MYO PYROLATE IV INJECTION

Manufacturer : NEP-NEON LABORATORIES LTD
Composition : GLYCOPYRROLATE-0.5MG/5ML+NEOSTIGMINE-2.5MG/5ML
Dose Form : INJECTION
Description : MYO-PYROLATE IV INJ
Route Of Administration : PARENTERAL
Pack : 1
In stock
SKU
MYO0014
₹77.20
Manufacturer : NEP-NEON LABORATORIES LTD
Composition : GLYCOPYRROLATE-0.5MG/5ML+NEOSTIGMINE-2.5MG/5ML
Dose Form : INJECTION
Description : MYO-PYROLATE IV INJ
Route Of Administration : PARENTERAL
Pack : 1

Drug Ingredient Information

GLYCOPYRROLATE-0.5MG/5ML+NEOSTIGMINE-2.5MG/5ML

GLYCOPYRROLATE

Information for patients
Drug Information Glycopyrrolate is used with other drugs to treat a certain type of stomach/intestinal ulcer (peptic ulcer). This medication may help relieve stomach/abdominal pain. However, it has not been shown to be effective in healing these ulcers, preventing them from returning, or preventing other problems caused by ulcers. Glycopyrrolate works by decreasing the amount of acid in the stomach. It also slows the natural movements of the gut and relaxes the muscles in the stomach/intestines. Glycopyrrolate belongs to a class of drugs known as anticholinergics.
Drug Alert
Alert This drug should be used with great caution, if at all, in patients with glaucoma. Exposure to excessive amounts of benzyl alcohol has been associated with toxicity (hypotension, metabolic acidosis), particularly in neonates, and an increased incidence of kernicterus, particularly in small preterm infants. There have been rare reports of deaths, primarily in preterm infants, associated with exposure to excessive amounts of benzyl alcohol. The amount of benzyl alcohol from medications is usually considered negligible compared to that received in flush solutions containing benzyl alcohol. Administration of high dosages of medications containing this preservative must take into account the total amount of benzyl alcohol administered. The amount of benzyl alcohol at which toxicity may occur is not known. If the patient requires more than the recommended dosages or other medications containing this preservative, the practitioner must consider the daily metabolic load of benzyl alcohol from these combined sources. (see PRECAUTIONS, Pediatric Use). Robinul Injection (glycopyrrolate) may produce drowsiness or blurred vision. The patient should be cautioned regarding activities requiring mental alertness such as operating a motor vehicle or other machinery or performing hazardous work while taking this drug. In addition, in the presence of fever, high environmental temperature and/or during physical exercise, heat prostration can occur with use of anticholinergic agents including glycopyrrolate (due to decreased sweating), particularly in children and the elderly. Diarrhea may be an early symptom of incomplete intestinal obstruction, especially in patients with ileostomy or colostomy. In this instance treatment with Robinul Injection (glycopyrrolate) would be inappropriate and possibly harmful.
Before Consuming the Medicine
Avoid Drug Before taking glycopyrrolate, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Drug Special Care Before using this medication, tell your doctor or pharmacist your medical history, especially of: glaucoma, enlarged prostate, problems with urination due to a blocked urinary tract, other stomach/intestinal problems (such as slow gut, blockage, ulcerative colitis, infection, ileostomy/colostomy patients with diarrhea), overactive thyroid, heart problems (such as coronary artery disease, angina, congestive heart failure, fast/irregular heartbeat, heart problems due to severe bleeding), high blood pressure, heartburn problems (such as acid reflux, hiatal hernia, esophagus problems), certain nervous system problem (autonomic neuropathy), myasthenia gravis, liver problems, kidney problems. This drug may make you dizzy or drowsy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Limit alcoholic beverages. This medication may make you sweat less which can increase your risk for heat stroke, a very serious condition. Avoid activities that might cause you to overheat (such as doing strenuous work/exercise in hot weather, using hot tubs). Drink plenty of fluids, and dress lightly while in hot weather or when exercising. If you become overheated, stop exercising and promptly seek cooler shelter. Seek immediate medical attention if you develop a fever, mental/mood changes, headache, or dizziness. Older adults may be more sensitive to the side effects of this drug, especially drowsiness, confusion, unusual excitement, constipation, and urination problems.
Drug Drug Interactions amantadine (Symmetrel); quinidine (Quinaglute, Cardioquin, Quinora, Quinidex); antihistamines such as diphenhydramine (Benadryl, many others), brompheniramine (Dimetapp, Bromphen, many others), triprolidine (Actifed, others), and chlorpheniramine (Chlor-Trimeton, others), which are found in many over-the-counter and prescription cough, cold, and allergy medications; decongestants and appetite suppressants such as phenylpropanolamine (Dexatrim, others), phenylephrine (Neo-Synephrine, others), and pseudoephedrine (Sudafed, others), which are also found in many over-the-counter and prescription products; phenothiazines such as chlorpromazine (Thorazine) and prochlorperazine (Compazine); other commonly used phenothiazines, including fluphenazine (Prolixin), mesoridazine (Serentil), perphenazine (Trilafon), thioridazine (Mellaril), trifluoperazine (Stelazine), and promazine (Sparine); tricyclic antidepressants such as amitriptyline (Elavil, Endep), doxepin (Sinequan), and nortriptyline (Pamelor); or other commonly used tricyclic antidepressants, including amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), imipramine (Tofranil), protriptyline (Vivactil), and trimipramine (Surmontil). Glycopyrrolate may increase the level of digoxin (Lanoxin, Lanoxicaps) in your blood. Tell your doctor if you are taking digoxin so that your digoxin levels can be monitored and changes in your dosage can be made if necessary. Drugs other than those listed here may also interact with glycopyrrolate. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.
