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CINNARIZINE+DOMPERIDONE

About

CINNARIZINE+DOMPERIDONE is a combination of anti-histamine and anti-emetic drugs, primarily used to treat Meniere's disease (inner ear disorder), which can cause vertigo (a spinning sensation or dizziness), ringing in the ears, nausea (feeling sick), vomiting, and loss of hearing. Meniere's disease occurs when the inner ear is affected and causes episodes of vertigo (spinning). It also leads to hearing problems and a ringing sound in the ear.

CINNARIZINE+DOMPERIDONE consists of 'Cinnarizine' (anti-histamine) and 'Domperidone' (anti-emetic). Cinnarizine is an anti-histamine drug that blocks the effects of histamine (a chemical substance produced in response to allergy) in the brain to reduce the symptoms of travel sickness. It is also a calcium channel blocker and improves blood circulation in the inner ear, thus reducing symptoms caused by vertigo, tinnitus (ringing in the ear), and Meniere's disease. Domperidone is an anti-emetic drug (that eases vomiting symptoms) and dopamine (chemical messenger) antagonist. It works by blocking the action of dopamine in the brain, which causes nausea and vomiting. It also increases the movements and contractions of stomach muscles. Domperidone is also a prokinetic agent that controls acid reflux. 

Your doctor will decide the dose and duration based on the severity of your disease. Common side effects of CINNARIZINE+DOMPERIDONE include drowsiness, nausea, dry mouth, indigestion, and weight gain. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

If you use other prescription or non-prescription medicines, inform your doctor before using CINNARIZINE+DOMPERIDONE. Let your doctor know if you have any liver, kidney, or heart diseases, Parkinson's disease, blood disorders (porphyria), and allergic reactions before starting CINNARIZINE+DOMPERIDONE. CINNARIZINE+DOMPERIDONE may cause weight gain in some cases, so avoid eating junk and eat a healthy, balanced diet, including home-cooked food. Consult your doctor before taking CINNARIZINE+DOMPERIDONE if you are pregnant, planning for pregnancy, or breastfeeding. Avoid consuming alcohol along with CINNARIZINE+DOMPERIDONE as it could lead to increased drowsiness. 

Uses of CINNARIZINE+DOMPERIDONE

Meniere's disease, vertigo, tinnitus, nausea, and vomiting.

Medicinal Benefits

CINNARIZINE+DOMPERIDONE is used to treat inner ear disorders, vertigo, nausea, and vomiting. It consists of Cinnarizine and Domperidone. Cinnarizine is an antihistamine drug that blocks the effects of histamine (a chemical substance produced in response to allergy) in the brain to reduce symptoms of travel sickness. It is also a calcium channel blocker and improves blood circulation in the inner ear, thus reducing symptoms caused by vertigo, tinnitus (ringing in the ear), and Meniere's disease. Domperidone is an anti-emetic drug (that eases vomiting symptoms) that works by blocking the action of dopamine in the brain, which causes nausea and vomiting. It is also a prokinetic agent that controls acid reflux and increases stomach muscle movements and contractions.

Directions for Use

Swallow CINNARIZINE+DOMPERIDONE as a whole with a glass of water, do not chew, crush or break it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of CINNARIZINE+DOMPERIDONE

  • Drowsiness
  • Nausea
  • Dry mouth
  • Indigestion
  • Weight gain 
  • Headache
  • Tiredness

In-Depth Precautions and Warning

Drug Warnings

Inform your doctor if you have a history of renal failure, liver diseases, Parkinson's disease (brain disorder), blood disorders (porphyria), heart rhythm problems, and cardiac arrest before starting CINNARIZINE+DOMPERIDONE. Let your doctor know in advance if you use any medicines that treat fungal/bacterial infections and AIDS/HIV. CINNARIZINE+DOMPERIDONE can cause weight gain; hence it is advised to maintain a well-balanced, healthy lifestyle. Please consult your doctor if you are pregnant, planning to conceive or a breastfeeding mother if the doctor advised you CINNARIZINE+DOMPERIDONE. Avoid consuming alcohol along with CINNARIZINE+DOMPERIDONE as it could lead to increased dizziness and drowsiness. CINNARIZINE+DOMPERIDONE may cause sleepiness, so drive only if you are alert. 

Drug Interactions

Drug-Drug Interaction: CINNARIZINE+DOMPERIDONE may interact with antidepressants (escitalopram, amitriptyline), anti-fungal agents (ketoconazole), antibiotics (erythromycin, moxifloxacin), heart-related drugs (amiodarone, sotalol), antipsychotics (haloperidol, pimozide), stomach related drugs (cisapride, dolasetron), anti-allergic drugs (mequitazine), anti-malarial medicine (halofantrine), anti-cancer drugs (toremifene, vandetanib), drugs treating HIV/AIDS (ritonavir), and pain killers (opioids).

Drug-Food Interaction: Alcohol may cause dizziness and drowsiness when taken with CINNARIZINE+DOMPERIDONE.

Drug-Disease Interaction: Before using CINNARIZINE+DOMPERIDONE, let your doctor know if you have any history of renal failure, liver diseases, Parkinson's disease (brain disorder), blood disorders (porphyria), heart rhythm problems, and cardiac arrest.

