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Kombiglyze XR 5 mg/1000 mg Tablet is used in the treatment of type 2 diabetes in adults. Kombiglyze XR 5 mg/1000 mg Tablet is prescribed for the condition of type 2 diabetes when diet and exercise alone cannot control blood sugar levels. People with type 2 diabetes either do not produce enough insulin, or the insulin produced is unable to perform its function in the body (insulin resistance). Middle-aged or older individuals are most likely to suffer from type 2 diabetes, so it is also known as adult-onset diabetes.
Kombiglyze XR 5 mg/1000 mg Tablet contains two medications: Saxagliptin and Metformin. Saxagliptin works by blocking the action of DPP-4/dipeptidyl peptidase-4 (an enzyme which destroys the hormone ‘Incretin’). The enzyme ‘Incretins’ helps produce more insulin only when required and reduces blood sugar produced by the liver when not needed. On the other hand, Metformin, a 'biguanide', lowers the liver's glucose production, delays glucose absorption from the intestines, and increases the body's response to insulin. Together, they prevent the blood glucose levels from rising to very high levels, thus keeping your diabetes under control.
You are suggested to take Kombiglyze XR 5 mg/1000 mg Tablet for as long as your doctor has prescribed it. The most common side effects of Kombiglyze XR 5 mg/1000 mg Tablet are hypoglycemia (low blood glucose levels), upper respiratory tract infection, nasopharyngitis (nose and throat infection with common cold), and headache. Most of these side effects do not require medical attention and gradually resolve over time. If the side effects persist or worsen, consult a doctor.
Kombiglyze XR 5 mg/1000 mg Tablet should not be stopped even if you feel better. If you stop taking Kombiglyze XR 5 mg/1000 mg Tablet abruptly, it may increase your sugar levels, which could further increase the risk of eyesight loss (retinopathy), kidney (nephropathy), and nerve damage (neuropathy). Kombiglyze XR 5 mg/1000 mg Tablet should not be taken if you have severe kidney or liver disease. Please inform your doctor if you have any heart disease, are planning to get pregnant or are breastfeeding. Safety and efficacy of Kombiglyze XR 5 mg/1000 mg Tablet in children under 18 years have not been established, so it should not be given to them. Patients taking digoxin (a heart medicine) with Kombiglyze XR 5 mg/1000 mg Tablet should be closely monitored as severe drug interaction has been observed.
Kombiglyze XR 5 mg/1000 mg Tablet is used to treat high blood sugar levels in individuals with type 2 diabetes mellitus. The detailed uses of Kombiglyze XR 5 mg/1000 mg Tablet are as follows:
Kombiglyze XR 5 mg/1000 mg Tablet contains two medications: Saxagliptin and Metformin. Kombiglyze XR 5 mg/1000 mg Tablet helps keep your blood sugar levels under check. Kombiglyze XR 5 mg/1000 mg Tablet shows optimum effects when taken along with healthy lifestyle changes like weight loss, regular exercise, healthy diet, etc. Kombiglyze XR 5 mg/1000 mg Tablet plays a vital role in controlling blood sugar levels and prevents serious complications of diabetes like eyesight loss (retinopathy), kidney (nephropathy), nerve damage (neuropathy), diabetic foot ulcer, and delayed wound healing.
Unsafe
Kombiglyze XR 5 mg/1000 mg Tablet is not advised to be taken with alcohol as it causes bizarre interactions. Both hypoglycemia (low blood sugar) and hyperglycemia (high blood sugar) may occur, depending on how much and how often you drink.
Caution
No harmful interaction has been reported in pregnant mothers, yet the patient is advised to consult a doctor before taking this drug during pregnancy.
Caution
No harmful interaction has been reported in breastfeeding mothers, yet the patient is advised to consult a doctor before taking this drug.
Caution
Caution is to be taken. If a patient feels dizzy while taking Kombiglyze XR 5 mg/1000 mg Tablet, do not drive or use any tools or machines. Hypoglycaemia may affect your ability to drive and use machines or work with a safe foothold, and there is a risk of hypoglycaemia after taking this medicine in combination with other medicines known to cause hypoglycaemia, such as insulin and sulphonylureas.