Drug Pregnancy Interaction During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
Drug Breast feeding Interaction It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.
Drug Machinery Interaction Use caution when driving, operating machinery, or performing other hazardous activities. Glycopyrrolate may cause dizziness, drowsiness, or blurred vision. If you experience dizziness, drowsiness, or blurred vision, avoid these activities.
Drug More Information Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking glycopyrrolate.Avoid becoming overheated in hot weather. Glycopyrrolate increases the risk of heat stroke because it causes decreased sweating.
How to take the Medicine
Consumption Info no data available
Drug quanitty Adults Preanesthetic Medication. The recommended dose of Robinul Injection (glycopyrrolate) is 0.004 mg/kg by intramuscular injection, given 30 to 60 minutes prior to the anticipated time of induction of anesthesia or at the time the preanesthetic narcotic and/or sedative are administered. Intraoperative Medication. Robinul Injection (glycopyrrolate) may be used during surgery to counteract drug-induced or vagal reflexes and their associated arrhythmias (e.g., bradycardia). It should be administered intravenously as single doses of 0.1 mg and repeated, as needed, at intervals of 2 to 3 minutes. The usual attempts should be made to determine the etiology of the arrhythmia, and the surgical or anesthetic manipulations necessary to correct parasympathetic imbalance should be performed. Reversal of Neuromuscular Blockade. The recommended dose of Robinul Injection (glycopyrrolate) is 0.2 mg for each 1.0 mg of neostigmine or 5.0 mg of pyridostigmine. In order to minimize the appearance of cardiac side effects, the drugs may be administered simultaneously by intravenous injection and may be mixed in the same syringe. Peptic Ulcer. The usual recommended dose of Robinul Injection (glycopyrrolate) is 0.1 mg administered at 4-hour intervals, 3 or 4 times daily intravenously or intramuscularly. Where more profound effect is required, 0.2 mg may be given. Some patients may need only a single dose, and frequency of administration Preanesthetic Medication. The recommended dose of Robinul Injection (glycopyrrolate) in pediatric patients is 0.004 mg/kg intramuscularly, given 30 to 60 minutes prior to the anticipated time of induction of anesthesia or at the time the preanesthetic narcotic and/or sedative are administered. Infants. (1 month to 2 years of age) may require up to 0.009 mg/kg. Intraoperative Medication. Because of the long duration of action of Robinul Injection (glycopyrrolate) if used as preanesthetic medication, additional Robinul Injection (glycopyrrolate) for anticholinergic effect intraoperatively is rarely needed; in the event it is required the recommended pediatric dose is 0.004 mg/kg intravenously, not to exceed 0.1 mg in a single dose which may be repeated, as needed, at intervals of 2 to 3 minutes. The usual attempts should be made to determine the etiology of the arrhythmia, and the surgical or anesthetic manipulations necessary to correct parasympathetic imbalance should be performed. Reversal of Neuromuscular Blockade. The recommended pediatric dose of Robinul Injection (glycopyrrolate) is 0.2 mg for each 1.0 mg of neostigmine or 5.0 mg of pyridostigmine. In order to minimize the appearance of cardiac side effects, the drugs may be administered simultaneously by intravenous injection and may be mixed in the same syringe. Peptic Ulcer. Robinul Injection (glycopyrrolate) is not recommended for the treatment of peptic ulcer in pediatric patients.
Drug Dose Take this medication by mouth, usually 2 to 3 times a day or as directed by your doctor. The dosage is based on your medical condition and response to treatment. The manufacturer recommends that adults should not take more than 8 milligrams a day of glycopyrrolate. Do not increase your dose or take this drug more often without your doctor's approval. Your condition will not improve any faster and the risk of serious side effects may increase.
Excess Drug Consumption Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication.
Forgot Drug Consumption If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
Stop Drug Consumption Do not stop the drug untill your doctor says you to do so.
Possible Side Effects
General Information xerostomia (dry mouth); urinary hesitancy and retention; blurred vision and photophobia due to mydriasis (dilation of the pupil); cycloplegia; increased ocular tension; tachycardia; palpitation; decreased sweating; loss of taste; headache; nervousness; drowsiness; weakness; dizziness; insomnia; nausea; vomiting; impotence; suppression of lactation; constipation; bloated feeling; severe allergic reactions including anaphylactic/anaphylactoid reactions; hypersensitivity; urticaria, pruritus, dry skin, and other dermal manifestations; some degree of mental confusion and/or excitement, especially in elderly persons.
Common Drug Side Effects malignant hyperthermia; cardiac arrhythmias (including bradycardia, ventricular tachycardia, ventricular fibrillation); cardiac arrest; hypertension; hypotension; seizures; and respiratory arrest. Post-marketing reports have included cases of heart block and QTc interval prolongation associated with the combined use of glycopyrrolate and an anticholinesterase. Injection site reactions including pruritus, edema, erythema, and pain have also been reported.
Rare Drug Side Effects no data available
Very Rare Drug Side Effects no data available
Drug Side Effects Symptoms chemically a quaternary ammonium compound; hence, its passage across lipid membranes, such as the blood-brain barrier is limited in contrast to atropine sulfate and scopolamine hydrobromide. For this reason the occurrence of CNS-related side effects is lower, in comparison to their incidence following administration of anticholinergics which are chemically tertiary amines that can cross this barrier readily.
How to Store the Medicine
How to Store the Medicine Store at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Do not store in the bathroom. Keep all medicines away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

