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ACETAMINOPHEN+NIMESULIDE belongs to a class of medicines known as 'non-steroidal anti-inflammatory drugs (NSAIDs)', primarily indicated in the treatment of mild to moderate pain. Pain can be temporary (acute) or long-lasting (chronic) in nature. ACETAMINOPHEN+NIMESULIDE relieves symptoms of arthritis, dysmenorrhea (painful periods or menstrual cramps) and reduces fever. Acute pain is caused by damage to the tissues of the muscle, bone, or other organs for a short time. While, chronic pain lasts for a long duration and is caused due to pathologies like nerve damage, mild migraine, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, etc. Besides this, it is also useful for dental pain, which can occur due to damage to the tooth nerve, infection, decay, extraction or injury.

ACETAMINOPHEN+NIMESULIDE is composed of two medicines: Nimesulide and Acetaminophen. Nimesulide is known to have an analgesic and anti-inflammatory effect for reducing mild to moderate pain. It works by blocking the effect of a chemical known as prostaglandin responsible for inducing pain and inflammation in our body. Acetaminophen acts as a mild analgesic and antipyretic (fever reducer). It lowers the elevated body temperature and mild pain by inhibiting the synthesis of a chemical messenger (prostaglandin) and promoting heat loss (through sweating) that helps reset the hypothalamic thermostat. Together it helps in reducing mild to moderate pain in a shorter duration.

Take ACETAMINOPHEN+NIMESULIDE as prescribed by your doctor. You are advised to take ACETAMINOPHEN+NIMESULIDE for as long as your doctor has prescribed it for you depending on your medical condition. Like all medicines, ACETAMINOPHEN+NIMESULIDE may cause side effects, although not everybody gets them. Stop taking this medicine if you experience symptoms like chest tightness, breathing difficulties, fever, skin rashes, increased heart rate, and or in case of any signs of hypersensitivity.

Do not take ACETAMINOPHEN+NIMESULIDE if you are allergic to painkillers like aspirin, ibuprofen, naproxen or diclofenac. It is not recommended for use in children, people with liver disease, heart disease or gastric ulcers/bleeding problems. ACETAMINOPHEN+NIMESULIDE may be associated with a small increase in heart attack risk (myocardial infarction). Avoid alcohol consumption as it may damage your liver and cause increased side effects from taking this drug. Consult your doctor if your pain, inflammation and fever symptoms do not disappear even after ten days. ACETAMINOPHEN+NIMESULIDE is usually safe to be taken in pregnancy and breastfeeding females, however, an individual should consult their doctor before taking it. ACETAMINOPHEN+NIMESULIDE is well tolerated by elderly persons.


Pain relief

Medicinal Benefits

ACETAMINOPHEN+NIMESULIDE is composed of nimesulide and acetaminophen, primarily used to treat mild to moderate pain. ACETAMINOPHEN+NIMESULIDE is prescribed mainly to treat pain and get relief from discomfort caused by conditions like mild migraine, tooth pain, arthritis, period pain, back pain, cold/ flu pain and other types of short-term pains. Acetaminophen has got the advantage of producing less gastric irritation compared to other painkillers like aspirin.

Directions for Use

ACETAMINOPHEN+NIMESULIDE can be taken with or after the meal. It should be swallowed as a whole with a glass of water. Do not crush or chew it. Do not take ACETAMINOPHEN+NIMESULIDE if your pain lasts for more than ten days or fever stays for more than three days, and consult your doctor immediately. Do not take a double dose if you missed one dose.


Store in a cool and dry place away from sunlight


  • Nausea
  • Vomiting
  • Stomach pain
  • Diarrhoea
  • Constipation
  • Indigestion
  • Headache

In-Depth Precautions and Warning

Drug Warnings

Please inform your doctor before starting ACETAMINOPHEN+NIMESULIDE if you have an active stomach ulcer, recent gastrointestinal bleeding, asthma, recent by-pass heart surgery or severe kidney/liver impairment. Nimesulide present in ACETAMINOPHEN+NIMESULIDE is known to affect fertility, so if you are planning for pregnancy contact doctor. ACETAMINOPHEN+NIMESULIDE should be avoided in both pregnant (especially last trimester of pregnancy) and breastfeeding women, as it may pass the milk affecting the baby. Patients with heart diseases and recent stroke (bleeding in the brain) should not take ACETAMINOPHEN+NIMESULIDE as a substitute for aspirin. It should not be given to children (below 12 years) with symptoms of fever and chills or suffering from influenza (flu) or chickenpox.

Drug Interactions

Drug-Drug Interaction: ACETAMINOPHEN+NIMESULIDE is shown to interact with various drugs. Some of them include lithium, anticancer/antimetabolites (methotrexate), blood thinner or anticoagulant (warfarin, aspirin), blood pressure or heart medicine, nausea medicine (metoclopramide, domperidone), diuretic/water pills (furosemide), steroid medicine (prednisone), quinolones antibiotics (ciprofloxacin), respiratory medicines (theophyllines, ephedrine), immune system affecting medicine (cyclosporine) and antidepressants (duloxetine). These drugs may affect the working of ACETAMINOPHEN+NIMESULIDE and may alter its efficacy.

Drug-Food Interaction: Excessive intake of alcoholic beverages, caffeine-containing food or drinks like coffee, tea, chocolate and some fizzy drinks should be avoided while taking ACETAMINOPHEN+NIMESULIDE. Taking together may lead to drowsiness and dizziness and sleepiness.