Caution
It should be used with caution if you have liver conditions. Patients with severe liver problems are advised to take this drug with a doctor's consultation.
Caution
It should be used with caution if you have kidney problems. Patients with reduced kidney function are advised to consult with a doctor before taking Kombiglyze XR 5 mg/1000 mg Tablet as the doctor may decrease the dose as per his own judgment.
Caution
Kombiglyze XR 5 mg/1000 mg Tablet is not recommended for children and adolescents under 18 years. It is not known if this medicine is safe and effective when used in children and adolescents under 18 years of age. Consult your doctor for more information.
Caution
Let your doctor know if you have any history of heart problems. Your doctor will weigh the benefits and potential risks before prescribing Kombiglyze XR 5 mg/1000 mg Tablet.
Caution
Kombiglyze XR 5 mg/1000 mg Tablet should be given to elderly patients only when prescribed by a doctor. If you have any concerns, please consult your doctor.
Invest at least 150 min of your week in moderate-intensity physical activity or one hour and 15 minutes of high-intensity exercise every week.
Replace refined carbohydrate-containing foods with whole grain foods and increase intake of fruits and vegetables and other fibre-enriched foods.
Reduce saturated fat (or hidden fats) intake in food like chips, crisps, pastries, biscuits, and samosas. Choose omega-3 fatty acid-containing oils for daily cooking. For frying, you can use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil.
Avoid taking too much stress as it may elevate your blood sugar level. You can adopt stress management techniques like mindfulness to control stress-related blood sugar changes or meditation or yoga.
Opt for low-fat dairy products (low-fat yoghurt, fat-free milk, cheese, etc.).
G.santoshini Reddy
M Pharmacy (Pharmaceutics)
G.santoshini Reddy
M Pharmacy (Pharmaceutics)
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A prolonged intake of Kombiglyze XR 5 mg/1000 mg Tablet may cause acute pancreatitis (swollen pancreas) and critical kidney problem. Increased risk of hypoglycemia (low blood sugar level) can occur when Kombiglyze XR 5 mg/1000 mg Tablet is added to other anti-diabetic agents or insulin therapy. In this case, your doctor may adjust the dose of Kombiglyze XR 5 mg/1000 mg Tablet. Severe allergic reactions might occur in some patients taking Kombiglyze XR 5 mg/1000 mg Tablet, like anaphylaxis, angioedema (swelling under the skin), and exfoliative skin conditions, including Stevens-Johnson syndrome.
Drug-Drug Interaction: Kombiglyze XR 5 mg/1000 mg Tablet interacts with an anti-depressant (bupropion), drugs used to treat glaucoma, antibiotics (cephalexin, ciprofloxacin), anti-acidity drugs (cimetidine), heart condition drugs (digoxin), anti-HIV drugs (dolutegravir), ethanol, saliva reducing drugs (glycopyrrolate), iodinated X-ray contrast agents, anti-epileptic drugs (topiramate, lamotrigine), heart-related chest medicine (ranolazine). Other drug interactions can contribute to an increased low blood sugar, including sex hormones (androgens), anti-oxidant (alpha-lipoic acid), painkillers (aspirin), anti-TB drugs (prothionamide), growth hormones (pegvisomant), and other antidiabetic medicines.
Drug-Food Interaction: Intake of excessive alcoholic beverages may increase the chance of a life-threatening condition known as Lactic Acidosis. So, avoid intake of alcoholic beverages with Kombiglyze XR 5 mg/1000 mg Tablet.
Drug-Disease Interaction: Kombiglyze XR 5 mg/1000 mg Tablet should be used with caution in patients with a history of pancreatitis/pancreatic disease and renal dysfunction.
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Kombiglyze XR 5 mg/1000 mg Tablet is used in the treatment of type 2 diabetes in adults. It is prescribed for the condition of type 2 diabetes when diet and exercise alone cannot control blood sugar levels.