NEOSTIGMINE

Information for patients
Drug Information Neostigmine injection belongs to a group of medicines used to: •Treat abnormally tired and weak muscles (myasthenia gravis). •Reverse the effects of muscle relaxants. •Improve movement in the small intestine. •Reduce urine retention after surgical procedures.
Drug Alert
Alert
Before Consuming the Medicine
Avoid Drug •are sensitive or allergic to neostigmine or any of the other ingredients in this injection. •have an intestinal obstruction or cannot urinate. •have peritonitis (an infection or inflammation of the outer layer of your stomach or intestines). •have a condition where your bowel may no longer be functioning. • you are receiving certain muscle relaxants (e.g. Suxamethonium).
Drug Special Care •asthma •epilepsy •a slow pulse •any heart disease •vagotonia (you may suffer from sweating, constipation and involuntary movements) •an overactive thyroid gland •a stomach ulcer •Parkinson’s Disease •an anastomosis (an opening created by surgery, trauma, or disease) in your intestine •a controlled low sodium diet (this medicinal product contains approximately 3.54 mg sodium per ml)
Drug Drug Interactions Please tell your doctor or nurse if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. This is especially important with the following medicines as they may interact with your Neostigmine Methylsulphate Injection : •you are receiving antibiotics known as aminoglycosides. Pregnancy or breast feeding:
Drug Pregnancy Interaction Please tell your doctor or nurse before being given this injection if you are pregnant or breast feeding. The doctor will then decide if the injection is suitable for you.
Drug Breast feeding Interaction Please tell your doctor or nurse before being given this injection if you are pregnant or breast feeding. The doctor will then decide if the injection is suitable for you.
Drug Machinery Interaction You should not drive or use machinery if you are affected by the administration of Neostigmine Methylsulphate Injection .
Drug More Information
How to take the Medicine
Consumption Info
Drug quanitty Your nurse or doctor will give you the injection. Your doctor will decide the correct dosage for you and how and when the injection will be given. Since the injection will be given to you by a doctor or nurse, it is unlikely that you will be given too much.
Drug Dose
Excess Drug Consumption If you think you have been given too much, you must tell the person giving you the injection.
Forgot Drug Consumption
Stop Drug Consumption
Possible Side Effects
General Information
Common Drug Side Effects •feel or actually be sick •produce more saliva than usual •produce more tears than usual •suffer from bronchial spasm and increased bronchial secretion •suffer from diarrhoea and stomach cramps •have constricted (pin-point) pupils in your eye •suffer from urinary incontinence (you pass urine when you do not mean to) •suffer from excessive sweating •have a slow pulse •suffer from hypotension (blood pressure that is much lower than usual) •suffer from muscle spasms
Rare Drug Side Effects
Very Rare Drug Side Effects
Drug Side Effects Symptoms
How to Store the Medicine
How to Store the Medicine Your injection will be stored at less than 25°C and protected from light. The nurse or doctor will check that the injection is not past its expiry date before giving you the injection.

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