Drug-Drug Interactions Checker List:

  • ESCITALOPRAM
  • AMITRIPTYLINE
  • KETOCONAZOLE
  • ERYTHROMYCIN
  • MOXIFLOXACIN
  • AMIODARONE
  • HALOPERIDOL
  • PIMOZIDE
  • CISAPRIDE
  • DOLASETRON
  • MEQUITAZINE
  • HALOFANTRINE
  • VANDETANIB
  • RITONAVIR
  • Safety Advice

    • Safety Warning

      Alcohol

      unsafe

      You are recommended to avoid alcohol consumption while taking CINNARIZINE+DOMPERIDONE. Alcohol intake, along with CINNARIZINE+DOMPERIDONE, may cause increased dizziness and drowsiness.

    • Safety Warning

      Pregnancy

      caution

      Please consult your doctor if you are pregnant or planning to conceive before starting CINNARIZINE+DOMPERIDONE.

    • Safety Warning

      Breast Feeding

      caution

      Please consult your doctor before taking CINNARIZINE+DOMPERIDONE if you are breastfeeding mother.

    • Safety Warning

      Driving

      unsafe

      CINNARIZINE+DOMPERIDONE may make you feel drowsy. Do not drive or operate machinery if you experience drowsiness.

    • Safety Warning

      Liver

      caution

      CINNARIZINE+DOMPERIDONE should be cautiously administered in patients with liver diseases. Please consult your doctor if you have a history of liver impairment before starting CINNARIZINE+DOMPERIDONE.

    • Safety Warning

      Kidney

      caution

      CINNARIZINE+DOMPERIDONE should be cautiously administered in patients with kidney problems. Please consult your doctor if you have a history of kidney impairment/kidney disease.

    • Safety Warning

      Children

      caution

      CINNARIZINE+DOMPERIDONE is not recommended for children below five years of age. Domperidone in CINNARIZINE+DOMPERIDONE is not recommended in children who weigh less than 35kg.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Avoid chocolates, junk food, cheese, processed food, alcohol, and smoking. Instead, eat a healthy diet and do regular exercise to avoid weight gain caused due to CINNARIZINE+DOMPERIDONE.
    • You can try increasing your mindfulness by doing yoga, meditation, mindfulness-based cognitive therapy, and stress reduction techniques.
    • Drink enough water to stay hydrated and limit or avoid alcohol and caffeine.
    • Include a diet rich in whole grains, vegetables, and fruits. This is a healthier option than eating a lot of simple carbohydrates found in processed foods.
    • You can include antioxidants in your daily diet like ashwagandha, omega-3 fatty acids, green tea, and lemon balm.
    • Try to spend time with your friends and family. Having a strong social network may help you lower your risk of anxiety.
    • You can manage vertigo by avoiding dehydration, taking a low sodium diet, reducing alcohol intake, and managing stress. 
    • Sitting down right away and rising slowly may help relieve vertigo. To improve your balance, you can also use a cane. 
    • Your doctor may also suggest physiotherapy exercises to manage your posture and balance.

    Special Advise

    • Let your doctor know that you are taking CINNARIZINE+DOMPERIDONE if you are undergoing any medical tests.
    • CINNARIZINE+DOMPERIDONE may cause abnormal liver function tests, hence caution is recommended.

    Patients Concern

    Disease/Condition Glossary

    Meniere's disease occurs when the inner ear is affected and causes vertigo episodes (spinning sensation). Meniere's disease usually affects one ear. Symptoms include severe dizziness (vertigo), ringing in the ears (tinnitus), hearing loss, and a feeling of fullness or congestion in the ear.

    Nausea is defined as stomach discomfort and the sensation of an urge to vomit.

    Vomiting is the forcible voluntary or involuntary emptying of contents of the stomach through the mouth. Nausea or vomiting may be triggered by many factors, including food poisoning, gastritis (inflammation of the stomach lining), an ulcer, or bulimia (eating disorder).

    FAQs

    CINNARIZINE+DOMPERIDONE is used to treat Meniere's disease (inner ear disorder), which can cause vertigo (a spinning sensation or dizziness), ringing in the ears, nausea (feeling sick), vomiting, and loss of hearing.

    CINNARIZINE+DOMPERIDONE is a combination of Cinnarizine and Domperidone. Cinnarizine improves blood circulation in the inner ear. Domperidone controls acid reflux and increases the movements and contractions of stomach muscles. Collectively, CINNARIZINE+DOMPERIDONE treats Meniere's disease, vertigo, nausea, and vomiting.

    CINNARIZINE+DOMPERIDONE may sometimes cause weight gain during its prolonged use. It is always advised to maintain a well-balanced, healthy diet and exercise regularly.

    CINNARIZINE+DOMPERIDONE is contraindicated in renal failure, liver diseases, Parkinson's disease (brain disorder), blood disorders (porphyria), heart rhythm problems, and cardiac arrest. Inform your doctor beforehand if you use any medicines treating fungal/bacterial infections and AIDS/HIV. Please consult your doctor before starting CINNARIZINE+DOMPERIDONE if you have a medical history.

    You are advised to complete the course prescribed by your doctor. Please do not stop taking this medicine unless advised by your doctor since it may lead to recurrent episodes of dizziness and spinning.

    Apart from medications, you can manage vertigo by avoiding dehydration, taking a low sodium diet, reducing alcohol intake, and managing stress. Sitting down right away and rising slowly may help relieve vertigo. To improve your balance, you can also use a cane. Your doctor may also suggest physiotherapy exercises to manage your balance.

    Available Medicines for

    CINNARIZINE+DOMPERIDONE

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