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  1. Home
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  3. Zrepag-2 MF Tablet 10's

Prescription drug
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Zrepag-2 MF Tablet 10's, Pack of 10 TabletS
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Composition :

METFORMIN-500MG + REPAGLINIDE-2MG

Manufacturer/Marketer :

Daylon healthcare pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Zrepag-2 MF Tablet

Zrepag-2 MF Tablet is used to treat type 2 diabetes. Type 2 diabetes is a chronic or lifelong condition affecting how your body processes glucose. People with type 2 diabetes either do not produce enough insulin, or if the insulin is produced, it cannot perform its function in the body (insulin resistance).

Zrepag-2 MF Tablet contains Repaglinide and Metformin. Repaglinide acts by increasing the amount of insulin released by the pancreas. Metformin acts by lowering the liver's glucose production, delaying glucose absorption from the intestines, and increasing the body's response to insulin. Together, Zrepag-2 MF Tablet helps treat type II diabetes.

In some cases, Zrepag-2 MF Tablet may cause side effects like taste change, nausea, diarrhoea, stomach pain, headache, and upper respiratory symptoms. Most of these side effects may not require medical attention and resolve gradually overtime. However, if the side effects persist or worsen, consult the doctor.

Do not take Zrepag-2 MF Tablet if you are allergic to any of its components. Inform the doctor if you have renal impairment, metabolic acidosis, or diabetic ketoacidosis (excess acids in your blood). Consult the doctor if you are pregnant, planning to get pregnant, or are breastfeeding. Let the doctor know about your health conditions and medications.

Uses of Zrepag-2 MF Tablet

Treatment of type 2 diabetes mellitus

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Directions for Use

• Take Zrepag-2 MF Tablet within 30 minutes before a meal or as advised by a doctor.• Recommended to take the medicine 2 to 3 times a day or as advised by your doctor.• Swallow the medicine as a whole with glass of water.• Do not crush, break, or chew it.

Medicinal Benefits

Zrepag-2 MF Tablet belongs to the class of antidiabetic medicines used to treat type 2 diabetes. Zrepag-2 MF Tablet contains Repaglinide and Metformin. Repaglinide acts by increasing the amount of insulin released by the pancreas. Metformin acts by lowering the liver's glucose production, delaying glucose absorption from the intestines, and increasing the body's response to insulin. Together, Zrepag-2 MF Tablet helps treat type II diabetes.

How Zrepag-2 MF Tablet Works

Zrepag-2 MF Tablet contains Repaglinide and Metformin. Repaglinide acts by increasing the amount of insulin released by the pancreas. Metformin acts by lowering the liver's glucose production, delaying glucose absorption from the intestines, and increasing the body's response to insulin. Together, Zrepag-2 MF Tablet helps treat type II diabetes.
Side effects of Zrepag-2 MF Tablet
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
  • Try eating smaller meals (4-5 times) instead of large ones to make it easier on your stomach.
  • Avoid foods that are spicy, fatty, or high in insoluble fibre.
  • Consuming soluble fibre (such as psyllium) can help with constipation, and probiotics may reduce bloating and discomfort.
  • Stay away from carbonated drinks, alcohol, caffeine, and smoking, as they can upset your stomach.
  • Reducing stress, losing weight, and exercising regularly for 20-30 minutes can help improve digestion and reduce stomach issues.
  • Poor sleep can worsen stomach problems, so focus on good sleep habits or use tools like Sleepio to improve your sleep.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • If you experience low blood sugar levels, inform your doctor. They will assess the severity and make recommendations for the next actions.
  • Your doctor will assess your symptoms, blood sugar levels, and overall health before recommending the best course of action, which may include treatment, lifestyle modifications, or prescription adjustments.
  • Follow your doctor's instructions carefully to manage the episode and adjust your treatment plan.
  • Make medication adjustments as recommended by your doctor to prevent future episodes.
  • Implement diet and lifestyle modifications as your doctor advises to manage low blood sugar levels.
  • Monitor your blood sugar levels closely for patterns and changes.
  • Track your progress by recording your blood sugar levels, food intake, and physical activity.
  • Seek further guidance from your doctor if symptoms persist or worsen so that your treatment plan can be revised.
  • Eat heart-healthy diet rich in fruits, vegetables, whole grains, and low in saturated fat and cholesterol to support cardiovascular well-being.
  • Prioritize consuming omega-3 fatty acid-rich foods, antioxidants, and fiber to promote overall health and reduce inflammation.
  • Engage in regular aerobic exercise, such as brisk walking, cycling, or swimming, as recommended by your doctor to improve cardiovascular health.
  • Maintain a healthy weight through regular exercise and a balanced diet to reduce the risk of cardiovascular disease.
  • Quit smoking completely to reduce cardiovascular risk and improve overall health.
  • Practice relaxation techniques like mindful breathing exercises, guided meditation, or gentle yoga practices to effectively manage stress and promote calmness.
  • Limit alcohol intake to moderate levels to minimize negative impacts on cardiovascular health.
  • Regularly monitor your blood pressure, cholesterol levels, and blood sugar (if diabetic) to stay informed about your health and make adjustments as needed.
  • Be aware of potential symptoms of myocardial ischemia, such as chest pain, shortness of breath, nausea, or fatigue, and seek immediate medical attention if you experience any of these symptoms.
  • Collaborate with your healthcare provider to create a personalized treatment strategy that addresses your unique needs and health goals.
  • Chest pain may last for a while and needs immediate medical attention as it is a significant health issue to be attended to.
  • Take rest and refrain from doing physical activity for a while, and restart after a few days.
  • Try applying an ice pack to the strained area for at least 20 minutes thrice a day. Ice pack thus helps reduce inflammation.
  • Sit upright and maintain proper posture if there is persistent chest pain. Use extra pillows to elevate your position and prop your chest up while sleeping.