Yes, Kombiglyze XR 5 mg/1000 mg Tablet is known to cause stomach upset, indigestion, nausea, and diarrhoea. To avoid these side effects, please take Kombiglyze XR 5 mg/1000 mg Tablet with a meal. Also, Kombiglyze XR 5 mg/1000 mg Tablet should be taken at evenly spaced intervals to avoid any unpleasant side effects and for best results.
Kombiglyze XR 5 mg/1000 mg Tablet has been reported to increase blood cholesterol levels in a normal patient and thus not recommended in patients with hyperlipidemia.
The patient is advised to take the missed dose as soon as possible; otherwise, jump to the next dose. A patient should never take a double dose to compensate for the missed dose. It may aggravate harmful side effects.
According to American Diabetes Association, most of the studies carried out on Kombiglyze XR 5 mg/1000 mg Tablet and its ability to cause cancer resulted in a conclusion that Kombiglyze XR 5 mg/1000 mg Tablet is not associated with any form of cancer & hence is safe to use.
A patient who accidentally takes an overdose of Kombiglyze XR 5 mg/1000 mg Tablet may experience collapse, seizure attack, and troubled breathing. In such a case, without any delay, emergency health services must be contacted, and medical help should be sought.
Before taking Kombiglyze XR 5 mg/1000 mg Tablet inform your doctor if you have any kidney or liver problems, a history of pancreatitis (swollen pancreas), heart disease, alcohol use, or if you are pregnant or breastfeeding. Also, mention any other medications you are taking, especially those for diabetes.
Kombiglyze XR 5 mg/1000 mg Tablet is not advised to be used in individuals with a history of severe allergic reactions such as difficulty breathing, or serious skin conditions. Kombiglyze XR 5 mg/1000 mg Tablet is also not recommended for those with renal dysfunction (kidney problems), pancreatitis, or pancreatic disease. Kombiglyze XR 5 mg/1000 mg Tablet is also contraindicated in pregnant or breastfeeding women. Therefore, always consult a healthcare provider before use.
Kombiglyze XR 5 mg/1000 mg Tablet is not usually associated with significant weight gain. However, some people may experience mild weight changes. It is important to monitor any changes with your healthcare provider.
Kombiglyze XR 5 mg/1000 mg Tablet may not be suitable for individuals with kidney problems, as it can impact kidney function. Kombiglyze XR 5 mg/1000 mg Tablet should be used with caution or avoided in those with renal issues (kidney problems). Always, consult a physician if you have kidney concerns.
Yes, it is essential to maintain a healthy diet and exercise routine while taking Kombiglyze XR 5 mg/1000 mg Tablet. Although Kombiglyze XR 5 mg/1000 mg Tablet helps control blood sugar, proper diet and regular physical activity are crucial for managing diabetes and supporting overall health. Your healthcare provider can offer guidance in best manner on how to include these habits in your treatment plan.
Kombiglyze XR 5 mg/1000 mg Tablet alone is unlikely to cause low blood sugar (hypoglycemia). However, if taken with other diabetes medicines, such as insulin or sulfonylureas, the risk of low blood sugar may increase. It is important to regularly check your blood sugar and follow your doctor's advice to avoid hypoglycemia (low blood sugar).
You are recommended to take Kombiglyze XR 5 mg/1000 mg Tablet for as long as it is advised by your doctor for effective results. If your symptoms continue or worsen, seek further advice from your doctor.
Kombiglyze XR 5 mg/1000 mg Tablet, can be safe for the long-term if taken as advised by your doctor. However, potential risks include acute pancreatitis (swollen pancreas), kidney problems, and hypoglycaemia (low blood sugar). Regular check-ups are essential to assess your health, especially if you have a history of kidney, liver, or heart issues. Always, follow your doctor's recommendations to manage any risks and ensure safe long-term use.
Kombiglyze XR 5 mg/1000 mg Tablet causes side effects such as dizziness, sweating, palpitations, dry mouth and skin and hypoglycaemia (low blood glucose levels). Please, contact a doctor if these side effects or any other concerns persist for longer durations.
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