Drug-Disease Interaction: ACETAMINOPHEN+NIMESULIDE should not recommend for people having bleeding disorders, like hemophilia, von Willebrand disease or low blood platelets. Besides this, it should not be given to children suffering from influenza (flu) or chickenpox. It should also be avoided in case of the presence of gastric or duodenal ulcers.

Drug-Drug Interactions Checker List:

  • Safety Advice

    • Safety Warning



      Taking ACETAMINOPHEN+NIMESULIDE with alcohol may cause dizziness or drowsiness. Besides this, it can also damage your liver if taken for a longer duration. So, avoid or limit the intake of alcoholic beverages with ACETAMINOPHEN+NIMESULIDE.

    • Safety Warning



      Use of ACETAMINOPHEN+NIMESULIDE during pregnancy is not recommended as taking this medicine during the last 3 months of pregnancy may harm the unborn baby. Consult your doctor for further advice.

    • Safety Warning

      Breast Feeding


      Use of ACETAMINOPHEN+NIMESULIDE during breastfeeding is not recommended as it may pass in very less amount through the milk and may harm the baby. Consult your doctor for further advice.

    • Safety Warning



      After taking ACETAMINOPHEN+NIMESULIDE, you may notice dizziness, sleepiness, drowsiness. So, you should stop taking ACETAMINOPHEN+NIMESULIDE and contact your doctor.

    • Safety Warning



      ACETAMINOPHEN+NIMESULIDE to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

    • Safety Warning



      ACETAMINOPHEN+NIMESULIDE to be taken with caution, especially if you have a history of Kidney diseases/conditions. The dose may have to be adjusted by your doctor.

    • Safety Warning



      ACETAMINOPHEN+NIMESULIDE is contraindicated in children below 20 kg body weight or younger than 6 years of age. It may cause kidney problems in children and adolescents who are dehydrated.

    Habit Forming


    Diet & Lifestyle Advise

    • Include more glucosamine, chondroitin sulfate, vitamin D, calcium-enriched supplements. Besides this, turmeric and fish oils can help in reducing inflammation in the tissue.
    • Please do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do stretching, low impact aerobic exercise like walking on a treadmill, bike riding and swimming. You can also strengthen your muscles by lifting light weights.
    • In chronic conditions of arthritis or joint pain, fish like salmon, trout, tuna and sardines. These fishes are enriched with omega-3 fatty acids that minimize chemical cytokines, which ramp up inflammation.
    • Your sitting posture is important, especially when you have pain and inflammation. Try to sit as little as possible and only for a short duration of time. Long term immobility is harmful in conditions like arthritis. Use back support like a rolled-up towel at the back of your spine curve to minimize pain. Keep your knees and hips at a right angle. Besides this, you can also use a footrest if required.

    Special Advise

    Inform your doctor about any bleeding disorders as nimesulide in ACETAMINOPHEN+NIMESULIDE should be taken with care as it may interference in the functioning of platelets.

    Patients Concern

    Disease/Condition Glossary

    Pain can be short term (acute) or long term (chronic) in nature. Acute pain is for a short time caused by damage to the tissues of the muscle, bone or organs. At the same time, chronic pain lasts for longer duration, it is caused due to pathologies like nerve damage, migraine, osteoarthritis and dental pain due to damage to the tooth nerve, infection, decay, extraction or injury. Many women have painful periods known as dysmenorrhea, most often menstrual cramps. On the other hand, Osteoarthritis is a degenerative disease that results in chronic pain in joints (especially the knee) and stiffness making daily tasks difficult.


    I am planning to get pregnant, is it safe to take ACETAMINOPHEN+NIMESULIDE?

    It is advised not to take ACETAMINOPHEN+NIMESULIDE if you planning to get pregnant as it contains nimesulide, which may affect your fertility. So, before starting ACETAMINOPHEN+NIMESULIDE, please consult your doctor.

    Can I take ACETAMINOPHEN+NIMESULIDE as a long term medication?

    It is advised not to take ACETAMINOPHEN+NIMESULIDE as a long term medication as it may lead to stomach ulcers/bleeding and kidney problems. For best results of ACETAMINOPHEN+NIMESULIDE, take it in doses and duration mentioned by your doctor.

    Can I take ACETAMINOPHEN+NIMESULIDE with food?

    Yes, ACETAMINOPHEN+NIMESULIDE should be preferably be taken with food to avoid an upset stomach. If taken on an empty stomach, it may cause stomach irritation and upset stomach.

    In which gastrointestinal disorders, shall I avoid taking ACETAMINOPHEN+NIMESULIDE?

    You should not take ACETAMINOPHEN+NIMESULIDE if you have a history of peptic ulceration, a history of gastrointestinal hemorrhage, Crohn's disease or ulcerative colitis.

    In which conditions should I avoid taking ACETAMINOPHEN+NIMESULIDE?

    You should avoid intake of ACETAMINOPHEN+NIMESULIDE if you are allergic to ACETAMINOPHEN+NIMESULIDE, nimesulide or paracetamol, a regular heavy alcohol drinker, liver disease (increased liver enzyme), any type of recent ulcer or bleeding, suffering from flu or fever (with chills), in the last trimester of pregnancy or breastfeeding mother.

    Does ACETAMINOPHEN+NIMESULIDE treat migraine

    No, ACETAMINOPHEN+NIMESULIDE does not treat migraine, it is used to relive from symptoms of mild migraine.

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