What if I have taken an overdose of Zrepag-2 MF Tablet

Do not take more than the prescribed dose of Zrepag-2 MF Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Some diabetic patients taking Zrepag-2 MF Tablet may develop a rare but serious condition called lactic acidosis. In this condition, too much lactic acid is accumulated in the blood. So, your liver and kidney's proper functioning is required to eliminate excess lactic acid from the blood. Zrepag-2 MF Tablet may lower vitamin B12 levels, so try to have blood tests for vitamins. Zrepag-2 MF Tablet , when used with or without insulin, tends to lower the blood sugar level extremely. So, the doctor may lower the dose of insulin. Zrepag-2 MF Tablet may lower your thyroid-stimulating hormone (TSH), so an annual check-up of TSH is suggested.

Drug-Drug Interactions

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RepaglinideGemfibrozil
Critical
RepaglinideGatifloxacin
Critical

Drug-Drug Interactions

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RepaglinideGemfibrozil
Critical
How does the drug interact with Zrepag-2 MF Tablet:
When Zrepag-2 MF Tablet is taken with Gemfibrozil, the level of Zrepag-2 MF Tablet in the blood can go up. This can increase the risk or severity of side effects.

How to manage the interaction:
Taking Zrepag-2 MF Tablet with Gemfibrozil can possibly result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RepaglinideGatifloxacin
Critical
How does the drug interact with Zrepag-2 MF Tablet:
Coadministration of Zrepag-2 MF Tablet with Gatifloxacin may sometimes affect blood glucose levels. Both low blood glucose and, less frequently, high blood glucose have been reported.

