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About GUAIFENESIN+DEXTROMETHORPHAN+PHENYLEPHRINE+CHLORPHENIRAMINE

CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE belongs to a class of medications called ‘expectorants’ primarily used to treat dry cough. Additionally, CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE also treats allergy symptoms such as sneezing, runny nose, throat irritation or watery eyes. Coughing (dry or productive) is a body’s way of clearing irritants (like allergens, mucus or smoke) from airways and preventing infection. There are two types of coughs, namely: Dry cough and chesty cough. A dry cough is tickly and doesn't produce any vicious or thick mucus, while a chesty cough (wet cough) means mucous or sputum is produced to help clear your airways. 

CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE is a combination of four drugs, namely: Guaifenesin (expectorant), Dextromethorphan (cough suppressant), Phenylephrine (decongestant) and Chlorpheniramine (antihistamine). Guaifenesin belongs to the class of expectorants that increase the volume of fluid in the airways, reduce the stickiness of mucus, and remove it from the airways. Dextromethorphan is a cough suppressant that works by blocking the transmission of nerve signals from the cough centre in the brain to the muscles that produce cough. Thus, it decreases the need to cough. Phenylephrine is a decongestant that works by contracting and narrowing the blood vessels. Thereby, provides relief from congestion and decreases mucus production. Chlorpheniramine belongs to the class of antihistamines (anti-allergic drugs) that works by blocking the action of histamine, a substance responsible for causing allergic reactions.

Take CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE with or without food as advised by your doctor with the help of a measuring cup. Your doctor will recommend how often you take CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE based on your medical condition. Some people may experience nausea, stomach upset, vomiting, loss of appetite, drowsiness, headache, diarrhoea, dizziness or skin rash. Most of these side effects of CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to inform your doctor before using CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE. CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE is not recommended for children below 12 years of age. If you are about to undergo any medical tests or surgery, please inform your doctor that you are taking CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE. Drink plenty of fluids while taking CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE to loosen the congestion. If you have high blood pressure, fits, glaucoma, hyperthyroidism (overactive thyroid), chronic bronchitis, asthma, cough with mucus, cough caused by smoking, chronic bronchitis or emphysema (a lung condition causing shortness of breath), chronic obstructive pulmonary disease (COPD), blockage in stomach or intestines, phenylketonuria (a congenital disability that causes accumulation of amino acid, phenylalanine in the body), enlarged prostate, pheochromocytoma (tumour in the adrenal glands), kidney, liver, heart or urinary problems, inform your doctor before taking CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE.

Uses of GUAIFENESIN+DEXTROMETHORPHAN+PHENYLEPHRINE+CHLORPHENIRAMINE

Dry cough

Medicinal Benefits

CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE is a combination of four drugs, namely: Guaifenesin, Dextromethorphan, Phenylephrine and Chlorpheniramine. Guaifenesin belongs to the class of expectorants that works by increasing the volume of fluid in the airways, reduce the stickiness of mucus and helps to remove it from airways. Dextromethorphan is a cough suppressant that blocks the transmission of nerve signals from the cough centre in the brain to the muscles that produce cough. Thus, it decreases the need to cough. Phenylephrine is a decongestant that works by contracting and narrowing the blood vessels. Thereby, provides relief from congestion and decreases mucus production. Chlorpheniramine is an antihistamine (anti-allergic drug) that works by blocking the action of histamine, a substance responsible for causing allergic reactions and provides relief from symptoms of allergy such as sneezing, running nose, watery eyes, itching, swelling, and congestion or stiffness.

Directions for Use

Shake the bottle well before use. Check the label for directions and take CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE with or without food in doses as prescribed by your doctor with the help of a measuring cup that is provided with the pack.

Storage

Store in a cool and dry place away from sunlight

Side Effects of GUAIFENESIN+DEXTROMETHORPHAN+PHENYLEPHRINE+CHLORPHENIRAMINE

Like all medicines, CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE can cause some common side effects such as nausea, stomach upset, vomiting, loss of appetite, drowsiness, headache, diarrhoea, dizziness or skin rash. Most of these side effects of CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE do not require medical attention and gradually resolve over time. However, if the side effects worsen or persist, please consult your doctor.

In-Depth Precautions and Warning

Drug Warnings

If you are allergic to CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to inform your doctor before using CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE. CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE is not recommended for children below 12 years of age. If you are about to undergo any medical tests or surgery, please inform your doctor that you are taking CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE. Avoid using CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE if you have taken medicines such as linezolid, phenelzine, selegiline, rasagiline, isocarboxazid, tranylcypromine and methylene blue injection in the past 14 days. If you have high blood pressure, fits, glaucoma, hyperthyroidism (overactive thyroid), chronic bronchitis, asthma, cough with mucus, cough caused by smoking, chronic bronchitis or emphysema (a lung condition causing shortness of breath), chronic obstructive pulmonary disease (COPD), blockage in stomach or intestines, phenylketonuria (a birth defect that causes accumulation of amino acid, phenylalanine in the body), enlarged prostate, pheochromocytoma (tumour in the adrenal glands), kidney, liver, heart or urinary problems, inform your doctor before taking CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE.

Drug Interactions

Drug-Drug Interaction: CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE may have interaction with anti-allergic drugs (diphenhydramine, cetirizine), antidepressants (duloxetine, sertraline, escitalopram), narcotic analgesics (hydrocodone, codeine), antianxiety drug (alprazolam), central nervous system stimulants (methylphenidate), antipsychotics  (quetiapine), medicines used to treat irregular heartbeats  (quinidine), anticonvulsants (pregabalin), a central nervous system stimulant (amphetamine).

