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compositionComposition:METFORMIN-500MG+REPAGLINIDE-2MG
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Prescription Medicine
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Zrepag-2 MF Tablet is used to treat type 2 diabetes by helping control blood sugar levels. It supports better insulin release and helps the body use insulin more effectively. It also helps reduce excess sugar production and absorption. This helps regulate blood sugar and promotes overall wellness.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

METFORMIN-500MG+REPAGLINIDE-2MG

Manufacturer/Marketer :

Daylon healthcare pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Zrepag-2 MF Tablet

Zrepag-2 MF Tablet is a prescription oral medicine used to help control blood glucose levels in adults with type 2 diabetes. It helps improve blood sugar control, including postprandial blood sugar (blood sugar after meals), when diet, exercise, or a single diabetes medicine alone does not provide adequate results. By improving insulin action and reducing high blood sugar levels, this combination can help lower the risk of long-term diabetes-related complications when used as part of a comprehensive diabetes management plan.

Common Brand Names in India: This combination may be available under brand names such as Reclimate M, Eurepa M, and other equivalent products. Brand availability may vary by location and manufacturer. If you are unsure whether your prescribed brand contains repaglinide and metformin, consult your doctor or pharmacist.

To get the best results, you must take Zrepag-2 MF Tablet consistently and exactly as prescribed, usually two to four times every day. It should be taken shortly before your main meals to help control postprandial blood sugar spikes. For optimal blood glucose control, continue following a balanced diabetes-friendly diet, regular physical activity routine, and your recommended HbA1c monitoring schedule.

While taking Zrepag-2 MF Tablet , you may experience common side effects such as mild stomach discomfort, nausea, or occasional episodes of low blood sugar. However, seek medical attention immediately if you notice symptoms of lactic acidosis, severe dizziness, or yellowing of the eyes or skin.

Before starting treatment, tell your doctor if you have kidney disease, liver impairment, heart problems, or other significant medical conditions. Do not take this medicine if you have severe kidney damage, type 1 diabetes, or diabetic ketoacidosis.

This medicine can interact with alcohol and certain other medications, potentially increasing the risk of low blood sugar or lactic acidosis. If you are pregnant, planning a pregnancy, breastfeeding, or elderly, consult your healthcare provider before starting treatment.

Uses of Zrepag-2 MF Tablet

Zrepag-2 MF Tablet is used in the treatment of type 2 diabetes mellitus. The detailed uses of Zrepag-2 MF Tablet are as follows:

  • Type 2 Diabetes Management: Helps improve blood glucose control in adults when diet, exercise, or a single diabetes medicine alone does not provide adequate results.
     