How to manage the interaction:
Although there is a possible interaction, Zrepag-2 MF Tablet can be taken with Gatifloxacin if prescribed by the doctor. However, consult the doctor if you experience unusual symptoms. Do not stop using any medications without first talking to your doctor.
MetforminIoglycamic acid
Critical
How does the drug interact with Zrepag-2 MF Tablet:
Co-administration of Ioglycamic acid with Zrepag-2 MF Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Zrepag-2 MF Tablet with Ioglycamic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIobenzamic acid
Critical
How does the drug interact with Zrepag-2 MF Tablet:
Co-administration of Zrepag-2 MF Tablet and Iobenzamic acid can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Zrepag-2 MF Tablet with Iobenzamic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIomeprol
Critical
How does the drug interact with Zrepag-2 MF Tablet:
Co-administration of Iomeprol with Zrepag-2 MF Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Zrepag-2 MF Tablet with Iomeprol is not recommended, please consult a doctor before taking it. Do not discontinue the medications without consulting a doctor.
MetforminIoglicic acid
Critical
How does the drug interact with Zrepag-2 MF Tablet:
Co-administration of Ioglicic acid with Zrepag-2 MF Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Zrepag-2 MF Tablet with Ioglicic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIopanoic acid
Critical
How does the drug interact with Zrepag-2 MF Tablet:
Co-administration of Iopanoic acid with Zrepag-2 MF Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Zrepag-2 MF Tablet with Iopanoic acid is not recommended, please consult your doctor before taking it.
MetforminIoversol
Critical
How does the drug interact with Zrepag-2 MF Tablet:
Co-administration of Ioversol with Zrepag-2 MF Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Zrepag-2 MF Tablet with Ioversol is not recommended, please consult your doctor before taking it.
MetforminIohexol
Critical
How does the drug interact with Zrepag-2 MF Tablet:
Co-administration of Iohexol with Zrepag-2 MF Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Zrepag-2 MF Tablet with Iohexol is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIopromide
Critical
How does the drug interact with Zrepag-2 MF Tablet:
Co-administration of Iopromide with Zrepag-2 MF Tablet can increase the risk of lactic acidosis.

How to manage the interaction:
Taking Iopromide with Zrepag-2 MF Tablet is not recommended, please consult a doctor before taking it. Do not discontinue the medication without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Fill your half plate with starchy veggies, a quarter with proteins, and a quarter with whole grains.
  • Eat at regular intervals. Do not take the long gap between a meal or snack.
  • Monitor your blood sugar level regularly, especially when there are a lot of fluctuations.
  • Invest in at least 150 minutes of moderate-intensity physical activity and 15 minutes of high-intensity exercise weekly.
  • Lose weight gradually to achieve a healthy body mass index (18.5 to 24.9).
  • Replace refined carbohydrates containing whole-grain foods and increase the intake of fruits, veggies, and other fibre-enriched foods.
  • Reduce saturated fat (or hidden fats) intake in food like chips, crisps, pastries, biscuits, and samosas. Choose omega-3 fatty acid-containing oils for daily cooking. For frying, you may use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil.
  • Do not take stress as it may elevate your blood sugar level. You may adopt stress management techniques like mindfulness, yoga, or meditation to control stress-related blood sugar changes.
  • Opt for low-fat dairy products (low-fat yoghurt, fat-free milk, cheese, etc.).
  • Keep your blood pressure as normal (120/80) as possible, as it reduces the risk of cardiovascular diseases in diabetes patients.

Habit Forming

No

Therapeutic Class

ANTIDIABETICS

Zrepag-2 MF Tablet Substitute

Substitutes safety advice
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Alcohol

Unsafe

You are recommended not to consume alcohol along with Zrepag-2 MF Tablet to avoid unpleasant side effects.

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Pregnancy

Caution

Please consult your doctor before taking Zrepag-2 MF Tablet in case you are pregnant.

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Breast Feeding

Caution

Caution should be exercised, and it is advisable to consult a doctor before using Zrepag-2 MF Tablet .

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Driving

Caution

Zrepag-2 MF Tablet may cause hypoglycemia (low blood sugar levels), whose symptoms include unusual sleepiness, shivering, palpitations, sweating, etc. This may affect your ability to drive. Use caution while driving or doing anything that requires concentration.

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Liver

Caution

Zrepag-2 MF Tablet to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Zrepag-2 MF Tablet to be taken with caution, especially if you have a history of Kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Unsafe

Zrepag-2 MF Tablet is not recommended in children, as the safety and efficacy have not been established.

FAQs

Zrepag-2 MF Tablet is used to treat type 2 diabetes. It works by increasing the amount of insulin released by the pancreas, lowering the liver's glucose production, delaying glucose absorption from the intestines, and increasing the body's response to insulin.

A common side effect of Zrepag-2 MF Tablet is hypoglycaemia (low blood glucose levels), characterized by dizziness, sweating, palpitations, hunger pangs, dry mouth, or skin. Hypoglycemia can occur if you miss or delay your food, drink alcohol, over-exercise, or take other antidiabetic medicine along with this medicine. It is important to monitor blood sugar levels regularly. Also, avoid missing meals and carry some form of sugar along with you.

