Pantoprazole+amoxycillin+clarithromycin
About Pantoprazole+amoxycillin+clarithromycin
Amoxycillin+clarithromycin+pantoprazole is used in the treatment of peptic ulcer disease caused by infection with a common type of bacteria called Helicobacter pylori (H. pylori). Peptic ulcers are sores (small, shallow wounds) that develop on the intestine and stomach's inner lining.
Amoxycillin+clarithromycin+pantoprazole is a combination of three drugs, namely: Pantoprazole, amoxycillin, and clarithromycin. Amoxycillin works by preventing the formation of bacterial cell covering (protective cell wall) necessary for their survival, thereby preventing the growth of bacteria. Clarithromycin stops bacterial growth but does not necessarily kill them. Pantoprazole reduces the amount of acid produced in the stomach. Altogether, Amoxycillin+clarithromycin+pantoprazole helps treat peptic ulcer disease.
In some cases, you may experience certain common side effects, such as nausea, diarrhoea, vomiting, stomach pain, taste change, and headache. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
Do not take Amoxycillin+clarithromycin+pantoprazole if you are pregnant or breastfeeding unless prescribed by the doctor. Amoxycillin+clarithromycin+pantoprazole causes drowsiness, so drive only if you are alert. Amoxycillin+clarithromycin+pantoprazole should not be given to children as safety has not been established. Avoid consuming alcohol along with Amoxycillin+clarithromycin+pantoprazole as it could lead to increased drowsiness and can elevate the production of stomach acid.
Uses of Pantoprazole+amoxycillin+clarithromycin
Medicinal Benefits
- Amoxycillin+clarithromycin+pantoprazole effectively treats Helicobacter pylori (H. pylori) infection in the stomach.
- Helps heal and prevent recurrence of peptic ulcers and gastric or duodenal ulcers.
- Pantoprazole reduces stomach acid production, creating a favourable environment for ulcer healing.
- Amoxycillin and clarithromycin work together to eliminate the H. pylori bacteria causing infection.
- Reduces symptoms such as heartburn, acidity, stomach pain, bloating, and indigestion.
- Offers a triple therapy approach for complete eradication of the infection.
- Improves digestive comfort and promotes long-term gastrointestinal health.
Directions for Use
- Take Amoxycillin+clarithromycin+pantoprazole 30-60 minutes before food as advised by your doctor.
- It is advised to take Amoxycillin+clarithromycin+pantoprazole as directed by your doctor, at the same time each day for best results.
- Swallow Amoxycillin+clarithromycin+pantoprazole as a whole with a glass of water.
- Do not crush, chew, or break it.
Storage
Side Effects of Pantoprazole+amoxycillin+clarithromycin
- Upset stomach or throwing up
- Diarrhoea
- Headache
- Bad taste in your mouth
- Belly pain
- Headache
- Rash
Drug Warnings
- Inform your doctor before taking Amoxycillin+clarithromycin+pantoprazole if you have a history of liver disease, kidney disease, or myasthenia gravis (neuromuscular disease).
- Do not take Amoxycillin+clarithromycin+pantoprazole if you are pregnant or breastfeeding unless prescribed by the doctor.
- Amoxycillin+clarithromycin+pantoprazole causes drowsiness, so drive only if you are alert.
- Amoxycillin+clarithromycin+pantoprazole should not be given to children as safety has not been established.
- Avoid consuming alcohol along with Amoxycillin+clarithromycin+pantoprazole as it could lead to increased drowsiness and can elevate the production of stomach acid.
- Keep your doctor informed about all the medicines and your health condition to rule out any side effects.
Drug Interactions
Drug-Drug Interactions: Amoxycillin+clarithromycin+pantoprazole may interact with medicines used to treat HIV (such as atazanavir, saquinavir, zidovudine), medicines used to treat fungal infections (such as fluconazole), medicines used to treat bacterial infections (such as itraconazole), medicines used to lower cholesterol levels (such as atorvastatin), medicines that help stop blood clots (such as warfarin), and vitamins (vitamin B12).
Food-Drug Interactions: Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
Drug-Disease Interactions: Amoxycillin+clarithromycin+pantoprazole may interact with gastrointestinal bleeding, diabetes, myasthenia gravis (neuromuscular disease), liver disease, bone fractures, hypomagnesemia (low levels of magnesium), and liver disease.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid consumption of alcohol while taking Amoxycillin+clarithromycin+pantoprazole. Alcohol intake leads to increased production of stomach acid.
Pregnancy
consult your doctorConsult your doctor before taking Amoxycillin+clarithromycin+pantoprazole if you are pregnant; your doctor will prescribe only if the benefits outweigh the risks.
Breast Feeding
consult your doctorConsult your doctor before taking Amoxycillin+clarithromycin+pantoprazole. Your doctor will decide whether Amoxycillin+clarithromycin+pantoprazole can be taken by breastfeeding mothers or not.
Driving
cautionAmoxycillin+clarithromycin+pantoprazole causes dizziness. Do not drive or operate machinery unless you are alert.
Liver
cautionDose adjustment may be needed. Consult your doctor before taking Amoxycillin+clarithromycin+pantoprazole if you have a liver impairment or any concerns regarding this.
Kidney
cautionDose adjustment may be needed. Consult your doctor before taking Amoxycillin+clarithromycin+pantoprazole if you have kidney impairment or any concerns regarding this.
Children
unsafeAmoxycillin+clarithromycin+pantoprazole should not be given to children as the safety and effectiveness were not established.