Key Benefits

  • Fast-acting mealtime protection: It starts working quickly after you take it, preventing sudden, sharp rises in blood sugar that typically happen right after you eat.
  • Long-term health protection: By keeping your daily blood sugar levels stable, this medicine helps reduce your risk of serious long-term complications, such as kidney damage, nerve pain, and vision loss.
  • Dual-action control: Because it contains two different active medicines, it works in two distinct ways to provide better and more consistent blood sugar control than either medicine could provide alone.
Side effects of Zrepag-2 MF Tablet
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
  • Try eating smaller meals (4-5 times) instead of large ones to make it easier on your stomach.
  • Avoid foods that are spicy, fatty, or high in insoluble fibre.
  • Consuming soluble fibre (such as psyllium) can help with constipation, and probiotics may reduce bloating and discomfort.
  • Stay away from carbonated drinks, alcohol, caffeine, and smoking, as they can upset your stomach.
  • Reducing stress, losing weight, and exercising regularly for 20-30 minutes can help improve digestion and reduce stomach issues.
  • Poor sleep can worsen stomach problems, so focus on good sleep habits or use tools like Sleepio to improve your sleep.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • If you experience low blood sugar levels, inform your doctor. They will assess the severity and make recommendations for the next actions.
  • Your doctor will assess your symptoms, blood sugar levels, and overall health before recommending the best course of action, which may include treatment, lifestyle modifications, or prescription adjustments.
  • Follow your doctor's instructions carefully to manage the episode and adjust your treatment plan.
  • Make medication adjustments as recommended by your doctor to prevent future episodes.
  • Implement diet and lifestyle modifications as your doctor advises to manage low blood sugar levels.
  • Monitor your blood sugar levels closely for patterns and changes.
  • Track your progress by recording your blood sugar levels, food intake, and physical activity.
  • Seek further guidance from your doctor if symptoms persist or worsen so that your treatment plan can be revised.
  • Eat heart-healthy diet rich in fruits, vegetables, whole grains, and low in saturated fat and cholesterol to support cardiovascular well-being.
  • Prioritize consuming omega-3 fatty acid-rich foods, antioxidants, and fiber to promote overall health and reduce inflammation.
  • Engage in regular aerobic exercise, such as brisk walking, cycling, or swimming, as recommended by your doctor to improve cardiovascular health.
  • Maintain a healthy weight through regular exercise and a balanced diet to reduce the risk of cardiovascular disease.
  • Quit smoking completely to reduce cardiovascular risk and improve overall health.
  • Practice relaxation techniques like mindful breathing exercises, guided meditation, or gentle yoga practices to effectively manage stress and promote calmness.
  • Limit alcohol intake to moderate levels to minimize negative impacts on cardiovascular health.
  • Regularly monitor your blood pressure, cholesterol levels, and blood sugar (if diabetic) to stay informed about your health and make adjustments as needed.
  • Be aware of potential symptoms of myocardial ischemia, such as chest pain, shortness of breath, nausea, or fatigue, and seek immediate medical attention if you experience any of these symptoms.
  • Collaborate with your healthcare provider to create a personalized treatment strategy that addresses your unique needs and health goals.
  • Chest pain may last for a while and needs immediate medical attention as it is a significant health issue to be attended to.
  • Take rest and refrain from doing physical activity for a while, and restart after a few days.
  • Try applying an ice pack to the strained area for at least 20 minutes thrice a day. Ice pack thus helps reduce inflammation.
  • Sit upright and maintain proper posture if there is persistent chest pain. Use extra pillows to elevate your position and prop your chest up while sleeping.

Directions for Use

  • Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet, as this can affect how the medicine is absorbed in your body.
  • Take this medicine within 15 to 30 minutes before you start a main meal.
  • If you skip a main meal, skip your dose of Zrepag-2 MF Tablet for that meal to prevent your blood sugar from dropping too low.
  • Always follow your doctor's exact instructions regarding how often and when to take your medication.

How Zrepag-2 MF Tablet Works

Zrepag-2 MF Tablet contains two active ingredients that work in different ways to help control blood sugar levels: • Repaglinide: This ingredient stimulates the pancreas to release more insulin shortly after meals. This helps control postprandial blood sugar levels and reduces sudden rises in blood glucose after eating. • Metformin: This ingredient works in several ways to improve blood glucose control. It reduces the amount of sugar produced by the liver, decreases the absorption of sugar from the intestines, and helps reduce insulin resistance, allowing the body's cells to respond more effectively to insulin. Together, these medicines help control blood sugar levels during fasting periods and after meals, supporting overall type 2 diabetes management.
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Alcohol

Unsafe

You are recommended not to consume alcohol along with Zrepag-2 MF Tablet to avoid unpleasant side effects.

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Pregnancy

Caution

Please consult your doctor before taking Zrepag-2 MF Tablet in case you are pregnant.

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Breast Feeding

Caution

Caution should be exercised, and it is advisable to consult a doctor before using Zrepag-2 MF Tablet .

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Driving

Caution

Zrepag-2 MF Tablet may cause hypoglycemia (low blood sugar levels), whose symptoms include unusual sleepiness, shivering, palpitations, sweating, etc. This may affect your ability to drive. Use caution while driving or doing anything that requires concentration.

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Liver

Caution

Zrepag-2 MF Tablet to be taken with caution, especially if you have a history of liver diseases. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Zrepag-2 MF Tablet to be taken with caution, especially if you have a history of Kidney diseases. The dose may have to be adjusted by your doctor.

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Children

Unsafe

Zrepag-2 MF Tablet is not recommended in children, as the safety and efficacy have not been established.

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Heart

Consult your doctor

Please inform your doctor if you have any pre-existing heart problems

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Geriatrics

Safe if prescribed

Zrepag-2 MF Tablet can be safely given in elderly patients if recommended by the physician.