Consult the doctor if you experience unusual thirst or pass urine more than normal while taking Zrepag-2 MF Tablet , as it may be a sign that there is too much sugar in your blood, and treatment needs to be adjusted. It may also be because of dehydration as Zrepag-2 MF Tablet can lead to loss of fluids. Increase intake of fluids; if even then you feel thirsty, please consult your doctor.

Yes, long-term usage of Zrepag-2 MF Tablet can cause vitamin B12 deficiency as it interferes with the absorption of vitamin B12 in the stomach. The symptoms of vitamin B12 deficiency include fatigue, nerve problems, tingling sensation and numbness in hands and feet, weakness, urinary problems, affected mental status, and difficulty in maintaining balance. These symptoms can be managed by taking Vitamin B12 supplements as advised by your doctor.

If you feel that your blood sugar level is decreasing and you are feeling weak, immediately eat sugar candies or drink sugary beverages. It will help to balance the blood sugar level in your body. So, it is advisable to keep sugar candies with you.

Zrepag-2 MF Tablet helps control blood sugar levels in people with type 2 diabetes. It combines two medicines to regulate blood sugar and reduce HbA1c levels. This medication is used along with diet and exercise to improve blood sugar control.

Zrepag-2 MF Tablet can be taken with a glass of water. Do not chew, break, or crush it. Follow your doctor's instructions regarding the dose and duration, and take it as long as your doctor recommends.

Zrepag-2 MF Tablet should be used with caution in patients with kidney disease. If you have kidney problems, your doctor may need to adjust the dose of Zrepag-2 MF Tablet based on the severity of your condition and regularly monitor your kidney function tests while taking this medicine. It is essential to inform your doctor if you have pre-existing kidney disorders before they prescribe it to you.

When taking Zrepag-2 MF Tablet , it's essential to follow certain precautions. Take the medication exactly as your doctor prescribes and inform them about all your medical conditions, especially kidney or liver disease. Regularly monitor your blood sugar levels and follow a healthy diet and exercise plan. Avoid excessive alcohol consumption and be cautious when driving or operating heavy machinery. Also, inform your doctor about all your medications, including supplements, and regularly check your kidney and liver function.

Don’t stop taking Zrepag-2 MF Tablet on your own, as it may increase your blood sugar levels. Generally, diabetic medications need to be taken long-term to manage sugar levels as there is still no cure for diabetes. If you have concerns about your sugar levels, side effects, or the effectiveness of Zrepag-2 MF Tablet , please inform your doctor. They will assess your issues and provide personalized guidance without causing adverse health complications.

Zrepag-2 MF Tablet contains Repaglinide and Metformin. Repaglinide acts by increasing the amount of insulin released by the pancreas. Metformin lowers the liver's glucose production, delaying glucose absorption from the intestines and increasing the body's response to insulin. Together, helps treat type II diabetes.

Zrepag-2 MF Tablet should be used cautiously, especially in patients with pre-existing heart problems. Inform your doctor of any heart problems before they prescribe Zrepag-2 MF Tablet . Your doctor needs to assess your heart condition and will prescribe it only if the benefits outweigh the risks by making suitable adjustments in the dose and duration.

In some individuals, Zrepag-2 MF Tablet may cause certain common side effects, such as taste change, nausea, diarrhoea, stomach pain, headache, and upper respiratory symptoms. These side effects may not require medical attention and resolve gradually over time. However, if any side effects persist or worsen, consult the doctor.

Generally, it is essential to take your diabetes medication regularly to maintain consistent blood sugar levels. If you forget a dose of Zrepag-2 MF Tablet , take it as soon as you remember. However, if your next dose is near, skip the missed dose and continue with your regular schedule. Never double dose to make up for a missed dose, as this may increase side effects.

Country of origin

India

Manufacturer/Marketer address

715, Gold Crest Business Center, L.T Road, Borivali-W, Mumbai 400092
Other Info - ZRE0005

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Jul 18, 2025 | 6:44 AM IST

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Reference

  1. https://www.nhs.uk/conditions/type-2-diabetes/understanding-medication/
  2. https://patient.info/medicine/repaglinide-for-diabetes-enyglid-prandin
  3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022386s007lbl.pdf

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