| Information for
patients
|
| Drug Information |
Protionamide (or prothionamide) is a drug used in the treatment of tuberculosis.
It has also been tested for use in the treatment of leprosy |
| Drug Alert |
| Alert |
Contraindicated in Hypersensitivity. Severe hepatic disease, porphyria. |
| Before Consuming
the Medicine
|
| Avoid Drug |
patients who have Hypersensitivity to Prothionamide and impaired liver function should not use this medicine. |
| Drug Special Care |
Difficulty in managing DM. Monitor blood glucose, thyroid and visual function. Perform LFT before and during treatment with protionamide. Caution in patients with psychiatric illness or depression. Pregnancy and lactation. |
| Drug Drug Interactions |
Increased neurotoxic effects with cycloserine.
Potentially Fatal: Increased incidence of hepatotoxicity with rifampicin. |
| Drug Pregnancy Interaction |
no data |
| Drug Breast feeding Interaction |
no data |
| Drug Machinery Interaction |
no data |
| Drug More Information |
Protionamide inhibits peptide synthesis. It is active against mycobacteria species. Bacteriostatic against M. tuberculosis. Also active against atypical mycobacteria e.g. M. kansasii and some strains of M. avium complex, and M. leprae.
Onset: 30-60 min.
Duration: 12-16 hr.
Absorption: Readily absorbed form the GI tract (oral); peak plasma concentrations after 2 hr.
Distribution: Widely distributed into body fluids and CSF.
Metabolism: Converted to sulfoxide (active) and other metabolites.
Excretion: Via urine (<1% as unchanged).; |
| How to take the
Medicine
|
| Consumption Info |
Prothionamide is taken twice daily, generally one tablet (250 mg) in the daytime and 2 tablets (500 mg) at night.
Prothionamide is taken during the intensive and continuation phases of treatment. |
| Drug quanitty |
Dosage Adults 0. 5 to 1g daily in 2 to 3 divided doses along with other antitubercular drugs. Daily dose not to exceed 1G. Children 15mg to 20mg / kg in two divided doses. Daily dose not to exceed 0. 5 G. |
| Drug Dose |
to be taken orally. |
| Excess Drug Consumption |
no data |
| Forgot Drug Consumption |
no data |
| Stop Drug Consumption |
no data |
| Possible Side
Effects
|
| General Information |
The side effects of prothionamide are similar to ethionamide. Prothionamide is most commonly associated with nausea and vomiting. |
| Common Drug Side Effects |
Anorexia, excessive salivation, metallic taste, nausea, vomiting, abdominal pain, diarrhoea. Peripheral and/or optic neuritis, psychiatric disturbances e.g. depression, anxiety, psychosis, postural hypotension. Jaundice, hepatitis. Thrombocytopenia, skin rashes, stomatitis, gynaecomastia. |
| Rare Drug Side Effects |
no data |
| Very Rare Drug Side Effects |
no data |
| Drug Side Effects Symptoms |
no data |
| How to Store the
Medicine
|
| How to Store the Medicine |
Storage Store at a temperature upto 25 oC. Protected from light. Keep out of the reach of children. |
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