What if I have taken an overdose of Zrepag-2 MF Tablet

In case of an accidental overdose, seek immediate medical attention or contact your local emergency services. An overdose can cause severe low blood sugar or a life-threatening build-up of lactic acid in your blood.

Diet & Lifestyle Advise

  • Keep track of your daily carbohydrate intake and spread your meals evenly throughout the day to ensure stable blood sugar control.
  • Always match your medication timing to your eating schedule; do not take this medicine if you are not eating a full meal.
  • Engage in regular, moderate exercise like walking or cycling, but always carry a fast-acting sugar source (like glucose tablets or fruit juice) in case your blood sugar drops during physical activity.
  • Stay well-hydrated throughout the day, especially during hot weather or exercise, to help your kidneys safely clear the medicine.
  • Limit or completely avoid alcohol, as it can significantly increase your risk of severe low blood sugar and lactic acidosis.
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How Soon It Starts Working

  • The time required for Zrepag-2 MF Tablet to start to work: Zrepag-2 MF Tablet ideally shows its action within 15 to 60 minutes after administration.
  • The time for which the effects of Zrepag-2 MF Tablet last: The effect of Zrepag-2 MF Tablet lasts for 6 to 8 hours.

What if you forget to take Zrepag-2 MF Tablet

If you miss a dose, take it before your next main meal. If you have already finished your meal, skip the missed dose entirely and resume your regular schedule with your next meal. Do not take a double dose to make up for a missed one, as this can cause your blood sugar to drop to a dangerous level.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Check your blood glucose levels as recommended by your doctor, especially when changing your routine, diet, or medications.
  • Regular HbA1c monitoring helps assess your average blood sugar control over the previous 2 to 3 months and guides treatment decisions.
  • Your doctor may order kidney function tests, liver function tests, and other laboratory tests to ensure the medicine remains safe and effective for you.

Drug-Drug Interactions

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Drug-Drug Interactions:

  • Beta-blockers: May hide the warning signs of low blood sugar, such as a rapid heart rate or palpitations.
  • Contrast media (iodinated dyes): Can temporarily impair kidney function, increasing the risk of lactic acidosis. This medicine should be stopped before the procedure.
  • Corticosteroids, thyroid medicines, or diuretics (water pills): May raise your blood sugar levels, requiring a dose adjustment of your diabetes medication.
  • Gemfibrozil or rifampin: Can change how your body processes this medicine, leading to a much higher risk of low blood sugar or reduced effectiveness.

Drug-Food Interactions:

  • Alcohol: Increases the risk of severe low blood sugar (hypoglycemia) and the rare but serious risk of lactic acidosis.

Drug-Disease Interactions:

  • Severe kidney disease: This medicine must not be used if you have severe kidney impairment, as it significantly increases the risk of lactic acidosis.
  • Severe liver disease: May impair your body's ability to clear the medicine, increasing the risk of lactic acidosis and low blood sugar.
  • Diabetic ketoacidosis: This medicine is not suitable for treating diabetic ketoacidosis or type 1 diabetes.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIDIABETICS]

