After taking CEFOPERAZONE+SULBACTAM if you have allergy-like symptoms including rash, swelling of the face/lips/throat, difficulty in breathing, or tightness in the chest, immediately contact your doctor. Do not take CEFOPERAZONE+SULBACTAM if you have an allergy to CEFOPERAZONE+SULBACTAM, cephalosporins penicillin class of antibiotics as it may cause a skin rash, itching, and difficulty in breathing. People having liver disease or jaundice (yellowing of skin/eye) should not take CEFOPERAZONE+SULBACTAM, as it can damage your liver severely. You may have diarrhoea in some cases which can be managed by taking it with any probiotics and plenty of fluids. Do not take antacids along with CEFOPERAZONE+SULBACTAM; maintain a gap of 2-3 hours between both. Avoid alcohol consumption while taking CEFOPERAZONE+SULBACTAM to prevent unpleasant side-effects. CEFOPERAZONE+SULBACTAM may cause dizziness, so be cautious while driving. Inform your doctor about all the medicines you are taking and about your health condition to rule out any unpleasant side-effects.

Drug-Drug Interactions: CEFOPERAZONE+SULBACTAM may have interaction with a diuretic (furosemide), anticoagulants (warfarin), other antibiotics (gentamicin).

Drug-Food Interactions: No interactions found/established.

Drug-disease interactions: CEFOPERAZONE+SULBACTAM may have interactions with colitis (inflammation in the lining of the colon), seizures, dialysis, kidney, and liver dysfunction.

• Probiotics should be taken after taking the full course of CEFOPERAZONE+SULBACTAM in order to restore some healthy bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yoghurt, cheese, sauerkraut, kombucha, and kimchi can help to restore the good bacteria of the intestine.
• Include more fibre-enriched food in your diet, as it can be easily digested by your gut bacteria, which helps stimulate their growth. Thus, fibre-rich foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains like whole-grain bread, brown rice should be included in your diet.
• Avoid intake of alcoholic beverages with CEFOPERAZONE+SULBACTAM as it can make you dehydrated and may affect your sleep. This can make it harder for your body to aid the CEFOPERAZONE+SULBACTAM in fighting off infections.

• Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection harder to treat.
• Discontinue CEFOPERAZONE+SULBACTAM and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.
• Diarrhoea may occur as a side effect but should stop when your course is complete. Inform your doctor if it does not stop or if you find blood in your stools.
• CEFOPERAZONE+SULBACTAM is preferably taken with food to avoid an upset stomach.
• Some people may be allergic to CEFOPERAZONE+SULBACTAM or other penicillin or cephalosporin group of antibiotics. So a prior sensitivity test may be necessary. Inform your doctor if you are allergic to any medicine particularly antibiotics belong to these groups.
• If you feel nauseous after taking CEFOPERAZONE+SULBACTAM, stick to simple meals like porridge, khichdi, dal roti, and other home-cooked meals. Avoid spicy and fatty food.