Habit Forming
Diet & Lifestyle Advise
- Eat smaller meals more often.
- Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
- Avoid tight-fitting clothes.
- Avoid foods such as high-fat, spicy foods, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea, and soda.
- Avoid sitting continuously, as it may trigger acidity. Take a 5-minute break every hour by doing brisk walking or stretching.
Special Advise
- Do not stop taking Amoxycillin+clarithromycin+pantoprazole on your own. Stopping abruptly might cause the symptoms to reappear and will make the infection difficult to treat due to antibiotic resistance.
- Make sure you drink plenty of fluids when you are sick. This will, in general help you clear out the infection faster, protect you from dehydration.
- If you feel nauseous after taking Amoxycillin+clarithromycin+pantoprazole, stick to simple meals like khichdi, dal roti and other home-cooked meals. Avoid spicy and fatty food.
Patients Concern
Disease/Condition Glossary
Peptic ulcers: Peptic ulcers are sores (small, shallow wounds) that develop on the stomach and intestine lining due to erosion of the stomach's protective lining. Symptoms include nausea, changes in appetite, bloody or dark stools, unexplained weight loss, vomiting, and indigestion-like pain. The indigestion-like pain can be brief or may last for hours; one may experience more severe pain when the stomach is empty or right after eating. If the ulcer is untreated, it may lead to several complications, such as internal bleeding, peritonitis (an ulcer perforating the wall of the stomach or small intestine), and pyloric stenosis (chronic inflammation of the lining of the stomach or duodenum). Taking prescribed medicines like Amoxycillin+clarithromycin+pantoprazole helps to relieve symptoms associated with peptic ulcer disease.
FAQs
Amoxycillin+clarithromycin+pantoprazole is used in the treatment of peptic ulcer disease caused by infection with a common type of bacteria called Helicobacter pylori (H. pylori). It works by inhibiting the action of the gastric proton pump and preventing the growth of microorganisms.
Speak to your doctor if you do not feel better even after taking Amoxycillin+clarithromycin+pantoprazole for 14 days. Do not take Amoxycillin+clarithromycin+pantoprazole for longer durations unless prescribed by the doctor.
Amoxycillin+clarithromycin+pantoprazole may cause dizziness. Drive only if you are alert, and do not operate machinery if you feel dizzy after taking Amoxycillin+clarithromycin+pantoprazole.
Avoid or limit the consumption of alcohol while on Amoxycillin+clarithromycin+pantoprazole as it may lead to increased dizziness. Alcohol intake may also lead to excess production of stomach acid, thereby increasing acidity and heartburn.
Diarrhoea might be a side-effect of Amoxycillin+clarithromycin+pantoprazole. Drink enough fluids and eat fibre-rich food if you experience diarrhoea after taking Amoxycillin+clarithromycin+pantoprazole. If you find blood in your stools (tarry stools) or experience excess diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.
Amoxycillin+clarithromycin+pantoprazole contains pantoprazole, which may increase the risk of bone fracture in the hip, spine, or wrist. Recent clinical studies indicated that pantoprazole may affect the absorption of certain nutrients and minerals required for maintaining good bone health, leading to fractures. This mainly occurs in people taking higher doses of Amoxycillin+clarithromycin+pantoprazole for longer durations. Inform your doctor before taking Amoxycillin+clarithromycin+pantoprazole if you have osteoporosis or if you are already taking corticosteroids.
Dry mouth could be a side effect of Amoxycillin+clarithromycin+pantoprazole. Limiting caffeine intake, avoiding smoking, drinking enough water, and chewing sugar-free gum or candy might help stimulate saliva production and thereby prevent dry mouth.
Inform your doctor if you don’t get better after finishing the full course of treatment. Also, let your doctor know if your symptoms are getting worse while using Amoxycillin+clarithromycin+pantoprazole. Your doctor may need to reassess your condition, possibly perform additional tests, and prescribe a different treatment if necessary.
A peptic ulcer is a sore that develops on the lining of your stomach, lower esophagus, or small intestine. It's usually caused by an infection with Helicobacter pylori (H. pylori) bacteria or prolonged use of nonsteroidal anti-inflammatory drugs (NSAIDs).
Do not use Amoxycillin+clarithromycin+pantoprazole if you have a known hypersensitivity to Amoxycillin+clarithromycin+pantoprazole. Use Amoxycillin+clarithromycin+pantoprazole with caution if you have liver disease, as the antibiotics in Amoxycillin+clarithromycin+pantoprazole can affect liver function. Inform your doctor if you have or ever had gastrointestinal bleeding, diabetes, myasthenia gravis (neuromuscular disease), bone fractures, or hypomagnesemia (low levels of magnesium). Also, let your doctor know if you are breastfeeding, pregnant or planning pregnancy.
Take Amoxycillin+clarithromycin+pantoprazole 30-60 minutes before food or as advised by your doctor. Swallow it as a whole with a glass of water. But try to take it at the same time each day for better efficacy. Do not crush or chew it.
No, do not stop using Amoxycillin+clarithromycin+pantoprazole even if you feel better, as stopping Amoxycillin+clarithromycin+pantoprazole early can leave the infection untreated, which could lead to side effects. Therefore, complete the full course of treatment as prescribed by your doctor.
Common side effects of Amoxycillin+clarithromycin+pantoprazole include nausea, diarrhoea, vomiting, stomach pain, altered taste, and headache. If any of these side effects persist or worsen, please consult your doctor.