Drug-Food Interaction: Avoid or limit the intake of chocolate and caffeine-containing foods such as cocoa beans and tea leaves with CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE as they may increase the risk of severity of side effects. Also, avoid consumption of alcohol with CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE as it may increase the risk of adverse effects such as drowsiness, dizziness or difficulty in concentrating.

Drug-Disease Interaction: If you have high blood pressure, fits, glaucoma, hyperthyroidism (overactive thyroid), chronic bronchitis, asthma, cough with mucus, cough caused by smoking, chronic bronchitis or emphysema (a lung condition causing shortness of breath), chronic obstructive pulmonary disease (COPD), blockage in stomach or intestines, phenylketonuria (a birth defect that causes accumulation of amino acid, phenylalanine in the body), enlarged prostate, pheochromocytoma (tumour in the adrenal glands), kidney, liver, heart or urinary problems, inform your doctor before taking CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE.

Safety Advice

  • Safety Warning

    Alcohol

    Consult Your Doctor

    Avoid consumption of alcohol with CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE as it may increase adverse effects. Please consult a doctor before consuming alcohol with CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE.

  • Safety Warning

    Pregnancy

    Please consult a doctor if you are pregnant. CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE is given to pregnant women only if the doctor thinks benefits outweigh risks.

  • Safety Warning

    Breast Feeding

    It is unknown whether CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE is excreted in human milk. CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE is given to breastfeeding mothers only if the doctor thinks benefits are greater than risks.

  • Safety Warning

    Driving

    CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE may impair thinking or cause blurred vision in some people. Therefore, drive only if you are alert after taking CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE.

  • Safety Warning

    Liver

    Take CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

  • Safety Warning

    Kidney

    Take CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

Habit Forming

No

Diet & Lifestyle Advise

  • Avoid dairy products such as milk as they may increase mucus production. Also, avoid processed or refined foods to have relief from cough. Instead replace baked foods, fried foods, white bread, white pasta, French fries, sugary desserts and chips with green leafy vegetables.
  • Drink plenty of fluids to avoid dry throat while you have a cough and loosen mucus.
  • Avoid citrus fruits as they may worsen the cough. Eat fruits rich in water content such as pears, watermelon, peaches and pineapples.

Special Advise

  • You are recommended to inform your doctor that you are taking CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE before undergoing any medical tests or surgery.
  • Drink plenty of fluids while taking CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE to loosen the congestion of nasal passage and airways. If you are a kidney patient, ask a doctor before taking fluid. 

Patients Concern

Disease/Condition Glossary

Cough: Coughing is a body’s way of clearing irritants (like allergens, mucus or smoke) from airways and preventing infection. Coughs may be dry or productive. A productive cough (wet cough) brings up sputum (phlegm, mucus and other matter) from the lungs. Cough is commonly caused as a response to allergy or viral infection but coughing up mucus is possibly an indication of infection in the respiratory tract. If you are coughing thick, solid white mucus, it indicates you may have a bacterial infection in the airways. If the mucus is clear or light-coloured, it indicates you may have allergies or minor infection in the respiratory tract, and yellow or green mucus indicates a respiratory infection.

Allergies: It occurs when foreign elements known as allergens attacks and invade our body, thereby causing the release of histamines. This chemical messenger 'histamines' causes swelling, inflammation, redness, itchiness, itchy/watery nose and throat, and watery eyes. Allergies generally occur due to chemicals, air pollution, pet danders, dust, pollen hairs, seasonal allergies like hay fever etc.

FAQs

CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE contains Guaifenesin, Dextromethorphan, Phenylephrine and Chlorpheniramine. Guaifenesin belongs to the class of expectorants that works by increasing the volume of fluid in the airways, reduce the stickiness of mucus and helps to remove it from airways. Dextromethorphan is a cough suppressant that blocks the transmission of nerve signals from the cough centre in the brain to the muscles that produce cough. Thus, decreases the need to cough. Phenylephrine is a decongestant that works by contracting and narrowing the blood vessels. Thereby, provides relief from congestion and decreases mucus production. Chlorpheniramine is an antihistamine (anti-allergic drug) that works by blocking the action of histamine, a substance responsible for causing allergic reactions and provides relief from symptoms of allergy.

CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE may be used to provide relief from allergic symptoms such as sneezing, runny nose, throat irritation or watery eyes. CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE contains Triprolidine, an anti-allergic drug that works by blocking the action of histamine, a substance responsible for causing allergic reactions.

You are not recommended to take CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE with selegiline or other MAO inhibitors such as linezolid, phenelzine, selegiline, rasagiline, isocarboxazid, tranylcypromine and methylene blue injection at the same time as it may cause severe high blood pressure which may lead to stroke. Therefore, if you have taken any of these medicines in the past 14 days, avoid taking CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE and consult a doctor for proper advice.

You are recommended to avoid taking CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE if you have asthma, enlarged prostate, blockage in stomach or intestines, glaucoma or if you are unable to urinate. However, please consult a doctor if you have any of these conditions before taking CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE.

You are not recommended to take CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE with duloxetine as it may lead to a severe condition called ‘serotonin syndrome’ and cause symptoms such as blurred vision, stomach cramps, diarrhoea, hallucination, extreme changes in blood pressure, confusion, excessive sweating, increased heart rate, fever, shivering or shaking, tremor, incoordination, muscle spasm or stiffness. However, please consult a doctor before taking CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE with other medicines.

You are recommended to take CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE for as long as your doctor has prescribed it. However, if the symptoms persist or worsen with rash, fever or persistent headache after 1 week of using CHLORPHENIRAMINE+DEXTROMETHORPHAN+GUAIFENESIN+PHENYLEPHRINE, please consult your doctor.