FAQs

Zrepag-2 MF Tablet is used to treat type 2 diabetes. It works by increasing insulin secretion from the pancreas, lowering hepatic glucose production, delaying intestinal glucose absorption, and enhancing the body's response to insulin.
A common side effect of Zrepag-2 MF Tablet is hypoglycaemia (low blood glucose levels), characterised by dizziness, sweating, palpitations, hunger pangs, dry mouth, or skin. Hypoglycemia can occur if you miss or delay your food, drink alcohol, over-exercise, or take other antidiabetic medicine along with this medicine. It is important to monitor blood sugar levels regularly. Additionally, avoid skipping meals and carry some form of sugar with you.
Consult the doctor if you experience unusual thirst or pass urine more than normal while taking Zrepag-2 MF Tablet , as it may be a sign that there is too much sugar in your blood, and treatment needs to be adjusted. It may also be due to dehydration, as Zrepag-2 MF Tablet can lead to fluid loss. Increase fluid intake; if you still feel thirsty, consult your physician.
Yes, long-term use of Zrepag-2 MF Tablet can cause vitamin B12 deficiency by interfering with its absorption in the stomach. The symptoms of vitamin B12 deficiency include fatigue, nerve problems, tingling and numbness in the hands and feet, weakness, urinary problems, altered mental status, and difficulty maintaining balance. These symptoms can be managed by taking Vitamin B12 supplements as advised by your doctor.
If you feel your blood sugar is dropping and you are feeling weak, immediately eat sugar candies or drink sugary beverages. It will help balance your blood sugar levels. So, it is advisable to keep sugar candies with you.
Zrepag-2 MF Tablet should be used with caution in patients with kidney disease. If you have kidney problems, your doctor may need to adjust the dose of Zrepag-2 MF Tablet based on the severity of your condition and regularly monitor your kidney function tests while taking this medicine. It is essential to inform your doctor if you have pre-existing kidney disorders before they prescribe it to you.
When taking Zrepag-2 MF Tablet , it's essential to follow certain precautions. Take the medication exactly as your doctor prescribes and inform them about all your medical conditions, especially kidney or liver disease. Regularly monitor your blood sugar levels and follow a healthy diet and exercise plan. Avoid excessive alcohol consumption and be cautious when driving or operating heavy machinery. Also, inform your doctor about all your medications, including supplements, and regularly check your kidney and liver function.
Don’t stop taking Zrepag-2 MF Tablet on your own, as it may increase your blood sugar levels. Generally, diabetic medications need to be taken long-term to manage sugar levels, as there is still no cure for diabetes. If you have concerns regarding your blood sugar levels, side effects, or the effectiveness of Zrepag-2 MF Tablet , please inform your physician. They will assess your issues and provide personalised guidance without causing adverse health complications.
Zrepag-2 MF Tablet should be used cautiously, especially in patients with pre-existing heart problems. Inform your doctor of any heart problems before they prescribe Zrepag-2 MF Tablet . Your doctor needs to assess your heart condition and will prescribe it only if the benefits outweigh the risks by making suitable adjustments in the dose and duration.
No, you should skip the dose if you skip a main meal. Taking Zrepag-2 MF Tablet without eating may increase the risk of low blood sugar (hypoglycemia). Resume your usual dosing schedule with your next meal and consult your doctor if your eating habits change frequently.
Lactic acidosis is a rare but very serious build-up of lactic acid in the blood, primarily linked to the metformin component in this medicine. It is more likely to occur if you have severe kidney or liver disease, dehydration, or consume excess alcohol. Talk to your doctor immediately if you experience unexplained muscle pain, trouble breathing, or severe fatigue.
It is highly recommended to limit or avoid alcohol. Alcohol can increase your risk of low blood sugar and the serious condition called lactic acidosis. Talk to your doctor about safe limits.
No, this medicine is generally not recommended during pregnancy or breastfeeding. Insulin is typically used instead to manage blood sugar during this time. Talk to your doctor to discuss safer alternatives.
Yes, Zrepag-2 MF Tablet may be used long term when prescribed and monitored by a healthcare professional. Regular follow-up visits, blood glucose checks, HbA1c monitoring, and kidney function tests are important to ensure the medicine remains safe and effective. Do not stop or change your treatment without consulting your doctor.
Yes, your doctor will order regular blood tests to monitor your kidney function, liver function, and HbA1c levels to ensure the medicine is working safely and effectively. Talk to your doctor about your scheduled lab appointments.
Yes, Zrepag-2 MF Tablet can help lower HbA1c levels when taken regularly as prescribed. By improving blood glucose control throughout the day, including postprandial blood sugar levels, this combination may help reduce your average blood sugar over time. Your doctor will monitor your HbA1c periodically to assess how well the treatment is working.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. National Health Service (NHS). Understanding Medication - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 022386S007Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. DailyMed DailyMed. [Accessed on 08 Apr. 2019]Check here
  4. Repaglinide for diabetes. [Accessed on 02 Jun. 2026]Check here
  5. Novo Nordisk A/S. Efficacy and Safety of Repaglinide and Metformin Combination Therapy in Type 2 Diabetes Failing on Oral Anti-diabetic Drugs. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in March 2016] [Accessed on 11th April 2022]Check here
  6. Torrent Pharmaceuticals Ltd. Eurepa MF (Repaglinide and Metformin Hydrochloride Tablets). [Revised in August 2016] [Accessed on 11th April 2022] Sheet/1718.pdfCheck here

Country of origin

India

Manufacturer/Marketer address

715, Gold Crest Business Center, L.T Road, Borivali-W, Mumbai 400092
Other Info - ZRE0005
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