

Unsafe

Zoryl MS IR 1/1000 Tablet is not recommended for children below 18 years as the safety and effectiveness were not established.

Have a query?

FAQs

Zoryl MS IR 1/1000 Tablet is an antidiabetic medicine used to treat type II diabetes.

Zoryl MS IR 1/1000 Tablet is a combination medicine containing Sitagliptin that enhances glucose-mediated insulin secretion, thereby reducing fasting and post-prandial blood sugar concentrations. Metformin helps reduce the sugar production by cells in the liver and delays sugar absorption from the intestines. Glimepiride works by stimulating beta cells in the pancreas that produce insulin.

If you forget to take Zoryl MS IR 1/1000 Tablet , take it as soon as you remember. However, if it&#039;s time for the next dose, avoid taking it and do not double dose to make up the missed dose. Taking an overdose might cause your sugar level to fall down rapidly.

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - ZOR0214

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 7:07 AM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022044s022lbl.pdf
  2. https://medlineplus.gov/druginfo/meds/a606023.html
  3. https://www.drugs.com/metformin.html
  4. https://www.nhs.uk/medicines/sitagliptin/about-sitagliptin/#:~:text=Sitagliptin%20is%20prescribed%20for%20people,is%20only%20available%20on%20prescription.

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